Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model.

abstract：:Environmental pollution in the form of particulate matter <2.5 μm (PM2.5 ) is a major risk factor for diseases such as lung cancer, chronic respiratory infections, and major cardiovascular diseases. Our goal was to show that PM2.5 eliciting a proinflammatory response activates the immune-pineal axis, reducing the pine...

journal_title：Journal of pineal research

authors： Carvalho-Sousa CE,Pereira EP,Kinker GS,Veras M,Ferreira ZS,Barbosa-Nunes FP,Martins JO,Saldiva PHN,Reiter RJ,Fernandes PA,da Silveira Cruz-Machado S,Markus RP

更新日期：2020-04-01 00:00:00

abstract：:A major goal of plant biotechnology is to improve the nutritional qualities of crop plants through metabolic engineering. Melatonin is a well-known bioactive molecule with an array of health-promoting properties, including potent antioxidant capability. To generate melatonin-rich rice plants, we first independently ov...

journal_title：Journal of pineal research

authors： Byeon Y,Park S,Lee HY,Kim YS,Back K

更新日期：2014-04-01 00:00:00

abstract：:The frequency of mitoses of adrenaline (A) cells and noradrenaline (N) cells in the adrenal medulla of nonoperated (NO), sham-operated (SPX), and pinealectomized (PX) male, 53-day-old Holtzman rats (n = 133) was investigated by means of light microscopy. Animals were killed at eight time points during a standardized 2...

journal_title：Journal of pineal research

authors： Kachi T,Quay WB,Banerji TK,Imagawa T

更新日期：1990-01-01 00:00:00

abstract：:There still lacking effective treatment for bladder cancer. This study investigated whether melatonin (Mel) can suppress the growth and invasion of bladder cancer cells. Male C57B/L6 mice were categorized into control group (ie, subcutaneous injection of HT1197 bladder cancer cell line at the back] and treatment group...

journal_title：Journal of pineal research

authors： Chen YT,Yang CC,Shao PL,Huang CR,Yip HK

更新日期：2019-01-01 00:00:00

abstract：:Excessive production of nitric oxide (NO) may play a detrimental role in the process of hypoxia-related neuropathology. This study explored whether treatment with melatonin would attenuate the neuropathological changes in the vagal ganglia following a severe hypoxic insult. Thirty minutes prior to hypoxia treatment, y...

journal_title：Journal of pineal research

authors： Chang HM,Ling EA,Chen CF,Lue H,Wen CY,Shieh JY

更新日期：2002-03-01 00:00:00

abstract：:N-acetylserotonin methyltransferase (ASMT) is the final enzyme in a biosynthetic pathway that produces melatonin. ASMT may play a rate-limiting role in the production of this bioactive molecule in plants. There are three ASMT genes (ASMT1-ASMT3) in the rice genome, but only ASMT1 has been functionally characterized. A...

journal_title：Journal of pineal research

authors： Park S,Byeon Y,Back K

更新日期：2013-11-01 00:00:00

abstract：:Day and nighttime melatonin production in the pineal gland was compared in normal and cardiomyopathic (polydystrophic) adult male Syrian hamsters. These strains of hamsters were selected for comparison because the cardiomyopathetic hamster displays a deficient transmembrane Ca(2+)-pump in a number of tissues, and intr...

journal_title：Journal of pineal research

authors： Reiter RJ,White T,Lerchl A,Stokkan KA,Rodriguez C

更新日期：1991-10-01 00:00:00

abstract：:The association of seasonal changes in health and disease has been known for centuries. The prevalence of psychopathological symptoms with seasonal fluctuations and the use of melatonin as a biological marker of circadian and circannual rhythms is well documented. The aim of this work was to study the variability of m...

journal_title：Journal of pineal research

authors： Morera AL,Abreu P

更新日期：2006-10-01 00:00:00

abstract：:Four-week-old male hamsters, born and raised in total darkness or in LD 14:10 (hr) were exposed to several low levels of illumination for 14 weeks. Analyses showed that testicular weights were significantly affected by both photic history and illuminance levels. Animals born in the dark possessed larger testes than th...

journal_title：Journal of pineal research

authors： Hoffman RA,Johnson LB

更新日期：1985-01-01 00:00:00

abstract：:Hypochlorous acid (HOCl) is a potent cytotoxic oxidant generated by the enzyme myeloperoxidase (MPO) in the presence of hydrogen peroxide (H2 O2 ) and chloride (Cl- ). Elevated levels of HOCl play an important role in various pathological conditions through oxidative modification of several biomolecules. Recently, we ...

journal_title：Journal of pineal research

authors： Jeelani R,Maitra D,Chatzicharalampous C,Najeemuddin S,Morris RT,Abu-Soud HM

