Influence of the light and dark phase of the cycle on the cellular proliferation in the pineal gland of the adult rat: a bromodeoxyuridine immunohistochemical study.

abstract：:The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade. Cigarette smoke (CS) is the most important risk factor in the development of COPD. In this study, we investigated the effects of melatonin on the development of COPD using a CS and lipopolysaccharide (LPS)-induc...

journal_title：Journal of pineal research

authors： Shin IS,Shin NR,Park JW,Jeon CM,Hong JM,Kwon OK,Kim JS,Lee IC,Kim JC,Oh SR,Ahn KS

更新日期：2015-01-01 00:00:00

abstract：:The effect of melatonin on thrombin-induced [3H]-arachidonic acid (AA) metabolism to cyclooxygenase derivatives was determined in platelets obtained from normal volunteers at 0830 and 2030 h. Percent conversion of radioactive AA was generally greater at 2030 h than at 0830 h for every cyclooxygenase derivative analyze...

journal_title：Journal of pineal research

authors： Martinuzzo M,Del Zar MM,Cardinali DP,Carreras LO,Vacas MI

更新日期：1991-10-01 00:00:00

abstract：:Melatonin regulates mitogen-activated protein kinase (MAPK) and Akt signaling pathways. The MAPK family mainly includes extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK). Our previous study documented that melatonin delays osteoblast proliferation; however, the mechanism of action of ...

journal_title：Journal of pineal research

authors： Liu L,Zhu Y,Xu Y,Reiter RJ

更新日期：2012-08-01 00:00:00

abstract：:Melatonin is a potent scavenger of free radicals and an indirect antioxidant. Recent studies have shown that melatonin possesses beneficial effects in experimental models of brain trauma and global cerebral ischemia. The effects of pretreatment with melatonin on volume of cerebral infarction were investigated in the p...

journal_title：Journal of pineal research

authors： Pei Z,Pang SF,Cheung RT

更新日期：2002-04-01 00:00:00

abstract：:The present study analyzes the participation of pineal stalk and superior cervical ganglia (SCG) in the conduction of photic evoked potentials (PEP) to the pineal body (PB) in unanesthetized freely moving rats implanted with semimicroelectrodes. The PEPs were recorded in PB, lateral hypothalamus (LH), and habenular co...

journal_title：Journal of pineal research

authors： Barajas-López C,Barrientos-Martinez MA,Reyes-Vázquez C

更新日期：1987-01-01 00:00:00

abstract：:The oncostatic effects of melatonin on the mammary gland have been studied in transgenic mice carrying the N-ras proto-oncogene under the control of the MMTV-LTR. Female (4-week-old) virgin mice with positive transgenic pedigrees were injected with melatonin (200 micrograms/mouse/ day, five times a week) or vehicle la...

journal_title：Journal of pineal research

authors： Mediavilla MD,Güezmez A,Ramos S,Kothari L,Garijo F,Sánchez Barceló EJ

更新日期：1997-03-01 00:00:00

abstract：:A role of D2-dopaminergic neurotransmission in the regulation of melatonin biosynthesis in retina was studied in vivo in chickens. The nighttime rise in serotonin N-acetyltransferase (NAT)--the penultimate and key regulatory melatonin-synthesizing enzyme--was potently inhibited by both acute light exposure and agonist...

journal_title：Journal of pineal research

authors： Zawilska JB,Kazula A,Zurawska E,Nowak JZ

更新日期：1991-10-01 00:00:00

abstract：:In desert areas, mammals such as camel and goat are exposed to harsh environmental conditions. The ambient temperature (Ta) cycles have been shown to entrain the circadian clock in the camel. In the present work, we assumed that, in the goat living in a desert biotope, Ta cycles would have the same synchronizing effec...

journal_title：Journal of pineal research

authors： Farsi H,Harti D,Achaâban MR,Piro M,Raverot V,Bothorel B,Ouassat M,Challet E,Pévet P,El Allali K

更新日期：2020-04-01 00:00:00

abstract：:Classical anticancer therapies often are ineffective in patients with malignant glioma who have a survival of <1 year. Our previous studies showed a potent inhibitory effect of melatonin on glioma cell proliferation. This effect seems to be mediated by the well-known antioxidant properties of this molecule and the neg...

journal_title：Journal of pineal research

authors： Martín V,Herrera F,García-Santos G,Antolín I,Rodriguez-Blanco J,Medina M,Rodriguez C

更新日期：2007-10-01 00:00:00

abstract：:Hypochlorous acid (HOCl) is a potent cytotoxic oxidant generated by the enzyme myeloperoxidase (MPO) in the presence of hydrogen peroxide (H2 O2 ) and chloride (Cl- ). Elevated levels of HOCl play an important role in various pathological conditions through oxidative modification of several biomolecules. Recently, we ...

