Direct and indirect cost burden associated with multiple sclerosis relapses: excess costs of persons with MS and their spouse caregivers.

Abstract:

BACKGROUND:MS relapses are unpredictable and can be concerning to patients and their caregivers. OBJECTIVE:To assess the direct and indirect cost burden associated with relapses of different severities in MS patients and with MS relapse frequency on spouse caregivers. METHODS:Using a U.S. insurance claims and employee disability database (1999-2011), we studied adult MS patients (ICD-9-CM: 340.x) and their spouse caregivers. A previously published algorithm to identify relapses was used to stratify: (1) MS patients into cohorts of no, low/moderate, and high severity relapse based on the most severe relapse within one year of follow-up (if any); (2) caregivers into cohorts of no, less, and more frequent relapses based on the overall frequency of relapses of their spouse. Adjusted cost differences and 95% confidence intervals evaluating the yearly incremental costs at 12 months of follow-up (MS patients) and overall (caregivers) associated with relapses are reported. RESULTS:Among the 9421 MS patients (N: no relapse=7686; low/moderate severity relapse=1220; high severity relapse=515) identified, both relapse cohorts incurred significantly higher annual incremental direct costs than the no relapse cohort (low/moderate severity=$8269 [6565-10,115]; high severity=$24,180 [20,263-28,482]) and indirect costs (low/moderate severity=$1429 [759-2147]; high severity=$2714 [1468-4035]). More frequent relapses versus no relapse also translated into a significantly greater cost burden for caregivers (direct+indirect=$1725 [376-2885]) but less frequent relapses did not. CONCLUSIONS:Relapse severity was significantly and increasingly associated with greater direct and indirect costs in MS patients. More frequent relapses also translated into a significant cost burden in spouse caregivers.

journal_name

J Neurol Sci

authors

Parisé H,Laliberté F,Lefebvre P,Duh MS,Kim E,Agashivala N,Abouzaid S,Weinstock-Guttman B

doi

10.1016/j.jns.2013.04.007

subject

Has Abstract

pub_date

2013-07-15 00:00:00

pages

71-7

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(13)00169-X

journal_volume

330

pub_type

杂志文章
  • Cytokine and chemokine mRNA expressing cells in muscle tissues of experimental autoimmune myasthenia gravis.

    abstract::In-situ hybridization with labeled oligonucleotide probes was applied to explore cytokine and chemokine mRNA expression in sections of striated muscle, the target organ in experimental autoimmune myasthenia gravis (EAMG), induced in Lewis rats by immunization with acetylcholine receptor (AChR) and complete Freund's ad...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(98)00181-6

    authors: Li H,Shi FD,Bai X,Huang Y,Diab A,He B,Link H

    更新日期:1998-11-26 00:00:00

  • Bilateral basal ganglia lesions as initial manifestation of CNS invasion in adult T-cell leukemia.

    abstract::We describe the case of a 67-year-old man who exhibited unsteadiness in walking, topographical disorientation, and urinary incontinence. Neurological examination revealed somnolence and mild weakness in the lower limbs with slight rigidity in the upper limbs. Cerebrospinal fluid examination showed pleocytosis with "fl...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2013.01.035

    authors: Matsuo Y,Yamashita S,Honda S,Nakajima M,Ueda A,Hirahara T,Yamashita T,Maeda Y,Hirano T,Ando Y

    更新日期:2013-04-15 00:00:00

  • Neuronal type of Charcot-Marie-Tooth disease with a syndrome of continuous motor unit activity.

    abstract::The clinical, genetic and electrophysiological study of 3 patients with an association of a neuronal form of Charcot-Marie-Tooth Disease (CMTD) with a syndrome of continuous motor unit activity (CMUA) are reported, with light and electron microscopy of muscle and sural nerve biopsies in 2 patients. The unusual clinica...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(84)90105-9

    authors: Vasilescu C,Alexianu M,Dan A

    更新日期:1984-01-01 00:00:00

  • Metronidazole-induced encephalopathy.

