Abstract:
:The gut microbiome has been shown to play a significant role in human healthy and diseased states. The dynamic signaling that occurs between the host and microbiome is critical for the maintenance of host homeostasis. Analyzing the human microbiome with metaproteomics, metabolomics, and integrative multi-omics analyses can provide significant information on markers for healthy and diseased states, allowing for the eventual creation of microbiome-targeted treatments for diseases associated with dysbiosis. Metaproteomics enables functional activity information to be gained from the microbiome samples, while metabolomics provides insight into the overall metabolic states affecting/representing the host-microbiome interactions. Combining these functional -omic platforms together with microbiome composition profiling allows for a holistic overview on the functional and metabolic state of the microbiome and its influence on human health. Here the benefits of metaproteomics, metabolomics, and the integrative multi-omic approaches to investigating the gut microbiome in the context of human health and diseases are reviewed.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Peters DL,Wang W,Zhang X,Ning Z,Mayne J,Figeys Ddoi
10.1002/pmic.201800363subject
Has Abstractpub_date
2019-08-01 00:00:00pages
e1800363issue
16eissn
1615-9853issn
1615-9861journal_volume
19pub_type
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