Upregulation of stanniocalcin-1 inhibits the development of osteoarthritis by inhibiting survival and inflammation of fibroblast-like synovial cells.

abstract：:There has been an impressive emergence of mass spectrometry based technologies applied toward the study of proteins. Equally notable is the rapid adaptation of these technologies to biomedical approaches in the realm of clinical proteomics. Concerted efforts toward the elucidation of the proteomes of organ sites or sp...

journal_title：Journal of cellular biochemistry

authors： Semmes OJ,Malik G,Ward M

更新日期：2006-06-01 00:00:00

abstract：:The activity of α-type cytosolic phospholipase A2 (cPLA2 α, group IVA PLA2 ), which releases arachidonic acid (AA), is mainly regulated by the Ca2+ -induced intracellular translocation/attachment of the enzyme to substrate membranes and its phosphorylation. We previously reported that tumor necrosis factor-α (TNFα) st...

journal_title：Journal of cellular biochemistry

authors： Nakamura H,Moriyama Y,Watanabe K,Tomizawa S,Yamazaki R,Takahashi H,Murayama T

更新日期：2017-12-01 00:00:00

abstract：:Bladder cancer is the most common malignancy with high recurrence. Currently, the long noncoding RNAs (lncRNAs) have been suggested to play vital roles in the pathogenesis of bladder cancer. The present study investigated the role of lncRNA MIR503 host gene (MIR503HG) in the pathogenesis of bladder cancer by using bot...

journal_title：Journal of cellular biochemistry

authors： Qiu F,Zhang MR,Zhou Z,Pu JX,Zhao XJ

更新日期：2019-06-01 00:00:00

abstract：:Amplification of MYCN is one of the most important prognostic markers for neuroblastoma and is correlated with rapid tumor progression and poor prognosis. MYCN belongs to the Myc/Max/Mad/Mnt network of proteins that regulate proliferation, apoptosis, and differentiation. It is well established that MYCN is downregulat...

journal_title：Journal of cellular biochemistry

authors： Smith AG,Popov N,Imreh M,Axelson H,Henriksson M

更新日期：2004-08-15 00:00:00

abstract：:In the heart, Ca2+/calmodulin-dependent protein kinase II is critically involved in the regulation of Ca2+ homeostasis. Previously the predominant expression of a subclass of Ca2+/calmodulin-dependent protein kinase II delta-subunit, containing a second variable domain, was demonstrated in cardiac tissue. Here we repo...

journal_title：Journal of cellular biochemistry

authors： Hagemann D,Hoch B,Krause EG,Karczewski P

更新日期：1999-08-01 00:00:00

abstract：:The recently identified 53-kDa substrate of the insulin receptor family was further characterized in several retroviral-generated stable cell lines overexpressing the wild type and various mutant forms of the protein. To facilitate the study of its subcellular localization in NIH3T3 cells overexpressing insulin recept...

journal_title：Journal of cellular biochemistry

authors： Yeh TC,Li W,Keller GA,Roth RA

更新日期：1998-02-01 00:00:00

abstract：:The catalytic domain of protein tyrosine phosphatase SHP-1 possesses distinct substrate specificity. It recognizes the P-3 to P-5 residues of its substrates via the beta5-loop-beta6 region. To study the substrate specificity further, we determined the structure of the catalytic domain of SHP-1 (C455S) complexed with a...

journal_title：Journal of cellular biochemistry

authors： Yang J,Cheng Z,Niu T,Liang X,Zhao ZJ,Zhou GW

更新日期：2001-06-26 00:00:00

abstract：:The role of circular RNAs (circRNAs) in regulating cartilage homeostasis in osteoarthritis (OA) has been reported. However, the regulatory mechanisms of circRNAs in OA synovium remains basically unidentified. The current study intended to divulge the expression profile of circRNAs in OA synovium and investigate the po...

journal_title：Journal of cellular biochemistry

authors： Xiang S,Li Z,Bian Y,Weng X

更新日期：2019-10-01 00:00:00

abstract：:Burkitt lymphoma (BL) commonly exhibits Epstein-Barr virus (EBV) positivity associated with latent chronic infection. Models of acute EBV infection have been associated with cellular resistance to apoptosis. However, the effect of latent long-term EBV infection on apoptosis induced by drugs is not well defined. To det...

journal_title：Journal of cellular biochemistry

authors： Lima RT,Seca H,Soares P,Nascimento MS,Vasconcelos MH

更新日期：2011-01-01 00:00:00

abstract：:Evidence for multiprotein complexes playing a role in DNA replication has been growing over the years. We have previously reported on a replication-competent multiprotein form of DNA polymerase isolated from human (HeLa) cell extracts. The proteins that were found at that time to co-purify with the human cell multipro...

