Plasma, cerebrospinal fluid, and brain distribution of 14C-melatonin in rat: a biochemical and autoradiographic study.

abstract：:Melatonin is an indoleamine synthesized in the pineal gland, and after its release into the blood, it has an extensive repertoire of biological activities, including antitumoral properties. In this study, we found that melatonin reduced the growth of the human melanoma cells SK-MEL-1. The antiproliferative effect was ...

journal_title：Journal of pineal research

authors： Cabrera J,Negrín G,Estévez F,Loro J,Reiter RJ,Quintana J

更新日期：2010-08-01 00:00:00

abstract：:The role of antioxidants in reducing cancer initiation and progression has been highlighted in recent years. Not only antioxidants limit cancer cell growth but also, in some situations, they promote the effectiveness of conventional treatments. Melatonin, an endogenously synthesized antioxidant, reduces cell growth of...

journal_title：Journal of pineal research

authors： Sainz RM,Reiter RJ,Tan DX,Roldan F,Natarajan M,Quiros I,Hevia D,Rodriguez C,Mayo JC

更新日期：2008-10-01 00:00:00

abstract：:The quantitative autoradiographic 2-[14C]deoxyglucose method was employed to map the metabolic activity of the superior cervical ganglion and the entire brain during unilateral electrical stimulation of the cervical sympathetic trunk in the urethane-anesthetized rat. Stimulation of the cervical sympathetic trunk incre...

journal_title：Journal of pineal research

authors： Ito M,Kadekaro M,Sokoloff L

更新日期：1988-01-01 00:00:00

abstract：:The purpose of the present studies using artificial light was to determine how the timing and duration of exposure influence the light-induced suppression of pineal melatonin levels in hamsters. An 8-min exposure to 0.186 microW/cm2 of cool white fluorescent light caused a continued depression of pineal melatonin even...

journal_title：Journal of pineal research

authors： Brainard GC,Richardson BA,Hurlbut EC,Steinlechner S,Matthews SA,Reiter RJ

更新日期：1984-01-01 00:00:00

abstract：:Recent investigations have demonstrated that melatonin influences carbohydrate metabolism mediated by insulin-inhibiting effects on pancreatic β-cells. This study evaluated whether melatonin has also an effect on pancreatic α-cells and glucagon expression as well as the glucagon secretion in vitro and in vivo. Glucago...

journal_title：Journal of pineal research

authors： Bähr I,Mühlbauer E,Schucht H,Peschke E

更新日期：2011-04-01 00:00:00

abstract：:Melatonin, a neurohormone that binds to two G protein-coupled receptors MT1 and MT2, is involved in pain regulation, but the distinct role of each receptor has yet to be defined. We characterized the nociceptive responses of mice with genetic inactivation of melatonin MT1 (MT1-/- ), or MT2 (MT2-/- ), or both MT1 /MT2 ...

journal_title：Journal of pineal research

authors： Posa L,Lopez-Canul M,Rullo L,De Gregorio D,Dominguez-Lopez S,Kaba Aboud M,Caputi FF,Candeletti S,Romualdi P,Gobbi G

更新日期：2020-10-01 00:00:00

abstract：:Irradiation of the melatonin metabolite N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) with UV light of 254 nm causes the release of carbon monoxide (CO) and, thus, deformylation to N(1)-acetyl-5-methoxykynuramine (AMK). Liberation of CO was demonstrated by reduction of PdCl(2) to metallic palladium, under avoidan...

journal_title：Journal of pineal research

authors： Seever K,Hardeland R

更新日期：2008-05-01 00:00:00

abstract：:The effect of melatonin administration on nerve growth factor (NGF) was studied in the submandibular glands of adult Swiss male mice. Melatonin injection, at 1 microg daily for 30 days, resulted in an increase in the NGF content as detected by immunohistochemistry. The submandibular gland weight and the area of the gr...

journal_title：Journal of pineal research

authors： Pongsa-Asawapaiboon A,Asavaritikrai P,Withyachumnarnkul B,Sumridthong A

更新日期：1998-03-01 00:00:00

abstract：:Melatonin has been shown to have a direct inhibitory action on the proliferation of estrogen-responsive MCF-7 human breast cancer cells in culture. In the present study, we examined by flow cytometry whether this inhibitory effect might be exerted on the G1 phase of the cell cycle, thus causing a transition delay into...

journal_title：Journal of pineal research

authors： Cos S,Blask DE,Lemus-Wilson A,Hill AB

更新日期：1991-01-01 00:00:00

abstract：:Elevated levels of soluble cellular adhesion molecules have been reported in patients with acute coronary syndromes. Likewise, a relation between decreased nocturnal melatonin levels and coronary artery disease has been suggested. The aim of the present study was to investigate the day-night variations in the concentr...

journal_title：Journal of pineal research

authors： Dominguez-Rodriguez A,Abreu-Gonzalez P,Garcia-Gonzalez MJ,Samimi-Fard S,Kaski JC,Reiter RJ

