Melatonin increases nerve growth factor in mouse submandibular gland.

abstract：:We studied the role of nocturnal illuminance as a possible regulatory factor in the production and secretion of reproductive hormones. Adult male rats were kept under artificial lighting conditions (LD 12/12 hours) where the daily illuminance was 520-550 lx and the nocturnal illuminance 0, less than 0.1, or 1-1.5 lx. ...

journal_title：Journal of pineal research

authors： Laakso ML,Porkka-Heiskanen T,Alila A,Kajander S,Stenberg D,Johansson G

更新日期：1989-01-01 00:00:00

abstract：:Melatonin, a molecule produced in the pineal gland and retina of vertebrates, plays a major role in day-night circadian rhythms and other physiological processes, including the immune responses. Because little is known in this respect in fish, we have evaluated the in vivo role of melatonin in the main innate immune a...

journal_title：Journal of pineal research

authors： Cuesta A,Cerezuela R,Esteban MA,Meseguer J

更新日期：2008-08-01 00:00:00

abstract：:We tested the hypothesis that melatonin (Mel) enhances exogenous mitochondria (Mito) treatment against rodent hepatic ischemia-reperfusion (IR) injury. In vitro study utilized three groups of hepatocytes (i.e. nontreatment, menadione, and menadione-melatonin treatment, 4.0 × 10(5) each), while in vivo study used adult...

journal_title：Journal of pineal research

authors： Chen HH,Chen YT,Yang CC,Chen KH,Sung PH,Chiang HJ,Chen CH,Chua S,Chung SY,Chen YL,Huang TH,Kao GS,Chen SY,Lee MS,Yip HK

更新日期：2016-08-01 00:00:00

abstract：:Melatonin regulates mitogen-activated protein kinase (MAPK) and Akt signaling pathways. The MAPK family mainly includes extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK). Our previous study documented that melatonin delays osteoblast proliferation; however, the mechanism of action of ...

journal_title：Journal of pineal research

authors： Liu L,Zhu Y,Xu Y,Reiter RJ

更新日期：2012-08-01 00:00:00

abstract：:The effect of melatonin on thrombin-induced [3H]-arachidonic acid (AA) metabolism to cyclooxygenase derivatives was determined in platelets obtained from normal volunteers at 0830 and 2030 h. Percent conversion of radioactive AA was generally greater at 2030 h than at 0830 h for every cyclooxygenase derivative analyze...

journal_title：Journal of pineal research

authors： Martinuzzo M,Del Zar MM,Cardinali DP,Carreras LO,Vacas MI

更新日期：1991-10-01 00:00:00

abstract：:The cellular proliferative activity in the adult rat pineal gland was studied using bromodeoxyuridine immunohistochemistry during the light and dark phases of an artificial 12L:12D photoperiod. The results showed statistically significant differences in the number of labeled cells between the light and dark phases, wi...

journal_title：Journal of pineal research

authors： Calvo JL,Boya J,Carbonell AL,García-Mauriño JE

更新日期：1997-08-01 00:00:00

abstract：:The objective of this study was to determine the role of alpha-adrenoceptors in melatonin production by rat pineal gland. Pineal glands were isolated from adult male rats and maintained in organ baths. The perfusate was sampled every 5 min, stored, and later assayed for melatonin. Exposure to norepinephrine (10 microM...

journal_title：Journal of pineal research

authors： Tobin VA,McCance I,Coleman HA,Parkington HC

更新日期：2002-05-01 00:00:00

abstract：:The rod outer segment (ROSg) membranes are essentially lipoprotein complexes. Rhodopsin, the major integral protein of ROSg, is surrounded by phospholipids highly enriched in docosahexaenoic acid (22:6 n3). This fluid environment plays an important role for conformational changes after photo-activation. Thus, ROSg mem...

journal_title：Journal of pineal research

authors： Guajardo MH,Terrasa AM,Catalá A

更新日期：2006-10-01 00:00:00

abstract：:The presence of melatonin and the enzymes (transcripts and activities) involved in its synthesis, i.e. arylalkylamine N-acetyltransferase (AA-NAT) and hydroxyindole-O-methyltransferase (HIOMT), was investigated in the eggs and early embryos of Japanese quail at Hamburger-Hamilton stages 1-10. Melatonin was present in ...

journal_title：Journal of pineal research

authors： Olszańska B,Majewski P,Lewczuk B,Stepińska U

更新日期：2007-04-01 00:00:00

abstract：:This study aimed to elucidate whether melatonin would exert beneficial effects on the neuronal functions of the nodose ganglion (NG) following acute hypoxic insult. The cytochrome oxidase (COX) and the nicotinamine adenine dinucleotide phosphate diaphorase (NADPH-d) histochemistry along with the nitric oxide synthase ...

