Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1 /MT2 receptor knockout mice.

abstract：:Grapes are an important economic crop and are widely cultivated around the world. Most grapes are grown in arid or semi-arid regions, and droughts take a heavy toll in grape and wine production areas. Developing effective drought-resistant cultivation measures is a priority for viticulture. Melatonin, an indoleamine, ...

journal_title：Journal of pineal research

authors： Meng JF,Xu TF,Wang ZZ,Fang YL,Xi ZM,Zhang ZW

更新日期：2014-09-01 00:00:00

abstract：:Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocy...

journal_title：Journal of pineal research

authors： Zhang M,Dai X,Lu Y,Miao Y,Zhou C,Cui Z,Liu H,Xiong B

更新日期：2017-04-01 00:00:00

abstract：:The effect of melatonin was evaluated on three phosphatidylcholine-based membrane models. Changes in liposome dynamics were monitored by fluorescence, following the response of the probe merocyanine-540, as well as by differential scanning calorimetry (DSC). Langmuir monolayers were investigated using molecular area m...

journal_title：Journal of pineal research

authors： de Lima VR,Caro MS,Munford ML,Desbat B,Dufourc E,Pasa AA,Creczynski-Pasa TB

更新日期：2010-09-01 00:00:00

abstract：:Excessive activity of NADPH oxidase (Nox) is considered to be of importance for the progress of diabetic nephropathy. The aim of the study was to elucidate the effect of melatonin, known for its nephroprotective properties, on Nox activity under diabetic conditions. The experiments were performed on three groups of an...

journal_title：Journal of pineal research

authors： Winiarska K,Dzik JM,Labudda M,Focht D,Sierakowski B,Owczarek A,Komorowski L,Bielecki W

更新日期：2016-01-01 00:00:00

abstract：:The distribution of nerve fibers immunoreactive (IR) to catecholamine-synthesizing enzymes, tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (D beta H), and phenylethanolamine-N-methyltransferase (PNMT) as well as neuropeptide Y (NPY), in the pineal gland of adult sows was investigated by the use of double-labelin...

journal_title：Journal of pineal research

authors： Kaleczyc J,Przybylska B,Majewski M,Lewczuk B

更新日期：1994-08-01 00:00:00

abstract：:Glaucoma may be associated with circadian disruption due to its association with a loss of intrinsically photosensitive retinal ganglion cells. Clinical evidence demonstrating an association between glaucoma and circadian disruption is limited, and no large-scale studies have been performed. The purpose of this cross-...

journal_title：Journal of pineal research

authors： Yoshikawa T,Obayashi K,Miyata K,Saeki K,Ogata N

更新日期：2020-09-01 00:00:00

abstract：:We studied the role of nocturnal illuminance as a possible regulatory factor in the production and secretion of reproductive hormones. Adult male rats were kept under artificial lighting conditions (LD 12/12 hours) where the daily illuminance was 520-550 lx and the nocturnal illuminance 0, less than 0.1, or 1-1.5 lx. ...

journal_title：Journal of pineal research

authors： Laakso ML,Porkka-Heiskanen T,Alila A,Kajander S,Stenberg D,Johansson G

更新日期：1989-01-01 00:00:00

abstract：:Malaria, which infects more than 300 million people annually, is a serious disease. Epidemiological surveys indicate that of those who are affected, malaria will claim the lives of more than one million individuals, mostly children. There is evidence that the synchronous maturation of Plasmodium falciparum, the parasi...

journal_title：Journal of pineal research

authors： Srinivasan V,Spence DW,Moscovitch A,Pandi-Perumal SR,Trakht I,Brown GM,Cardinali DP

更新日期：2010-01-01 00:00:00

abstract：:Improved survival because of advances in neonatal care has resulted in an increased number of infants at risk for chronic lung disease. Even though the etiology of lung injury is multifactorial, recent animal and clinical data indicate that pulmonary damage depends in large part on the ventilatory strategies used. Ven...

journal_title：Journal of pineal research

authors： Gitto E,Reiter RJ,Sabatino G,Buonocore G,Romeo C,Gitto P,Buggé C,Trimarchi G,Barberi I

更新日期：2005-10-01 00:00:00

abstract：:The pineal gland of poikilothermic vertebrates originates as an evagination from the diencephalic roof between the habenular and the posterior commissures, and associates with a parapineal organ to form the so-called pineal complex. The pinealocytes may be photosensitive, secretory or intermediate cells between both. ...

