The protective effect of melatonin on methamphetamine-induced calpain-dependent death pathway in human neuroblastoma SH-SY5Y cultured cells.

abstract：:Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression, and type 2 diabetes development. Melatonin receptors are approved drug targets for insomnia, non-24-hour sleep-wake disorders, and major depressive disorders. In mammal...

journal_title：Journal of pineal research

authors： Cecon E,Ivanova A,Luka M,Gbahou F,Friederich A,Guillaume JL,Keller P,Knoch K,Ahmad R,Delagrange P,Solimena M,Jockers R

更新日期：2019-03-01 00:00:00

abstract：:The effect on nocturnal melatonin secretion of acute administration of the indirectly acting serotonin (5-HT) receptor agonists d-fenfluramine (30 mg) and paroxetine (20 mg) and a partial 5-HT1A receptor agonist ipsapirone (20 mg) was investigated in healthy male volunteers and compared to a placebo condition. Each su...

journal_title：Journal of pineal research

authors： Nathan PJ,Norman TR,Burrows GD

更新日期：1996-09-01 00:00:00

abstract：:The effect of melatonin injection on Freund's adjuvant-induced changes in levels and 24-hr rhythms of circulating ACTH, growth hormone (GH), prolactin (PRL), luteinizing hormone (LH), and insulin was assessed in rats. Animals received subcutaneous (s.c.) injections of melatonin (30 microg) or vehicle, 1 hr before ligh...

journal_title：Journal of pineal research

authors： Esquifino AI,Castrillón P,García-Bonacho M,Vara E,Cardinali DP

更新日期：1999-08-01 00:00:00

abstract：:Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties. There are also experimental and clinical data supporting an analgesic role of melatonin. In experimental studies, melatonin sho...

journal_title：Journal of pineal research

authors： Wilhelmsen M,Amirian I,Reiter RJ,Rosenberg J,Gögenur I

更新日期：2011-10-01 00:00:00

abstract：:The ultrastructure of the pineal gland in the adult cat is described and compared with that of other mammals. Connective tissue spaces showed capillaries with nonfenestrated endothelia and numerous unmyelinated nerve fibers. In the proximal region of the gland, myelinated nerve fibers coming from the anterior commissu...

journal_title：Journal of pineal research

authors： Boya J,Calvo JL,Rancaño D

更新日期：1995-03-01 00:00:00

abstract：:Sirtuin 1 is a member of the sirtuin family of protein deacetylases, which have attracted considerable attention as mediators of lifespan extension in several model organisms. Induction of sirtuin 1 expression also attenuates neuronal degeneration and death in animal models of Alzheimer's disease and Huntington's dise...

journal_title：Journal of pineal research

authors： Tajes M,Gutierrez-Cuesta J,Ortuño-Sahagun D,Camins A,Pallàs M

更新日期：2009-10-01 00:00:00

abstract：:In three separate experiments, the effect of acute exposure to either artificial or natural light during darkness of pineal N-acetyltransferase (NAT) activity and melatonin content was studied in the cotton rat (Sigmodon hispidus). The exposure of animals to an artificial-light irradiance of 160,000 microW/cm2 during ...

journal_title：Journal of pineal research

authors： Nürnberger F,Joshi BN,Heinzeller T,Milin J,Reiter RJ

更新日期：1985-01-01 00:00:00

abstract：:Antioxidant activity of a molecule is attributed to various mechanisms such as prevention of chain initiation, binding of transition metal ion catalysts and decomposition of peroxides. This study was aimed at evaluating the metal chelating and hydrogen peroxide (H2O2) scavenging activity of melatonin. The metal chelat...

journal_title：Journal of pineal research

authors： Gulcin I,Buyukokuroglu ME,Kufrevioglu OI

更新日期：2003-05-01 00:00:00

abstract：:Classical anticancer therapies often are ineffective in patients with malignant glioma who have a survival of <1 year. Our previous studies showed a potent inhibitory effect of melatonin on glioma cell proliferation. This effect seems to be mediated by the well-known antioxidant properties of this molecule and the neg...

journal_title：Journal of pineal research

authors： Martín V,Herrera F,García-Santos G,Antolín I,Rodriguez-Blanco J,Medina M,Rodriguez C

更新日期：2007-10-01 00:00:00

abstract：:Although there is an increasing evidence that the pineal gland may play a role in human malignancy, the studies on melatonin concentrations in different types of malignant tumors brought about controversial results. However, changes in melatonin concentrations have been observed in some types of human malignant tumors...

