Light/dark patterns of soluble vascular cell adhesion molecule-1 in relation to melatonin in patients with ST-segment elevation myocardial infarction.

abstract：:Melatonin, the main secretary product of the pineal gland, is potentially effective in the prevention of a number of diseases in which free radical processes are involved. The development of hypercholesterolemia is a multifactorial process in which elevated oxidized low-density lipoprotein (ox-LDL) levels play a centr...

journal_title：Journal of pineal research

authors： Zhu HQ,Cheng XW,Xiao LL,Jiang ZK,Zhou Q,Gui SY,Wei W,Wang Y

更新日期：2008-10-01 00:00:00

abstract：:We investigated the role of melatonin on water avoidance stress (WAS)-induced degeneration of the gastric, ileal and colonic mucosa. Wistar albino rats were exposed to acute WAS (aWAS group) or chronic WAS (cWAS group). Before exposing animals to acute (aWAS + mel group) or chronic WAS (cWAS + mel group), 10 mg/kg mel...

journal_title：Journal of pineal research

authors： Ercan F,Cetinel S,Contuk G,Cikler E,Sener G

更新日期：2004-09-01 00:00:00

abstract：:Antioxidant activity of a molecule is attributed to various mechanisms such as prevention of chain initiation, binding of transition metal ion catalysts and decomposition of peroxides. This study was aimed at evaluating the metal chelating and hydrogen peroxide (H2O2) scavenging activity of melatonin. The metal chelat...

journal_title：Journal of pineal research

authors： Gulcin I,Buyukokuroglu ME,Kufrevioglu OI

更新日期：2003-05-01 00:00:00

abstract：:A link between endotoxemia and nonalcoholic fatty liver disease (NAFLD) has been demonstrated in human and rodent animals. Nevertheless, the molecular mechanisms of endotoxin-evoked NAFLD remain poorly understood. We hypothesize that reactive oxygen species (ROS) mediate lipopolysaccharide (LPS)-evoked hepatic lipid a...

journal_title：Journal of pineal research

authors： Chen X,Zhang C,Zhao M,Shi CE,Zhu RM,Wang H,Zhao H,Wei W,Li JB,Xu DX

更新日期：2011-11-01 00:00:00

abstract：:Malaria, which infects more than 300 million people annually, is a serious disease. Epidemiological surveys indicate that of those who are affected, malaria will claim the lives of more than one million individuals, mostly children. There is evidence that the synchronous maturation of Plasmodium falciparum, the parasi...

journal_title：Journal of pineal research

authors： Srinivasan V,Spence DW,Moscovitch A,Pandi-Perumal SR,Trakht I,Brown GM,Cardinali DP

更新日期：2010-01-01 00:00:00

abstract：:Earlier studies showed that melatonin reduced the growth of 17-beta-estradiol (E(2))-induced rat pituitary prolactin-secreting tumor (prolactinoma) in vivo. The mechanisms of melatonin's inhibitory action on the prolactin-secreting tumor were further explored by investigating the in vitro effects of melatonin on the g...

journal_title：Journal of pineal research

authors： Yang QH,Xu JN,Xu RK,Pang SF

更新日期：2007-03-01 00:00:00

abstract：:The effect of various cations on activity of hydroxyindole-O-methyltransferase (HIOMT) and N-acetyltransferase (NAT) from pineal gland was studied. Copper inhibited both enzymes while calcium and magnesium inhibited HIOMT; the mechanisms of these inhibitions are unknown at this stage. Calcium, magnesium, potassium, an...

journal_title：Journal of pineal research

authors： Morton DJ

更新日期：1987-01-01 00:00:00

abstract：:In the present research, we studied the effect of the administration of melatonin or S-adenosyl-L-methionine (S-AMe) on oxidative stress and hepatic cholestasis produced by double ligature of the extra-hepatic biliary duct (LBD) in adult male Wistar rats. Hepatic oxidative stress was evaluated by the changes in the am...

journal_title：Journal of pineal research

authors： López PM,Fiñana IT,De Agueda MC,Sánchez EC,Muñoz MC,Alvarez JP,De La Torre Lozano EJ

更新日期：2000-04-01 00:00:00

abstract：:Melatonin and its precursor, l-tryptophan, have been shown to exert gastroprotective effects in animals, but their influence on the gastric damage by aspirin (ASA) in humans has been sparingly investigated. In this study, we designed to determine the effects of melatonin and l-tryptophan on ASA-induced gastric mucosal...

journal_title：Journal of pineal research

authors： Konturek PC,Konturek SJ,Celinski K,Slomka M,Cichoz-Lach H,Bielanski W,Reiter RJ

更新日期：2010-05-01 00:00:00

abstract：:Rat pineal hydroxyindole-O-methyltransferase (HIOMT; EC 2.1.1.4) was purified by affinity chromatography using an S-adenosyl-L-homocysteine agarose column. This single-step procedure, which is rapid, simple, and applicable to small quantities of tissue, gave a large enrichment of a protein (Mr approximately 38,000) id...

