当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum. Electron-microscopic observations.

Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum. Electron-microscopic observations.

Abstract：

:Under electrophysiological control, a focal demyelinating lesion can be produced in the corpus callosum of the rabbit by slow pressure injection of a 1% solution of lysophosphatidyl choline (LPC). Light- and electron-microscopic examination of the LPC demyelinated corpus callosum indicates that many axons remain structurally intact after LPC injection. In addition, some axons show early signs of remyelination. Our results indicate that small diameter, central nervous system myelinated axons can be focally demyelinated with LPC. Furthermore, our procedure for producing demyelination in the corpus callosum is particularly suitable for combined anatomical and electrophysiological study of small demyelinated axons.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Foster RE,Kocsis JD,Malenka RC,Waxman SG

doi

10.1016/0022-510x(80)90202-6

subject

Has Abstract

pub_date

1980-11-01 00:00:00

pages

221-31

issue

2

eissn

0022-510X

issn

1878-5883

pii

0022-510X(80)90202-6

journal_volume

48

pub_type

杂志文章

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