Melatonin secretion in rams maintained in constant darkness depends on the timing of a single 1-hour light pulse given the previous night.

abstract：:Melatonin is a highly effective treatment in different animal models of excitotoxicity or ischemia/reperfusion injury. Due to a lack of patentability, commercial sponsors are not interested in funding clinical evaluations of melatonin. Investigators may initiate small-scale clinical evaluation, and intravenous (i.v.) ...

journal_title：Journal of pineal research

authors： Cheung RT,Tipoe GL,Tam S,Ma ES,Zou LY,Chan PS

更新日期：2006-11-01 00:00:00

abstract：:Entraining effect of melatonin on the circadian rhythm in rat pineal N-acetyltransferase (NAT) activity was studied under various photoperiods. Melatonin administration prior to dark onset for 5 successive days phase-advanced the evening NAT rise under the light:dark (LD) cycle of either LD 10:14 or LD 8:16, but not u...

journal_title：Journal of pineal research

authors： Humlová M,Illnerová H

更新日期：1992-11-01 00:00:00

abstract：:Retinopathy of prematurity is a vision-threatening disease associated with retinal hypoxia-ischemia, leading to the death of retinal neurons and chronic neuronal degeneration. During this study, we used the oxygen-induced retinopathy mice model to mimic retinal hypoxia-ischemia phenotypes to investigate further the ne...

journal_title：Journal of pineal research

authors： Huang R,Xu Y,Lu X,Tang X,Lin J,Cui K,Yu S,Shi Y,Ye D,Liu Y,Liang X

更新日期：2021-01-11 00:00:00

abstract：:Melatonin (MT), endogenously secreted by the pineal gland, is closely related to multiple biological processes; however, its effect on thrombopoiesis is still not well illustrated. Here, we demonstrate that MT administration can elevate peripheral platelet levels. Analysis of different stages in thrombopoiesis reveals...

journal_title：Journal of pineal research

authors： Chen S,Qi Y,Wang S,Xu Y,Shen M,Hu M,Du C,Chen F,Chen M,Lu Y,Zhang Z,Quan Y,Wang C,Wang F,Wang J

更新日期：2020-04-01 00:00:00

abstract：:Light and electron microscopic demonstrations for acid phosphatase (AcPase) activity in the chicken pineal gland were studied with special reference to the changes induced by the light-dark cycle. AcPase-positive lysosomes and Golgi cisternae and vesicles located in the pinealocyte in the light period are well develop...

journal_title：Journal of pineal research

authors： Ohshima K,Matsuo S

更新日期：1989-01-01 00:00:00

abstract：:Melatonin injected in a single intraperitoneal dose of 100 micrograms/100 g b.w. to euhydrated rats resulted in a decrease of neurohypophysial oxytocin content but the hypothalamic oxytocin storage as well as the hypothalamo-neurohypophysial storage of vasopressin were not changed. Following 8 d of once-daily melatoni...

journal_title：Journal of pineal research

authors： Juszczak M,Guzek JW,Lewy A

更新日期：1986-01-01 00:00:00

abstract：:Melatonin is found in a wide variety of plant species. Several investigators have studied the physiological roles of melatonin in plants. However, its role is not well understood because of the limited information on its biosynthetic pathway. To clarify melatonin biosynthesis in plants, we isolated a cDNA-coded arylal...

journal_title：Journal of pineal research

authors： Okazaki M,Higuchi K,Hanawa Y,Shiraiwa Y,Ezura H

更新日期：2009-05-01 00:00:00

abstract：:Melatonin and its precursor, l-tryptophan, have been shown to exert gastroprotective effects in animals, but their influence on the gastric damage by aspirin (ASA) in humans has been sparingly investigated. In this study, we designed to determine the effects of melatonin and l-tryptophan on ASA-induced gastric mucosal...

journal_title：Journal of pineal research

authors： Konturek PC,Konturek SJ,Celinski K,Slomka M,Cichoz-Lach H,Bielanski W,Reiter RJ

更新日期：2010-05-01 00:00:00

abstract：:The rod outer segment (ROSg) membranes are essentially lipoprotein complexes. Rhodopsin, the major integral protein of ROSg, is surrounded by phospholipids highly enriched in docosahexaenoic acid (22:6 n3). This fluid environment plays an important role for conformational changes after photo-activation. Thus, ROSg mem...

journal_title：Journal of pineal research

authors： Guajardo MH,Terrasa AM,Catalá A

更新日期：2006-10-01 00:00:00

abstract：:Melatonin has been shown to improve in vitro fertilization and offspring survival after bacterial infection, but its role in regulating maternal-fetal communication during early pregnancy has not been investigated. Results of this study demonstrated expression of abundant melatonin receptors in conceptus and endometri...

