Local glucose utilization of the brain and pineal gland during stimulation of the cervical sympathetic trunk.

abstract：:Our daily rhythmicity is controlled by a circadian clock with a specific set of genes located in the suprachiasmatic nucleus in the hypothalamus. Mast cells (MCs) are major effector cells that play a protective role against pathogens and inflammation. MC distribution and activation are associated with the circadian rh...

journal_title：Journal of pineal research

authors： Pham L,Baiocchi L,Kennedy L,Sato K,Meadows V,Meng F,Huang CK,Kundu D,Zhou T,Chen L,Alpini G,Francis H

更新日期：2020-10-05 00:00:00

abstract：:N-[2-(6-methoxyquinazolin-4-yl)-ethyl] acetamide (MQA) is a compound formed from the melatonin metabolite N(1)-acetyl-5-methoxykynuramine (AMK). We followed MQA production in reaction systems containing various putative reaction partners, in the absence and presence of hydrogen peroxide and/or copper(II). Although MQA...

journal_title：Journal of pineal research

authors： Kuesel JT,Hardeland R,Pfoertner H,Aeckerle N

更新日期：2010-01-01 00:00:00

abstract：:Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant. Among a great number of metabolites that have been tried before, only a few were found (cerulein and quinaldic acid in mice and kynurenic acid in rats). In SHR (bred from Swiss) male mice, intrac...

journal_title：Journal of pineal research

authors： Lapin IP,Mirzaev SM,Ryzov IV,Oxenkrug GF

更新日期：1998-05-01 00:00:00

abstract：:Although there is an increasing evidence that the pineal gland may play a role in human malignancy, the studies on melatonin concentrations in different types of malignant tumors brought about controversial results. However, changes in melatonin concentrations have been observed in some types of human malignant tumors...

journal_title：Journal of pineal research

authors： Karasek M,Kowalski AJ,Suzin J,Zylinska K,Swietoslawski J

更新日期：2005-08-01 00:00:00

abstract：:The cellular proliferative activity in the adult rat pineal gland was studied using bromodeoxyuridine immunohistochemistry during the light and dark phases of an artificial 12L:12D photoperiod. The results showed statistically significant differences in the number of labeled cells between the light and dark phases, wi...

journal_title：Journal of pineal research

authors： Calvo JL,Boya J,Carbonell AL,García-Mauriño JE

更新日期：1997-08-01 00:00:00

abstract：:Improved survival because of advances in neonatal care has resulted in an increased number of infants at risk for chronic lung disease. Even though the etiology of lung injury is multifactorial, recent animal and clinical data indicate that pulmonary damage depends in large part on the ventilatory strategies used. Ven...

journal_title：Journal of pineal research

authors： Gitto E,Reiter RJ,Sabatino G,Buonocore G,Romeo C,Gitto P,Buggé C,Trimarchi G,Barberi I

更新日期：2005-10-01 00:00:00

abstract：:Adult female golden hamsters were used to study the effect of short photoperiod on the endogenous opioid system and the effect of pinealectomy on the serum beta-endorphin-like immunoreactivity (beta-end LI) levels. Hamsters were housed under either long photoperiod (14L:10D) or short photoperiod (2L:22D) and the regul...

journal_title：Journal of pineal research

authors： Kumar MS,Besch EL,Millard WJ,Sharp DC,Leadem CA

更新日期：1984-01-01 00:00:00

abstract：:Ischemia/reperfusion injury (IRI) is harmful to the cardiovascular system and causes mitochondrial oxidative stress. Numerous data indicate that the JAK2/STAT3 signaling pathway is specifically involved in preventing myocardial IRI. Melatonin has potent activity against IRI and may regulate JAK2/STAT3 signaling. This ...

journal_title：Journal of pineal research

authors： Yang Y,Duan W,Jin Z,Yi W,Yan J,Zhang S,Wang N,Liang Z,Li Y,Chen W,Yi D,Yu S

更新日期：2013-10-01 00:00:00

abstract：:Classical anticancer therapies often are ineffective in patients with malignant glioma who have a survival of <1 year. Our previous studies showed a potent inhibitory effect of melatonin on glioma cell proliferation. This effect seems to be mediated by the well-known antioxidant properties of this molecule and the neg...

journal_title：Journal of pineal research

authors： Martín V,Herrera F,García-Santos G,Antolín I,Rodriguez-Blanco J,Medina M,Rodriguez C

更新日期：2007-10-01 00:00:00

abstract：:Day and nighttime melatonin production in the pineal gland was compared in normal and cardiomyopathic (polydystrophic) adult male Syrian hamsters. These strains of hamsters were selected for comparison because the cardiomyopathetic hamster displays a deficient transmembrane Ca(2+)-pump in a number of tissues, and intr...