journal_title：Journal of pineal research

authors： Chang HM,Tseng CY,Wei IH,Lue JH,Wen CY,Shieh JY

更新日期：2005-09-01 00:00:00

abstract：:Glaucoma may be associated with circadian disruption due to its association with a loss of intrinsically photosensitive retinal ganglion cells. Clinical evidence demonstrating an association between glaucoma and circadian disruption is limited, and no large-scale studies have been performed. The purpose of this cross-...

journal_title：Journal of pineal research

authors： Yoshikawa T,Obayashi K,Miyata K,Saeki K,Ogata N

更新日期：2020-09-01 00:00:00

abstract：:Melatonin (MT), endogenously secreted by the pineal gland, is closely related to multiple biological processes; however, its effect on thrombopoiesis is still not well illustrated. Here, we demonstrate that MT administration can elevate peripheral platelet levels. Analysis of different stages in thrombopoiesis reveals...

journal_title：Journal of pineal research

authors： Chen S,Qi Y,Wang S,Xu Y,Shen M,Hu M,Du C,Chen F,Chen M,Lu Y,Zhang Z,Quan Y,Wang C,Wang F,Wang J

更新日期：2020-04-01 00:00:00

abstract：:By use of Phaseolus vulgaris-leucoagglutinin as an anterograde in vivo tracer, a direct projection from the dorsal raphe nucleus to the pineal complex of the rat was demonstrated. The nerve fibers extended from the dorsal raphe nucleus rostrally through the mesencephalic periaqueductal grey and entered the deep pineal...

journal_title：Journal of pineal research

authors： Møller M,Hay-Schmidt A

更新日期：1998-08-01 00:00:00

abstract：:Oxidative stress is reported as one of the most widely accepted mechanisms of maneb (MB)- and paraquat (PQ)-induced nigrostriatal dopaminergic neurodegeneration leading to the Parkinson's disease (PD) phenotype. The study investigated the effects of silymarin, an antioxidant of plant origin, and melatonin, an indoleam...

journal_title：Journal of pineal research

authors： Singhal NK,Srivastava G,Patel DK,Jain SK,Singh MP

更新日期：2011-03-01 00:00:00

abstract：:Recent investigations of our group established that melatonin modulates hormone secretion of pancreatic islets via melatonin receptor types MT1 and MT2. Expression of MT1 and MT2 has been shown in mouse, rat, and human pancreatic islets as well as in the β-, α-, and δ-cell lines INS-1, αTC1.9, and QGP-1. In view of th...

journal_title：Journal of pineal research

authors： Zibolka J,Bazwinsky-Wutschke I,Mühlbauer E,Peschke E

更新日期：2018-08-01 00:00:00

abstract：:It is well established that some agents such as aminoglycosides generate free oxygen radicals, leading to an increased oxireductase production, which in turn increases tissue toxicity. The aim of this study is to test whether melatonin, the chief secretory product of the pineal gland and a highly effective antioxidant...

journal_title：Journal of pineal research

authors： Parlakpinar H,Ozer MK,Sahna E,Vardi N,Cigremis Y,Acet A

更新日期：2003-09-01 00:00:00

abstract：:Senescence-accelerated mice (SAMP8) and senescence-accelerated resistant mice (SAMR1) were studied at 5 and 10 months of age, respectively. In the animals, neurodegenerative processes and how they were influenced by melatonin were examined. Melatonin (10 mg/kg) or vehicle (ethanol at 0.066%) treatments were administra...

journal_title：Journal of pineal research

authors： Caballero B,Vega-Naredo I,Sierra V,Huidobro-Fernández C,Soria-Valles C,De Gonzalo-Calvo D,Tolivia D,Gutierrez-Cuesta J,Pallas M,Camins A,Rodríguez-Colunga MJ,Coto-Montes A

更新日期：2008-10-01 00:00:00

abstract：:The binding characteristics of the tritiated pineal hormone, [3H] melatonin, were studied in brain tissues using in vitro binding techniques. In synaptosomal membranes prepared from rat hippocampus and subjected to preincubation at 37 degrees C and multiple washings, high-affinity binding of [3H] melatonin significant...

journal_title：Journal of pineal research

authors： Niles LP

更新日期：1987-01-01 00:00:00

abstract：:Our objective was to suppress the daily surge of melatonin in serum of prepubertal dairy heifers by manipulating intensity of light (Experiment 1) and duration of exposure to light (Experiment 2). Heifers in Experiment 1 were exposed to either 12 hr of darkness (000 lux, control), or 400, 800, or 1,200 lux of light du...

journal_title：Journal of pineal research

authors： Buchanan BA,Chapin LT,Tucker HA

更新日期：1992-05-01 00:00:00

abstract：:As for many hormones, melatonin levels in the blood suggest that it is discharged from the pineal gland in a pulsatile manner. Recently, the existence of short-term episodes, superimposed on the circadian pattern of circulating melatonin, has been questioned. Because plasma melatonin levels reflect not only the secret...

