Abstract：
:Chronic hyperhomocysteinemia is a risk factor in cardiovascular diseases and neurodegeneration. Among the putative mechanisms of homocysteine-induced neurotoxicity, an increased production of reactive oxygen species has been suggested. However, elevated homocysteine levels might disturb neurogenesis during brain development and lead to persistent congenital malformations in the fetus. In this study, we examined whether administration of melatonin inhibits maternal hyperhomocysteinemia-induced cognitive deficits in offspring. Hyperhomocysteinemia was induced in female rats by administration of methionine during pregnancy at a dose of 1 g/kg body weight dissolved in drinking water. Some animals received methionine plus 10 mg/kg/day melatonin subcutaneously throughout pregnancy. The levels of glial fibrillary acidic protein, S100B protein, and neural cell adhesion molecules were determined in the brain tissue from the pups. Learning and memory performances of the young-adult offspring were tested using the Morris water maze test. There were significant reductions in the expression of glial fibrillary acidic protein and S100 B protein in the brains of pups from hyperhomocysteinemic rat dams. Furthermore, maternal hyperhomocysteinemia altered the expression pattern of neural cell adhesion molecules in the fetal brain. In addition, maternal hyperhomocysteinemia significantly reduced learning abilities in offspring. Treatment with melatonin during pregnancy improved learning deficits and prevented the reduction of glial and neuronal markers induced by hyperhomocysteinemia. In conclusion, administration of melatonin throughout pregnancy reduces the effects of hyperhomocysteinemia on the development of fetal brain; therefore, it might be beneficial in preventing persistent congenital malformations.
journal_name
J Pineal Resjournal_title
Journal of pineal researchauthors
Baydas G,Koz ST,Tuzcu M,Nedzvetsky VSdoi
10.1111/j.1600-079X.2007.00506.xsubject
Has Abstractpub_date
2008-03-01 00:00:00pages
181-8issue
2eissn
0742-3098issn
1600-079Xpii
JPI506journal_volume
44pub_type
杂志文章abstract：:Female rats exposed to long (LD 18:6) or short (LD 6:18) photoperiods from 21 days of age were mated when they reached 55 days of age. On day 2 of gestation animals of each group were either pinealectomized or sham-operated. Lighting regimens were not changed during the course of the study. Male offspring of the four ...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1992.tb00056.x
更新日期：1992-09-01 00:00:00
abstract：:Previous human studies have indicated that daytime melatonin levels increase when the organism is subjected to the stress of fasting and exercise. Melatonin, epinephrine, and norepinephrine levels were measured during a mock run and in the course of treadmill exercise performed before (T-1), during (T-2), and followin...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1989.tb00666.x
更新日期：1989-01-01 00:00:00
abstract：:An important role for melatonin in bone formation and restructuring has emerged, and studies demonstrate the multiple mechanisms for these beneficial actions. Statistical analysis shows that even with existing osteoporotic therapies, bone-related disease, and mortality are on the rise, creating a huge financial burden...
journal_title：Journal of pineal research
pub_type： 杂志文章,评审
doi：10.1111/jpi.12116
更新日期：2014-03-01 00:00:00
abstract：:A review of the literature indicates that the absolute oral bioavailability of exogenous melatonin in humans or in preclinical animal models has not been adequately characterized; hence, this study was undertaken. Pharmacokinetics of melatonin was studied in rats, dogs, and monkeys following intravenous and oral admin...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1997.tb00302.x
更新日期：1997-01-01 00:00:00
abstract：:No previous reports have described the effects of an increase in endogenous melatonin levels on plant yield and reproduction. Here, the phenotypes of melatonin-rich transgenic rice plants overexpressing sheep serotonin N-acetyltransferase were investigated under field conditions. Early seedling growth of melatonin-ric...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/jpi.12129
更新日期：2014-05-01 00:00:00
abstract：:We examined the association between 6-sulphatoxymelatonin (6-SMT) excretion and sleep in 68 volunteers 60-79 years of age who complained of insomnia or depression. An Actillume wrist monitor was worn for 5-7 consecutive days and nights in home-living conditions. Activity was used to estimate total sleep time (TST) and...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1998.tb00526.x
更新日期：1998-04-01 00:00:00
abstract：:Four weeks of administration of melatonin mixed in the diet (5 mg/kg of food) significantly reduced the incidence of gastric ulcers in young pigs. In control and melatonin supplemented animals, significantly higher levels of melatonin were found in the stomach tissues as compared to jejunum, ileum, or colon. Pigs with...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1998.tb00367.x
更新日期：1998-01-01 00:00:00
abstract：:The effect on nocturnal melatonin secretion of acute administration of the indirectly acting serotonin (5-HT) receptor agonists d-fenfluramine (30 mg) and paroxetine (20 mg) and a partial 5-HT1A receptor agonist ipsapirone (20 mg) was investigated in healthy male volunteers and compared to a placebo condition. Each su...