journal_title：Journal of pineal research

authors： Filadelfi AM,Castrucci AM

更新日期：1996-05-01 00:00:00

abstract：:The aim of this study was to determine, in the rat, the interaction between melatonin and cholecystokinin in the regulation of the ileal interdigestive motility. This was analyzed by the chronic electromyography technique. Ileal motility was defined by the presence of intermittent spike bursts corresponding to the con...

journal_title：Journal of pineal research

authors： Bonouali-Pellissier S

更新日期：1994-09-01 00:00:00

abstract：:We have studied the effect of the administration of two doses of melatonin (melatonin 100 and melatonin 200 microg/kg bw) on diabetes and oxidative stress experimentally induced by the injection of streptozotocin (STZ) in female Wistar rats. STZ was injected as a single dose (60 mg/kg i.p. in buffered citrate solution...

journal_title：Journal of pineal research

authors： Montilla PL,Vargas JF,Túnez IF,Muñoz de Agueda MC,Valdelvira ME,Cabrera ES

更新日期：1998-09-01 00:00:00

abstract：:To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every ...

journal_title：Journal of pineal research

authors： Luboshitzky R,Lavi S,Thuma I,Lavie P

更新日期：1996-03-01 00:00:00

abstract：:Despite state-of-the-art pharmaceutical regimens, continuous improvements in diagnostic techniques as well as refinements in equipment and interventional procedures, many diseases remain refractory to conventional therapies. Recent advances in stem cell (SC) biology have opened an avenue to exploring its therapeutic p...

journal_title：Journal of pineal research

authors： Lee MS,Yin TC,Sung PH,Chiang JY,Sun CK,Yip HK

更新日期：2017-03-01 00:00:00

abstract：:Methamphetamine (METH) is a potent psychostimulant drug that may cause neuronal cell degeneration. The underlying mechanisms of METH-induced neuronal toxicity remains poorly understood. In this study, we investigated an important role of calpain-dependent cascades in methamphetamine-induced toxicity in human dopaminer...

journal_title：Journal of pineal research

authors： Suwanjang W,Phansuwan-Pujito P,Govitrapong P,Chetsawang B

更新日期：2010-03-01 00:00:00

abstract：:Melatonin is part of the evolutionary conserved highly functional network in vertebrates. It plays a central role in the adaptative behavior of the animal to the environment, including entrainment of daily and annual physiological rhythms, reproductive behavior, food intake, locomotor activity, growth, and breeding pe...

journal_title：Journal of pineal research

authors： Lima-Cabello E,Díaz-Casado ME,Guerrero JA,Otalora BB,Escames G,López LC,Reiter RJ,Acuña-Castroviejo D

更新日期：2014-08-01 00:00:00

abstract：:The age-related changes and the acute effects of intravenous melatonin on the activity of striatal neurons of 1-, 3-, 6-, 12-, and 18-month-old sham-operated and pinealectomized rats were investigated. There was a decline in responsiveness from 3- to 18-months of age, although in sham-pinealectomized rats the response...

journal_title：Journal of pineal research

authors： Castillo-Romero JL,Acuña-Castroviejo D,Escamaes G,Vives F

更新日期：1995-09-01 00:00:00

abstract：:The effect of various cations on activity of hydroxyindole-O-methyltransferase (HIOMT) and N-acetyltransferase (NAT) from pineal gland was studied. Copper inhibited both enzymes while calcium and magnesium inhibited HIOMT; the mechanisms of these inhibitions are unknown at this stage. Calcium, magnesium, potassium, an...

journal_title：Journal of pineal research

authors： Morton DJ

更新日期：1987-01-01 00:00:00

abstract：:Melatonin has been identified in primitive photosynthetic bacteria, fungi, plants, and animals including humans. Vegetables, fruits, cereals, wine, and beers all contain melatonin. However, the melatonin content in meats has not been reported previously. Here, for the first time, we report melatonin in meats, eggs, co...

journal_title：Journal of pineal research

authors： Tan DX,Zanghi BM,Manchester LC,Reiter RJ

更新日期：2014-09-01 00:00:00

abstract：:Urotoxicity is one of the major problems associated with cyclophosphamide (CP) chemotherapy in cancer patients. Melatonin is a potent antioxidant and reduces CP-induced urotoxicity. However, the molecular mechanisms of protection offered by melatonin are not yet clear. The present study investigated the role of nuclea...

journal_title：Journal of pineal research

authors： Tripathi DN,Jena GB

更新日期：2010-05-01 00:00:00

abstract：:Five adult pasture-bred Prim Holstein cows were used to document the time invariance of melatonin disposition in the cow. Melatonin was administered by an intravenous route as a bolus (5 micrograms/kg of body weight) at either 1430 or 2230. Data were analysed according to a three-compartment open model with melatonin ...

