Role of melatonin in reducing water avoidance stress-induced degeneration of the gastrointestinal mucosa.

abstract：:Melatonin regulates mitogen-activated protein kinase (MAPK) and Akt signaling pathways. The MAPK family mainly includes extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK). Our previous study documented that melatonin delays osteoblast proliferation; however, the mechanism of action of ...

journal_title：Journal of pineal research

authors： Liu L,Zhu Y,Xu Y,Reiter RJ

更新日期：2012-08-01 00:00:00

abstract：:The oncostatic effects of melatonin on the mammary gland have been studied in transgenic mice carrying the N-ras proto-oncogene under the control of the MMTV-LTR. Female (4-week-old) virgin mice with positive transgenic pedigrees were injected with melatonin (200 micrograms/mouse/ day, five times a week) or vehicle la...

journal_title：Journal of pineal research

authors： Mediavilla MD,Güezmez A,Ramos S,Kothari L,Garijo F,Sánchez Barceló EJ

更新日期：1997-03-01 00:00:00

abstract：:Melatonin, an antioxidant, protects the pancreas against acute inflammation but, although this indole is released mainly at night, no study has been undertaken to determine circadian changes of plasma melatonin levels and the severity of acute pancreatitis. The aims of this study were: (a) to compare the severity of c...

journal_title：Journal of pineal research

authors： Jaworek J,Konturek SJ,Tomaszewska R,Leja-Szpak A,Bonior J,Nawrot K,Palonek M,Stachura J,Pawlik WW

更新日期：2004-10-01 00:00:00

abstract：:Previously it has been found that pinealectomy in rats was associated with increased small bowel crypt cell proliferation. The hypothalamus is thought to play a role in the neural control of crypt cell proliferation and the pineal gland is known to be functionally connected with this component of the autonomic nervous...

journal_title：Journal of pineal research

authors： Callaghan BD

更新日期：1991-01-01 00:00:00

abstract：:The objective of this study was to apply the radioimmunoassay for 6-sulphatoxymelatonin (aMT6s) to rat urine, and use it to study the source of aMT6s. The radioimmunoassay was found to have acceptable within- and between-assay variation, excellent specificity, and good parallelism between the standard and unknown. Bec...

journal_title：Journal of pineal research

authors： Brown GM,Bar-Or A,Grossi D,Kashur S,Johannson E,Yie SM

更新日期：1991-04-01 00:00:00

abstract：:In the current study, a fundamental question, that is, the mechanisms related to the beneficial effects of melatonin on mammalian embryonic development, was addressed. To examine the potential beneficial effects of melatonin on bovine embryonic development, different concentrations of melatonin (10(-11), 10(-9), 10(-7...

journal_title：Journal of pineal research

authors： Wang F,Tian X,Zhang L,Gao C,He C,Fu Y,Ji P,Li Y,Li N,Liu G

更新日期：2014-04-01 00:00:00

abstract：:Cell movement is generated by a driving force provided by dynamic cytoskeletal organization. Two main cytoskeletal-dependent features, essential for migration, are the highly cell polarized structure and focal adhesion complexes. Cell migration and substrate anchorage are finely regulated by external signaling exerted...

journal_title：Journal of pineal research

authors： Ortíz-López L,Morales-Mulia S,Ramírez-Rodríguez G,Benítez-King G

更新日期：2009-01-01 00:00:00

abstract：:Melatonin signaling dysfunction has been associated with the etiology of adolescent idiopathic scoliosis (AIS). Genetic analysis has also associated the occurrence of AIS with the MT2 gene. Thus, we determined whether there is abnormality in the protein expression of melatonin receptors (MT) in AIS osteoblasts. In thi...

journal_title：Journal of pineal research

authors： Man GC,Wong JH,Wang WW,Sun GQ,Yeung BH,Ng TB,Lee SK,Ng BK,Qiu Y,Cheng JC

更新日期：2011-05-01 00:00:00

abstract：:Our objective was to suppress the daily surge of melatonin in serum of prepubertal dairy heifers by manipulating intensity of light (Experiment 1) and duration of exposure to light (Experiment 2). Heifers in Experiment 1 were exposed to either 12 hr of darkness (000 lux, control), or 400, 800, or 1,200 lux of light du...

journal_title：Journal of pineal research

authors： Buchanan BA,Chapin LT,Tucker HA

更新日期：1992-05-01 00:00:00

abstract：:When organic compounds are irradiated with UV light at 254 nm, part of their covalent bonds can dissociate if the compound absorbs light at that wavelength. Therefore, photo-degradation depends strongly on the wavelength used. The energy of a light quanta at 254 nm amounts to approximately 110 kcal/mol quanta, which i...