journal_title：Journal of pineal research

authors： Bae H,Yang C,Lee JY,Park S,Bazer FW,Song G,Lim W

更新日期：2020-09-01 00:00:00

abstract：:Both autophagy and melatonin play important roles in plant development and stress response. However, the direct correlation between autophagy and melatonin as well as the underlying mechanism remains elusive in plants. In this study, we discovered that the expression of three autophagy-associated genes (MeATG8b, 8c, a...

journal_title：Journal of pineal research

authors： Wei Y,Bai Y,Cheng X,Zhu B,Reiter RJ,Shi H

更新日期：2020-08-01 00:00:00

abstract：:Rat pineal hydroxyindole-O-methyltransferase (HIOMT; EC 2.1.1.4) was purified by affinity chromatography using an S-adenosyl-L-homocysteine agarose column. This single-step procedure, which is rapid, simple, and applicable to small quantities of tissue, gave a large enrichment of a protein (Mr approximately 38,000) id...

journal_title：Journal of pineal research

authors： Sugden D,Voisin P,Klein DC

更新日期：1986-01-01 00:00:00

abstract：:Melatonin protects cells against various types of oxidative stress-induced apoptosis due primarily to its ability to effectively scavenge pathological and disease condition-augmented generation of mitochondrial reactive oxygen species (mROS). Once produced, mROS indiscriminately damage mitochondrial components and mor...

journal_title：Journal of pineal research

authors： Jou MJ,Peng TI,Hsu LF,Jou SB,Reiter RJ,Yang CM,Chiao CC,Lin YF,Chen CC

更新日期：2010-01-01 00:00:00

abstract：:As for many hormones, melatonin levels in the blood suggest that it is discharged from the pineal gland in a pulsatile manner. Recently, the existence of short-term episodes, superimposed on the circadian pattern of circulating melatonin, has been questioned. Because plasma melatonin levels reflect not only the secret...

journal_title：Journal of pineal research

authors： Follenius M,Weibel L,Brandenberger G

更新日期：1995-04-01 00:00:00

abstract：:While ectopic overexpression of serotonin N-acetyltransferase (SNAT) in plants has been accomplished using animal SNAT genes, ectopic overexpression of plant SNAT genes in plants has not been investigated. Because the plant SNAT protein differs from that of animals in its subcellular localization and enzyme kinetics, ...

journal_title：Journal of pineal research

authors： Lee K,Back K

更新日期：2017-04-01 00:00:00

abstract：:Melatonin biosynthesis was examined in Sekiguchi mutant rice lacking functional tryptamine 5-hydroxylase (T5H) activity, which is the terminal enzyme for serotonin biosynthesis in rice. During senescence process, the leaves of Sekiguchi mutant rice produced more tryptamine and N-acetyltryptamine compared with the wild...

journal_title：Journal of pineal research

authors： Park S,Lee K,Kim YS,Back K

更新日期：2012-03-01 00:00:00

abstract：:Human placental mitochondria might be a significant source of NADPH- and iron-dependent production of reactive oxygen species (ROS). Preeclampsia is believed to be a consequence of overproduction of ROS in human placenta. The experimental results presented here show that melatonin inhibits NADPH- and iron-dependent li...

journal_title：Journal of pineal research

authors： Milczarek R,Hallmann A,Sokołowska E,Kaletha K,Klimek J

更新日期：2010-09-01 00:00:00

abstract：:The frequency of mitoses of adrenaline (A) cells and noradrenaline (N) cells in the adrenal medulla of nonoperated (NO), sham-operated (SPX), and pinealectomized (PX) male, 53-day-old Holtzman rats (n = 133) was investigated by means of light microscopy. Animals were killed at eight time points during a standardized 2...

journal_title：Journal of pineal research

authors： Kachi T,Quay WB,Banerji TK,Imagawa T

更新日期：1990-01-01 00:00:00

abstract：:The effects of housing condition and type of stimulation on serum melatonin and N-acetylserotonin (NAS) were investigated. Male rats were housed under a 12/12-hour light-dark cycle, with ad libitum food and water, either individually or in groups of four. At the start of the light phase, separate groups were sacrifice...

journal_title：Journal of pineal research

authors： Seggie J,Campbell L,Brown GM,Grota LJ

更新日期：1985-01-01 00:00:00

abstract：:N-[2-(6-methoxyquinazolin-4-yl)-ethyl] acetamide (MQA) is a compound formed from the melatonin metabolite N(1)-acetyl-5-methoxykynuramine (AMK). We followed MQA production in reaction systems containing various putative reaction partners, in the absence and presence of hydrogen peroxide and/or copper(II). Although MQA...