journal_title：Journal of pineal research

authors： Karasek M,Kowalski AJ,Suzin J,Zylinska K,Swietoslawski J

更新日期：2005-08-01 00:00:00

abstract：:N-nitrosomelatonin (NOMela) is well-known for its capabilities of transnitrosating nucleophiles such as thiols and ascorbate, thereby generating nitric oxide (NO)-releasing compounds. It is unknown, however, whether NOMela can be successfully applied as a precursor of NO in a complex biological environment like a cell...

journal_title：Journal of pineal research

authors： Berchner-Pfannschmidt U,Tug S,Trinidad B,Becker M,Oehme F,Flamme I,Fandrey J,Kirsch M

更新日期：2008-11-01 00:00:00

abstract：:Optic atrophy 1 (OPA1)-related mitochondrial fusion and mitophagy are vital to sustain mitochondrial homeostasis under stress conditions. However, no study has confirmed whether OPA1-related mitochondrial fusion/mitophagy is activated by melatonin and, consequently, attenuates cardiomyocyte death and mitochondrial str...

journal_title：Journal of pineal research

authors： Zhang Y,Wang Y,Xu J,Tian F,Hu S,Chen Y,Fu Z

更新日期：2019-03-01 00:00:00

abstract：:UV radiation (UVR) induces serious structural and functional alterations in human skin leading to skin aging and carcinogenesis. Reactive oxygen species are key players in UVR-mediated photodamage and induce the DNA-base-oxidized, intermediate 8-hydroxy-2'-deoxyguanosine (8-OHdG). Herein, we report the protective acti...

journal_title：Journal of pineal research

authors： Fischer TW,Kleszczyński K,Hardkop LH,Kruse N,Zillikens D

更新日期：2013-04-01 00:00:00

abstract：:Irradiation of the melatonin metabolite N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) with UV light of 254 nm causes the release of carbon monoxide (CO) and, thus, deformylation to N(1)-acetyl-5-methoxykynuramine (AMK). Liberation of CO was demonstrated by reduction of PdCl(2) to metallic palladium, under avoidan...

journal_title：Journal of pineal research

authors： Seever K,Hardeland R

更新日期：2008-05-01 00:00:00

abstract：:An important role for melatonin in bone formation and restructuring has emerged, and studies demonstrate the multiple mechanisms for these beneficial actions. Statistical analysis shows that even with existing osteoporotic therapies, bone-related disease, and mortality are on the rise, creating a huge financial burden...

journal_title：Journal of pineal research

authors： Maria S,Witt-Enderby PA

更新日期：2014-03-01 00:00:00

abstract：:Oxidative stress is reported as one of the most widely accepted mechanisms of maneb (MB)- and paraquat (PQ)-induced nigrostriatal dopaminergic neurodegeneration leading to the Parkinson's disease (PD) phenotype. The study investigated the effects of silymarin, an antioxidant of plant origin, and melatonin, an indoleam...

journal_title：Journal of pineal research

authors： Singhal NK,Srivastava G,Patel DK,Jain SK,Singh MP

更新日期：2011-03-01 00:00:00

abstract：:We tested the hypothesis that melatonin (Mel) enhances exogenous mitochondria (Mito) treatment against rodent hepatic ischemia-reperfusion (IR) injury. In vitro study utilized three groups of hepatocytes (i.e. nontreatment, menadione, and menadione-melatonin treatment, 4.0 × 10(5) each), while in vivo study used adult...

journal_title：Journal of pineal research

authors： Chen HH,Chen YT,Yang CC,Chen KH,Sung PH,Chiang HJ,Chen CH,Chua S,Chung SY,Chen YL,Huang TH,Kao GS,Chen SY,Lee MS,Yip HK

更新日期：2016-08-01 00:00:00

abstract：:The effect of melatonin administration on nerve growth factor (NGF) was studied in the submandibular glands of adult Swiss male mice. Melatonin injection, at 1 microg daily for 30 days, resulted in an increase in the NGF content as detected by immunohistochemistry. The submandibular gland weight and the area of the gr...

journal_title：Journal of pineal research

authors： Pongsa-Asawapaiboon A,Asavaritikrai P,Withyachumnarnkul B,Sumridthong A

更新日期：1998-03-01 00:00:00

abstract：:In healthy young men, administration of a single light pulse (5000 lux for 3 hr) or a single melatonin pill (5 mg) at 20:40 hr under controlled constant routine conditions of <10 lux, yielded a phase delay and a phase advance, respectively, in the circadian marker of dim light melatonin onset 24 hr later. Phase shifts...

journal_title：Journal of pineal research

authors： Wirz-Justice A,Kräuchi K,Cajochen C,Danilenko KV,Renz C,Weber JM

更新日期：2004-04-01 00:00:00

abstract：:We have studied the postnatal evolution of the glial cells in the rat pineal gland after its chemical pre- and perinatal denervation, by the assessment of the immunocytochemical expression of three antigens characteristic of glial cells i.e., vimentin (VIM), glial fibrillary acidic protein (GFAP), and S-100 protein. T...

