Characterization of a [3H]glutamate binding site in rat pineal gland: enhanced affinity following superior cervical ganglionectomy.

abstract：:Atherosclerosis (AS) is an inflammatory disease linked to endothelial dysfunction. Melatonin is reported to possess substantial anti-inflammatory properties, which has proven to be effective in AS. Emerging literature suggests that pyroptosis plays a critical role during AS progression. However, whether pyroptosis con...

journal_title：Journal of pineal research

authors： Zhang Y,Liu X,Bai X,Lin Y,Li Z,Fu J,Li M,Zhao T,Yang H,Xu R,Li J,Ju J,Cai B,Xu C,Yang B

更新日期：2018-03-01 00:00:00

abstract：:In a recent study melatonin (N-acetyl-5-methoxytryptamine), a well-investigated animal molecule but minimally studied in plants, was seen to have a physiological role as growth-promoting molecule in lupin hypocotyls. In the present study, the role of melatonin as a growth promoter is extended to coleoptiles of canary ...

journal_title：Journal of pineal research

authors： Hernández-Ruiz J,Cano A,Arnao MB

更新日期：2005-09-01 00:00:00

abstract：:We tested whether combined melatonin (Mel) and exendin-4 (Ex4) treatment can better preserve glomerular structural integrity after ischemia-reperfusion (IR) injury compared with either alone. Adult male Sprague Dawley rats (n = 50) were equally divided into sham control (SC), IR, IR-Ex4 (10 μg/kg subcutaneously 30 min...

journal_title：Journal of pineal research

authors： Yip HK,Yang CC,Chen KH,Huang TH,Chen YL,Zhen YY,Sung PH,Chiang HJ,Sheu JJ,Chang CL,Chen CH,Chang HW,Chen YT

更新日期：2015-11-01 00:00:00

abstract：:The effects of housing condition and type of stimulation on serum melatonin and N-acetylserotonin (NAS) were investigated. Male rats were housed under a 12/12-hour light-dark cycle, with ad libitum food and water, either individually or in groups of four. At the start of the light phase, separate groups were sacrifice...

journal_title：Journal of pineal research

authors： Seggie J,Campbell L,Brown GM,Grota LJ

更新日期：1985-01-01 00:00:00

abstract：:Seasonal day length has been linked to the prevalence of mood disorders, and however, the mechanisms underlying this relationship remain unknown. Previous work in our laboratory has shown that developmental exposure to seasonal photoperiods has enduring effects on the activity of mouse dorsal raphe serotonergic neuron...

journal_title：Journal of pineal research

authors： Giannoni-Guzmán MA,Kamitakahara A,Magalong V,Levitt P,McMahon DG

更新日期：2020-11-19 00:00:00

abstract：:Melatonin is involved in the control of various physiological functions, such as sleep, cell growth and free radical scavenging. The ability of melatonin to behave as an antioxidant, together with the fact that the Alzheimer-related amyloid β-peptide (Aβ) triggers oxidative stress through hydroxyl radical-induced cell...

journal_title：Journal of pineal research

authors： Panmanee J,Nopparat C,Chavanich N,Shukla M,Mukda S,Song W,Vincent B,Govitrapong P

更新日期：2015-10-01 00:00:00

abstract：:Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocy...

journal_title：Journal of pineal research

authors： Zhang M,Dai X,Lu Y,Miao Y,Zhou C,Cui Z,Liu H,Xiong B

更新日期：2017-04-01 00:00:00

abstract：:The effect of daily injection of the pineal hormone melatonin and naltrexone, an opioid antagonist, on the circadian rhythm and the level of immune parameters (plaque forming cell [PFC] number, serum agglutinin titer, lymphoid gland weight, total white blood cells (WBC) and their fraction number, and serum lysozyme [L...

journal_title：Journal of pineal research

authors： Skwarło-Sońta K,Thaela MJ,Midura M,Lech B,Głuchowska B,Drela N,Kozłowska E,Kowalczyk R

更新日期：1992-01-01 00:00:00

abstract：:Melatonin is a powerful antioxidant and free radical scavenger. A large body of in vivo and in vitro evidence shows that melatonin effectively inhibits membrane lipid peroxidation; this damage was based on the measurement of malondialdehyde and/or 4-hydroxynonenal levels. In the current study, for the first time using...

journal_title：Journal of pineal research

authors： Zhang L,Wei W,Xu J,Min F,Wang L,Wang X,Cao S,Tan DX,Qi W,Reiter RJ

更新日期：2006-05-01 00:00:00

abstract：:Abnormal proliferation and motility of retinal pigment epithelial cells leads to proliferative vitreoretinopathy (PVR). Melatonin is a known effective antitumour and anti-invasive agent, but whether it affects the formation and underlying mechanisms of PVR remains unclear. In this study, the results of the MTT assay, ...