journal_title：Journal of pineal research

authors： Reiter RJ,White T,Lerchl A,Stokkan KA,Rodriguez C

更新日期：1991-10-01 00:00:00

abstract：:Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure, which leads to right ventricular (RV) hypertrophy and failure. The pathophysiological mechanisms of PH remain unclear but oxidative stress is believed to contribute to RV dysfunction. Melatonin is a powerful antioxidant and is cardio...

journal_title：Journal of pineal research

authors： Maarman G,Blackhurst D,Thienemann F,Blauwet L,Butrous G,Davies N,Sliwa K,Lecour S

更新日期：2015-10-01 00:00:00

abstract：:Sirtuin 1 is a member of the sirtuin family of protein deacetylases, which have attracted considerable attention as mediators of lifespan extension in several model organisms. Induction of sirtuin 1 expression also attenuates neuronal degeneration and death in animal models of Alzheimer's disease and Huntington's dise...

journal_title：Journal of pineal research

authors： Tajes M,Gutierrez-Cuesta J,Ortuño-Sahagun D,Camins A,Pallàs M

更新日期：2009-10-01 00:00:00

abstract：:Light and electron microscopic demonstrations for acid phosphatase (AcPase) activity in the chicken pineal gland were studied with special reference to the changes induced by the light-dark cycle. AcPase-positive lysosomes and Golgi cisternae and vesicles located in the pinealocyte in the light period are well develop...

journal_title：Journal of pineal research

authors： Ohshima K,Matsuo S

更新日期：1989-01-01 00:00:00

abstract：:The rod outer segment (ROSg) membranes are essentially lipoprotein complexes. Rhodopsin, the major integral protein of ROSg, is surrounded by phospholipids highly enriched in docosahexaenoic acid (22:6 n3). This fluid environment plays an important role for conformational changes after photo-activation. Thus, ROSg mem...

journal_title：Journal of pineal research

authors： Guajardo MH,Terrasa AM,Catalá A

更新日期：2006-10-01 00:00:00

abstract：:The effect on nocturnal melatonin secretion of acute administration of the indirectly acting serotonin (5-HT) receptor agonists d-fenfluramine (30 mg) and paroxetine (20 mg) and a partial 5-HT1A receptor agonist ipsapirone (20 mg) was investigated in healthy male volunteers and compared to a placebo condition. Each su...

journal_title：Journal of pineal research

authors： Nathan PJ,Norman TR,Burrows GD

更新日期：1996-09-01 00:00:00

abstract：:Glioblastoma stem-like cells (GSCs) displaying self-renewing and tumor-propagating capacity play a particularly important role in maintaining tumor growth, therapeutic resistance, and tumor recurrence. Therefore, new therapeutic strategies focusing on impairing GSC maintenance are urgently needed. Here, we used GSCs i...

journal_title：Journal of pineal research

authors： Chen X,Hao A,Li X,Du Z,Li H,Wang H,Yang H,Fang Z

更新日期：2016-09-01 00:00:00

abstract：:Oxidative stress is involved in ischemia-reperfusion injury and allograft rejection after transplantation. We studied two well-known antioxidants, melatonin and ascorbic acid (AA), in relation to the survival of a pancreas transplantation model without immunosuppression. Forty-eight Landrace pigs were divided into thr...

journal_title：Journal of pineal research

authors： García-Gil FA,Albendea CD,Escartín J,Lampreave F,Fuentes-Broto L,Roselló-Catafau J,López-Pingarrón L,Reiter RJ,Alvarez-Alegret R,García JJ

更新日期：2011-11-01 00:00:00

abstract：:Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocy...

journal_title：Journal of pineal research

authors： Zhang M,Dai X,Lu Y,Miao Y,Zhou C,Cui Z,Liu H,Xiong B

更新日期：2017-04-01 00:00:00

abstract：:Melatonin is part of the evolutionary conserved highly functional network in vertebrates. It plays a central role in the adaptative behavior of the animal to the environment, including entrainment of daily and annual physiological rhythms, reproductive behavior, food intake, locomotor activity, growth, and breeding pe...

journal_title：Journal of pineal research

authors： Lima-Cabello E,Díaz-Casado ME,Guerrero JA,Otalora BB,Escames G,López LC,Reiter RJ,Acuña-Castroviejo D

更新日期：2014-08-01 00:00:00

abstract：:Recent investigations have demonstrated that melatonin influences carbohydrate metabolism mediated by insulin-inhibiting effects on pancreatic β-cells. This study evaluated whether melatonin has also an effect on pancreatic α-cells and glucagon expression as well as the glucagon secretion in vitro and in vivo. Glucago...

