Cuprizone neurotoxicity in the rat: morphologic observations.

abstract：:A 55-year-old woman developed an intractable right orbitofrontal headache. The symptoms subsided spontaneously 2 months after onset, but diplopia due to right abducens nerve palsy had occurred, and gradually worsened. Orbito-ocular signs were never observed throughout the clinical course. Brain MRI and MR angiography ...

journal_title：Journal of the neurological sciences

authors： Ikeda K,Deguchi K,Tsukaguchi M,Sasaki I,Shimamura M,Urai Y,Touge T,Kawanishi M,Takeuchi H,Kuriyama S

更新日期：2005-09-15 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Multiple sclerosis (MS) has been consistently associated with the HLA-DR2 haplotype and particularly with the HLA-DRB1*15 allele. Epistatic interactions between both parental alleles in the DRB1 loci have been shown to modify the MS susceptibility risk. This study investigated the frequencies o...

journal_title：Journal of the neurological sciences

authors： Romero-Pinel L,Pujal JM,Martínez-Yélamos S,Gubieras L,Matas E,Bau L,Torrabadella M,Azqueta C,Arbizu T

更新日期：2010-11-15 00:00:00

abstract：:An accumulation of SCA6 cases has been observed in the Chugoku area of Western Japan. In the Tottori prefecture, located in the northeastern part of the Chugoku district, we observed a cluster of SCA6 families within the eastern area, suggesting that there may be a founder in the Japanese SCA6 population. Genotyping w...

journal_title：Journal of the neurological sciences

authors： Mori M,Adachi Y,Kusumi M,Nakashima K

更新日期：2001-03-15 00:00:00

abstract：:Genetic Creutzfeldt-Jakob disease (gCJD) is caused by a range of mutations in the prion protein gene (PRNP). We describe the first Italian case of gCJD associated with the rare PRNP E196K mutation. The disease showed an atypical presentation featuring dementia without motor signs in a 75-year-old woman. The case lacke...

journal_title：Journal of the neurological sciences

authors： Clerici F,Elia A,Girotti F,Contri P,Mariani C,Tagliavini F,Di Fede G

更新日期：2008-12-15 00:00:00

abstract：BACKGROUND:We recently reported that left versus right hemisphere cerebral infarctions patients more frequently have worse outcomes. However our clinical experience led us to suspect that the incidence of malignant middle cerebral artery infarctions (MMCA) was higher in the right compared to the left hemispheric stroke...

journal_title：Journal of the neurological sciences

authors： Rastogi V,Lamb DG,Williamson JB,Stead TS,Penumudi R,Bidari S,Ganti L,Heilman KM,Hedna VS

更新日期：2015-01-01 00:00:00

abstract：:The cause of multiple sclerosis is unknown although it is recognised to involve an inflammatory process associated with demyelinating plaques and more widespread neurodegeneration. It appears to have become progressively more common in females which is further discussed in this issue, and genetic factors, as identifie...

journal_title：Journal of the neurological sciences

authors： Palace J

更新日期：2009-11-15 00:00:00

abstract：:Encephalitogenic activity of myelin basic protein (MBP) isolated in a form retaining binding to all myelin lipids was tested in Lewis rats. Immunization with this new stable lipid-bound and native-like preparation (LB-MBP), induced experimental autoimmune encephalomyelitis (EAE) as intensively as the classical lipid f...

journal_title：Journal of the neurological sciences

authors： Massacesi L,Vergelli M,Zehetbauer B,Liuzzi GM,Olivotto J,Ballerini C,Uccelli A,Mancardi L,Riccio P,Amaducci L

更新日期：1993-10-01 00:00:00

abstract：:REM sleep behavior disorder (RBD) is characterized by vigorous movements during REM sleep. Here, the authors report the case of a patient who presented such a disorder immediately after the implantation of the definitive electrode for left subthalamic stimulation. Interestingly, this was and has remained a unique epis...

journal_title：Journal of the neurological sciences

authors： Piette T,Mescola P,Uytdenhoef P,Henriet M,Vanderkelen B,Jacquy J,Seeldrayers P,Godaux E

更新日期：2007-02-15 00:00:00

abstract：:In order to compare the effects of total catecholamine (CA) or noradrenaline (NA) depletions on cholinergic systems, and the mechanisms of receptor regulation in various brain regions, the regional changes in the levels of acetylcholine (ACh), M1-receptor (M1-R) binding, and M1-R messenger RNA (mRNA) were mainly exami...

journal_title：Journal of the neurological sciences

authors： Asanuma M,Ogawa N,Haba K,Hirata H,Mori A

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Autonomic disturbances and sleep problems are common non-motor symptoms in patients with Parkinson's disease (PD). Orthostatic hypotension, supine hypertension (SH), and nocturnal hypertension (NH) are inter-related in patients with PD. These abnormalities might be associated with restless legs...

