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Muscle mitochondrial DNA deletion and 31P-NMR spectroscopy alterations in a migraine patient.

Abstract：

:A 40-year-old female suffering from recurrent migrainous strokes is reported. She did not show any muscle weakness or wasting. Ragged red and cytochrome c oxidase negative fibers were present in the muscle biopsy. Muscle mitochondrial DNA analysis showed a 5 kb deletion, without a point mutation at nucleotide pair 3243 in the mitochondrial tRNALeu(UUR) gene. Phosphorus nuclear magnetic resonance spectroscopy of brain and gastrocnemius muscle showed a defective energy metabolism in both organs. An increased inorganic phosphate to phosphocreatine ratio due to a decreased phosphocreatine content was found in the occipital lobes, while an abnormal work-energy cost transfer function and a low rate of phosphocreatine post-exercise recovery were found in the muscle.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Bresolin N,Martinelli P,Barbiroli B,Zaniol P,Ausenda C,Montagna P,Gallanti A,Comi GP,Scarlato G,Lugaresi E

doi

10.1016/0022-510x(91)90308-t

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

182-9

issue

2

eissn

0022-510X

issn

1878-5883

pii

0022-510X(91)90308-T

journal_volume

104

pub_type

杂志文章

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