Abstract：
:When organic compounds are irradiated with UV light at 254 nm, part of their covalent bonds can dissociate if the compound absorbs light at that wavelength. Therefore, photo-degradation depends strongly on the wavelength used. The energy of a light quanta at 254 nm amounts to approximately 110 kcal/mol quanta, which is in many cases higher than the binding energy of a variety of covalent bonds. As a consequence, the absorbing molecule is degraded. As melatonin absorbs light at 254 nm, this compound is vulnerable to UV light. In order to minimize undesired effects of other absorbing substances, we used as solvent mostly pure water and analyzed the influence of lambda irr = 254 nm on the disappearance of the educt (melatonin) as well as on the appearance of products derived from melatonin in the presence of oxygen, argon, hydrogen peroxide, and ethanol by UV-VIS spectroscopy and high-performance liquid chromatography (HPLC) technique. N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) appears to be the main, but obviously not the only product of photo-degradation of melatonin, independently of whether the system contains oxygen or not. If the system contains additionally hydrogen peroxide, a very strong oxidant, the hydroxyl radical (*OH), is formed. Under such conditions, melatonin is not solely photo-degraded but also attacked by the formed *OH which interact similarly with the formed main photo-product AFMK. Ethanol, as a potent scavenger of *OH, efficiently blocks the effect of this aggressive radical even at low concentrations of that scavenger (0.1% v/v) but is less effective in preventing photo-degradation of melatonin.
journal_name
J Pineal Resjournal_title
Journal of pineal researchauthors
Brömme HJ,Peschke E,Israel Gdoi
10.1111/j.1600-079x.2007.00536.xsubject
Has Abstractpub_date
2008-05-01 00:00:00pages
366-72issue
4eissn
0742-3098issn
1600-079Xjournal_volume
44pub_type
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journal_title：Journal of pineal research
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abstract：:Nasopharyngeal carcinoma (NPC), a disease common in the South-East Asian population, has high lymph node metastatic ability. Melatonin, an endogenously produced substance present in animals, plants, fungi, and bacteria, has oncostatic activity via several mechanisms. The molecular mechanisms involved in melatonin-medi...
journal_title：Journal of pineal research
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journal_title：Journal of pineal research
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doi：10.1034/j.1600-079x.2003.00083.x
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pub_type： 杂志文章
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journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1997.tb00318.x
更新日期：1997-04-01 00:00:00
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journal_title：Journal of pineal research
pub_type： 杂志文章,评审
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journal_title：Journal of pineal research
pub_type： 杂志文章
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doi：10.1111/j.1600-079X.2010.00848.x
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journal_title：Journal of pineal research
pub_type： 杂志文章
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journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079X.2006.00330.x
更新日期：2006-08-01 00:00:00
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journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1991.tb00475.x
更新日期：1991-10-01 00:00:00
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journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079X.2005.00287.x
更新日期：2006-03-01 00:00:00
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journal_title：Journal of pineal research
pub_type： 杂志文章
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journal_title：Journal of pineal research
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journal_title：Journal of pineal research
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journal_title：Journal of pineal research
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journal_title：Journal of pineal research
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Journal of pineal research
pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1600-079x.1985.tb00633.x
更新日期：1985-01-01 00:00:00
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journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1992.tb00031.x
更新日期：1992-03-01 00:00:00
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journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079X.2008.00573.x
更新日期：2008-09-01 00:00:00
abstract：:Melatonin (MEL) has been found in some medicinal and food plants, including grapevine, a commodity of particular interest for the production of wine, a beverage of economic relevance. It has also been suggested that MEL in wine may, at least in part, contribute to the health-promoting properties attributed to this bev...
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