当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > A systematic review of closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and cryptogenic stroke or transient ischemic attack.

A systematic review of closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and cryptogenic stroke or transient ischemic attack.

Abstract：

:The optimal treatment for secondary prevention in patients who have a patent foramen ovale (PFO) and history of cryptogenic stroke is still uncertain and controversial. In view of this, we performed a systematic review of randomized controlled trials (RCTs) to investigate whether PFO closure was superior to medical therapy for prevention of recurrent stroke or transient ischemic attack (TIA) in patients with PFO after cryptogenic stroke. We searched the Cochrane Central Register of Controlled Trials, Embase, PubMed, Web of Science, and ClinicalTrials.gov. Three randomized controlled trials with a total of 2303 patients were included and analyzed. A fixed-effect model was used by Review Manager 5.2 (RevMan 5.2) software. The pooled risk ratio (RR) of recurrent stroke or TIA was 0.70, with 95% confidence interval (CI) = 0.47 to 1.04, p = 0.08. The results were similar in the incidence of death and adverse events, and the pooled RR was 0.92 (95% CI = 0.34 to 2.45, p = 0.86) and 1.08 (95% CI = 0.93 to 1.26, p = 0.32), respectively. The data of this systematic review did not show superiority of closure over medical therapy for secondary prevention after cryptogenic stroke. Due to some limitations of the included studies, more randomized controlled trials are needed for further investigation regarding this field.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Chen L,Luo S,Yan L,Zhao W

doi

10.1016/j.jns.2013.11.027

subject

Has Abstract

pub_date

2014-02-15 00:00:00

pages

3-7

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(13)03056-6

journal_volume

337

pub_type

杂志文章,评审

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