journal_title：Journal of pineal research

authors： Yang SF,Chen YS,Chien HW,Wang K,Lin CL,Chiou HL,Lee CY,Chen PN,Hsieh YH

更新日期：2020-01-01 00:00:00

abstract：:The aim of this study was to compare the circadian control of melatonin production in teleosts. To do so, the effects of ophthalmectomy on circulating melatonin rhythms were studied along with ex vivo pineal culture in six different teleosts. Results strongly suggested that the circadian control of melatonin productio...

journal_title：Journal of pineal research

authors： Migaud H,Davie A,Martinez Chavez CC,Al-Khamees S

更新日期：2007-11-01 00:00:00

abstract：:The purpose of this study was to determine whether melatonin treatment would mitigate retinal ganglion cell (RGC) death in the developing retina following a hypoxic insult. Lipid peroxidation (LPO), glutathione (GSH), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) concentrations, expression of vascular end...

journal_title：Journal of pineal research

authors： Kaur C,Sivakumar V,Robinson R,Foulds WS,Luu CD,Ling EA

更新日期：2013-03-01 00:00:00

abstract：:Melatonin is a potent scavenger of free radicals and an indirect antioxidant. Recent studies have shown that melatonin possesses beneficial effects in experimental models of brain trauma and global cerebral ischemia. The effects of pretreatment with melatonin on volume of cerebral infarction were investigated in the p...

journal_title：Journal of pineal research

authors： Pei Z,Pang SF,Cheung RT

更新日期：2002-04-01 00:00:00

abstract：:Melatonin is produced following circadian rhythm with high levels being released at night and has been implicated in the regulation of physiological processes in major tissues, including the pancreas. The aim of our study was to examine the effects of melatonin on intracellular free Ca(2+) concentration ([Ca(2+) ](c))...

journal_title：Journal of pineal research

authors： del Castillo-Vaquero A,Salido GM,Gonzalez A

更新日期：2010-10-01 00:00:00

abstract：:The activity of N-acetyltransferase (NAT) and the content of melatonin (MEL) in the rat pineal have been shown to be sensitive to several types of stressors. This study was designed to assess the role of the adrenals in mediating the effect of one such stressor, insulin-induced hypoglycemia, on pineal synthetic activi...

journal_title：Journal of pineal research

authors： Tannenbaum MG,Reiter RJ,Vaughan MK,Troiani ME,Gonzalez-Brito A

更新日期：1987-01-01 00:00:00

abstract：:Production of melatonin in the pineal gland of inbred mice such as C57B1/6J, BALB/c and AKR strains is still a matter of debate. In previous studies, we and other authors showed that these strains of inbred mice have a clear-cut circadian rhythm of serum melatonin and urinary 6-hydroxy-melatonin-sulphate. In contrast,...

journal_title：Journal of pineal research

authors： Conti A,Maestroni GJ

更新日期：1996-04-01 00:00:00

abstract：:Melatonin, an endogenous neurohormone secreted by the pineal gland, has a variety of physiological functions and neuroprotective effects. However, its protective role on the neural tube defects (NTDs) was not very clear. The aim of this study was to investigate the effects of melatonin on the incidence of NTDs (includ...

journal_title：Journal of pineal research

authors： Liu S,Guo Y,Yuan Q,Pan Y,Wang L,Liu Q,Wang F,Wang J,Hao A

更新日期：2015-11-01 00:00:00

abstract：:Female rats exposed to long (LD 18:6) or short (LD 6:18) photoperiods from 21 days of age were mated when they reached 55 days of age. On day 2 of gestation animals of each group were either pinealectomized or sham-operated. Lighting regimens were not changed during the course of the study. Male offspring of the four ...

journal_title：Journal of pineal research

authors： Jarrige JF,Boucher D

更新日期：1992-09-01 00:00:00

abstract：:The effect of melatonin administration on nerve growth factor (NGF) was studied in the submandibular glands of adult Swiss male mice. Melatonin injection, at 1 microg daily for 30 days, resulted in an increase in the NGF content as detected by immunohistochemistry. The submandibular gland weight and the area of the gr...

journal_title：Journal of pineal research

authors： Pongsa-Asawapaiboon A,Asavaritikrai P,Withyachumnarnkul B,Sumridthong A

更新日期：1998-03-01 00:00:00

abstract：:Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties. There are also experimental and clinical data supporting an analgesic role of melatonin. In experimental studies, melatonin sho...