    abstract::We report the clinical, neuropsychological, and neuroimaging findings of two patients of diffuse encephalopathy associated with the use of metronidazole. Both patients showed characteristic abnormalities on magnetic resonance imaging (MRI) with diffusion weighted imaging (DWI) and recovered incompletely after the disc...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2004.06.012

    authors: Kim DW,Park JM,Yoon BW,Baek MJ,Kim JE,Kim S

    更新日期:2004-09-15 00:00:00

  • Acute vertigo due to hemispheric stroke: a case report and comprehensive review of the literature.

    abstract::Acute cortical lesions rarely cause vertigo. We report a 51-year-old patient presenting with an acute vestibular syndrome including spontaneous vertigo and nystagmus, lateropulsion and nausea due to middle cerebral artery infarction. The central origin of the acute vestibular syndrome was revealed by a normal head imp...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.jns.2014.02.005

    authors: von Brevern M,Süßmilch S,Zeise D

    更新日期:2014-04-15 00:00:00

  • Anosmia is associated with lower in-hospital mortality in COVID-19.

    abstract:BACKGROUND:Anosmia is common in Coronavirus disease 2019, but its impact on prognosis is unknown. We analysed whether anosmia predicts in-hospital mortality; and if patients with anosmia have a different clinical presentation, inflammatory response, or disease severity. METHODS:Retrospective cohort study including all...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2020.117163

    authors: Talavera B,García-Azorín D,Martínez-Pías E,Trigo J,Hernández-Pérez I,Valle-Peñacoba G,Simón-Campo P,de Lera M,Chavarría-Miranda A,López-Sanz C,Gutiérrez-Sánchez M,Martínez-Velasco E,Pedraza M,Sierra Á,Gómez-Vicente B,Guerre

    更新日期:2020-12-15 00:00:00

  • Serial diffusion-weighted magnetic resonance imaging in adult-onset citrullinaemia.

    abstract::A 25-year-old Chinese man presented with a 2-year history of recurrent coma. His plasma ammonia level was extremely elevated, with raised citrulline level and absence of argininosuccinic acid. Adult-onset citrullinaemia, a condition rarely reported outside the Japanese population, was diagnosed. Serial magnetic resona...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(02)00439-2

    authors: Au WL,Lim TC,Seow DC,Koh PL,Loh NK,Lim MS,Tan IK,Yee WC

    更新日期:2003-05-15 00:00:00

  • Crossed cerebellar diaschisis and brain tumor biochemistry studied with positron emission tomography, [18F]fluorodeoxyglucose and [11C]methionine.

    abstract::Cerebral gliomas may cause a reduction of glucose metabolism in the cerebellum contralateral to the tumor side (crossed cerebellar diaschisis, CCD). We investigated whether CCD is related to tumor localization, histological grade, size and tumor biochemistry. Cerebellar glucose metabolism was measured in 44 glioma pat...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(98)00019-7

    authors: Otte A,Roelcke U,von Ammon K,Hausmann O,Maguire RP,Missimer J,Müller-Brand J,Radü EW,Leenders KL

    更新日期:1998-01-01 00:00:00

  • Encephalitis related to primary varicella-zoster virus infection in immunocompetent children.

    abstract:INTRODUCTION:Encephalitis is a rare complication of primary varicella-zoster virus (VZV) infection in immunocompetent children. METHODS:The clinical and laboratory findings of two girls with VZV-related encephalitis are reported. RESULTS:Both children presented with focal epileptic seizures, corresponding to cortical...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(02)00017-5

    authors: Häusler M,Schaade L,Kemény S,Schweizer K,Schoenmackers C,Ramaekers VT

    更新日期:2002-03-30 00:00:00

  • Sarcolemmal K+ channel activity in developing rat skeletal muscle membranes.

    abstract::A method has been adapted to produce membrane vesicles suitable for routine membrane patch clamping from neonate rat skeletal muscle. Single K+ channel activity was recorded from cell-free inside-out patches. Most Ca2(+)-activated voltage sensitive channels had large conductances of up to 300 pS, as determined from th...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(90)90142-a

    authors: Wareham AC,Rowe IC,Whittle MA

    更新日期:1990-05-01 00:00:00

  • Short-term motor improvement after sub-threshold 5-Hz repetitive transcranial magnetic stimulation of the primary motor hand area in Parkinson's disease.

