Abstract：
BACKGROUND:Transverse myelitis is the common presentation in demyelinating conditions. OBJECTIVE:To determine the characteristics of spinal lesions among each type of demyelinating diseases. METHODS:Medical records and spinal imaging of patients who were [1] older than 18years, [2] had at least one attack of TM, [3] had available spinal MRI data and [4] were tested for aquaporin-4 antibody were included. RESULTS:One hundred and fifty-eight patients were eligible (27 clinically isolated syndrome [CIS], 38 MS, 55 seropositive neuromyelitis optica spectrum disorders [NMOSD], 9 seronegative NMOSD, and 29 idiopathic transverse myelitis [IDD-TM]). All groups showed female preponderance and no difference of age at onset. In each patient group, no significant difference in the mean number of spinal lesions was found. The most common levels of involvement were thoracic in IDD-TM, cervical in CIS and MS, as well as cervico-thoracic in both NMOSD groups. Long extensive TM was the most common finding in both the seropositive and seronegative NMOSD groups compared to the other groups. Peripheral location and <30% of spinal cord area involvement were the characteristic findings in CIS and MS. Central location and intermediately involved of the cross-sectional cord area were the determinants for the seropositive and seronegative NMOSD groups, respectively. CONCLUSION:Spinal MRI findings can help to differentiate among demyelinating diseases in who presented with TM.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Dumrikarnlert C,Siritho S,Chulapimphan P,Ngamsombat C,Satukijchai C,Prayoonwiwat Ndoi
10.1016/j.jns.2016.11.035subject
Has Abstractpub_date
2017-01-15 00:00:00pages
138-143eissn
0022-510Xissn
1878-5883pii
S0022-510X(16)30738-9journal_volume
372pub_type
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