journal_title：Journal of pineal research

authors： Follenius M,Weibel L,Brandenberger G

更新日期：1995-04-01 00:00:00

abstract：:Irradiation of the melatonin metabolite N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) with UV light of 254 nm causes the release of carbon monoxide (CO) and, thus, deformylation to N(1)-acetyl-5-methoxykynuramine (AMK). Liberation of CO was demonstrated by reduction of PdCl(2) to metallic palladium, under avoidan...

journal_title：Journal of pineal research

authors： Seever K,Hardeland R

更新日期：2008-05-01 00:00:00

abstract：:In the mammalian pineal gland, the rhythm in melatonin biosynthesis depends on the norepinephrine (NE)-driven regulation of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme of melatonin biosynthesis. A recent study showed that phytocannabinoids like tetrahydrocannabinol reduce AANAT activity and atte...

journal_title：Journal of pineal research

authors： Koch M,Habazettl I,Dehghani F,Korf HW

更新日期：2008-11-01 00:00:00

abstract：:Melatonin, a potent antioxidant, has shown to be beneficial in murine Venezuelan equine encephalomyelitis (VEE) virus infection. In addition, melatonin can induces the production of interleukin-1 beta (IL-1beta), a cytokine capable of inducing increased expression of inducible nitric oxide synthase; the activity of th...

journal_title：Journal of pineal research

authors： Valero N,MarinaEspina L,Bonilla E,Mosquera J

更新日期：2007-03-01 00:00:00

abstract：:The permeability of the pineal gland to lanthanum was investigated by means of transmission electron microscopy and X-ray microanalysis. Different pineal cell populations were studied. Light pinealocytes as well as glial cells were not permeated by the tracer lanthanum, which normally stays extracellularly. Dark pinea...

journal_title：Journal of pineal research

authors： Humbert W,Pévet P

更新日期：1992-03-01 00:00:00

abstract：:Early studies on the physiological effects of melatonin typically reported hypnotic 'side-effects'. Later studies, specifically addressing this action, failed to reliably replicate hypnotic effects using standard polysomnography. This difference may be related to differences in the basic physiological action of melato...

journal_title：Journal of pineal research

authors： Dawson D,Encel N

更新日期：1993-08-01 00:00:00

abstract：:Grapes are an important economic crop and are widely cultivated around the world. Most grapes are grown in arid or semi-arid regions, and droughts take a heavy toll in grape and wine production areas. Developing effective drought-resistant cultivation measures is a priority for viticulture. Melatonin, an indoleamine, ...

journal_title：Journal of pineal research

authors： Meng JF,Xu TF,Wang ZZ,Fang YL,Xi ZM,Zhang ZW

更新日期：2014-09-01 00:00:00

abstract：:Day and nighttime melatonin production in the pineal gland was compared in normal and cardiomyopathic (polydystrophic) adult male Syrian hamsters. These strains of hamsters were selected for comparison because the cardiomyopathetic hamster displays a deficient transmembrane Ca(2+)-pump in a number of tissues, and intr...

journal_title：Journal of pineal research

authors： Reiter RJ,White T,Lerchl A,Stokkan KA,Rodriguez C

更新日期：1991-10-01 00:00:00

abstract：:Our daily rhythmicity is controlled by a circadian clock with a specific set of genes located in the suprachiasmatic nucleus in the hypothalamus. Mast cells (MCs) are major effector cells that play a protective role against pathogens and inflammation. MC distribution and activation are associated with the circadian rh...

journal_title：Journal of pineal research

authors： Pham L,Baiocchi L,Kennedy L,Sato K,Meadows V,Meng F,Huang CK,Kundu D,Zhou T,Chen L,Alpini G,Francis H

更新日期：2020-10-05 00:00:00

abstract：:A link between endotoxemia and nonalcoholic fatty liver disease (NAFLD) has been demonstrated in human and rodent animals. Nevertheless, the molecular mechanisms of endotoxin-evoked NAFLD remain poorly understood. We hypothesize that reactive oxygen species (ROS) mediate lipopolysaccharide (LPS)-evoked hepatic lipid a...

journal_title：Journal of pineal research

authors： Chen X,Zhang C,Zhao M,Shi CE,Zhu RM,Wang H,Zhao H,Wei W,Li JB,Xu DX

更新日期：2011-11-01 00:00:00

abstract：:Melatonin, a neurohormone that binds to two G protein-coupled receptors MT1 and MT2, is involved in pain regulation, but the distinct role of each receptor has yet to be defined. We characterized the nociceptive responses of mice with genetic inactivation of melatonin MT1 (MT1-/- ), or MT2 (MT2-/- ), or both MT1 /MT2 ...

journal_title：Journal of pineal research

authors： Posa L,Lopez-Canul M,Rullo L,De Gregorio D,Dominguez-Lopez S,Kaba Aboud M,Caputi FF,Candeletti S,Romualdi P,Gobbi G

更新日期：2020-10-01 00:00:00