Abstract:
:Melatonin, a potent antioxidant, has shown to be beneficial in murine Venezuelan equine encephalomyelitis (VEE) virus infection. In addition, melatonin can induces the production of interleukin-1 beta (IL-1beta), a cytokine capable of inducing increased expression of inducible nitric oxide synthase; the activity of this enzyme is increased in the brain of mice infected with VEE virus. The aim of this study was to determine the effect of VEE virus on the nitric oxide (NO) production, lipid peroxidation and IL-1beta production in the brain and serum of mice infected with VEE virus, and to investigate the modulatory role of melatonin during this viral infection. Mice were infected with 10 LD(50) of VEE virus and treated with melatonin (500 microg/kg of body weight) starting 3 days before and continuing for 5 days after virus inoculation. Mice were sacrificed on days 1, 3 and 5 postinfection and brains and blood samples were obtained. NO and IL-1beta production and lipid peroxidation levels were measured in perfused brain homogenates and serum. Increased production of brain nitrite was found on days 1, 3 and 5 postinfection and lipid peroxidation products were increased at day 5. Levels of serum nitrite were found elevated on days 3 and 5 postinfection; however, lipid peroxidation products remained similar to basal levels. Melatonin treatment decreased nitrite concentration in brain and serum of infected mice as well as the lipid peroxidation products in the brain. IL-1beta was found to be increased in the brain and serum of infected animals, and melatonin treatment induced higher levels of this cytokine (brain: about 4-fold; serum: about 8-fold). These results may be related to the beneficial effect of melatonin in the VEE experimental disease and address the possible therapeutic potential of the indoleamine in human VEE virus infection.
journal_name
J Pineal Resjournal_title
Journal of pineal researchauthors
Valero N,MarinaEspina L,Bonilla E,Mosquera Jdoi
10.1111/j.1600-079X.2006.00381.xsubject
Has Abstractpub_date
2007-03-01 00:00:00pages
107-12issue
2eissn
0742-3098issn
1600-079Xpii
JPI381journal_volume
42pub_type
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journal_title:Journal of pineal research
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journal_title:Journal of pineal research
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journal_title:Journal of pineal research
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journal_title:Journal of pineal research
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journal_title:Journal of pineal research
pub_type: 杂志文章
doi:10.1111/jpi.12508
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journal_title:Journal of pineal research
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journal_title:Journal of pineal research
pub_type: 杂志文章
doi:10.1111/j.1600-079X.2010.00850.x
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abstract::The effect of melatonin was evaluated on three phosphatidylcholine-based membrane models. Changes in liposome dynamics were monitored by fluorescence, following the response of the probe merocyanine-540, as well as by differential scanning calorimetry (DSC). Langmuir monolayers were investigated using molecular area m...
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pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:Journal of pineal research
pub_type: 杂志文章
doi:10.1111/j.1600-079x.1994.tb00117.x
更新日期:1994-09-01 00:00:00
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journal_title:Journal of pineal research
pub_type: 杂志文章
doi:10.1111/j.1600-079x.1996.tb00236.x
更新日期:1996-01-01 00:00:00
abstract::As for many hormones, melatonin levels in the blood suggest that it is discharged from the pineal gland in a pulsatile manner. Recently, the existence of short-term episodes, superimposed on the circadian pattern of circulating melatonin, has been questioned. Because plasma melatonin levels reflect not only the secret...
journal_title:Journal of pineal research
pub_type: 杂志文章
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journal_title:Journal of pineal research
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更新日期:1996-10-01 00:00:00
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journal_title:Journal of pineal research
pub_type: 杂志文章
doi:10.1111/j.1600-079x.1991.tb00472.x
更新日期:1991-10-01 00:00:00
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journal_title:Journal of pineal research
pub_type: 杂志文章
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journal_title:Journal of pineal research
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journal_title:Journal of pineal research
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journal_title:Journal of pineal research
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journal_title:Journal of pineal research
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abstract::The role played by postsynaptic alpha-adrenergic receptors in the stimulation of pineal melatonin production was investigated in the Syrian hamster. The studies were conducted using organ cultured pineal glands collected from both anatomically intact and superior cervical ganglionectomized hamsters. Results obtained i...
journal_title:Journal of pineal research
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journal_title:Journal of pineal research
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abstract::Melatonin is a very potent and efficient endogenous radical scavenger. The pineal indolamine reacts with the highly toxic hydroxyl radical and provides on-site protection against oxidative damage to biomolecules within every cellular compartment. Melatonin acts as a primary non-enzymatic antioxidative defense against ...
journal_title:Journal of pineal research
pub_type: 杂志文章,评审
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journal_title:Journal of pineal research
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:Journal of pineal research
pub_type: 杂志文章
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