journal_title：Journal of cellular biochemistry

authors： Applegren N,Hickey RJ,Kleinschmidt AM,Zhou Q,Coll J,Wills P,Swaby R,Wei Y,Quan JY,Lee MY

更新日期：1995-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been identified as key players in cardiogenesis and heart pathophysiological processes. However, many miRNAs are still not recognized for their roles in cardiomyocytes differentiation. In this study, we evaluated the effects of microRNA-218 (miR-218) in cardiomyocyte differentiation of the mous...

journal_title：Journal of cellular biochemistry

authors： Xu T,Liu N,Shao Y,Huang Y,Zhu D

更新日期：2019-03-01 00:00:00

abstract：:Basic helix-loop-helix (bHLH) transcription factors have been shown to play an important role in controlling cell type determination and differentiation. TWIST, a member of the bHLH transcription factor family, is involved in the development of mesodermally derived tissue, including the skeleton. We examined the role ...

journal_title：Journal of cellular biochemistry

authors： Lee MS,Lowe GN,Strong DD,Wergedal JE,Glackin CA

更新日期：1999-12-15 00:00:00

abstract：:Promyelocytic leukemia nuclear bodies (PML-NBs) are multiprotein complexes that include PML protein and localize in nuclear foci. PML-NBs are implicated in multiple stress responses, including apoptosis, DNA repair, and p53-dependent growth inhibition. ALT-associated PML bodies (APBs) are specialized PML-NBs that incl...

journal_title：Journal of cellular biochemistry

authors： Shen H,Maki CG

更新日期：2010-12-01 00:00:00

abstract：:Androgen-regulated genes (ARG) are implicated in normal and neoplastic growth of the prostate. Recently, we reported genomic amplification and/or overexpression of a previously known neurotrophic factor, prosaposin, in androgen-independent (AI) or metastatic prostate cancer (PCa) cells and tissues. Prosaposin and/or i...

journal_title：Journal of cellular biochemistry

authors： Koochekpour S,Lee TJ,Wang R,Sun Y,Delorme N,Hiraiwa M,Grabowski GA,Culig Z,Minokadeh A

更新日期：2007-06-01 00:00:00

abstract：:Ceruloplasmin (CP) is essential for brain iron homeostasis. However, its precise function in brain iron transport has not been definitely determined. In this study, we investigated the effects of soluble CP on iron influx and efflux in primary neuronal culture from the midbrain (the substantia nigra and striatum) and ...

journal_title：Journal of cellular biochemistry

authors： Ke Y,Ho K,Du J,Zhu L,Xu Y,Wang Q,Wang CY,Li L,Ge X,Chang Y,Qian ZM

更新日期：2006-07-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSC) hold tremendous potential for personalized cell-based repair strategies to treat musculoskeletal disorders. To establish human iPSCs as a potential source of viable chondroprogenitors for articular cartilage repair, we assessed the in vitro chondrogenic potential of the pluripoten...

journal_title：Journal of cellular biochemistry

authors： Guzzo RM,Gibson J,Xu RH,Lee FY,Drissi H

更新日期：2013-02-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone-binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization-embryo transfer (IVF-ET) in PCOS patients. PCOS patients ...

journal_title：Journal of cellular biochemistry

authors： Liu Y,Zhao XX,Hu XJ,Yang F,Lin P,Cui SC,Zhao W,Cao XY,Wang YS

更新日期：2019-03-01 00:00:00

abstract：:It is known that the MyoD family members (MyoD, Myf5, myogenin, and MRF4) play a pivotal role in the complex mechanism of skeletal muscle cell differentiation. However, fragmentary information on transcription factor-specific regulation is available and data on their post-transcriptional and post-translational behavio...

journal_title：Journal of cellular biochemistry

authors： Ferri P,Barbieri E,Burattini S,Guescini M,D'Emilio A,Biagiotti L,Del Grande P,De Luca A,Stocchi V,Falcieri E

更新日期：2009-12-15 00:00:00

abstract：:Diabetic retinopathy (DR) is a leading cause of adult visual impairment and loss. This study aims to explore the effects of microRNA-9 (miR-9) on retinal neovascularization during DR by targeting the vascular endothelial growth factor A (VEGFA). DR rat models were successfully established. Retinal microvascular endoth...

journal_title：Journal of cellular biochemistry

authors： Liu WL

更新日期：2018-11-28 00:00:00

abstract：:c-fos gene has a close relationship with the osteoblasts. Mechanical signal effect on osteoblasts would change the expression level of c-fos. Authors introduce the signal pathways of four cis-response elements on the promoter of c-fos, that is, CRE (cAMP responsive element), FAP-1 (Fbs-AP-1 site), SRE (serum response ...