journal_title：Journal of pineal research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-079x.1996.tb00271.x
更新日期：1996-09-01 00:00:00
abstract：:During the past decade, a number of reports indicated that the mammalian pineal gland is magnetosensitive in terms of spatial orientation. This indication is based on observations that artificial alterations of the direction of the earth's magnetic field (MF) markedly decreased the gland's capability to synthesize mel...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1991.tb00826.x
更新日期：1991-04-01 00:00:00
abstract：:Melatonin is an indoleamine synthesized in the pineal gland, and after its release into the blood, it has an extensive repertoire of biological activities, including antitumoral properties. In this study, we found that melatonin reduced the growth of the human melanoma cells SK-MEL-1. The antiproliferative effect was ...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079X.2010.00765.x
更新日期：2010-08-01 00:00:00
abstract：:In the present paper, binding of melatonin to purified cell nuclei from harderian glands of male and female hamsters was assessed. Binding of 125I-melatonin to cell nuclei fulfills the criteria for binding to a receptor site. Binding kinetics exhibit properties such as dependence on time and temperature as well as rev...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1034/j.1600-079x.2003.00029.x
更新日期：2003-04-01 00:00:00
abstract：:The production of oxygen free radicals has been strongly implicated as an important pathophysiological mechanism mediating myocardial ischemia/reperfusion (I/R) injury. Various antioxidants have cardioprotective effects. Melatonin, an indoleamine synthesized by the pineal gland, is a potent antioxidant and a direct fr...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1034/j.1600-079x.2002.01869.x
更新日期：2002-09-01 00:00:00
abstract：:The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade. Cigarette smoke (CS) is the most important risk factor in the development of COPD. In this study, we investigated the effects of melatonin on the development of COPD using a CS and lipopolysaccharide (LPS)-induc...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/jpi.12192
更新日期：2015-01-01 00:00:00
abstract：:Melatonin is a very potent and efficient endogenous radical scavenger. The pineal indolamine reacts with the highly toxic hydroxyl radical and provides on-site protection against oxidative damage to biomolecules within every cellular compartment. Melatonin acts as a primary non-enzymatic antioxidative defense against ...
journal_title：Journal of pineal research
pub_type： 杂志文章,评审
doi：10.1111/j.1600-079x.1993.tb00498.x
更新日期：1993-05-01 00:00:00
abstract：:Melatonin, an endogenous neurohormone secreted by the pineal gland, has a variety of physiological functions and neuroprotective effects. However, its protective role on the neural tube defects (NTDs) was not very clear. The aim of this study was to investigate the effects of melatonin on the incidence of NTDs (includ...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/jpi.12282
更新日期：2015-11-01 00:00:00
abstract：:Recent investigations of our group established that melatonin modulates hormone secretion of pancreatic islets via melatonin receptor types MT1 and MT2. Expression of MT1 and MT2 has been shown in mouse, rat, and human pancreatic islets as well as in the β-, α-, and δ-cell lines INS-1, αTC1.9, and QGP-1. In view of th...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/jpi.12480
更新日期：2018-08-01 00:00:00
abstract：:A decrease in nocturnal serum melatonin levels was reported in patients with clinically uncharacterized coronary artery disease. To assess whether there was a correlation between melatonin production and disease stage, we measured the nocturnal urinary excretion of 6-sulphatoxymelatonin (an index of blood melatonin co...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1034/j.1600-079x.2000.290302.x
更新日期：2000-10-01 00:00:00
abstract：:The European hedgehog (Erinaceus europaeus L.) is a hibernating mammal and seasonal breeder in which numerous circadian and circannual rhythms are entrained and synchronized by photoperiod. The present study was undertaken in order to establish the involvement of the pineal gland in transducing the photoperiodic messa...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1991.tb00462.x
更新日期：1991-09-01 00:00:00
abstract：:N-[2-(6-methoxyquinazolin-4-yl)-ethyl] acetamide (MQA) is a compound formed from the melatonin metabolite N(1)-acetyl-5-methoxykynuramine (AMK). We followed MQA production in reaction systems containing various putative reaction partners, in the absence and presence of hydrogen peroxide and/or copper(II). Although MQA...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079X.2009.00723.x