更新日期：2008-01-01 00:00:00

abstract：:The frequency of mitoses of adrenaline (A) cells and noradrenaline (N) cells in the adrenal medulla of nonoperated (NO), sham-operated (SPX), and pinealectomized (PX) male, 53-day-old Holtzman rats (n = 133) was investigated by means of light microscopy. Animals were killed at eight time points during a standardized 2...

journal_title：Journal of pineal research

authors： Kachi T,Quay WB,Banerji TK,Imagawa T

更新日期：1990-01-01 00:00:00

abstract：:Melatonin is a very potent and efficient endogenous radical scavenger. The pineal indolamine reacts with the highly toxic hydroxyl radical and provides on-site protection against oxidative damage to biomolecules within every cellular compartment. Melatonin acts as a primary non-enzymatic antioxidative defense against ...

journal_title：Journal of pineal research

authors： Poeggeler B,Reiter RJ,Tan DX,Chen LD,Manchester LC

更新日期：1993-05-01 00:00:00

abstract：:Chronic hyperhomocysteinemia is a risk factor in cardiovascular diseases and neurodegeneration. Among the putative mechanisms of homocysteine-induced neurotoxicity, an increased production of reactive oxygen species has been suggested. However, elevated homocysteine levels might disturb neurogenesis during brain devel...

journal_title：Journal of pineal research

authors： Baydas G,Koz ST,Tuzcu M,Nedzvetsky VS

更新日期：2008-03-01 00:00:00

abstract：:Melatonin (MEL) has been found in some medicinal and food plants, including grapevine, a commodity of particular interest for the production of wine, a beverage of economic relevance. It has also been suggested that MEL in wine may, at least in part, contribute to the health-promoting properties attributed to this bev...

journal_title：Journal of pineal research

authors： Vigentini I,Gardana C,Fracassetti D,Gabrielli M,Foschino R,Simonetti P,Tirelli A,Iriti M

更新日期：2015-05-01 00:00:00

abstract：:Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocy...

journal_title：Journal of pineal research

authors： Zhang M,Dai X,Lu Y,Miao Y,Zhou C,Cui Z,Liu H,Xiong B

更新日期：2017-04-01 00:00:00

abstract：:During the past decade, a number of reports indicated that the mammalian pineal gland is magnetosensitive in terms of spatial orientation. This indication is based on observations that artificial alterations of the direction of the earth's magnetic field (MF) markedly decreased the gland's capability to synthesize mel...

journal_title：Journal of pineal research

authors： Lerchl A,Nonaka KO,Reiter RJ

更新日期：1991-04-01 00:00:00

abstract：:We have studied the postnatal evolution of the glial cells in the rat pineal gland after its chemical pre- and perinatal denervation, by the assessment of the immunocytochemical expression of three antigens characteristic of glial cells i.e., vimentin (VIM), glial fibrillary acidic protein (GFAP), and S-100 protein. T...

journal_title：Journal of pineal research

authors： López-Muñoz F,Boya J

更新日期：1995-05-01 00:00:00

abstract：:An interaction between melatonin and adrenocorticotropin (ACTH) seems to occur in humans and both hormones respond to beta-adrenergic stimulation. As in lower animal species, human pineal gland also contains alpha2-adrenergic receptors as does the hypothalamus-pituitary axis. In this study the response of the pineal g...

journal_title：Journal of pineal research

authors： Muñóz-Hoyos A,Fernández-García JM,Molina-Carballo A,Macías M,Escames G,Ruiz-Cosano C,Acuña-Castroviejo D

更新日期：2000-08-01 00:00:00

abstract：:Melatonin has previously been shown to be neuroprotective in rodent models of ischemic stroke. Herein, we tested whether this antioxidant may also be suitable for prophylactic use against stroke. To clarify this issue, melatonin was administrated orally for 9 wk (4 mg/kg/day) in mice and its effects on subsequent inju...

journal_title：Journal of pineal research

authors： Kilic E,Kilic U,Reiter RJ,Bassetti CL,Hermann DM

更新日期：2004-11-01 00:00:00

abstract：:Optic atrophy 1 (OPA1)-related mitochondrial fusion and mitophagy are vital to sustain mitochondrial homeostasis under stress conditions. However, no study has confirmed whether OPA1-related mitochondrial fusion/mitophagy is activated by melatonin and, consequently, attenuates cardiomyocyte death and mitochondrial str...

journal_title：Journal of pineal research

authors： Zhang Y,Wang Y,Xu J,Tian F,Hu S,Chen Y,Fu Z

更新日期：2019-03-01 00:00:00

abstract：:Four-week-old male hamsters, born and raised in total darkness or in LD 14:10 (hr) were exposed to several low levels of illumination for 14 weeks. Analyses showed that testicular weights were significantly affected by both photic history and illuminance levels. Animals born in the dark possessed larger testes than th...