journal_title：Journal of pineal research

authors： Brömme HJ,Peschke E,Israel G

更新日期：2008-05-01 00:00:00

abstract：:The effect on nocturnal melatonin secretion of acute administration of the indirectly acting serotonin (5-HT) receptor agonists d-fenfluramine (30 mg) and paroxetine (20 mg) and a partial 5-HT1A receptor agonist ipsapirone (20 mg) was investigated in healthy male volunteers and compared to a placebo condition. Each su...

journal_title：Journal of pineal research

authors： Nathan PJ,Norman TR,Burrows GD

更新日期：1996-09-01 00:00:00

abstract：:Melatonin, a molecule produced in the pineal gland and retina of vertebrates, plays a major role in day-night circadian rhythms and other physiological processes, including the immune responses. Because little is known in this respect in fish, we have evaluated the in vivo role of melatonin in the main innate immune a...

journal_title：Journal of pineal research

authors： Cuesta A,Cerezuela R,Esteban MA,Meseguer J

更新日期：2008-08-01 00:00:00

abstract：:Melatonin is an indoleamine synthesized in the pineal gland, and after its release into the blood, it has an extensive repertoire of biological activities, including antitumoral properties. In this study, we found that melatonin reduced the growth of the human melanoma cells SK-MEL-1. The antiproliferative effect was ...

journal_title：Journal of pineal research

authors： Cabrera J,Negrín G,Estévez F,Loro J,Reiter RJ,Quintana J

更新日期：2010-08-01 00:00:00

abstract：:In this study, the effect of melatonin on sodium arsenite (arsenite)-induced peripheral neurotoxicity was investigated using dorsal root ganglion (DRG) explants. After 24-hr incubation, arsenite (30 microm) consistently elevated the expression of heat shock protein 70 and haeme oxygenase-1, two well-known stress prote...

journal_title：Journal of pineal research

authors： Lin AM,Feng SF,Chao PL,Yang CH

更新日期：2009-01-01 00:00:00

abstract：:Melatonin has shown particular promise as a neuroprotective agent to prevent motoneuron death in animal models of both amyotrophic lateral sclerosis (ALS) and spinal cord injuries (SCI). However, an understanding of the roles of endogenous melatonin receptors including MT1, MT2, and orphan G-protein receptor 50 (GPR50...

journal_title：Journal of pineal research

authors： Das A,Wallace G 4th,Reiter RJ,Varma AK,Ray SK,Banik NL

更新日期：2013-01-01 00:00:00

abstract：:Melatonin, which is contained in certain vegetables, may have an influence on circulatory melatonin concentrations. This study examined the effects of the consumption of vegetables on 6-sulfatoxymelatonin concentrations in morning urine. Ninety-four healthy women aged 24-55 were recruited through a city public health ...

journal_title：Journal of pineal research

authors： Oba S,Nakamura K,Sahashi Y,Hattori A,Nagata C

更新日期：2008-08-01 00:00:00

abstract：:Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant. Among a great number of metabolites that have been tried before, only a few were found (cerulein and quinaldic acid in mice and kynurenic acid in rats). In SHR (bred from Swiss) male mice, intrac...

journal_title：Journal of pineal research

authors： Lapin IP,Mirzaev SM,Ryzov IV,Oxenkrug GF

更新日期：1998-05-01 00:00:00

abstract：:Experiments were conducted to determine whether daily melatonin injections could influence reentrainment of circadian locomotor activity rhythms in male Long-Evans rats after phase shifts of the light dark (LD) cycle. When exposed to a 5-h advance of the LD cycle, six out of 15 rats injected daily with melatonin at th...

journal_title：Journal of pineal research

authors： Redman JR,Armstrong SM

更新日期：1988-01-01 00:00:00

abstract：:Ischemia/reperfusion injury (IRI) is harmful to the cardiovascular system and causes mitochondrial oxidative stress. Numerous data indicate that the JAK2/STAT3 signaling pathway is specifically involved in preventing myocardial IRI. Melatonin has potent activity against IRI and may regulate JAK2/STAT3 signaling. This ...

journal_title：Journal of pineal research

authors： Yang Y,Duan W,Jin Z,Yi W,Yan J,Zhang S,Wang N,Liang Z,Li Y,Chen W,Yi D,Yu S

更新日期：2013-10-01 00:00:00

abstract：:Obesity, a major risk factor for ischemic heart disease, is associated with increased oxidative stress and reduced antioxidant status. Melatonin, a potent free radical scavenger and antioxidant, has powerful cardioprotective effects in lean animals but its efficacy in obesity is unknown. We investigated the effects of...