journal_title：Journal of pineal research

authors： Jeelani R,Maitra D,Chatzicharalampous C,Najeemuddin S,Morris RT,Abu-Soud HM

更新日期：2018-04-01 00:00:00

abstract：:The circadian clock plays a vital role in physiology and behavior such as the sleep-wake cycle and blood pressure and hormone levels. Immune responses also display circadian rhythmicity and particularly pineal melatonin contributes to immunological processes. Little attention, however, is given to mechanisms underlyin...

journal_title：Journal of pineal research

authors： Ren DL,Li YJ,Hu BB,Wang H,Hu B

更新日期：2015-05-01 00:00:00

abstract：:The aim of this study was to investigate the localization in the superior cervical ganglia (SCG) of neuropeptide Y-containing neurons innervating the pineal gland. Following injection of the fluorescent tracer Fluoro-Gold (FG) into the superficial part of the pineal gland and retrograde axonal transport, labeled cells...

journal_title：Journal of pineal research

authors： Reuss S,Moore RY

更新日期：1989-01-01 00:00:00

abstract：:Melatonin, the main secretary product of the pineal gland, is potentially effective in the prevention of a number of diseases in which free radical processes are involved. The development of hypercholesterolemia is a multifactorial process in which elevated oxidized low-density lipoprotein (ox-LDL) levels play a centr...

journal_title：Journal of pineal research

authors： Zhu HQ,Cheng XW,Xiao LL,Jiang ZK,Zhou Q,Gui SY,Wei W,Wang Y

更新日期：2008-10-01 00:00:00

abstract：:Dim light exposure of the mother during pregnancy has been proposed as one of the environmental factors that affect the fetal brain development in schizophrenia. Melatonin circulating levels are regulated by the environmental light/dark cycle. This hormone stimulates neuronal differentiation in the adult brain. Howeve...

journal_title：Journal of pineal research

authors： Galván-Arrieta T,Trueta C,Cercós MG,Valdés-Tovar M,Alarcón S,Oikawa J,Zamudio-Meza H,Benítez-King G

更新日期：2017-10-01 00:00:00

abstract：:Lower global cognitive function scores are a common symptom of autism spectrum disorders (ASDs). This study investigates the effects of melatonin on hippocampal serine/threonine kinase signaling in an experimental ASD model. We found that chronic melatonin (1.0 or 5.0 mg/kg/day, 28 days) treatment significantly rescue...

journal_title：Journal of pineal research

authors： Tian Y,Yabuki Y,Moriguchi S,Fukunaga K,Mao PJ,Hong LJ,Lu YM,Wang R,Ahmed MM,Liao MH,Huang JY,Zhang RT,Zhou TY,Long S,Han F

更新日期：2014-01-01 00:00:00

abstract：:Cardiac tissue loss is one of the most important factors leading to the unsatisfactory recovery even after treatment of ischemic heart disease. Melatonin, a circadian molecule with marked antioxidant properties, protects against ischemia-reperfusion (IR) injury. In particular, the myocardial protection of melatonin is...

journal_title：Journal of pineal research

authors： Yang Y,Sun Y,Yi W,Li Y,Fan C,Xin Z,Jiang S,Di S,Qu Y,Reiter RJ,Yi D

更新日期：2014-11-01 00:00:00

abstract：:We evaluated the antioxidant property of melatonin as it relates to the vasospastic effect of hydrogen peroxide (H2O2) on the human umbilical artery. Helical sections of umbilical arteries were obtained from healthy pregnant women who were delivered between weeks 37 and 39 of gestation. Changes in maximal potassium ch...

journal_title：Journal of pineal research

authors： Okatani Y,Watanabe K,Hayashi K,Wakatsuki A,Sagara Y

更新日期：1997-04-01 00:00:00

abstract：:Aging is accompanied by changes in the morphology and physiology of organs and tissues, such as the liver. This process might be due to the accumulation of oxidative damage induced by reactive oxygen (ROS) and reactive nitrogen species (RNS). Hepatocytes are very rich in mitochondria and have a high respiratory rate, ...

journal_title：Journal of pineal research

authors： Kireev RA,Tresguerres AC,Castillo C,Salazar V,Ariznavarreta C,Vara E,Tresguerres JA

更新日期：2007-01-01 00:00:00

abstract：:Melatonin has been shown to improve in vitro fertilization and offspring survival after bacterial infection, but its role in regulating maternal-fetal communication during early pregnancy has not been investigated. Results of this study demonstrated expression of abundant melatonin receptors in conceptus and endometri...

journal_title：Journal of pineal research

authors： Bae H,Yang C,Lee JY,Park S,Bazer FW,Song G,Lim W

更新日期：2020-09-01 00:00:00

abstract：:The effects of noradrenergic and cholinergic receptor agonists on intracellular Ca2+ concentration ([Ca2+]i) in single dissociated rat pineal cells were investigated by microfluorimetric measurements in Fura-2 acetoxymethyl ester (Fura-2/AM) loaded cells. Noradrenaline (NA) evoked characteristic biphasic increments of...

