The dual roles of melatonin biosynthesis enzymes in the coordination of melatonin biosynthesis and autophagy in cassava.

abstract：:Melatonin is a powerful antioxidant and free radical scavenger. A large body of in vivo and in vitro evidence shows that melatonin effectively inhibits membrane lipid peroxidation; this damage was based on the measurement of malondialdehyde and/or 4-hydroxynonenal levels. In the current study, for the first time using...

journal_title：Journal of pineal research

authors： Zhang L,Wei W,Xu J,Min F,Wang L,Wang X,Cao S,Tan DX,Qi W,Reiter RJ

更新日期：2006-05-01 00:00:00

abstract：:Maternal hyperthermia induces early embryonic death via increased oxidative stress to the embryo. In this study, we examined whether melatonin administered to heat-stressed pregnant mice would reduce hyperthermia-induced embryonic death. Mice were heat stressed (12 hr at 35 degrees C, 60% relative humidity) on the day...

journal_title：Journal of pineal research

authors： Matsuzuka T,Sakamoto N,Ozawa M,Ushitani A,Hirabayashi M,Kanai Y

更新日期：2005-10-01 00:00:00

abstract：:Melatonin injected in a single intraperitoneal dose of 100 micrograms/100 g b.w. to euhydrated rats resulted in a decrease of neurohypophysial oxytocin content but the hypothalamic oxytocin storage as well as the hypothalamo-neurohypophysial storage of vasopressin were not changed. Following 8 d of once-daily melatoni...

journal_title：Journal of pineal research

authors： Juszczak M,Guzek JW,Lewy A

更新日期：1986-01-01 00:00:00

abstract：:We investigated the role of melatonin on water avoidance stress (WAS)-induced degeneration of the gastric, ileal and colonic mucosa. Wistar albino rats were exposed to acute WAS (aWAS group) or chronic WAS (cWAS group). Before exposing animals to acute (aWAS + mel group) or chronic WAS (cWAS + mel group), 10 mg/kg mel...

journal_title：Journal of pineal research

authors： Ercan F,Cetinel S,Contuk G,Cikler E,Sener G

更新日期：2004-09-01 00:00:00

abstract：:Most contemporary progress in Alzheimer's disease (AD) stems from the study of a 42 43 amino acid peptide. called the amyloid beta protein (Abeta), as the main neuropathologic marker of the disorder. It has been demonstrated that Abeta has neurotoxic properties and that such effects are mediated by free-radicals. Expo...

journal_title：Journal of pineal research

authors： Pappolla MA,Chyan YJ,Poeggeler B,Bozner P,Ghiso J,LeDoux SP,Wilson GL

更新日期：1999-11-01 00:00:00

abstract：:The role played by postsynaptic alpha-adrenergic receptors in the stimulation of pineal melatonin production was investigated in the Syrian hamster. The studies were conducted using organ cultured pineal glands collected from both anatomically intact and superior cervical ganglionectomized hamsters. Results obtained i...

journal_title：Journal of pineal research

authors： Santana C,Guerrero JM,Reiter RJ,Menendez-Pelaez A

更新日期：1989-01-01 00:00:00

abstract：:It is well established that some agents such as aminoglycosides generate free oxygen radicals, leading to an increased oxireductase production, which in turn increases tissue toxicity. The aim of this study is to test whether melatonin, the chief secretory product of the pineal gland and a highly effective antioxidant...

journal_title：Journal of pineal research

authors： Parlakpinar H,Ozer MK,Sahna E,Vardi N,Cigremis Y,Acet A

更新日期：2003-09-01 00:00:00

abstract：:Melatonin (MEL) has been found in some medicinal and food plants, including grapevine, a commodity of particular interest for the production of wine, a beverage of economic relevance. It has also been suggested that MEL in wine may, at least in part, contribute to the health-promoting properties attributed to this bev...

journal_title：Journal of pineal research

authors： Vigentini I,Gardana C,Fracassetti D,Gabrielli M,Foschino R,Simonetti P,Tirelli A,Iriti M

更新日期：2015-05-01 00:00:00

abstract：:Antioxidant activity of a molecule is attributed to various mechanisms such as prevention of chain initiation, binding of transition metal ion catalysts and decomposition of peroxides. This study was aimed at evaluating the metal chelating and hydrogen peroxide (H2O2) scavenging activity of melatonin. The metal chelat...

journal_title：Journal of pineal research

authors： Gulcin I,Buyukokuroglu ME,Kufrevioglu OI

更新日期：2003-05-01 00:00:00

abstract：:The distribution of 14C-Melatonin (14C-MT) after systemic injection was studied in the plasma, cerebrospinal fluid (CSF), and brain of rats. Chromatographic analysis (thin-layer chromatography and high-performance liquid chromatography) indicated that the radioactivity from biological samples taken at various times fo...