journal_title：Journal of pineal research

authors： López-Muñoz F,Boya J

更新日期：1995-05-01 00:00:00

abstract：:The activity of N-acetyltransferase (NAT) and the content of melatonin (MEL) in the rat pineal have been shown to be sensitive to several types of stressors. This study was designed to assess the role of the adrenals in mediating the effect of one such stressor, insulin-induced hypoglycemia, on pineal synthetic activi...

journal_title：Journal of pineal research

authors： Tannenbaum MG,Reiter RJ,Vaughan MK,Troiani ME,Gonzalez-Brito A

更新日期：1987-01-01 00:00:00

abstract：:The presence of melatonin and the enzymes (transcripts and activities) involved in its synthesis, i.e. arylalkylamine N-acetyltransferase (AA-NAT) and hydroxyindole-O-methyltransferase (HIOMT), was investigated in the eggs and early embryos of Japanese quail at Hamburger-Hamilton stages 1-10. Melatonin was present in ...

journal_title：Journal of pineal research

authors： Olszańska B,Majewski P,Lewczuk B,Stepińska U

更新日期：2007-04-01 00:00:00

abstract：:Liver fibrosis is scar tissue resulting from an uncontrolled wound-healing process in response to chronic liver injury. Liver damage generates an inflammatory reaction that activates hepatic stellate cells (HSC) that transdifferentiate from quiescent cells that control retinol metabolism to proliferative and migratory...

journal_title：Journal of pineal research

authors： Shajari S,Laliena A,Heegsma J,Tuñón MJ,Moshage H,Faber KN

更新日期：2015-10-01 00:00:00

abstract：:Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant. Among a great number of metabolites that have been tried before, only a few were found (cerulein and quinaldic acid in mice and kynurenic acid in rats). In SHR (bred from Swiss) male mice, intrac...

journal_title：Journal of pineal research

authors： Lapin IP,Mirzaev SM,Ryzov IV,Oxenkrug GF

更新日期：1998-05-01 00:00:00

abstract：:Experiments were designed to test the hypothesis that the pineal gland mediates the effects of changing day length and thereby synchronizes implantation within the population of spotted skunks. Intact, sham-superior cervical ganglionectomized (SCGx), SCGx, and SCGx/bilateral orbitally enucleated (B1) pregnant skunks w...

journal_title：Journal of pineal research

authors： May R,Mead RA

更新日期：1986-01-01 00:00:00

abstract：:Melatonin is a highly effective treatment in different animal models of excitotoxicity or ischemia/reperfusion injury. Due to a lack of patentability, commercial sponsors are not interested in funding clinical evaluations of melatonin. Investigators may initiate small-scale clinical evaluation, and intravenous (i.v.) ...

journal_title：Journal of pineal research

authors： Cheung RT,Tipoe GL,Tam S,Ma ES,Zou LY,Chan PS

更新日期：2006-11-01 00:00:00

abstract：:Transgenic rice plants overexpressing a sheep serotonin N-acetyltransferase led to an enhanced production of melatonin with various physiological effects, including seminal root elongation and resistance against cold and oxidative stress, which raises the possibility that melatonin may alter gene expression profiles i...

journal_title：Journal of pineal research

authors： Byeon Y,Park S,Kim YS,Back K

更新日期：2013-11-01 00:00:00

abstract：:Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the brain detects the light through retinas and regulates rhythms and melatonin secretion throughout the body, the liver has independent circadian rhyth...

journal_title：Journal of pineal research

authors： Sato K,Meng F,Francis H,Wu N,Chen L,Kennedy L,Zhou T,Franchitto A,Onori P,Gaudio E,Glaser S,Alpini G

更新日期：2020-04-01 00:00:00

abstract：:The influence of the pineal gland on the histopathologic changes induced in mammary glands by 7, 12-dimethylbenz(a)-anthracene (DMBA) has been studied. To achieve the maximum expression of pineal action in animals, 28-day-old female Sprague-Dawley rats were subjected to one of the following treatments: blindness + olf...

journal_title：Journal of pineal research

authors： Cos S,Garijo F,Corral J,Mediavilla MD,Sánchez-Barceló EJ

更新日期：1989-01-01 00:00:00

abstract：:Recently, a species-dependent distribution of melatonin binding sites have been found in lamina I-V and lamina X of the spinal cord. In order to learn more about the function of spinal melatonin receptors, we investigated (i) the gene expression for melatonin receptor subtypes in lumbar and thoracal spinal cord tissue...

journal_title：Journal of pineal research

authors： Zahn PK,Lansmann T,Berger E,Speckmann EJ,Musshoff U

更新日期：2003-08-01 00:00:00