更新日期：2018-04-01 00:00:00

abstract：:A decrease in nocturnal serum melatonin levels was reported in patients with clinically uncharacterized coronary artery disease. To assess whether there was a correlation between melatonin production and disease stage, we measured the nocturnal urinary excretion of 6-sulphatoxymelatonin (an index of blood melatonin co...

journal_title：Journal of pineal research

authors： Girotti L,Lago M,Ianovsky O,Carbajales J,Elizari MV,Brusco LI,Cardinali DP

更新日期：2000-10-01 00:00:00

abstract：:Melatonin, a neurohormone that binds to two G protein-coupled receptors MT1 and MT2, is involved in pain regulation, but the distinct role of each receptor has yet to be defined. We characterized the nociceptive responses of mice with genetic inactivation of melatonin MT1 (MT1-/- ), or MT2 (MT2-/- ), or both MT1 /MT2 ...

journal_title：Journal of pineal research

authors： Posa L,Lopez-Canul M,Rullo L,De Gregorio D,Dominguez-Lopez S,Kaba Aboud M,Caputi FF,Candeletti S,Romualdi P,Gobbi G

更新日期：2020-10-01 00:00:00

abstract：:Previous data have demonstrated that a single 1-hr light pulse at night affects the secretion of melatonin in the ram if it was given at the appropriate time. This paper reports the effect on melatonin secretion of a 1-hr light pulse given at two different times at night to two groups of rams kept in constant darkness...

journal_title：Journal of pineal research

authors： Ravault JP,Chesneau D

更新日期：1996-11-01 00:00:00

abstract：:The circadian clock plays a vital role in physiology and behavior such as the sleep-wake cycle and blood pressure and hormone levels. Immune responses also display circadian rhythmicity and particularly pineal melatonin contributes to immunological processes. Little attention, however, is given to mechanisms underlyin...

journal_title：Journal of pineal research

authors： Ren DL,Li YJ,Hu BB,Wang H,Hu B

更新日期：2015-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers and its incidence is increasing worldwide. Melatonin, an indoleamine hormone, exerts anti-oxidant, immunomodulatory, anti-aging, and antitumor effects. Previous studies have shown that melatonin can act through specific receptors, including MT(1), MT(2),...

journal_title：Journal of pineal research

authors： Carbajo-Pescador S,Martín-Renedo J,García-Palomo A,Tuñón MJ,Mauriz JL,González-Gallego J

更新日期：2009-11-01 00:00:00

abstract：:While ectopic overexpression of serotonin N-acetyltransferase (SNAT) in plants has been accomplished using animal SNAT genes, ectopic overexpression of plant SNAT genes in plants has not been investigated. Because the plant SNAT protein differs from that of animals in its subcellular localization and enzyme kinetics, ...

journal_title：Journal of pineal research

authors： Lee K,Back K

更新日期：2017-04-01 00:00:00

abstract：:This study aimed to elucidate whether melatonin would exert beneficial effects on the neuronal functions of the nodose ganglion (NG) following acute hypoxic insult. The cytochrome oxidase (COX) and the nicotinamine adenine dinucleotide phosphate diaphorase (NADPH-d) histochemistry along with the nitric oxide synthase ...

journal_title：Journal of pineal research

authors： Chang HM,Tseng CY,Wei IH,Lue JH,Wen CY,Shieh JY

更新日期：2005-09-01 00:00:00

abstract：:The pineal hormone melatonin, due to its lipophilic nature, has access to every cell and every part of a cell in the body, suggesting that it could exert effects on blood immune cells. The regulation of the activation of monocytes may be important in a number of diseases, especially pathophysiological conditions assoc...

journal_title：Journal of pineal research

authors： Fjaerli O,Lund T,Osterud B

更新日期：1999-01-01 00:00:00

abstract：:Melatonin as a potent antioxidant exhibits important nutritional and medicinal values. To produce melatonin-enriched milk will benefit the consumers. In this study, a sheep bioreactor which generates melatonin-enriched milk has been successfully developed by the technology that combined CRISPR/Cas9 system and microinj...

journal_title：Journal of pineal research

authors： Ma T,Tao J,Yang M,He C,Tian X,Zhang X,Zhang J,Deng S,Feng J,Zhang Z,Wang J,Ji P,Song Y,He P,Han H,Fu J,Lian Z,Liu G

更新日期：2017-08-01 00:00:00

abstract：:Cell movement is generated by a driving force provided by dynamic cytoskeletal organization. Two main cytoskeletal-dependent features, essential for migration, are the highly cell polarized structure and focal adhesion complexes. Cell migration and substrate anchorage are finely regulated by external signaling exerted...

journal_title：Journal of pineal research

authors： Ortíz-López L,Morales-Mulia S,Ramírez-Rodríguez G,Benítez-King G

更新日期：2009-01-01 00:00:00

abstract：:The role played by postsynaptic alpha-adrenergic receptors in the stimulation of pineal melatonin production was investigated in the Syrian hamster. The studies were conducted using organ cultured pineal glands collected from both anatomically intact and superior cervical ganglionectomized hamsters. Results obtained i...

