Permeability of the pineal gland of the rat to lanthanum: significance of dark pinealocytes.

abstract：:The effect of melatonin on thrombin-induced [3H]-arachidonic acid (AA) metabolism to cyclooxygenase derivatives was determined in platelets obtained from normal volunteers at 0830 and 2030 h. Percent conversion of radioactive AA was generally greater at 2030 h than at 0830 h for every cyclooxygenase derivative analyze...

journal_title：Journal of pineal research

authors： Martinuzzo M,Del Zar MM,Cardinali DP,Carreras LO,Vacas MI

更新日期：1991-10-01 00:00:00

abstract：:Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression, and type 2 diabetes development. Melatonin receptors are approved drug targets for insomnia, non-24-hour sleep-wake disorders, and major depressive disorders. In mammal...

journal_title：Journal of pineal research

authors： Cecon E,Ivanova A,Luka M,Gbahou F,Friederich A,Guillaume JL,Keller P,Knoch K,Ahmad R,Delagrange P,Solimena M,Jockers R

更新日期：2019-03-01 00:00:00

abstract：:Excessive production of nitric oxide (NO) may play a detrimental role in the process of hypoxia-related neuropathology. This study explored whether treatment with melatonin would attenuate the neuropathological changes in the vagal ganglia following a severe hypoxic insult. Thirty minutes prior to hypoxia treatment, y...

journal_title：Journal of pineal research

authors： Chang HM,Ling EA,Chen CF,Lue H,Wen CY,Shieh JY

更新日期：2002-03-01 00:00:00

abstract：:Five adult pasture-bred Prim Holstein cows were used to document the time invariance of melatonin disposition in the cow. Melatonin was administered by an intravenous route as a bolus (5 micrograms/kg of body weight) at either 1430 or 2230. Data were analysed according to a three-compartment open model with melatonin ...

journal_title：Journal of pineal research

authors： Berthelot X,Ravault JP,Concordet D,Ferney J,Toutain PL

更新日期：1993-10-01 00:00:00

abstract：:Elevated levels of soluble cellular adhesion molecules have been reported in patients with acute coronary syndromes. Likewise, a relation between decreased nocturnal melatonin levels and coronary artery disease has been suggested. The aim of the present study was to investigate the day-night variations in the concentr...

journal_title：Journal of pineal research

authors： Dominguez-Rodriguez A,Abreu-Gonzalez P,Garcia-Gonzalez MJ,Samimi-Fard S,Kaski JC,Reiter RJ

更新日期：2008-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers and its incidence is increasing worldwide. Melatonin, an indoleamine hormone, exerts anti-oxidant, immunomodulatory, anti-aging, and antitumor effects. Previous studies have shown that melatonin can act through specific receptors, including MT(1), MT(2),...

journal_title：Journal of pineal research

authors： Carbajo-Pescador S,Martín-Renedo J,García-Palomo A,Tuñón MJ,Mauriz JL,González-Gallego J

更新日期：2009-11-01 00:00:00

abstract：:Possible role of melatonin in the germination of negatively photoblastic and thermosensitive seeds of Phacelia tanacetifolia Benth was studied. Final germination percentage (FGP) was determined in the presence or absence of light at various temperatures, ranging from 0 to 40°C. The highest FGP was determined as 48.7% ...

journal_title：Journal of pineal research

authors： Tiryaki I,Keles H

更新日期：2012-04-01 00:00:00

abstract：:Exposure of rats to light during darkness or blockade of the pineal beta-adrenoceptor in stimulated pineal glands results in a rapid fall in pineal N-acetyltransferase (NAT) activity. Maintenance of a high level of NAT activity requires continuous stimulation of the pineal beta-adrenoceptors. It is not known what fact...

journal_title：Journal of pineal research

authors： Olivieri G,Daya S

更新日期：1992-03-01 00:00:00

abstract：:The purpose of this study was to determine and compare the effects of chronic melatonin treatment in vivo on several aspects of prolactin (PRL) cell activity (PRL synthesis, storage, and release) in vitro in male and female Syrian hamsters. Adult male and female hamsters were maintained on long photoperiod and treated...

journal_title：Journal of pineal research

authors： Blask DE

更新日期：1989-01-01 00:00:00

abstract：:Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocy...

journal_title：Journal of pineal research

authors： Zhang M,Dai X,Lu Y,Miao Y,Zhou C,Cui Z,Liu H,Xiong B

更新日期：2017-04-01 00:00:00

abstract：:N-acetylserotonin methyltransferase (ASMT) is the final enzyme in a biosynthetic pathway that produces melatonin. ASMT may play a rate-limiting role in the production of this bioactive molecule in plants. There are three ASMT genes (ASMT1-ASMT3) in the rice genome, but only ASMT1 has been functionally characterized. A...

