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Relation between MRI features and dementia in cerebrovascular disease patients with leukoaraiosis: a longitudinal study.

Abstract：

:We examined selective MRI features (localization and degree of white matter abnormalities, cortical and subcortical atrophy) in relation to cognitive decline in patients with cerebrovascular disease (CVD) and leukoaraiosis (LA). We enrolled 6 female and 18 male CVD patients (mean age 66.2 +/- 6.6 years) whose Magnetic Resonance Images (MRI) revealed LA and who displayed a history of stroke or TIA; none showed signs of cortical infarcts or normal pressure hydrocephalus. Two blind raters independently scored MRI scans with a high level of agreement. All patients underwent extensive clinico-neuropsychological assessment upon admission to the study and 19 were followed for an average of 48 +/- 7.6 months. Twelve patients were initially classified as non-demented and 12 as demented. Three years later, one in the former group had become demented and mental impairment had worsened for 6 patients in the latter group; these 7 subjects were labeled as "decliners". Ventricular indexes were significantly higher in the demented group and correlated with severity of mental impairment, while the degree of LA was similar in demented and non-demented subjects. Neither white matter lesions nor sulcal and ventricular enlargement differed statistically between decliners and non-decliners.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Bracco L,Campani D,Baratti E,Lippi A,Inzitari D,Pracucci G,Amaducci L

doi

10.1016/0022-510x(93)90263-x

subject

Has Abstract

pub_date

1993-12-15 00:00:00

pages

131-6

issue

2

eissn

0022-510X

issn

1878-5883

pii

0022-510X(93)90263-X

journal_volume

120

pub_type

杂志文章

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