journal_title：Journal of pineal research

authors： Vitte PA,Harthe C,Lestage P,Claustrat B,Bobillier P

更新日期：1988-01-01 00:00:00

abstract：:Oxidative stress is reported as one of the most widely accepted mechanisms of maneb (MB)- and paraquat (PQ)-induced nigrostriatal dopaminergic neurodegeneration leading to the Parkinson's disease (PD) phenotype. The study investigated the effects of silymarin, an antioxidant of plant origin, and melatonin, an indoleam...

journal_title：Journal of pineal research

authors： Singhal NK,Srivastava G,Patel DK,Jain SK,Singh MP

更新日期：2011-03-01 00:00:00

abstract：:Four weeks of administration of melatonin mixed in the diet (5 mg/kg of food) significantly reduced the incidence of gastric ulcers in young pigs. In control and melatonin supplemented animals, significantly higher levels of melatonin were found in the stomach tissues as compared to jejunum, ileum, or colon. Pigs with...

journal_title：Journal of pineal research

authors： Bubenik GA,Ayles HL,Friendship RM,Brown GM,Ball RO

更新日期：1998-01-01 00:00:00

abstract：:Resistance inducers are a class of agrochemicals, including benzothiadiazole and chitosan, which activate the plant own defence mechanisms. In this work, open-field treatments with plant activators were performed on two red grape (Vitis vinifera L.) varieties cultivated in different localities, Groppello (Brescia, Lom...

journal_title：Journal of pineal research

authors： Vitalini S,Gardana C,Zanzotto A,Fico G,Faoro F,Simonetti P,Iriti M

更新日期：2011-10-01 00:00:00

abstract：:Retinopathy of prematurity is a vision-threatening disease associated with retinal hypoxia-ischemia, leading to the death of retinal neurons and chronic neuronal degeneration. During this study, we used the oxygen-induced retinopathy mice model to mimic retinal hypoxia-ischemia phenotypes to investigate further the ne...

journal_title：Journal of pineal research

authors： Huang R,Xu Y,Lu X,Tang X,Lin J,Cui K,Yu S,Shi Y,Ye D,Liu Y,Liang X

更新日期：2021-01-11 00:00:00

abstract：:The protective role of exogenous melatonin on U-induced nephrotoxicity was investigated in rats. Animals were given single doses of uranyl acetate dihydrate (UAD) at 5 mg/kg (subcutaneous), melatonin at 10 or 20 mg/kg (intraperitoneal), and UAD (5 mg/kg) plus melatonin (10 or 20 mg/kg), or vehicle (control group). In ...

journal_title：Journal of pineal research

authors： Bellés M,Linares V,Luisa Albina M,Sirvent J,Sánchez DJ,Domingo JL

更新日期：2007-08-01 00:00:00

abstract：:Entraining effect of melatonin on the circadian rhythm in rat pineal N-acetyltransferase (NAT) activity was studied under various photoperiods. Melatonin administration prior to dark onset for 5 successive days phase-advanced the evening NAT rise under the light:dark (LD) cycle of either LD 10:14 or LD 8:16, but not u...

journal_title：Journal of pineal research

authors： Humlová M,Illnerová H

更新日期：1992-11-01 00:00:00

abstract：:N-[2-(6-methoxyquinazolin-4-yl)-ethyl] acetamide (MQA) is a compound formed from the melatonin metabolite N(1)-acetyl-5-methoxykynuramine (AMK). We followed MQA production in reaction systems containing various putative reaction partners, in the absence and presence of hydrogen peroxide and/or copper(II). Although MQA...

journal_title：Journal of pineal research

authors： Kuesel JT,Hardeland R,Pfoertner H,Aeckerle N

更新日期：2010-01-01 00:00:00

abstract：:Melatonin is known to regulate a variety of physiological processes including control of circadian rhythms, regulation of seasonal reproductive function, regulation of body temperature, and so forth. Accumulating evidence from in vitro and in vivo experiments using rodent and chicken has also suggested that melatonin ...

journal_title：Journal of pineal research

authors： Satomura K,Tobiume S,Tokuyama R,Yamasaki Y,Kudoh K,Maeda E,Nagayama M

更新日期：2007-04-01 00:00:00

abstract：:A link between endotoxemia and nonalcoholic fatty liver disease (NAFLD) has been demonstrated in human and rodent animals. Nevertheless, the molecular mechanisms of endotoxin-evoked NAFLD remain poorly understood. We hypothesize that reactive oxygen species (ROS) mediate lipopolysaccharide (LPS)-evoked hepatic lipid a...

journal_title：Journal of pineal research

authors： Chen X,Zhang C,Zhao M,Shi CE,Zhu RM,Wang H,Zhao H,Wei W,Li JB,Xu DX

更新日期：2011-11-01 00:00:00

abstract：:Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocy...

