Melatonin prevents neural tube defects in the offspring of diabetic pregnancy.

abstract：:Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant. Among a great number of metabolites that have been tried before, only a few were found (cerulein and quinaldic acid in mice and kynurenic acid in rats). In SHR (bred from Swiss) male mice, intrac...

journal_title：Journal of pineal research

authors： Lapin IP,Mirzaev SM,Ryzov IV,Oxenkrug GF

更新日期：1998-05-01 00:00:00

abstract：:While ectopic overexpression of serotonin N-acetyltransferase (SNAT) in plants has been accomplished using animal SNAT genes, ectopic overexpression of plant SNAT genes in plants has not been investigated. Because the plant SNAT protein differs from that of animals in its subcellular localization and enzyme kinetics, ...

journal_title：Journal of pineal research

authors： Lee K,Back K

更新日期：2017-04-01 00:00:00

abstract：:Melatonin, the main secretory product of the pineal gland, has been shown to be potentially effective in prevention of numerous types of neurodegenerative disorders in which free radical processes are involved. Homocysteine (Hcy), an independent risk factor for atherosclerosis, undergoes auto-oxidation and generates r...

journal_title：Journal of pineal research

authors： Baydas G,Kutlu S,Naziroglu M,Canpolat S,Sandal S,Ozcan M,Kelestimur H

更新日期：2003-01-01 00:00:00

abstract：:To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every ...

journal_title：Journal of pineal research

authors： Luboshitzky R,Lavi S,Thuma I,Lavie P

更新日期：1996-03-01 00:00:00

abstract：:The effects of housing condition and type of stimulation on serum melatonin and N-acetylserotonin (NAS) were investigated. Male rats were housed under a 12/12-hour light-dark cycle, with ad libitum food and water, either individually or in groups of four. At the start of the light phase, separate groups were sacrifice...

journal_title：Journal of pineal research

authors： Seggie J,Campbell L,Brown GM,Grota LJ

更新日期：1985-01-01 00:00:00

abstract：:There are functional inter-relationships between the beta cells of the endocrine pancreas and the pineal gland, where the synchronizing circadian molecule melatonin originates. The aim of this study was to elucidate a putative interaction between insulin and melatonin in diabetic patients and a diabetic rat model. We ...

journal_title：Journal of pineal research

authors： Peschke E,Frese T,Chankiewitz E,Peschke D,Preiss U,Schneyer U,Spessert R,Mühlbauer E

更新日期：2006-03-01 00:00:00

abstract：:Melatonin secretion is an endogenous synchronizer, and it may possess some anti-aging properties. Thus we examined melatonin levels in physiological aging, in extreme senescence and in senile dementia. In healthy old (age 66-94 yr) and young subjects (age 23-39 yr) and in demented patients (age 68-91 yr) plasma melato...

journal_title：Journal of pineal research

authors： Magri F,Sarra S,Cinchetti W,Guazzoni V,Fioravanti M,Cravello L,Ferrari E

更新日期：2004-05-01 00:00:00

abstract：:5-Methoxycarbonylamino-N-acetyltryptamine (MCA-NAT) has been initially described as a ligand at non MT(1), non MT(2) melatonin binding site (MT3) selective versus MT(1) and MT(2), two membrane melatonin receptors. MCA-NAT activity has been reported by others in different models, in vivo, particularly in the intra-ocul...

journal_title：Journal of pineal research

authors： Vincent L,Cohen W,Delagrange P,Boutin JA,Nosjean O

更新日期：2010-04-01 00:00:00

abstract：:Melatonin, which is contained in certain vegetables, may have an influence on circulatory melatonin concentrations. This study examined the effects of the consumption of vegetables on 6-sulfatoxymelatonin concentrations in morning urine. Ninety-four healthy women aged 24-55 were recruited through a city public health ...

journal_title：Journal of pineal research

authors： Oba S,Nakamura K,Sahashi Y,Hattori A,Nagata C

更新日期：2008-08-01 00:00:00

abstract：:No previous reports have described the effects of an increase in endogenous melatonin levels on plant yield and reproduction. Here, the phenotypes of melatonin-rich transgenic rice plants overexpressing sheep serotonin N-acetyltransferase were investigated under field conditions. Early seedling growth of melatonin-ric...

journal_title：Journal of pineal research

authors： Byeon Y,Back K

更新日期：2014-05-01 00:00:00

abstract：:Environmental pollution in the form of particulate matter <2.5 μm (PM2.5 ) is a major risk factor for diseases such as lung cancer, chronic respiratory infections, and major cardiovascular diseases. Our goal was to show that PM2.5 eliciting a proinflammatory response activates the immune-pineal axis, reducing the pine...