journal_title：Journal of pineal research

authors： Sugden D,Voisin P,Klein DC

更新日期：1986-01-01 00:00:00

abstract：:Environmental pollution in the form of particulate matter <2.5 μm (PM2.5 ) is a major risk factor for diseases such as lung cancer, chronic respiratory infections, and major cardiovascular diseases. Our goal was to show that PM2.5 eliciting a proinflammatory response activates the immune-pineal axis, reducing the pine...

journal_title：Journal of pineal research

authors： Carvalho-Sousa CE,Pereira EP,Kinker GS,Veras M,Ferreira ZS,Barbosa-Nunes FP,Martins JO,Saldiva PHN,Reiter RJ,Fernandes PA,da Silveira Cruz-Machado S,Markus RP

更新日期：2020-04-01 00:00:00

abstract：:We examined the effects of a single 2.5-mg dose of melatonin on the thermoregulatory and circulatory responses to intermittent exercise at a room temperature of 27.2+/-0.4 degrees C (mean+/-S.D.), a relative humidity of 55+/-3% (mean+/-S.D.), and a light intensity of 200-300 lux. In a double-blind cross-over study, si...

journal_title：Journal of pineal research

authors： Atkinson G,Holder A,Robertson C,Gant N,Drust B,Reilly T,Waterhouse J

更新日期：2005-11-01 00:00:00

abstract：:The objective of this study was to determine the role of alpha-adrenoceptors in melatonin production by rat pineal gland. Pineal glands were isolated from adult male rats and maintained in organ baths. The perfusate was sampled every 5 min, stored, and later assayed for melatonin. Exposure to norepinephrine (10 microM...

journal_title：Journal of pineal research

authors： Tobin VA,McCance I,Coleman HA,Parkington HC

更新日期：2002-05-01 00:00:00

abstract：:Melatonin is part of the evolutionary conserved highly functional network in vertebrates. It plays a central role in the adaptative behavior of the animal to the environment, including entrainment of daily and annual physiological rhythms, reproductive behavior, food intake, locomotor activity, growth, and breeding pe...

journal_title：Journal of pineal research

authors： Lima-Cabello E,Díaz-Casado ME,Guerrero JA,Otalora BB,Escames G,López LC,Reiter RJ,Acuña-Castroviejo D

更新日期：2014-08-01 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter/neuromodulator involved in cell-to-cell communication within the central nervous system, is now believed to play a role in neuroendocrine function. In this study we describe a single, saturable, stereospecific, and temperature-, time-, and pH-dependent binding site for glutama...

journal_title：Journal of pineal research

authors： Kus L,Handa RJ,McNulty JA

更新日期：1993-01-01 00:00:00

abstract：:Melatonin, an endogenous neurohormone secreted by the pineal gland, has a variety of physiological functions and neuroprotective effects. However, its protective role on the neural tube defects (NTDs) was not very clear. The aim of this study was to investigate the effects of melatonin on the incidence of NTDs (includ...

journal_title：Journal of pineal research

authors： Liu S,Guo Y,Yuan Q,Pan Y,Wang L,Liu Q,Wang F,Wang J,Hao A

更新日期：2015-11-01 00:00:00

abstract：:Despite high in-hospital mortality associated with acute respiratory distress syndrome (ARDS), there is no effective therapeutic strategy. We tested the hypothesis that combined melatonin-mitochondria treatment ameliorates 100% oxygen-induced ARDS in rats. Adult male Sprague-Dawley rats (n = 40) were equally categoriz...

journal_title：Journal of pineal research

authors： Sun CK,Lee FY,Kao YH,Chiang HJ,Sung PH,Tsai TH,Lin YC,Leu S,Wu YC,Lu HI,Chen YL,Chung SY,Su HL,Yip HK

更新日期：2015-03-01 00:00:00

abstract：:Previously it has been found that pinealectomy in rats was associated with increased small bowel crypt cell proliferation. The hypothalamus is thought to play a role in the neural control of crypt cell proliferation and the pineal gland is known to be functionally connected with this component of the autonomic nervous...

journal_title：Journal of pineal research

authors： Callaghan BD

更新日期：1991-01-01 00:00:00

abstract：:Melatonin has previously been shown to be neuroprotective in rodent models of ischemic stroke. Herein, we tested whether this antioxidant may also be suitable for prophylactic use against stroke. To clarify this issue, melatonin was administrated orally for 9 wk (4 mg/kg/day) in mice and its effects on subsequent inju...