    abstract::Ten unmedicated patients with Parkinson's disease received sub-threshold 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor hand area (M1(HAND)) contralaterally to the more affected upper limb. Compared to a midfrontal sham-rTMS, real-rTMS over M1(HAND) was associated with a significant de...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0022-510x(00)00370-1

    authors: Siebner HR,Rossmeier C,Mentschel C,Peinemann A,Conrad B

    更新日期:2000-09-15 00:00:00

  • Depression in Tourette syndrome: A controlled and comparison study.

    abstract:BACKGROUND:Tourette syndrome (TS) is a neurodevelopmental condition characterised by multiple tics and co-morbid behavioural problems. Previous research found that up to 76% of patients with TS experience affective symptoms, with 13% fulfilling diagnostic criteria for depression. OBJECTIVES:We aimed to assess the seve...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jns.2016.03.030

    authors: Piedad JC,Cavanna AE

    更新日期:2016-05-15 00:00:00

  • Normal muscle CPT1 and CPT2 activities in hepatic presentation patients with CPT1 deficiency in fibroblasts. Tissue specific isoforms of CPT1?

    abstract::Human carnitine palmitoyltransferase (CPT) deficiency results in 2 clinical forms: a more common "muscular form" with myoglobinuria with or without delayed or impaired ketogenesis and a rare "hepatic form" with hypoketotic hypoglycemia, encephalopathy and seizures without muscular manifestations. We present 2 patients...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(89)90139-1

    authors: Tein I,Demaugre F,Bonnefont JP,Saudubray JM

    更新日期:1989-09-01 00:00:00

  • Incidence of rotational vertigo in supratentorial stroke: a prospective analysis of 112 consecutive patients.

    abstract:BACKGROUND:Single cases with hemispheric, cortical or subcortical, ischemic lesions presenting with rotational vertigo (RV), that challenge the notion of infratentorial or peripheral generation of RV have been published, but the incidence of this symptom in a larger series is unknown. The aim of this study was to inves...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2009.11.015

    authors: Anagnostou E,Spengos K,Vassilopoulou S,Paraskevas GP,Zis V,Vassilopoulos D

    更新日期:2010-03-15 00:00:00

  • Maintenance of anti-inflammatory cytokines and reduction of glial activation in the ischemic hippocampal CA1 region preconditioned with lipopolysaccharide.

    abstract::Lipopolysaccharide (LPS) induces a strong immune response, and pretreatment with low dose of LPS suppresses the production of proinflammatory mediators. In the present study, we investigated the effect of LPS preconditioning on the delayed neuronal death in the gerbil hippocampal CA1 region after 5 min of transient ce...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2010.06.004

    authors: Yu JT,Lee CH,Yoo KY,Choi JH,Li H,Park OK,Yan B,Hwang IK,Kwon YG,Kim YM,Won MH

    更新日期:2010-09-15 00:00:00

  • Central and peripheral SEP defects in neurologically symptomatic and asymptomatic subjects with low vitamin B12 levels.

    abstract::Somatosensory evoked potentials (SEPs) following median nerve stimulation were abnormal in 7 patients with sensory impairment due to vitamin B12 deficiency. Extensor plantar reflexes indicated a central sensory pathway lesion in 4 cases and absent tendon jerks suggested peripheral neuropathy in 4, but median nerve SEP...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(87)90006-2

    authors: Jones SJ,Yu YL,Rudge P,Kriss A,Gilois C,Hirani N,Nijhawan R,Norman P,Will R

    更新日期:1987-12-01 00:00:00

  • Bayesian mapping of multiple sclerosis prevalence in the province of Pavia, northern Italy.

    abstract::The geographical analysis of a disease risk is particularly difficult when the disease is non-frequent and the area units are small. The practical use of the Bayesian modelling, instead of the classical frequentist one, is applied to study the geographical variation of multiple sclerosis (MS) across the province of Pa...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2006.01.013

    authors: Bergamaschi R,Montomoli C,Candeloro E,Monti MC,Cioccale R,Bernardinelli L,Fratino P,Cosi V,PREMS (Pavia REgister of Multiple Sclerosis) Group.