journal_title：Journal of pineal research

authors： Kuesel JT,Hardeland R,Pfoertner H,Aeckerle N

更新日期：2010-01-01 00:00:00

abstract：:Resistance inducers are a class of agrochemicals, including benzothiadiazole and chitosan, which activate the plant own defence mechanisms. In this work, open-field treatments with plant activators were performed on two red grape (Vitis vinifera L.) varieties cultivated in different localities, Groppello (Brescia, Lom...

journal_title：Journal of pineal research

authors： Vitalini S,Gardana C,Zanzotto A,Fico G,Faoro F,Simonetti P,Iriti M

更新日期：2011-10-01 00:00:00

abstract：:It is well established that some agents such as aminoglycosides generate free oxygen radicals, leading to an increased oxireductase production, which in turn increases tissue toxicity. The aim of this study is to test whether melatonin, the chief secretory product of the pineal gland and a highly effective antioxidant...

journal_title：Journal of pineal research

authors： Parlakpinar H,Ozer MK,Sahna E,Vardi N,Cigremis Y,Acet A

更新日期：2003-09-01 00:00:00

abstract：:The serum levels of the pineal hormone melatonin were determined by radioimmunoassay (RIA) in 4-h intervals throughout a 24-h period in elderly men with different types of prostate tumors: benign prostatic hyperplasia (BPH, n = 13), incidental carcinoma (PCi, n = 5), and nonmetastasizing carcinoma (PC, n = 9), as well...

journal_title：Journal of pineal research

authors： Bartsch C,Bartsch H,Flüchter SH,Attanasio A,Gupta D

更新日期：1985-01-01 00:00:00

abstract：:The pineal hormone melatonin, due to its lipophilic nature, has access to every cell and every part of a cell in the body, suggesting that it could exert effects on blood immune cells. The regulation of the activation of monocytes may be important in a number of diseases, especially pathophysiological conditions assoc...

journal_title：Journal of pineal research

authors： Fjaerli O,Lund T,Osterud B

更新日期：1999-01-01 00:00:00

abstract：:In a recent study melatonin (N-acetyl-5-methoxytryptamine), a well-investigated animal molecule but minimally studied in plants, was seen to have a physiological role as growth-promoting molecule in lupin hypocotyls. In the present study, the role of melatonin as a growth promoter is extended to coleoptiles of canary ...

journal_title：Journal of pineal research

authors： Hernández-Ruiz J,Cano A,Arnao MB

更新日期：2005-09-01 00:00:00

abstract：:Improved survival because of advances in neonatal care has resulted in an increased number of infants at risk for chronic lung disease. Even though the etiology of lung injury is multifactorial, recent animal and clinical data indicate that pulmonary damage depends in large part on the ventilatory strategies used. Ven...

journal_title：Journal of pineal research

authors： Gitto E,Reiter RJ,Sabatino G,Buonocore G,Romeo C,Gitto P,Buggé C,Trimarchi G,Barberi I

更新日期：2005-10-01 00:00:00

abstract：:In mammals, the suprachiasmatic nuclei (SCN) constitute the main circadian clock, receiving input from the retina which allows synchronization of endogenous biological rhythms with the daily light/dark cycle. Over the year, the SCN encodes photoperiodic variations through duration of melatonin secretion, with abundant...

journal_title：Journal of pineal research

authors： Leclercq B,Hicks D,Laurent V

更新日期：2020-12-16 00:00:00

abstract：:A physiologically based model of arousal dynamics is improved to incorporate the effects of the light spectrum on circadian phase resetting, melatonin suppression, and subjective sleepiness. To account for these nonvisual effects of light, melanopic irradiance replaces photopic illuminance that was used previously in ...

journal_title：Journal of pineal research

authors： Tekieh T,Lockley SW,Robinson PA,McCloskey S,Zobaer MS,Postnova S

更新日期：2020-10-01 00:00:00

abstract：:Previous research has shown that antioxidant (butylated hydroxyanisole) treatment ameliorates respiratory syncytial virus (RSV)-induced disease and lung inflammation. Melatonin has been reported to exhibit a wide varieties of biological effects, including antioxidant and anti-inflammation, and has no evident toxicity ...

journal_title：Journal of pineal research

authors： Huang SH,Cao XJ,Liu W,Shi XY,Wei W

更新日期：2010-03-01 00:00:00

abstract：:Melatonin, a major pineal secretory product, exerts a range of physiological and neuroprotective effects. However, the functional significance of melatonin in determining neural identity, and the mechanisms by which this may occur, is unknown. In this study, P19 cells were used as a model system and cell behavior was ...

journal_title：Journal of pineal research

authors： Chen X,Li X,Du Z,Shi W,Yao Y,Wang C,He K,Hao A

更新日期：2014-09-01 00:00:00