journal_title：Journal of pineal research

authors： Hoffman RA,Johnson LB

更新日期：1985-01-01 00:00:00

abstract：:The rod outer segment (ROSg) membranes are essentially lipoprotein complexes. Rhodopsin, the major integral protein of ROSg, is surrounded by phospholipids highly enriched in docosahexaenoic acid (22:6 n3). This fluid environment plays an important role for conformational changes after photo-activation. Thus, ROSg mem...

journal_title：Journal of pineal research

authors： Guajardo MH,Terrasa AM,Catalá A

更新日期：2006-10-01 00:00:00

abstract：:A review of the literature indicates that the absolute oral bioavailability of exogenous melatonin in humans or in preclinical animal models has not been adequately characterized; hence, this study was undertaken. Pharmacokinetics of melatonin was studied in rats, dogs, and monkeys following intravenous and oral admin...

journal_title：Journal of pineal research

authors： Yeleswaram K,McLaughlin LG,Knipe JO,Schabdach D

更新日期：1997-01-01 00:00:00

abstract：:The milk-ejecting response of lactating mouse mammary gland tissue to ovine pineal extracts indicated the presence of a neurohormone-like bioactivity in this tissue. After successive fractionation on gel permeation chromatography and reversed-phase liquid chromatography (HPLC) in conjunction with radioimmunoassays (RI...

journal_title：Journal of pineal research

authors： Noteborn HP,Ebels I,Reinharz AC,Pévet P,Benson B,Salemink CA

更新日期：1988-01-01 00:00:00

abstract：:Previous studies have identified and characterized D1- and D2-dopamine receptors in bovine pineal glands. The data indicate that the density of D1-dopamine receptors (974 fmol/mg protein) far exceed that of D2-dopamine receptors (37 fmol/mg protein). The objective of this study was to identify the mRNAs for both D1- a...

journal_title：Journal of pineal research

authors： Santanavanich C,Chetsawang B,Ebadi M,Govitrapong P

更新日期：2003-10-01 00:00:00

abstract：:Melatonin is a powerful antioxidant and free radical scavenger. A large body of in vivo and in vitro evidence shows that melatonin effectively inhibits membrane lipid peroxidation; this damage was based on the measurement of malondialdehyde and/or 4-hydroxynonenal levels. In the current study, for the first time using...

journal_title：Journal of pineal research

authors： Zhang L,Wei W,Xu J,Min F,Wang L,Wang X,Cao S,Tan DX,Qi W,Reiter RJ

更新日期：2006-05-01 00:00:00

abstract：:The effect of melatonin on thrombin-induced [3H]-arachidonic acid (AA) metabolism to cyclooxygenase derivatives was determined in platelets obtained from normal volunteers at 0830 and 2030 h. Percent conversion of radioactive AA was generally greater at 2030 h than at 0830 h for every cyclooxygenase derivative analyze...

journal_title：Journal of pineal research

authors： Martinuzzo M,Del Zar MM,Cardinali DP,Carreras LO,Vacas MI

更新日期：1991-10-01 00:00:00

abstract：:In the present research, we studied the effect of the administration of melatonin or S-adenosyl-L-methionine (S-AMe) on oxidative stress and hepatic cholestasis produced by double ligature of the extra-hepatic biliary duct (LBD) in adult male Wistar rats. Hepatic oxidative stress was evaluated by the changes in the am...

journal_title：Journal of pineal research

authors： López PM,Fiñana IT,De Agueda MC,Sánchez EC,Muñoz MC,Alvarez JP,De La Torre Lozano EJ

更新日期：2000-04-01 00:00:00

abstract：:The pineal hormone melatonin has been reported to have in vitro antiproliferative effects on estrogen receptor-positive human breast cancer cell lines at concentrations near to plasma physiological concentrations (1 x 10(-11) to 1 x 10(-9) M). Its growth inhibitory actions have been thought to be linked to the estroge...

journal_title：Journal of pineal research

authors： Papazisis KT,Kouretas D,Geromichalos GD,Sivridis E,Tsekreli OK,Dimitriadis KA,Kortsaris AH

更新日期：1998-12-01 00:00:00

abstract：:We tested the hypothesis that melatonin (Mel) enhances exogenous mitochondria (Mito) treatment against rodent hepatic ischemia-reperfusion (IR) injury. In vitro study utilized three groups of hepatocytes (i.e. nontreatment, menadione, and menadione-melatonin treatment, 4.0 × 10(5) each), while in vivo study used adult...

journal_title：Journal of pineal research

authors： Chen HH,Chen YT,Yang CC,Chen KH,Sung PH,Chiang HJ,Chen CH,Chua S,Chung SY,Chen YL,Huang TH,Kao GS,Chen SY,Lee MS,Yip HK

更新日期：2016-08-01 00:00:00