journal_title：Journal of pineal research

authors： Bähr I,Mühlbauer E,Schucht H,Peschke E

更新日期：2011-04-01 00:00:00

abstract：:The purpose of this study was to determine and compare the light sensitivity of two commercially important, phylogenetically different teleost species in terms of melatonin production. Three series of experiments were performed on both Atlantic salmon and European sea bass. First, a range of light intensities were tes...

journal_title：Journal of pineal research

authors： Migaud H,Taylor JF,Taranger GL,Davie A,Cerdá-Reverter JM,Carrillo M,Hansen T,Bromage NR

更新日期：2006-08-01 00:00:00

abstract：:Melatonin, an endogenous neurohormone secreted by the pineal gland, has a variety of physiological functions and neuroprotective effects. However, its protective role on the neural tube defects (NTDs) was not very clear. The aim of this study was to investigate the effects of melatonin on the incidence of NTDs (includ...

journal_title：Journal of pineal research

authors： Liu S,Guo Y,Yuan Q,Pan Y,Wang L,Liu Q,Wang F,Wang J,Hao A

更新日期：2015-11-01 00:00:00

abstract：:Previous data have demonstrated that a single 1-hr light pulse at night affects the secretion of melatonin in the ram if it was given at the appropriate time. This paper reports the effect on melatonin secretion of a 1-hr light pulse given at two different times at night to two groups of rams kept in constant darkness...

journal_title：Journal of pineal research

authors： Ravault JP,Chesneau D

更新日期：1996-11-01 00:00:00

abstract：:The effects of housing condition and type of stimulation on serum melatonin and N-acetylserotonin (NAS) were investigated. Male rats were housed under a 12/12-hour light-dark cycle, with ad libitum food and water, either individually or in groups of four. At the start of the light phase, separate groups were sacrifice...

journal_title：Journal of pineal research

authors： Seggie J,Campbell L,Brown GM,Grota LJ

更新日期：1985-01-01 00:00:00

abstract：:The objective of this study was to apply the radioimmunoassay for 6-sulphatoxymelatonin (aMT6s) to rat urine, and use it to study the source of aMT6s. The radioimmunoassay was found to have acceptable within- and between-assay variation, excellent specificity, and good parallelism between the standard and unknown. Bec...

journal_title：Journal of pineal research

authors： Brown GM,Bar-Or A,Grossi D,Kashur S,Johannson E,Yie SM

更新日期：1991-04-01 00:00:00

abstract：:Melatonin, a molecule produced in the pineal gland and retina of vertebrates, plays a major role in day-night circadian rhythms and other physiological processes, including the immune responses. Because little is known in this respect in fish, we have evaluated the in vivo role of melatonin in the main innate immune a...

journal_title：Journal of pineal research

authors： Cuesta A,Cerezuela R,Esteban MA,Meseguer J

更新日期：2008-08-01 00:00:00

abstract：:Atherosclerosis (AS) is an inflammatory disease linked to endothelial dysfunction. Melatonin is reported to possess substantial anti-inflammatory properties, which has proven to be effective in AS. Emerging literature suggests that pyroptosis plays a critical role during AS progression. However, whether pyroptosis con...

journal_title：Journal of pineal research

authors： Zhang Y,Liu X,Bai X,Lin Y,Li Z,Fu J,Li M,Zhao T,Yang H,Xu R,Li J,Ju J,Cai B,Xu C,Yang B

更新日期：2018-03-01 00:00:00

abstract：:Melatonin has been shown to improve in vitro fertilization and offspring survival after bacterial infection, but its role in regulating maternal-fetal communication during early pregnancy has not been investigated. Results of this study demonstrated expression of abundant melatonin receptors in conceptus and endometri...

journal_title：Journal of pineal research

authors： Bae H,Yang C,Lee JY,Park S,Bazer FW,Song G,Lim W

更新日期：2020-09-01 00:00:00

abstract：:Cell movement is generated by a driving force provided by dynamic cytoskeletal organization. Two main cytoskeletal-dependent features, essential for migration, are the highly cell polarized structure and focal adhesion complexes. Cell migration and substrate anchorage are finely regulated by external signaling exerted...

journal_title：Journal of pineal research

authors： Ortíz-López L,Morales-Mulia S,Ramírez-Rodríguez G,Benítez-King G

更新日期：2009-01-01 00:00:00

abstract：:Carbon tetrachloride (CCl4) exerts its toxic effects by the generation of free radicals. In this study we investigated whether melatonin, a potent free radical scavenger, could prevent the deleterious effects of CCl4. Liver homogenates and liver microsomes were incubated with CCl4 in the presence of melatonin and lipi...

journal_title：Journal of pineal research

authors： Daniels WM,Reiter RJ,Melchiorri D,Sewerynek E,Pablos MI,Ortiz GG

更新日期：1995-08-01 00:00:00