更新日期：2010-01-01 00:00:00
abstract：:The known neuroprotective actions of melatonin could be due to its antioxidant or radical scavenging activity, or they could be due to specific interactions of the indole with its receptors. A study of structure-activity relationships may provide useful information when a validated macromolecular target has not been (...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1046/j.1600-079x.2003.00102.x
更新日期：2004-03-01 00:00:00
abstract：:Previous research has shown that antioxidant (butylated hydroxyanisole) treatment ameliorates respiratory syncytial virus (RSV)-induced disease and lung inflammation. Melatonin has been reported to exhibit a wide varieties of biological effects, including antioxidant and anti-inflammation, and has no evident toxicity ...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079X.2009.00733.x
更新日期：2010-03-01 00:00:00
abstract：:Melatonin displays antioxidant and free radical scavenger properties. Due to its ability with which it enters cells, these protective effects are manifested in all subcellular compartments. Recent studies suggest a role for melatonin in mitochondrial metabolism. To study the effects of melatonin on this organelle we u...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1034/j.1600-079x.2000.280407.x
更新日期：2000-05-01 00:00:00
abstract：:We have studied the postnatal evolution of the glial cells in the rat pineal gland after its chemical pre- and perinatal denervation, by the assessment of the immunocytochemical expression of three antigens characteristic of glial cells i.e., vimentin (VIM), glial fibrillary acidic protein (GFAP), and S-100 protein. T...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1995.tb00160.x
更新日期：1995-05-01 00:00:00
abstract：:We have studied the effect of the administration of two doses of melatonin (melatonin 100 and melatonin 200 microg/kg bw) on diabetes and oxidative stress experimentally induced by the injection of streptozotocin (STZ) in female Wistar rats. STZ was injected as a single dose (60 mg/kg i.p. in buffered citrate solution...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1998.tb00545.x
更新日期：1998-09-01 00:00:00
abstract：:Despite state-of-the-art pharmaceutical regimens, continuous improvements in diagnostic techniques as well as refinements in equipment and interventional procedures, many diseases remain refractory to conventional therapies. Recent advances in stem cell (SC) biology have opened an avenue to exploring its therapeutic p...
journal_title：Journal of pineal research
pub_type： 杂志文章,评审
doi：10.1111/jpi.12372
更新日期：2017-03-01 00:00:00
abstract：:The milk-ejecting response of lactating mouse mammary gland tissue to ovine pineal extracts indicated the presence of a neurohormone-like bioactivity in this tissue. After successive fractionation on gel permeation chromatography and reversed-phase liquid chromatography (HPLC) in conjunction with radioimmunoassays (RI...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1988.tb00800.x
更新日期：1988-01-01 00:00:00
abstract：:The effect of various cations on activity of hydroxyindole-O-methyltransferase (HIOMT) and N-acetyltransferase (NAT) from pineal gland was studied. Copper inhibited both enzymes while calcium and magnesium inhibited HIOMT; the mechanisms of these inhibitions are unknown at this stage. Calcium, magnesium, potassium, an...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1987.tb00852.x
更新日期：1987-01-01 00:00:00
abstract：:Atherosclerosis (AS) is an inflammatory disease linked to endothelial dysfunction. Melatonin is reported to possess substantial anti-inflammatory properties, which has proven to be effective in AS. Emerging literature suggests that pyroptosis plays a critical role during AS progression. However, whether pyroptosis con...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/jpi.12449
更新日期：2018-03-01 00:00:00
abstract：:The binding characteristics of the tritiated pineal hormone, [3H] melatonin, were studied in brain tissues using in vitro binding techniques. In synaptosomal membranes prepared from rat hippocampus and subjected to preincubation at 37 degrees C and multiple washings, high-affinity binding of [3H] melatonin significant...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/j.1600-079x.1987.tb00844.x
更新日期：1987-01-01 00:00:00
abstract：:Glaucoma may be associated with circadian disruption due to its association with a loss of intrinsically photosensitive retinal ganglion cells. Clinical evidence demonstrating an association between glaucoma and circadian disruption is limited, and no large-scale studies have been performed. The purpose of this cross-...
journal_title：Journal of pineal research
pub_type： 杂志文章
doi：10.1111/jpi.12662
更新日期：2020-09-01 00:00:00