journal_title：Journal of pineal research

authors： Wilhelmsen M,Amirian I,Reiter RJ,Rosenberg J,Gögenur I

更新日期：2011-10-01 00:00:00

abstract：:A decrease in nocturnal serum melatonin levels was reported in patients with clinically uncharacterized coronary artery disease. To assess whether there was a correlation between melatonin production and disease stage, we measured the nocturnal urinary excretion of 6-sulphatoxymelatonin (an index of blood melatonin co...

journal_title：Journal of pineal research

authors： Girotti L,Lago M,Ianovsky O,Carbajales J,Elizari MV,Brusco LI,Cardinali DP

更新日期：2000-10-01 00:00:00

abstract：:The role of antioxidants in reducing cancer initiation and progression has been highlighted in recent years. Not only antioxidants limit cancer cell growth but also, in some situations, they promote the effectiveness of conventional treatments. Melatonin, an endogenously synthesized antioxidant, reduces cell growth of...

journal_title：Journal of pineal research

authors： Sainz RM,Reiter RJ,Tan DX,Roldan F,Natarajan M,Quiros I,Hevia D,Rodriguez C,Mayo JC

更新日期：2008-10-01 00:00:00

abstract：:Most contemporary progress in Alzheimer's disease (AD) stems from the study of a 42 43 amino acid peptide. called the amyloid beta protein (Abeta), as the main neuropathologic marker of the disorder. It has been demonstrated that Abeta has neurotoxic properties and that such effects are mediated by free-radicals. Expo...

journal_title：Journal of pineal research

authors： Pappolla MA,Chyan YJ,Poeggeler B,Bozner P,Ghiso J,LeDoux SP,Wilson GL

更新日期：1999-11-01 00:00:00

abstract：:Optic atrophy 1 (OPA1)-related mitochondrial fusion and mitophagy are vital to sustain mitochondrial homeostasis under stress conditions. However, no study has confirmed whether OPA1-related mitochondrial fusion/mitophagy is activated by melatonin and, consequently, attenuates cardiomyocyte death and mitochondrial str...

journal_title：Journal of pineal research

authors： Zhang Y,Wang Y,Xu J,Tian F,Hu S,Chen Y,Fu Z

更新日期：2019-03-01 00:00:00

abstract：:Human placental mitochondria might be a significant source of NADPH- and iron-dependent production of reactive oxygen species (ROS). Preeclampsia is believed to be a consequence of overproduction of ROS in human placenta. The experimental results presented here show that melatonin inhibits NADPH- and iron-dependent li...

journal_title：Journal of pineal research

authors： Milczarek R,Hallmann A,Sokołowska E,Kaletha K,Klimek J

更新日期：2010-09-01 00:00:00

abstract：:Experiments were conducted to determine whether daily melatonin injections could influence reentrainment of circadian locomotor activity rhythms in male Long-Evans rats after phase shifts of the light dark (LD) cycle. When exposed to a 5-h advance of the LD cycle, six out of 15 rats injected daily with melatonin at th...

journal_title：Journal of pineal research

authors： Redman JR,Armstrong SM

更新日期：1988-01-01 00:00:00

abstract：:Methamphetamine (METH) is a potent psychostimulant drug that may cause neuronal cell degeneration. The underlying mechanisms of METH-induced neuronal toxicity remains poorly understood. In this study, we investigated an important role of calpain-dependent cascades in methamphetamine-induced toxicity in human dopaminer...

journal_title：Journal of pineal research

authors： Suwanjang W,Phansuwan-Pujito P,Govitrapong P,Chetsawang B

更新日期：2010-03-01 00:00:00

abstract：:The role played by postsynaptic alpha-adrenergic receptors in the stimulation of pineal melatonin production was investigated in the Syrian hamster. The studies were conducted using organ cultured pineal glands collected from both anatomically intact and superior cervical ganglionectomized hamsters. Results obtained i...

journal_title：Journal of pineal research

authors： Santana C,Guerrero JM,Reiter RJ,Menendez-Pelaez A

更新日期：1989-01-01 00:00:00

abstract：:The production of oxygen free radicals has been strongly implicated as an important pathophysiological mechanism mediating myocardial ischemia/reperfusion (I/R) injury. Various antioxidants have cardioprotective effects. Melatonin, an indoleamine synthesized by the pineal gland, is a potent antioxidant and a direct fr...

journal_title：Journal of pineal research

authors： Lee YM,Chen HR,Hsiao G,Sheu JR,Wang JJ,Yen MH

更新日期：2002-09-01 00:00:00

abstract：:To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every ...

journal_title：Journal of pineal research

authors： Luboshitzky R,Lavi S,Thuma I,Lavie P

更新日期：1996-03-01 00:00:00