journal_title：Journal of pineal research

authors： Park S,Byeon Y,Back K

更新日期：2013-11-01 00:00:00

abstract：:Hypochlorous acid (HOCl) is a potent cytotoxic oxidant generated by the enzyme myeloperoxidase (MPO) in the presence of hydrogen peroxide (H2 O2 ) and chloride (Cl- ). Elevated levels of HOCl play an important role in various pathological conditions through oxidative modification of several biomolecules. Recently, we ...

journal_title：Journal of pineal research

authors： Jeelani R,Maitra D,Chatzicharalampous C,Najeemuddin S,Morris RT,Abu-Soud HM

更新日期：2018-04-01 00:00:00

abstract：:In chronically inflamed animals, adrenal hormones exert a positive control on the secretion of melatonin by the pineal gland. In this paper, the mechanism of corticosterone as a modulator of melatonin and N-acetylserotonin (NAS) was determined. Rat pineal glands in culture, stimulated for 5 hr with noradrenaline (10 n...

journal_title：Journal of pineal research

authors： Ferreira ZS,Fernandes PA,Duma D,Assreuy J,Avellar MC,Markus RP

更新日期：2005-04-01 00:00:00

abstract：:The effect of melatonin was evaluated on three phosphatidylcholine-based membrane models. Changes in liposome dynamics were monitored by fluorescence, following the response of the probe merocyanine-540, as well as by differential scanning calorimetry (DSC). Langmuir monolayers were investigated using molecular area m...

journal_title：Journal of pineal research

authors： de Lima VR,Caro MS,Munford ML,Desbat B,Dufourc E,Pasa AA,Creczynski-Pasa TB

更新日期：2010-09-01 00:00:00

abstract：:Environmental pollution in the form of particulate matter <2.5 μm (PM2.5 ) is a major risk factor for diseases such as lung cancer, chronic respiratory infections, and major cardiovascular diseases. Our goal was to show that PM2.5 eliciting a proinflammatory response activates the immune-pineal axis, reducing the pine...

journal_title：Journal of pineal research

authors： Carvalho-Sousa CE,Pereira EP,Kinker GS,Veras M,Ferreira ZS,Barbosa-Nunes FP,Martins JO,Saldiva PHN,Reiter RJ,Fernandes PA,da Silveira Cruz-Machado S,Markus RP

更新日期：2020-04-01 00:00:00

abstract：:Melatonin is produced following circadian rhythm with high levels being released at night and has been implicated in the regulation of physiological processes in major tissues, including the pancreas. The aim of our study was to examine the effects of melatonin on intracellular free Ca(2+) concentration ([Ca(2+) ](c))...

journal_title：Journal of pineal research

authors： del Castillo-Vaquero A,Salido GM,Gonzalez A

更新日期：2010-10-01 00:00:00

abstract：:Entraining effect of melatonin on the circadian rhythm in rat pineal N-acetyltransferase (NAT) activity was studied under various photoperiods. Melatonin administration prior to dark onset for 5 successive days phase-advanced the evening NAT rise under the light:dark (LD) cycle of either LD 10:14 or LD 8:16, but not u...

journal_title：Journal of pineal research

authors： Humlová M,Illnerová H

更新日期：1992-11-01 00:00:00

abstract：:It is well established that some agents such as aminoglycosides generate free oxygen radicals, leading to an increased oxireductase production, which in turn increases tissue toxicity. The aim of this study is to test whether melatonin, the chief secretory product of the pineal gland and a highly effective antioxidant...

journal_title：Journal of pineal research

authors： Parlakpinar H,Ozer MK,Sahna E,Vardi N,Cigremis Y,Acet A

更新日期：2003-09-01 00:00:00

abstract：:In the current study, a fundamental question, that is, the mechanisms related to the beneficial effects of melatonin on mammalian embryonic development, was addressed. To examine the potential beneficial effects of melatonin on bovine embryonic development, different concentrations of melatonin (10(-11), 10(-9), 10(-7...

journal_title：Journal of pineal research

authors： Wang F,Tian X,Zhang L,Gao C,He C,Fu Y,Ji P,Li Y,Li N,Liu G

更新日期：2014-04-01 00:00:00

abstract：:An important role for melatonin in bone formation and restructuring has emerged, and studies demonstrate the multiple mechanisms for these beneficial actions. Statistical analysis shows that even with existing osteoporotic therapies, bone-related disease, and mortality are on the rise, creating a huge financial burden...