journal_title：Journal of pineal research

authors： Berthelot X,Ravault JP,Concordet D,Ferney J,Toutain PL

更新日期：1993-10-01 00:00:00

abstract：:In desert areas, mammals such as camel and goat are exposed to harsh environmental conditions. The ambient temperature (Ta) cycles have been shown to entrain the circadian clock in the camel. In the present work, we assumed that, in the goat living in a desert biotope, Ta cycles would have the same synchronizing effec...

journal_title：Journal of pineal research

authors： Farsi H,Harti D,Achaâban MR,Piro M,Raverot V,Bothorel B,Ouassat M,Challet E,Pévet P,El Allali K

更新日期：2020-04-01 00:00:00

abstract：:Adult female golden hamsters were used to study the effect of short photoperiod on the endogenous opioid system and the effect of pinealectomy on the serum beta-endorphin-like immunoreactivity (beta-end LI) levels. Hamsters were housed under either long photoperiod (14L:10D) or short photoperiod (2L:22D) and the regul...

journal_title：Journal of pineal research

authors： Kumar MS,Besch EL,Millard WJ,Sharp DC,Leadem CA

更新日期：1984-01-01 00:00:00

abstract：:The milk-ejecting response of lactating mouse mammary gland tissue to ovine pineal extracts indicated the presence of a neurohormone-like bioactivity in this tissue. After successive fractionation on gel permeation chromatography and reversed-phase liquid chromatography (HPLC) in conjunction with radioimmunoassays (RI...

journal_title：Journal of pineal research

authors： Noteborn HP,Ebels I,Reinharz AC,Pévet P,Benson B,Salemink CA

更新日期：1988-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the effect of melatonin on oxidative stress occurring in the brain after routine lobectomy neurosurgery procedures. Different concentrations of melatonin (5, 15 and 150 mg/kg) were administered 1 hr before lobectomy in a rodent surgical brain injury (SBI) model. Neurological o...

journal_title：Journal of pineal research

authors： Lee S,Jadhav V,Ayer RE,Rojas H,Hyong A,Lekic T,Tang J,Zhang JH

更新日期：2009-01-01 00:00:00

abstract：:The aim was to examine the effect of perioperative melatonin treatment on clinical cardiac morbidity and markers of myocardial ischemia in patients undergoing elective surgery for abdominal aortic aneurism. Reperfusion injury results in increased cardiac morbidity in patients undergoing surgery for abdominal aortic an...

journal_title：Journal of pineal research

authors： Gögenur I,Kücükakin B,Panduro Jensen L,Reiter RJ,Rosenberg J

更新日期：2014-08-01 00:00:00

abstract：:The purpose of this study was to determine and compare the light sensitivity of two commercially important, phylogenetically different teleost species in terms of melatonin production. Three series of experiments were performed on both Atlantic salmon and European sea bass. First, a range of light intensities were tes...

journal_title：Journal of pineal research

authors： Migaud H,Taylor JF,Taranger GL,Davie A,Cerdá-Reverter JM,Carrillo M,Hansen T,Bromage NR

更新日期：2006-08-01 00:00:00

abstract：:It has been suggested that oxidative stress is a feature of aging. The goal of the present study was to assess the oxidant effects related to aging and the protective role of exogenous melatonin in senescence-accelerated mice (SAMP8). Two groups of SAMP8 mice (males and females) were compared with their respective con...

journal_title：Journal of pineal research

authors： Nogués MR,Giralt M,Romeu M,Mulero M,Sánchez-Martos V,Rodríguez E,Acuña-Castroviejo D,Mallol J

更新日期：2006-09-01 00:00:00

abstract：:In previous studies, we have shown that mitochondrial respiratory chain (MRC) activity is decreased in patients with nonalcoholic steatohepatitis and in ob/ob mice and that peroxynitrite plays a pathogenic role. The present study examined whether melatonin, a peroxynitrite scavenger, prevents: (i) the in vitro effects...

journal_title：Journal of pineal research

authors： Solís-Muñoz P,Solís-Herruzo JA,Fernández-Moreira D,Gómez-Izquierdo E,García-Consuegra I,Muñoz-Yagüe T,García Ruiz I

更新日期：2011-08-01 00:00:00

abstract：:The role played by postsynaptic alpha-adrenergic receptors in the stimulation of pineal melatonin production was investigated in the Syrian hamster. The studies were conducted using organ cultured pineal glands collected from both anatomically intact and superior cervical ganglionectomized hamsters. Results obtained i...

journal_title：Journal of pineal research

authors： Santana C,Guerrero JM,Reiter RJ,Menendez-Pelaez A

更新日期：1989-01-01 00:00:00