journal_title：Journal of pineal research

authors： Marín A,Ureña J,Tabares L

更新日期：1996-08-01 00:00:00

abstract：:The aim was to examine the effect of perioperative melatonin treatment on clinical cardiac morbidity and markers of myocardial ischemia in patients undergoing elective surgery for abdominal aortic aneurism. Reperfusion injury results in increased cardiac morbidity in patients undergoing surgery for abdominal aortic an...

journal_title：Journal of pineal research

authors： Gögenur I,Kücükakin B,Panduro Jensen L,Reiter RJ,Rosenberg J

更新日期：2014-08-01 00:00:00

abstract：:The pineal hormone melatonin has been reported to have in vitro antiproliferative effects on estrogen receptor-positive human breast cancer cell lines at concentrations near to plasma physiological concentrations (1 x 10(-11) to 1 x 10(-9) M). Its growth inhibitory actions have been thought to be linked to the estroge...

journal_title：Journal of pineal research

authors： Papazisis KT,Kouretas D,Geromichalos GD,Sivridis E,Tsekreli OK,Dimitriadis KA,Kortsaris AH

更新日期：1998-12-01 00:00:00

abstract：:Melatonin secretion is an endogenous synchronizer, and it may possess some anti-aging properties. Thus we examined melatonin levels in physiological aging, in extreme senescence and in senile dementia. In healthy old (age 66-94 yr) and young subjects (age 23-39 yr) and in demented patients (age 68-91 yr) plasma melato...

journal_title：Journal of pineal research

authors： Magri F,Sarra S,Cinchetti W,Guazzoni V,Fioravanti M,Cravello L,Ferrari E

更新日期：2004-05-01 00:00:00

abstract：:Thrombocytopenia is a frequent complication of cancer and constitutes an absolute contraindication for chemotherapy. Recent studies have demonstrated that platelet generation may be influenced by both cytokines and neurohormones. In particular, the pineal indole melatonin has been proven to enhance platelet number in ...

journal_title：Journal of pineal research

authors： Lissoni P,Tancini G,Paolorossi F,Mandalà M,Ardizzoia A,Malugani F,Giani L,Barni S

更新日期：1999-04-01 00:00:00

abstract：:In a recent study melatonin (N-acetyl-5-methoxytryptamine), a well-investigated animal molecule but minimally studied in plants, was seen to have a physiological role as growth-promoting molecule in lupin hypocotyls. In the present study, the role of melatonin as a growth promoter is extended to coleoptiles of canary ...

journal_title：Journal of pineal research

authors： Hernández-Ruiz J,Cano A,Arnao MB

更新日期：2005-09-01 00:00:00

abstract：:Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression, and type 2 diabetes development. Melatonin receptors are approved drug targets for insomnia, non-24-hour sleep-wake disorders, and major depressive disorders. In mammal...

journal_title：Journal of pineal research

authors： Cecon E,Ivanova A,Luka M,Gbahou F,Friederich A,Guillaume JL,Keller P,Knoch K,Ahmad R,Delagrange P,Solimena M,Jockers R

更新日期：2019-03-01 00:00:00

abstract：:Chronic hyperhomocysteinemia is a risk factor in cardiovascular diseases and neurodegeneration. Among the putative mechanisms of homocysteine-induced neurotoxicity, an increased production of reactive oxygen species has been suggested. However, elevated homocysteine levels might disturb neurogenesis during brain devel...

journal_title：Journal of pineal research

authors： Baydas G,Koz ST,Tuzcu M,Nedzvetsky VS

更新日期：2008-03-01 00:00:00

abstract：:The pineal hormone melatonin, due to its lipophilic nature, has access to every cell and every part of a cell in the body, suggesting that it could exert effects on blood immune cells. The regulation of the activation of monocytes may be important in a number of diseases, especially pathophysiological conditions assoc...

journal_title：Journal of pineal research

authors： Fjaerli O,Lund T,Osterud B

更新日期：1999-01-01 00:00:00

abstract：:Early studies on the physiological effects of melatonin typically reported hypnotic 'side-effects'. Later studies, specifically addressing this action, failed to reliably replicate hypnotic effects using standard polysomnography. This difference may be related to differences in the basic physiological action of melato...

journal_title：Journal of pineal research

authors： Dawson D,Encel N

更新日期：1993-08-01 00:00:00

abstract：:Melatonin is produced following circadian rhythm with high levels being released at night and has been implicated in the regulation of physiological processes in major tissues, including the pancreas. The aim of our study was to examine the effects of melatonin on intracellular free Ca(2+) concentration ([Ca(2+) ](c))...

journal_title：Journal of pineal research

authors： del Castillo-Vaquero A,Salido GM,Gonzalez A

更新日期：2010-10-01 00:00:00