journal_title：Journal of pineal research

authors： Maria S,Witt-Enderby PA

更新日期：2014-03-01 00:00:00

abstract：:The activity of N-acetyltransferase (NAT) and the content of melatonin (MEL) in the rat pineal have been shown to be sensitive to several types of stressors. This study was designed to assess the role of the adrenals in mediating the effect of one such stressor, insulin-induced hypoglycemia, on pineal synthetic activi...

journal_title：Journal of pineal research

authors： Tannenbaum MG,Reiter RJ,Vaughan MK,Troiani ME,Gonzalez-Brito A

更新日期：1987-01-01 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter/neuromodulator involved in cell-to-cell communication within the central nervous system, is now believed to play a role in neuroendocrine function. In this study we describe a single, saturable, stereospecific, and temperature-, time-, and pH-dependent binding site for glutama...

journal_title：Journal of pineal research

authors： Kus L,Handa RJ,McNulty JA

更新日期：1993-01-01 00:00:00

abstract：:Oxidative stress is reported as one of the most widely accepted mechanisms of maneb (MB)- and paraquat (PQ)-induced nigrostriatal dopaminergic neurodegeneration leading to the Parkinson's disease (PD) phenotype. The study investigated the effects of silymarin, an antioxidant of plant origin, and melatonin, an indoleam...

journal_title：Journal of pineal research

authors： Singhal NK,Srivastava G,Patel DK,Jain SK,Singh MP

更新日期：2011-03-01 00:00:00

abstract：:By use of Phaseolus vulgaris-leucoagglutinin as an anterograde in vivo tracer, a direct projection from the dorsal raphe nucleus to the pineal complex of the rat was demonstrated. The nerve fibers extended from the dorsal raphe nucleus rostrally through the mesencephalic periaqueductal grey and entered the deep pineal...

journal_title：Journal of pineal research

authors： Møller M,Hay-Schmidt A

更新日期：1998-08-01 00:00:00

abstract：:The circadian system comprises several peripheral oscillators and a central rhythm generator that, in mammals, is located in the suprachiasmatic nucleus of the hypothalamus. Expression of clock genes is a characteristic feature of the central rhythm generator and the peripheral oscillators. With regard to the rhythmic...

journal_title：Journal of pineal research

authors： Torres-Farfan C,Serón-Ferré M,Dinet V,Korf HW

更新日期：2006-01-01 00:00:00

abstract：:The Syrian hamster pineal displays age-dependent changes in melatonin output measured in vitro. Between the ages of 4 and 19 days, pineal melatonin generation in response to 10 microM norepinephrine (NE) increased 34-fold. Production of melatonin by cultured pineals from 1-week-old hamsters showed a clear dose respons...

journal_title：Journal of pineal research

authors： Kaufman CM,Menaker M

更新日期：1991-10-01 00:00:00

abstract：:Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the brain detects the light through retinas and regulates rhythms and melatonin secretion throughout the body, the liver has independent circadian rhyth...

journal_title：Journal of pineal research

authors： Sato K,Meng F,Francis H,Wu N,Chen L,Kennedy L,Zhou T,Franchitto A,Onori P,Gaudio E,Glaser S,Alpini G

更新日期：2020-04-01 00:00:00

abstract：:Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure, which leads to right ventricular (RV) hypertrophy and failure. The pathophysiological mechanisms of PH remain unclear but oxidative stress is believed to contribute to RV dysfunction. Melatonin is a powerful antioxidant and is cardio...

journal_title：Journal of pineal research

authors： Maarman G,Blackhurst D,Thienemann F,Blauwet L,Butrous G,Davies N,Sliwa K,Lecour S

更新日期：2015-10-01 00:00:00

abstract：:Melatonin is a potent scavenger of free radicals and an indirect antioxidant. Recent studies have shown that melatonin possesses beneficial effects in experimental models of brain trauma and global cerebral ischemia. The effects of pretreatment with melatonin on volume of cerebral infarction were investigated in the p...

journal_title：Journal of pineal research

authors： Pei Z,Pang SF,Cheung RT

更新日期：2002-04-01 00:00:00

abstract：:Melatonin has been shown to have a direct inhibitory action on the proliferation of estrogen-responsive MCF-7 human breast cancer cells in culture. In the present study, we examined by flow cytometry whether this inhibitory effect might be exerted on the G1 phase of the cell cycle, thus causing a transition delay into...

journal_title：Journal of pineal research

authors： Cos S,Blask DE,Lemus-Wilson A,Hill AB

更新日期：1991-01-01 00:00:00