journal_title：Journal of the neurological sciences

authors： Oh YS,Kim JS,Park IS,Song IU,Son YM,Park JW,Yang DW,Kim HT,Lee KS

更新日期：2014-09-15 00:00:00

abstract：:Polyglutamine (poly-Q) diseases are late-onset neurodegenerative disorders arising from the expansion of an unstable CAG repeat in the affected gene, which is translated to a tract of glutamine residues. This kind of mutant proteins may be aggregated and accumulated, and thereby enhance cellular oxidative stress. In o...

journal_title：Journal of the neurological sciences

authors： Liu CS,Cheng WL,Kuo SJ,Li JY,Soong BW,Wei YH

更新日期：2008-01-15 00:00:00

abstract：UNLABELLED:Riluzole is currently the only drug that holds any hope of prolonging life in amyotrophic lateral sclerosis (ALS) by slowing the rate of disease progression. METHODS AND RESULTS:Between 1995 and 1997 a total of 7916 ALS patients in 39 countries, were given 100 mg riluzole per day for a mean of 7.2 months. T...

journal_title：Journal of the neurological sciences

authors： Pongratz D,Neundörfer B,Fischer W

更新日期：2000-11-01 00:00:00

abstract：:Pathologic laughter which usually occurs after bilateral or diffuse cerebral lesions was rarely reported in patients with unilateral stroke. I describe clinical and radiological findings of 13 patients presenting pathologic laughter due to unilateral stroke. Their laughter was excessive, unmotivated, uncontrollable an...

journal_title：Journal of the neurological sciences

authors： Kim JS

更新日期：1997-05-01 00:00:00

abstract：:Previously, we demonstrated that neuronal nitric oxide synthase (nNOS) is activated and promotes muscle atrophy in skeletal muscle during tail suspension, a model of unloading and denervation. Here, we examined patients with amyotrophic lateral sclerosis (ALS) and mutant (H46R) SOD1 transgenic (Tg) mice model using im...

journal_title：Journal of the neurological sciences

authors： Suzuki N,Mizuno H,Warita H,Takeda S,Itoyama Y,Aoki M

更新日期：2010-07-15 00:00:00

abstract：:We studied the limitations to early diagnosis in amyotrophic lateral sclerosis (ALS). The diagnostic process was assessed in 120 consecutive patients, including onset, interval to diagnosis, investigations, specialist assessment and pre-diagnostic management. Times from onset to first consultation (T1), second consult...

journal_title：Journal of the neurological sciences

authors： Nzwalo H,de Abreu D,Swash M,Pinto S,de Carvalho M

更新日期：2014-08-15 00:00:00

abstract：PURPOSE:Among different seizure types, tonic-clonic seizures are more significant because they are more often associated with morbidity. No prior study has been done to investigate risk factors associated with tonic-clonic seizures in patients with mesial temporal epilepsy. METHODS:In this retrospective study, all dru...

journal_title：Journal of the neurological sciences

authors： Asadi-Pooya AA,Rostami C,Rabiei AH,Sperling MR

更新日期：2015-12-15 00:00:00

abstract：:Monthly dual-echo spin-echo (SE) and enhanced magnetic resonance imaging (MRI) after the injection of a standard dose (SD) of gadolinium (Gd) is the conventional approach to monitor short-term disease activity in multiple sclerosis (MS). In this study, the sensitivity of this approach in detecting active lesions in MS...

journal_title：Journal of the neurological sciences

authors： Filippi M,Mastronardo G,Bastianello S,Rocca MA,Rovaris M,Gasperini C,Pozzilli C,Comi G

更新日期：1998-07-15 00:00:00

abstract：BACKGROUND AND PURPOSE:It is well known that inflammation influence chronic subdural hematoma (CSDH) formation to a large extent. Atorvastatin has pleiotropic effects on restraining inflammation and promoting angiogenesis besides its cholesterol-lowering function. Hence, atorvastatin may induce anti-inflammation effect...

journal_title：Journal of the neurological sciences

authors： Li T,Wang D,Tian Y,Yu H,Wang Y,Quan W,Cui W,Zhou L,Chen J,Jiang R,Zhang J

更新日期：2014-06-15 00:00:00

abstract：:Electron-microscopic X-ray microanalysis has been used to compare elemental concentrations in specific organelles in normal and diseased human muscle. An elevated calcium to phosphorus ratio has been found in both myonuclei and interstitial cell nuclei in diseased muscle compared with controls. Preliminary observation...

journal_title：Journal of the neurological sciences

authors： Maunder CA,Yarom R,Dubowitz V

更新日期：1977-09-01 00:00:00

abstract：:In the last two decades functional magnetic resonance imaging (fMRI) has dominated research in neuroscience. However, only recently has it taken the first steps in translation to the clinical field. In this paper we describe the advantages of fMRI and DTI and the possible benefits of implementing these methods in clin...

