Induction of experimental autoimmune encephalomyelitis in rats and immune response to myelin basic protein in lipid-bound form.

Abstract:

:Encephalitogenic activity of myelin basic protein (MBP) isolated in a form retaining binding to all myelin lipids was tested in Lewis rats. Immunization with this new stable lipid-bound and native-like preparation (LB-MBP), induced experimental autoimmune encephalomyelitis (EAE) as intensively as the classical lipid free MBP (LF-MBP). During the course of the disease, high affinity specific response to LB-MBP and high frequency of LB-MBP specific precursors was observed in peripheral lymphoid organs, indicating that the disease occurred in presence of anti LB-MBP specific T-cell responsivity. Short term lines, generated from lymphocytes collected at the onset of the disease from LB-MBP immunized rats, showed a strong dose-dependent response to LB-MBP, but not to LF-MBP. The present data indicate that in rat, LB-MBP maintains encephalitogenic activity and induces expansion of a specific T-cell population. These data suggest also that LB-MBP is a new autoantigen that may be relevant in human diseases.

journal_name

J Neurol Sci

authors

Massacesi L,Vergelli M,Zehetbauer B,Liuzzi GM,Olivotto J,Ballerini C,Uccelli A,Mancardi L,Riccio P,Amaducci L

doi

10.1016/0022-510x(93)90196-6

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

91-8

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(93)90196-6

journal_volume

119

pub_type

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