journal_title：Journal of pineal research

authors： Nduhirabandi F,Du Toit EF,Blackhurst D,Marais D,Lochner A

更新日期：2011-03-01 00:00:00

abstract：:The European hedgehog (Erinaceus europaeus L.) is a hibernating mammal and seasonal breeder in which numerous circadian and circannual rhythms are entrained and synchronized by photoperiod. The present study was undertaken in order to establish the involvement of the pineal gland in transducing the photoperiodic messa...

journal_title：Journal of pineal research

authors： Saboureau M,Vivien-Roels B,Pevet P

更新日期：1991-09-01 00:00:00

abstract：:Melatonin has demonstrated a potential protective effect in central nervous system. Thus, it is interesting to determine whether pre-ischemia melatonin administration could protect against cerebral ischemia/reperfusion (IR)-related injury and the underlying molecular mechanisms. In this study, we revealed that IR inju...

journal_title：Journal of pineal research

authors： Feng D,Wang B,Wang L,Abraham N,Tao K,Huang L,Shi W,Dong Y,Qu Y

更新日期：2017-04-01 00:00:00

abstract：:Antioxidant activity of a molecule is attributed to various mechanisms such as prevention of chain initiation, binding of transition metal ion catalysts and decomposition of peroxides. This study was aimed at evaluating the metal chelating and hydrogen peroxide (H2O2) scavenging activity of melatonin. The metal chelat...

journal_title：Journal of pineal research

authors： Gulcin I,Buyukokuroglu ME,Kufrevioglu OI

更新日期：2003-05-01 00:00:00

abstract：:Liver fibrosis is scar tissue resulting from an uncontrolled wound-healing process in response to chronic liver injury. Liver damage generates an inflammatory reaction that activates hepatic stellate cells (HSC) that transdifferentiate from quiescent cells that control retinol metabolism to proliferative and migratory...

journal_title：Journal of pineal research

authors： Shajari S,Laliena A,Heegsma J,Tuñón MJ,Moshage H,Faber KN

更新日期：2015-10-01 00:00:00

abstract：:Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality. There have been no material advances in the treatment of preeclampsia for nearly 50 years. Combining in vitro studies and a clinical trial, we aimed to determine whether melatonin could be a useful adjuvant therapy. In a xanthine/x...

journal_title：Journal of pineal research

authors： Hobson SR,Gurusinghe S,Lim R,Alers NO,Miller SL,Kingdom JC,Wallace EM

更新日期：2018-10-01 00:00:00

abstract：:We tested the hypothesis that melatonin (Mel) enhances exogenous mitochondria (Mito) treatment against rodent hepatic ischemia-reperfusion (IR) injury. In vitro study utilized three groups of hepatocytes (i.e. nontreatment, menadione, and menadione-melatonin treatment, 4.0 × 10(5) each), while in vivo study used adult...

journal_title：Journal of pineal research

authors： Chen HH,Chen YT,Yang CC,Chen KH,Sung PH,Chiang HJ,Chen CH,Chua S,Chung SY,Chen YL,Huang TH,Kao GS,Chen SY,Lee MS,Yip HK

更新日期：2016-08-01 00:00:00

abstract：:Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the brain detects the light through retinas and regulates rhythms and melatonin secretion throughout the body, the liver has independent circadian rhyth...

journal_title：Journal of pineal research

authors： Sato K,Meng F,Francis H,Wu N,Chen L,Kennedy L,Zhou T,Franchitto A,Onori P,Gaudio E,Glaser S,Alpini G

更新日期：2020-04-01 00:00:00

abstract：:Melatonin, a potent antioxidant, has shown to be beneficial in murine Venezuelan equine encephalomyelitis (VEE) virus infection. In addition, melatonin can induces the production of interleukin-1 beta (IL-1beta), a cytokine capable of inducing increased expression of inducible nitric oxide synthase; the activity of th...

journal_title：Journal of pineal research

authors： Valero N,MarinaEspina L,Bonilla E,Mosquera J

更新日期：2007-03-01 00:00:00

abstract：:The pineal gland of poikilothermic vertebrates originates as an evagination from the diencephalic roof between the habenular and the posterior commissures, and associates with a parapineal organ to form the so-called pineal complex. The pinealocytes may be photosensitive, secretory or intermediate cells between both. ...

journal_title：Journal of pineal research

authors： Filadelfi AM,Castrucci AM

更新日期：1996-05-01 00:00:00

abstract：:Glaucoma may be associated with circadian disruption due to its association with a loss of intrinsically photosensitive retinal ganglion cells. Clinical evidence demonstrating an association between glaucoma and circadian disruption is limited, and no large-scale studies have been performed. The purpose of this cross-...

journal_title：Journal of pineal research

authors： Yoshikawa T,Obayashi K,Miyata K,Saeki K,Ogata N

更新日期：2020-09-01 00:00:00