当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Frontal dysfunctions of ALS-PBP patients in relation to their bulbar symptoms and rCBF decline.

Frontal dysfunctions of ALS-PBP patients in relation to their bulbar symptoms and rCBF decline.

Abstract：

BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease characterized by progressive degeneration of spinal and bulbar motor neurons. However up to 50% ALS patients may also have cognitive dysfunction which has not been fully examined. METHODS:35 ALS patients [23 patients presenting with limb-type ALS (ALS-limb) and 12 patients presenting with primary bulbar palsy (PBP)-type ALS (ALS-PBP)] and 5 Spinal and Bulbar Muscular Atrophy (SBMA) patients have participated. To assess cognitive function mini-mental state examination (MMSE), Hasegawa dementia scale-revised (HDS-R), and frontal assessment battery (FAB) were performed. Additionally the time to complete card flipping with a computerized touch panel-type screening test was also examined. To investigate regional cerebral blood flow (rCBF), single-photon emission computed tomography (SPECT) using a (99m)Tc labeled ethyl cysteinate dimer ((99m)Tc-ECD) were performed. Statistical image analysis was performed using the easy Z-score imaging system (eZIS). RESULTS:HDS-R and FAB scores were significantly lower in the ALS-PBP group than in age- and gender-matched control subjects or ALS-limb groups (p<0.01). The time to complete card flipping was significantly longer in the ALS-PBP group than in the control and ALS-limb groups (p<0.01). Although MMSE, HDS-R and FAB scores and the time to complete card flipping had no correlation with ALS functional rating scale-revised (ALSFRS-R) or Norris-limb scale scores, FAB score (r=0.63, p <0.01) and the time to complete card flipping (r=-0.66, p<0.01) were strongly correlated with Norris-bulbar score. The eZIS showed that rCBF of the frontal lobe was more severely declined in ALS-PBP patients than in ALS-limb patients (p<0.05). CONCLUSION:These results suggest a selective decline of frontal cerebral functions in the ALS-PBP group in relation to their bulbar symptoms and rCBF decline.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Morimoto N,Kurata T,Sato K,Ikeda Y,Sato S,Abe K

doi

10.1016/j.jns.2012.04.020

subject

Has Abstract

pub_date

2012-08-15 00:00:00

pages

96-101

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(12)00213-4

journal_volume

319

pub_type

杂志文章

在线工具

Frontal dysfunctions of ALS-PBP patients in relation to their bulbar symptoms and rCBF decline.