journal_title：Journal of pineal research

authors： Carvalho-Sousa CE,Pereira EP,Kinker GS,Veras M,Ferreira ZS,Barbosa-Nunes FP,Martins JO,Saldiva PHN,Reiter RJ,Fernandes PA,da Silveira Cruz-Machado S,Markus RP

更新日期：2020-04-01 00:00:00

abstract：:When organic compounds are irradiated with UV light at 254 nm, part of their covalent bonds can dissociate if the compound absorbs light at that wavelength. Therefore, photo-degradation depends strongly on the wavelength used. The energy of a light quanta at 254 nm amounts to approximately 110 kcal/mol quanta, which i...

journal_title：Journal of pineal research

authors： Brömme HJ,Peschke E,Israel G

更新日期：2008-05-01 00:00:00

abstract：:Obesity, a major risk factor for ischemic heart disease, is associated with increased oxidative stress and reduced antioxidant status. Melatonin, a potent free radical scavenger and antioxidant, has powerful cardioprotective effects in lean animals but its efficacy in obesity is unknown. We investigated the effects of...

journal_title：Journal of pineal research

authors： Nduhirabandi F,Du Toit EF,Blackhurst D,Marais D,Lochner A

更新日期：2011-03-01 00:00:00

abstract：:The effect of melatonin on thrombin-induced [3H]-arachidonic acid (AA) metabolism to cyclooxygenase derivatives was determined in platelets obtained from normal volunteers at 0830 and 2030 h. Percent conversion of radioactive AA was generally greater at 2030 h than at 0830 h for every cyclooxygenase derivative analyze...

journal_title：Journal of pineal research

authors： Martinuzzo M,Del Zar MM,Cardinali DP,Carreras LO,Vacas MI

更新日期：1991-10-01 00:00:00

abstract：:We examined the association between 6-sulphatoxymelatonin (6-SMT) excretion and sleep in 68 volunteers 60-79 years of age who complained of insomnia or depression. An Actillume wrist monitor was worn for 5-7 consecutive days and nights in home-living conditions. Activity was used to estimate total sleep time (TST) and...

journal_title：Journal of pineal research

authors： Youngstedt SD,Kripke DF,Elliott JA

更新日期：1998-04-01 00:00:00

abstract：:The purpose of this study was to determine and compare the effects of chronic melatonin treatment in vivo on several aspects of prolactin (PRL) cell activity (PRL synthesis, storage, and release) in vitro in male and female Syrian hamsters. Adult male and female hamsters were maintained on long photoperiod and treated...

journal_title：Journal of pineal research

authors： Blask DE

更新日期：1989-01-01 00:00:00

abstract：:Melatonin is produced following circadian rhythm with high levels being released at night and has been implicated in the regulation of physiological processes in major tissues, including the pancreas. The aim of our study was to examine the effects of melatonin on intracellular free Ca(2+) concentration ([Ca(2+) ](c))...

journal_title：Journal of pineal research

authors： del Castillo-Vaquero A,Salido GM,Gonzalez A

更新日期：2010-10-01 00:00:00

abstract：:In healthy young men, administration of a single light pulse (5000 lux for 3 hr) or a single melatonin pill (5 mg) at 20:40 hr under controlled constant routine conditions of <10 lux, yielded a phase delay and a phase advance, respectively, in the circadian marker of dim light melatonin onset 24 hr later. Phase shifts...

journal_title：Journal of pineal research

authors： Wirz-Justice A,Kräuchi K,Cajochen C,Danilenko KV,Renz C,Weber JM

更新日期：2004-04-01 00:00:00

abstract：:Optic atrophy 1 (OPA1)-related mitochondrial fusion and mitophagy are vital to sustain mitochondrial homeostasis under stress conditions. However, no study has confirmed whether OPA1-related mitochondrial fusion/mitophagy is activated by melatonin and, consequently, attenuates cardiomyocyte death and mitochondrial str...

journal_title：Journal of pineal research

authors： Zhang Y,Wang Y,Xu J,Tian F,Hu S,Chen Y,Fu Z

更新日期：2019-03-01 00:00:00

abstract：:The aim of this study was to determine, in the rat, the interaction between melatonin and cholecystokinin in the regulation of the ileal interdigestive motility. This was analyzed by the chronic electromyography technique. Ileal motility was defined by the presence of intermittent spike bursts corresponding to the con...

