Cerebrospinal fluid and neuropathological study in Devic's syndrome. Evidence of intrathecal immune activation.

Abstract:

:Cerebrospinal fluid (CSF) was studied in 2 cases of Devic's syndrome (DS). In one of these cases autopsy was carried out. The main CSF feature in DS is the association of blood-brain barrier damage and intrathecal IgG synthesis. These findings are in keeping with our neuropathological observation of diffuse central nervous system vasculitis and leptomeningitis. As a whole, our CSF and neuropathological findings in DS are consistently different from those in multiple sclerosis.

journal_name

J Neurol Sci

authors

Leonardi A,Arata L,Farinelli M,Cocito L,Schenone A,Tabaton M,Mancardi GL

doi

10.1016/0022-510x(87)90024-4

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

281-90

issue

1-3

eissn

0022-510X

issn

1878-5883

pii

0022-510X(87)90024-4

journal_volume

82

pub_type

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