journal_title：Journal of cellular biochemistry

authors： He H,Ping F

更新日期：2009-04-01 00:00:00

abstract：:Multiple regulatory elements and intricate protein-DNA interactions mediate the transcription of the human histone H4 genes in a cell growth-dependent manner. Upon analysis of the regulatory elements of the FO108 histone H4 gene, we identified several potential YY1 binding sites. In this study, we have analyzed the ab...

journal_title：Journal of cellular biochemistry

authors： Last TJ,van Wijnen AJ,Birnbaum MJ,Stein GS,Stein JL

更新日期：1999-03-15 00:00:00

abstract：:Undecylenic acid (UDA), a naturally occurring 11-carbon unsaturated fatty acid, has been used for several years as an economical antifungal agent and a nutritional supplement. Recently, the potential usefulness of UDA as a neuroprotective drug has been suggested based on the ability of this agent to inhibit μ-calpain ...

journal_title：Journal of cellular biochemistry

authors： Jantas D,Piotrowski M,Lason W

更新日期：2015-12-01 00:00:00

abstract：:The aim of this study was to investigate the role of NYD-SP15 in the growth and oxidative-stress responses of ARPE-19 cells. ARPE-19 cell lines overexpressing wild type or RNA interference against NYD-SP15 were established via lentivirus transfection. Cell growth and proliferation, migration, apoptosis, and cell cycle...

journal_title：Journal of cellular biochemistry

authors： Xu Y,Wang L,Cao L,Chen L,Liu Q

更新日期：2018-10-28 00:00:00

abstract：:We have used a retroviral vector (RCAS) to overexpress wild-type chicken c-Jun or a deletion mutant of chicken c-Jun (Jun delta 7) lacking the DNA binding region to investigate the possible role of c-Jun in lens epithelial cell proliferation and differentiation. Both constructs were efficiently expressed in primary cu...

journal_title：Journal of cellular biochemistry

authors： Rinaudo JA,Vacchiano E,Zelenka PS

更新日期：1995-06-01 00:00:00

abstract：:Cancer stem cells (CSC) have a central role in driving tumor growth. Since metabolism is becoming an important diagnostic and therapeutic target, characterization of CSC line energetic properties is an emerging need. Embryonic and adult stem cells, compared to differentiated cells, exhibit a reduced mitochondrial acti...

journal_title：Journal of cellular biochemistry

authors： Palorini R,Votta G,Balestrieri C,Monestiroli A,Olivieri S,Vento R,Chiaradonna F

更新日期：2014-02-01 00:00:00

abstract：:The NAD-dependent deacetylase Sirtuin 1 (SIRT1) plays a vital role in leukemogenesis. Nicotinamide (NAM) is the principal NAD+ precursor and a noncompetitive inhibitor of SIRT1. In our study, we showed that NAM enhanced the sensitivity of chronic myeloid leukemia (CML) to doxorubicin (DOX) via SIRT1. We found that SIR...

journal_title：Journal of cellular biochemistry

authors： Pan S,Leng J,Deng X,Ruan H,Zhou L,Jamal M,Xiao R,Xiong J,Yin Q,Wu Y,Wang M,Yuan W,Shao L,Zhang Q

更新日期：2020-01-01 00:00:00

abstract：:Cervical cancer is a cancer arising from the cervix, and it is the fourth most common cause of death in women. Overexpression of fibronectin 1 (FN1) was observed in many tumors and associated with the survival and metastasis of cancer cells. However, the mechanism by which FN1 promotes cervical cancer cell viability, ...

journal_title：Journal of cellular biochemistry

authors： Zhou Y,Shu C,Huang Y

更新日期：2019-04-11 00:00:00

abstract：:Alkaline phosphatase (ALP) refers to a group of nonspecific phosphomonoesterases located primarily in cell plasma membrane. It has been described in different cell lines that ecto-ALP is directly or indirectly involved in the modulation of organic cation transport. We aimed to investigate, in Caco-2 cells, a putative ...

journal_title：Journal of cellular biochemistry

authors： Calhau C,Martel F,Hipólito-Reis C,Azevedo I

更新日期：2002-01-01 00:00:00

abstract：:Circular RNAs (circRNA) are endogenous noncoding RNAs and play important roles in cancer; however, the roles of circRNAs in colon cancer are far from clear. The circRNA expression profile in colon cancer tissues was analyzed by microarray. The data from microarray showed that there were 198 upregulated and 136 downreg...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Liu H,Zhao P,Zhou H,Mao T

更新日期：2019-03-01 00:00:00

abstract：:A circular form of bovine pancreatic trypsin inhibitor (BPTI) has been prepared by introducing a peptide bond between the N- and C-termini, which are in close proximity in the native conformation. The pathway and energetics of the disulphide-coupled folding transition of the circular protein have been studied using me...

journal_title：Journal of cellular biochemistry

authors： Goldenberg DP

更新日期：1985-01-01 00:00:00