journal_title：Journal of pineal research

authors： Zhang M,Dai X,Lu Y,Miao Y,Zhou C,Cui Z,Liu H,Xiong B

更新日期：2017-04-01 00:00:00

abstract：:The antioxidant and anti-inflammatory effects of melatonin on kainic acid (KA)-induced neurodegeneration in the hippocampus were evaluated in vivo. It has been suggested that the pineal secretory product, melatonin, protects neurons in vitro from excitotoxicity mediated by kainate-sensitive glutamate receptors, and fr...

journal_title：Journal of pineal research

authors： Chung SY,Han SH

更新日期：2003-03-01 00:00:00

abstract：:Day and nighttime melatonin production in the pineal gland was compared in normal and cardiomyopathic (polydystrophic) adult male Syrian hamsters. These strains of hamsters were selected for comparison because the cardiomyopathetic hamster displays a deficient transmembrane Ca(2+)-pump in a number of tissues, and intr...

journal_title：Journal of pineal research

authors： Reiter RJ,White T,Lerchl A,Stokkan KA,Rodriguez C

更新日期：1991-10-01 00:00:00

abstract：:Diurnal variations in serum melatonin levels and pineal concentrations of serotonin (5-HT), N-acetylserotonin (NAS), 5-hydroxyindole acetic acid (5-HIAA), and melatonin were estimated in adult male Djungarian hamsters kept under long-day (LD 16:8) or short-day (LD 8:16) photoperiods. The nocturnal increase in melatoni...

journal_title：Journal of pineal research

authors： Lerchl A,Schlatt S

更新日期：1992-04-01 00:00:00

abstract：:Melatonin, the main secretory product of the pineal gland, has been shown to be potentially effective in prevention of numerous types of neurodegenerative disorders in which free radical processes are involved. Homocysteine (Hcy), an independent risk factor for atherosclerosis, undergoes auto-oxidation and generates r...

journal_title：Journal of pineal research

authors： Baydas G,Kutlu S,Naziroglu M,Canpolat S,Sandal S,Ozcan M,Kelestimur H

更新日期：2003-01-01 00:00:00

abstract：:While ectopic overexpression of serotonin N-acetyltransferase (SNAT) in plants has been accomplished using animal SNAT genes, ectopic overexpression of plant SNAT genes in plants has not been investigated. Because the plant SNAT protein differs from that of animals in its subcellular localization and enzyme kinetics, ...

journal_title：Journal of pineal research

authors： Lee K,Back K

更新日期：2017-04-01 00:00:00

abstract：:Melatonin, an endogenous neurohormone secreted by the pineal gland, has a variety of physiological functions and neuroprotective effects. However, its protective role on the neural tube defects (NTDs) was not very clear. The aim of this study was to investigate the effects of melatonin on the incidence of NTDs (includ...

journal_title：Journal of pineal research

authors： Liu S,Guo Y,Yuan Q,Pan Y,Wang L,Liu Q,Wang F,Wang J,Hao A

更新日期：2015-11-01 00:00:00

abstract：:Melatonin, a major pineal secretory product, exerts a range of physiological and neuroprotective effects. However, the functional significance of melatonin in determining neural identity, and the mechanisms by which this may occur, is unknown. In this study, P19 cells were used as a model system and cell behavior was ...

journal_title：Journal of pineal research

authors： Chen X,Li X,Du Z,Shi W,Yao Y,Wang C,He K,Hao A

更新日期：2014-09-01 00:00:00

abstract：:Excessive production of nitric oxide (NO) may play a detrimental role in the process of hypoxia-related neuropathology. This study explored whether treatment with melatonin would attenuate the neuropathological changes in the vagal ganglia following a severe hypoxic insult. Thirty minutes prior to hypoxia treatment, y...

journal_title：Journal of pineal research

authors： Chang HM,Ling EA,Chen CF,Lue H,Wen CY,Shieh JY

更新日期：2002-03-01 00:00:00

abstract：:Irradiation of the melatonin metabolite N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) with UV light of 254 nm causes the release of carbon monoxide (CO) and, thus, deformylation to N(1)-acetyl-5-methoxykynuramine (AMK). Liberation of CO was demonstrated by reduction of PdCl(2) to metallic palladium, under avoidan...

journal_title：Journal of pineal research

authors： Seever K,Hardeland R

更新日期：2008-05-01 00:00:00

abstract：:A physiologically based model of arousal dynamics is improved to incorporate the effects of the light spectrum on circadian phase resetting, melatonin suppression, and subjective sleepiness. To account for these nonvisual effects of light, melanopic irradiance replaces photopic illuminance that was used previously in ...

journal_title：Journal of pineal research

authors： Tekieh T,Lockley SW,Robinson PA,McCloskey S,Zobaer MS,Postnova S

更新日期：2020-10-01 00:00:00