journal_title：Journal of pineal research

authors： Kilic E,Kilic U,Reiter RJ,Bassetti CL,Hermann DM

更新日期：2004-11-01 00:00:00

abstract：:The association of seasonal changes in health and disease has been known for centuries. The prevalence of psychopathological symptoms with seasonal fluctuations and the use of melatonin as a biological marker of circadian and circannual rhythms is well documented. The aim of this work was to study the variability of m...

journal_title：Journal of pineal research

authors： Morera AL,Abreu P

更新日期：2006-10-01 00:00:00

abstract：:Thrombocytopenia is a frequent complication of cancer and constitutes an absolute contraindication for chemotherapy. Recent studies have demonstrated that platelet generation may be influenced by both cytokines and neurohormones. In particular, the pineal indole melatonin has been proven to enhance platelet number in ...

journal_title：Journal of pineal research

authors： Lissoni P,Tancini G,Paolorossi F,Mandalà M,Ardizzoia A,Malugani F,Giani L,Barni S

更新日期：1999-04-01 00:00:00

abstract：:Abnormal proliferation and motility of retinal pigment epithelial cells leads to proliferative vitreoretinopathy (PVR). Melatonin is a known effective antitumour and anti-invasive agent, but whether it affects the formation and underlying mechanisms of PVR remains unclear. In this study, the results of the MTT assay, ...

journal_title：Journal of pineal research

authors： Yang SF,Chen YS,Chien HW,Wang K,Lin CL,Chiou HL,Lee CY,Chen PN,Hsieh YH

更新日期：2020-01-01 00:00:00

abstract：:Experiments were conducted to determine whether daily melatonin injections could influence reentrainment of circadian locomotor activity rhythms in male Long-Evans rats after phase shifts of the light dark (LD) cycle. When exposed to a 5-h advance of the LD cycle, six out of 15 rats injected daily with melatonin at th...

journal_title：Journal of pineal research

authors： Redman JR,Armstrong SM

更新日期：1988-01-01 00:00:00

abstract：:Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties. There are also experimental and clinical data supporting an analgesic role of melatonin. In experimental studies, melatonin sho...

journal_title：Journal of pineal research

authors： Wilhelmsen M,Amirian I,Reiter RJ,Rosenberg J,Gögenur I

更新日期：2011-10-01 00:00:00

abstract：:Four weeks of administration of melatonin mixed in the diet (5 mg/kg of food) significantly reduced the incidence of gastric ulcers in young pigs. In control and melatonin supplemented animals, significantly higher levels of melatonin were found in the stomach tissues as compared to jejunum, ileum, or colon. Pigs with...

journal_title：Journal of pineal research

authors： Bubenik GA,Ayles HL,Friendship RM,Brown GM,Ball RO

更新日期：1998-01-01 00:00:00

abstract：:Melatonin binding sites were characterized in rat spleen crude membranes. The specific binding of 2-[125I]iodomelatonin by spleen crude membranes fulfills all the criteria for binding to a receptor site. Thus, binding was dependent on time and temperature, stable, specific, and increased under constant light exposure ...

journal_title：Journal of pineal research

authors： Rafii-El-Idrissi M,Calvo JR,Giordano M,Guerrero JM

更新日期：1996-01-01 00:00:00

abstract：:Improved survival because of advances in neonatal care has resulted in an increased number of infants at risk for chronic lung disease. Even though the etiology of lung injury is multifactorial, recent animal and clinical data indicate that pulmonary damage depends in large part on the ventilatory strategies used. Ven...

journal_title：Journal of pineal research

authors： Gitto E,Reiter RJ,Sabatino G,Buonocore G,Romeo C,Gitto P,Buggé C,Trimarchi G,Barberi I

更新日期：2005-10-01 00:00:00

abstract：:Melatonin, a molecule produced in the pineal gland and retina of vertebrates, plays a major role in day-night circadian rhythms and other physiological processes, including the immune responses. Because little is known in this respect in fish, we have evaluated the in vivo role of melatonin in the main innate immune a...

journal_title：Journal of pineal research

authors： Cuesta A,Cerezuela R,Esteban MA,Meseguer J

更新日期：2008-08-01 00:00:00

abstract：:Melatonin, which is contained in certain vegetables, may have an influence on circulatory melatonin concentrations. This study examined the effects of the consumption of vegetables on 6-sulfatoxymelatonin concentrations in morning urine. Ninety-four healthy women aged 24-55 were recruited through a city public health ...

journal_title：Journal of pineal research

authors： Oba S,Nakamura K,Sahashi Y,Hattori A,Nagata C

更新日期：2008-08-01 00:00:00

abstract：:The binding characteristics of the tritiated pineal hormone, [3H] melatonin, were studied in brain tissues using in vitro binding techniques. In synaptosomal membranes prepared from rat hippocampus and subjected to preincubation at 37 degrees C and multiple washings, high-affinity binding of [3H] melatonin significant...

journal_title：Journal of pineal research

authors： Niles LP

更新日期：1987-01-01 00:00:00