journal_title：Journal of pineal research

authors： Santana C,Guerrero JM,Reiter RJ,Menendez-Pelaez A

更新日期：1989-01-01 00:00:00

abstract：:Despite high in-hospital mortality associated with acute respiratory distress syndrome (ARDS), there is no effective therapeutic strategy. We tested the hypothesis that combined melatonin-mitochondria treatment ameliorates 100% oxygen-induced ARDS in rats. Adult male Sprague-Dawley rats (n = 40) were equally categoriz...

journal_title：Journal of pineal research

authors： Sun CK,Lee FY,Kao YH,Chiang HJ,Sung PH,Tsai TH,Lin YC,Leu S,Wu YC,Lu HI,Chen YL,Chung SY,Su HL,Yip HK

更新日期：2015-03-01 00:00:00

abstract：:Melatonin, a major pineal secretory product, exerts a range of physiological and neuroprotective effects. However, the functional significance of melatonin in determining neural identity, and the mechanisms by which this may occur, is unknown. In this study, P19 cells were used as a model system and cell behavior was ...

journal_title：Journal of pineal research

authors： Chen X,Li X,Du Z,Shi W,Yao Y,Wang C,He K,Hao A

更新日期：2014-09-01 00:00:00

abstract：:The objective of this study was to apply the radioimmunoassay for 6-sulphatoxymelatonin (aMT6s) to rat urine, and use it to study the source of aMT6s. The radioimmunoassay was found to have acceptable within- and between-assay variation, excellent specificity, and good parallelism between the standard and unknown. Bec...

journal_title：Journal of pineal research

authors： Brown GM,Bar-Or A,Grossi D,Kashur S,Johannson E,Yie SM

更新日期：1991-04-01 00:00:00

abstract：:The rod outer segment (ROSg) membranes are essentially lipoprotein complexes. Rhodopsin, the major integral protein of ROSg, is surrounded by phospholipids highly enriched in docosahexaenoic acid (22:6 n3). This fluid environment plays an important role for conformational changes after photo-activation. Thus, ROSg mem...

journal_title：Journal of pineal research

authors： Guajardo MH,Terrasa AM,Catalá A

更新日期：2006-10-01 00:00:00

abstract：:Melatonin, the main secretory product of the pineal gland, has been shown to be potentially effective in prevention of numerous types of neurodegenerative disorders in which free radical processes are involved. Homocysteine (Hcy), an independent risk factor for atherosclerosis, undergoes auto-oxidation and generates r...

journal_title：Journal of pineal research

authors： Baydas G,Kutlu S,Naziroglu M,Canpolat S,Sandal S,Ozcan M,Kelestimur H

更新日期：2003-01-01 00:00:00

abstract：:Djungarian hamsters kept in long photoperiod (16:8 L:D) were injected daily at 0800, 1200, or 1600 with 25 micrograms of melatonin. During 90 days of treatment, body weight and fur coloration were checked at weekly intervals, and at the end of the treatment the reproductive status of the hamsters and their thermoregul...

journal_title：Journal of pineal research

authors： Holtorf AP,Heldmaier G,Thiele G,Steinlechner S

更新日期：1985-01-01 00:00:00

abstract：:Melatonin has been identified in primitive photosynthetic bacteria, fungi, plants, and animals including humans. Vegetables, fruits, cereals, wine, and beers all contain melatonin. However, the melatonin content in meats has not been reported previously. Here, for the first time, we report melatonin in meats, eggs, co...

journal_title：Journal of pineal research

authors： Tan DX,Zanghi BM,Manchester LC,Reiter RJ

更新日期：2014-09-01 00:00:00

abstract：:Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure, which leads to right ventricular (RV) hypertrophy and failure. The pathophysiological mechanisms of PH remain unclear but oxidative stress is believed to contribute to RV dysfunction. Melatonin is a powerful antioxidant and is cardio...

journal_title：Journal of pineal research

authors： Maarman G,Blackhurst D,Thienemann F,Blauwet L,Butrous G,Davies N,Sliwa K,Lecour S

更新日期：2015-10-01 00:00:00

abstract：:Melatonin is involved in the control of various physiological functions, such as sleep, cell growth and free radical scavenging. The ability of melatonin to behave as an antioxidant, together with the fact that the Alzheimer-related amyloid β-peptide (Aβ) triggers oxidative stress through hydroxyl radical-induced cell...

journal_title：Journal of pineal research

authors： Panmanee J,Nopparat C,Chavanich N,Shukla M,Mukda S,Song W,Vincent B,Govitrapong P

更新日期：2015-10-01 00:00:00