journal_title：Journal of the neurological sciences

authors： Bick AS,Mayer A,Levin N

更新日期：2012-01-15 00:00:00

abstract：:Sympathetic skin response (SSR) is a simple, reproducible test of function of a polysynaptic reflex having diverse afferents, a common efferent pathway through the spinal cord, pre and post-ganglionic sympathetic fibers and with sweat glands as effectors. The reflex is co-ordinated in the posterior hypothalamus or upp...

journal_title：Journal of the neurological sciences

authors： Arunodaya GR,Taly AB

更新日期：1995-04-01 00:00:00

abstract：:A case of chorea-acanthocytosis (CA) syndrome is described. The presence of acanthocytes has usually been considered an important diagnostic marker of CA. However, it is not specific and other neurological diseases have to be considered. In the present report we rule out other diagnostic possibilities and show that th...

journal_title：Journal of the neurological sciences

authors： Sorrentino G,De Renzo A,Miniello S,Nori O,Bonavita V

更新日期：1999-03-01 00:00:00

abstract：:Clinical awakening can be seen just before or after seizure onsets. In this study we determined the time between onset of seizures and awakening in patients with frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE). Sixty-eight patients who underwent video-EEG monitoring with simultaneous PSG were retrospectiv...

journal_title：Journal of the neurological sciences

authors： Yildiz FG,Tezer FI,Saygi S

更新日期：2012-04-15 00:00:00

abstract：OBJECTIVE:Despite the wide utilization of mechanical thrombectomy (MT) for acute ischemic stroke treatment, little is known about the incidence of early post-thrombectomy seizures, its predictors, and association with long-term outcome. METHODS:Using a prospective registry of mechanical thrombectomy in ischemic stroke...

journal_title：Journal of the neurological sciences

authors： Anadani M,Lekoubou A,Almallouhi E,Alawieh A,Chatterjee A,Vargas J,Spiotta AM

更新日期：2019-01-15 00:00:00

abstract：:Ultrastructural alterations were observed in the sciatic nerve of dystrophic mice. Myelin sheaths were abnormal in shape, abruptly ceased beyond a node of Ranvier, leaving the axon naked. These changes were seen in both afferent and efferent nerve fibres. Apparent embryonal Schwann cells and Schwann cells which were a...

journal_title：Journal of the neurological sciences

authors： Okada E,Mizuhira V,Nakamura H

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND:Repeated administration of Paced Auditory Serial Addition Test (PASAT) results in a considerable learning effect in short- or long-term follow-up studies. However, the relationship between PASAT learning and changes in magnetic resonance imaging (MRI) parameters is yet to be investigated. OBJECTIVES:The aim...

journal_title：Journal of the neurological sciences

authors： Uher T,Benedict RH,Horakova D,Bergsland N,Dusankova JB,Tyblova M,Ramasamy DP,Seidl Z,Vaneckova M,Krasensky J,Havrdova E,Zivadinov R

更新日期：2014-12-15 00:00:00

abstract：:Cerebrospinal fluid (CSF) was studied in 2 cases of Devic's syndrome (DS). In one of these cases autopsy was carried out. The main CSF feature in DS is the association of blood-brain barrier damage and intrathecal IgG synthesis. These findings are in keeping with our neuropathological observation of diffuse central ne...

journal_title：Journal of the neurological sciences

authors： Leonardi A,Arata L,Farinelli M,Cocito L,Schenone A,Tabaton M,Mancardi GL

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Contactin-associated protein 2 (Caspr2) antibody is a neuronal surface antibody (NSAb) capable of causing disorders involving central and peripheral nervous systems (PNS). Thymoma can be found in patients with Caspr2 antibodies and is most frequently associated with PNS symptoms. Myasthenia gravis can be fou...

journal_title：Journal of the neurological sciences

authors： Lee CH,Lin JJ,Lin KJ,Chang BL,Hsieh HY,Chen WH,Lin KL,Fung HC,Wu T

更新日期：2014-06-15 00:00:00

abstract：:There is evidence that visuo-spatial capacity can become overloaded when processing a secondary visual task (Dual Task, DT), as occurs in daily life. Hence, we investigated the influence of the visuo-spatial interference in the identification of emotional facial expressions (EFEs) in early stages of Parkinson's diseas...

journal_title：Journal of the neurological sciences

authors： García-Rodríguez B,Guillén CC,Barba RJ,io Valladolid GR,Arjona JA,Ellgring H

更新日期：2012-02-15 00:00:00

abstract：:Around 70% of Charcot-Marie-Tooth 1 (CMT1) cases are caused by a dominantly inherited 1.5-Mb duplication at 17p11.2-12 (CMT1A). Using photostimulated luminescence (PSL) imaging of MspI Southern blots, hybridization signals of the probe pVAW409R3a in relation to cohybridized probe SF85a, were densitometrically quantifi...

journal_title：Journal of the neurological sciences

authors： Aarskog NK,Aadland S,Gjerde IO,Vedeler CA

更新日期：2001-07-15 00:00:00