    更新日期:2006-05-15 00:00:00

  • Prevalence of MR imaging abnormalities in vitamin B12 deficiency patients presenting with clinical features of subacute combined degeneration of the spinal cord.

    abstract:BACKGROUND AND AIMS:Subacute combined degeneration (SACD) of the spinal cord, characterized by degeneration of lateral and posterior columns, is often found in vitamin B12 deficiency. Our aim was to look for sensitivity of imaging in depicting the spinal cord abnormality in vitamin B12 deficient patients and to find an...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2014.05.020

    authors: Jain KK,Malhotra HS,Garg RK,Gupta PK,Roy B,Gupta RK

    更新日期:2014-07-15 00:00:00

  • Brainstem auditory evoked potential (BAEP) abnormalities in brucellosis.

    abstract::Twelve patients with neurobrucellosis and 17 patients with systemic brucellosis without neurological involvement underwent a brainstem auditory evoked potentials (BAEP) study. All neurobrucellosis patients (100%) showed abnormalities in their BAEP recordings, suggestive of brainstem lesions at various levels. On the o...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(88)90255-9

    authors: Khuraibet AJ,Shakir RA,Trontelj JV,Butinar D,al-Din AS

    更新日期:1988-11-01 00:00:00

  • Spinal cord blood flow measured by a hydrogen clearance technique.

    abstract::Spinal cord blood flow (SCBF) has been measured in segments of the thoracolumbar cord of dogs using the hydrogen clearance technique. Clearances were recorded and flows calculated from electrodes placed in grey and white matter. The position of the recording electrodes was marked by diathermy and confirmed in each exp...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(75)90054-4

    authors: Griffiths IR,Rowan JO,Crawford RA

    更新日期:1975-12-01 00:00:00

  • Two-year outcome of thymectomy with or without immunosuppressive treatment in nonthymomatous myasthenia gravis and its effect on regulatory T cells.

    abstract:BACKGROUND:Myasthenia gravis (MG) is the autoimmune disorder in which the thymus is considered the pathogenic organ. Thymectomy (TE) is a therapeutic option for MG and often ameliorates clinical symptoms. METHODS:We evaluated clinical features and outcomes after TE in patients without thymoma and the influence of TE w...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2015.08.029

    authors: Jakubíková M,Piťha J,Marečková H,Týblová M,Nováková I,Schutzner J

    更新日期:2015-11-15 00:00:00

  • Central amygdalar nucleus treated with orexin neuropeptides evoke differing feeding and grooming responses in the hamster.

    abstract::Interaction of the orexinergic (ORXergic) neuronal system with the excitatory (glutamate, l-Glu) or the inhibitory (GABA) neurosignaling complexes evokes major homeostatic physiological events. In this study, effects of the two ORXergic neuropeptides (ORX-A/B) on their receptor (ORX-2R) expression changes were correla...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2015.02.030

    authors: Alò R,Avolio E,Mele M,Di Vito A,Canonaco M

    更新日期:2015-04-15 00:00:00

  • Cerebrovascular disease incidence in central Spain (NEDICES): a population-based prospective study.

    abstract:BACKGROUND:Stroke is one of the most disabling and burdensome health conditions worldwide, but no prospective population-based study has been conducted in Spain. Our aim was to assess age- and gender incidence rates of cerebrovascular disease, including stroke and transient ischemic attack, in three populations in cent...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2010.08.003

    authors: Martínez-Salio A,Benito-León J,Díaz-Guzmán J,Bermejo-Pareja F

    更新日期:2010-11-15 00:00:00

  • Evaluation of MS related central fatigue using MR neuroimaging methods: Scoping review.