journal_title：Journal of pineal research

authors： Bonouali-Pellissier S

更新日期：1994-09-01 00:00:00

abstract：:Melatonin is a highly effective treatment in different animal models of excitotoxicity or ischemia/reperfusion injury. Due to a lack of patentability, commercial sponsors are not interested in funding clinical evaluations of melatonin. Investigators may initiate small-scale clinical evaluation, and intravenous (i.v.) ...

journal_title：Journal of pineal research

authors： Cheung RT,Tipoe GL,Tam S,Ma ES,Zou LY,Chan PS

更新日期：2006-11-01 00:00:00

abstract：:The effect of anticonvulsant drugs on daytime and nighttime N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT) levels was investigated. Some of the drugs caused a significant reduction in daytime NAT and HIOMT levels, possibly owing to beta-receptor blockade although other mechanisms cannot be exc...

journal_title：Journal of pineal research

authors： Morton DJ

更新日期：1986-01-01 00:00:00

abstract：:The binding characteristics of the tritiated pineal hormone, [3H] melatonin, were studied in brain tissues using in vitro binding techniques. In synaptosomal membranes prepared from rat hippocampus and subjected to preincubation at 37 degrees C and multiple washings, high-affinity binding of [3H] melatonin significant...

journal_title：Journal of pineal research

authors： Niles LP

更新日期：1987-01-01 00:00:00

abstract：:Impaired Ca2+ homeostasis and smooth muscle contractility co-exist in acute cholecystitis (AC) leading to gallbladder dysfunction. There is no pharmacological treatment for this pathological condition. Our aim was to evaluate the effects of melatonin treatment on Ca2+ signaling pathways and contractility altered by ch...

journal_title：Journal of pineal research

authors： Gomez-Pinilla PJ,Camello PJ,Pozo MJ

更新日期：2008-04-01 00:00:00

abstract：:Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties. There are also experimental and clinical data supporting an analgesic role of melatonin. In experimental studies, melatonin sho...

journal_title：Journal of pineal research

authors： Wilhelmsen M,Amirian I,Reiter RJ,Rosenberg J,Gögenur I

更新日期：2011-10-01 00:00:00

abstract：:The aim of this study was to compare the circadian control of melatonin production in teleosts. To do so, the effects of ophthalmectomy on circulating melatonin rhythms were studied along with ex vivo pineal culture in six different teleosts. Results strongly suggested that the circadian control of melatonin productio...

journal_title：Journal of pineal research

authors： Migaud H,Davie A,Martinez Chavez CC,Al-Khamees S

更新日期：2007-11-01 00:00:00

abstract：:N-[2-(6-methoxyquinazolin-4-yl)-ethyl] acetamide (MQA) is a compound formed from the melatonin metabolite N(1)-acetyl-5-methoxykynuramine (AMK). We followed MQA production in reaction systems containing various putative reaction partners, in the absence and presence of hydrogen peroxide and/or copper(II). Although MQA...

journal_title：Journal of pineal research

authors： Kuesel JT,Hardeland R,Pfoertner H,Aeckerle N

更新日期：2010-01-01 00:00:00

abstract：:We evaluated the feasibility of using morning urine samples in epidemiological studies aimed at clarifying the relationship between nocturnal melatonin levels and breast cancer risk. Initially, a laboratory-based study of 29 women (40- 70 yr old) was performed to examine the correlation between plasma melatonin levels...

journal_title：Journal of pineal research

authors： Cook MR,Graham C,Kavet R,Stevens RG,Davis S,Kheifets L

更新日期：2000-01-01 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter/neuromodulator involved in cell-to-cell communication within the central nervous system, is now believed to play a role in neuroendocrine function. In this study we describe a single, saturable, stereospecific, and temperature-, time-, and pH-dependent binding site for glutama...

journal_title：Journal of pineal research

authors： Kus L,Handa RJ,McNulty JA

更新日期：1993-01-01 00:00:00

abstract：:Melatonin (MEL) has been found in some medicinal and food plants, including grapevine, a commodity of particular interest for the production of wine, a beverage of economic relevance. It has also been suggested that MEL in wine may, at least in part, contribute to the health-promoting properties attributed to this bev...

journal_title：Journal of pineal research

authors： Vigentini I,Gardana C,Fracassetti D,Gabrielli M,Foschino R,Simonetti P,Tirelli A,Iriti M

更新日期：2015-05-01 00:00:00