    abstract:BACKGROUND:Fatigue is a common and debilitating symptom in multiple sclerosis (MS). Over the past decade, a growing body of research has focussed on the pathophysiological mechanisms underlying central (cognitive and physical) fatigue in MS. The precise mechanisms causing fatigue in MS patients are complex and poorly u...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.jns.2019.03.007

    authors: Arm J,Ribbons K,Lechner-Scott J,Ramadan S

    更新日期:2019-05-15 00:00:00

  • Longitudinally extensive transverse myelitis immune-mediated in aquaporin-4 antibody negative patients: Disease heterogeneity.

    abstract:BACKGROUND:Longitudinally extensive transverse myelitis (LETM) is a frequent manifestation of neuromyelitis optica spectrum disorder (NMOSD). However, it can also occur in other immune-mediated diseases of the central nervous system (CNS). Positive aquoporin-4 antibodies (AQP4-ab) predict higher relapse rate after LETM...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2016.12.033

    authors: Carnero Contentti E,Hryb JP,Morales S,Gomez A,Chiganer E,Di Pace JL,Lessa C,Perassolo M

    更新日期:2017-02-15 00:00:00

  • Memantine abrogates neurological deficits, but not CNS inflammation, in Lewis rat experimental autoimmune encephalomyelitis.

    abstract::Memantine, a clinically employed drug with N-methyl-D-aspartate (NMDA) receptor antagonistic effects, dose-dependently ameliorates neurological deficits in Lewis rat experimental autoimmune encephalomyelitis (EAE). Interestingly, this therapeutic effect was not due to dampened CNS inflammation, as assessed by immunohi...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(95)00339-4

    authors: Wallström E,Diener P,Ljungdahl A,Khademi M,Nilsson CG,Olsson T

    更新日期:1996-05-01 00:00:00

  • The cerebrospinal fluid from patients with multiple sclerosis promotes neuronal and oligodendrocyte damage by delayed production of nitric oxide in vitro.

    abstract::Nitric oxide (NO) may be involved in myelin and oligodendrocyte injury associated with multiple sclerosis (MS), a demyelinating disease of unknown etiology. The cerebrospinal fluid (CSF) from MS patients may provide an important signal inducing a pathologic process within the central nervous system (CNS). To investiga...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(96)00164-5

    authors: Xiao BG,Zhang GX,Ma CG,Link H

    更新日期:1996-10-01 00:00:00

  • Brain volumetry counterparts of cognitive impairment in patients with multiple sclerosis.

    abstract:BACKGROUND:Cognitive impairment is frequent in multiple sclerosis (MS). Tissue-specific atrophy measures have been shown to correlate with cognitive performance in several studies. Voxel-based morphometry (VBM) aims to identify regional differences in the local composition of brain tissue and makes possible to correlat...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2008.12.019

    authors: Sastre-Garriga J,Arévalo MJ,Renom M,Alonso J,González I,Galán I,Montalban X,Rovira A

    更新日期:2009-07-15 00:00:00

  • Susceptibility of human skeletal muscle culture to influenza virus infection. Part 2. Ultrastructural cytopathology.

    abstract::Cultured post-fused human skeletal muscle monolayers exposed to WSN influenza A virus were analyzed by scanning and transmission electron microscopy. At 12-14h post-inoculation (p.i.), affected mononuclear cells retracted from the cell surface, but remained anchored to the substrate by taut filar processes. Retraction...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(78)90162-4

    authors: Miranda AF,Gamboa ET,Armstrong CL,Hsu KC

    更新日期:1978-03-01 00:00:00

  • Functional polymorphisms of the MAO gene with Parkinson disease susceptibility: a meta-analysis.

    abstract:OBJECTIVE:We carried out a meta-analysis focusing on the relationships between rs1137070 C>T and rs1799836 A>G polymorphisms in the MAO gene as a modifier of Parkinson disease (PD) susceptibility. METHOD:A literature search of the Cochrane Library Database, Web of Science, PubMed, CINAHL, EMBASE, and the Chinese Biome...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jns.2014.07.016

    authors: Sun YX,Wang XH,Xu AH,Zhao JH

    更新日期:2014-10-15 00:00:00