Overexpression of rice serotonin N-acetyltransferase 1 in transgenic rice plants confers resistance to cadmium and senescence and increases grain yield.


:While ectopic overexpression of serotonin N-acetyltransferase (SNAT) in plants has been accomplished using animal SNAT genes, ectopic overexpression of plant SNAT genes in plants has not been investigated. Because the plant SNAT protein differs from that of animals in its subcellular localization and enzyme kinetics, its ectopic overexpression in plants would be expected to give outcomes distinct from those observed from overexpression of animal SNAT genes in transgenic plants. Consistent with our expectations, we found that transgenic rice plants overexpressing rice (Oryza sativa) SNAT1 (OsSNAT1) did not show enhanced seedling growth like that observed in ovine SNAT-overexpressing transgenic rice plants, although both types of plants exhibited increased melatonin levels. OsSNAT1-overexpressing rice plants did show significant resistance to cadmium and senescence stresses relative to wild-type controls. In contrast to tomato, melatonin synthesis in rice seedlings was not induced by selenium and OsSNAT1 transgenic rice plants did not show tolerance to selenium. T2 homozygous OsSNAT1 transgenic rice plants exhibited increased grain yield due to increased panicle number per plant under paddy field conditions. These benefits conferred by ectopic overexpression of OsSNAT1 had not been observed in transgenic rice plants overexpressing ovine SNAT, suggesting that plant SNAT functions differently from animal SNAT in plants.


J Pineal Res


Lee K,Back K




Has Abstract


2017-04-01 00:00:00










  • Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status.

    abstract::There are functional inter-relationships between the beta cells of the endocrine pancreas and the pineal gland, where the synchronizing circadian molecule melatonin originates. The aim of this study was to elucidate a putative interaction between insulin and melatonin in diabetic patients and a diabetic rat model. We ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Peschke E,Frese T,Chankiewitz E,Peschke D,Preiss U,Schneyer U,Spessert R,Mühlbauer E

    更新日期:2006-03-01 00:00:00

  • Functional analyses of three ASMT gene family members in rice plants.

    abstract::N-acetylserotonin methyltransferase (ASMT) is the final enzyme in a biosynthetic pathway that produces melatonin. ASMT may play a rate-limiting role in the production of this bioactive molecule in plants. There are three ASMT genes (ASMT1-ASMT3) in the rice genome, but only ASMT1 has been functionally characterized. A...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Park S,Byeon Y,Back K

    更新日期:2013-11-01 00:00:00

  • Age-related changes in mitochondrial function of mouse colonic smooth muscle: beneficial effects of melatonin.

    abstract::Aging is a multifactorial process that involves biochemical, structural, and functional changes in mitochondria. The ability of melatonin to palliate the alterations induced by aging is based on its chronobiologic, antioxidant, and mitochondrial effects. There is little information about the effects of melatonin on th...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Martin-Cano FE,Camello-Almaraz C,Acuña-Castroviejo D,Pozo MJ,Camello PJ

    更新日期:2014-03-01 00:00:00

  • Direct neuronal projection from the dorsal raphe nucleus to the pineal complex of the rat: a Phaseolus vulgaris-leucoagglutinin in vivo neuronal tracing study.

    abstract::By use of Phaseolus vulgaris-leucoagglutinin as an anterograde in vivo tracer, a direct projection from the dorsal raphe nucleus to the pineal complex of the rat was demonstrated. The nerve fibers extended from the dorsal raphe nucleus rostrally through the mesencephalic periaqueductal grey and entered the deep pineal...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Møller M,Hay-Schmidt A

    更新日期:1998-08-01 00:00:00

  • Characterization of a [3H]glutamate binding site in rat pineal gland: enhanced affinity following superior cervical ganglionectomy.

    abstract::Glutamate, an excitatory neurotransmitter/neuromodulator involved in cell-to-cell communication within the central nervous system, is now believed to play a role in neuroendocrine function. In this study we describe a single, saturable, stereospecific, and temperature-, time-, and pH-dependent binding site for glutama...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Kus L,Handa RJ,McNulty JA

    更新日期:1993-01-01 00:00:00

  • Melatonin inhibits insulin secretion and decreases PKA levels without interfering with glucose metabolism in rat pancreatic islets.

    abstract::The effect of melatonin (0.1 microM) on freshly isolated islets from adult rats was investigated. Melatonin caused a marked decrease of insulin secretion by islets in response to glucose. The mechanism involved was then examined. Melatonin did not interfere with glucose metabolism as indicated by the measurement of gl...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Picinato MC,Haber EP,Cipolla-Neto J,Curi R,de Oliveira Carvalho CR,Carpinelli AR

    更新日期:2002-10-01 00:00:00

  • Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain.

    abstract::Melatonin is a powerful scavenger of oxygen free radicals. In humans, melatonin is rapidly transferred from the maternal to the fetal circulation. To investigate whether or not maternal melatonin administration can protect the fetal rat brain from radical-induced damage by increasing the activities of antioxidant enzy...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Okatani Y,Wakatsuki A,Kaneda C

    更新日期:2000-03-01 00:00:00

  • Dual effects of melatonin on oxidative stress after surgical brain injury in rats.

    abstract::The purpose of this study was to evaluate the effect of melatonin on oxidative stress occurring in the brain after routine lobectomy neurosurgery procedures. Different concentrations of melatonin (5, 15 and 150 mg/kg) were administered 1 hr before lobectomy in a rodent surgical brain injury (SBI) model. Neurological o...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Lee S,Jadhav V,Ayer RE,Rojas H,Hyong A,Lekic T,Tang J,Zhang JH

    更新日期:2009-01-01 00:00:00

  • Prolonged suppression of serum concentrations of melatonin in prepubertal heifers.

    abstract::Our objective was to suppress the daily surge of melatonin in serum of prepubertal dairy heifers by manipulating intensity of light (Experiment 1) and duration of exposure to light (Experiment 2). Heifers in Experiment 1 were exposed to either 12 hr of darkness (000 lux, control), or 400, 800, or 1,200 lux of light du...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Buchanan BA,Chapin LT,Tucker HA

    更新日期:1992-05-01 00:00:00

  • Immunocytochemical demonstration of day/night changes of clock gene protein levels in the murine adrenal gland: differences between melatonin-proficient (C3H) and melatonin-deficient (C57BL) mice.

    abstract::The circadian system comprises several peripheral oscillators and a central rhythm generator that, in mammals, is located in the suprachiasmatic nucleus of the hypothalamus. Expression of clock genes is a characteristic feature of the central rhythm generator and the peripheral oscillators. With regard to the rhythmic...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Torres-Farfan C,Serón-Ferré M,Dinet V,Korf HW

    更新日期:2006-01-01 00:00:00

  • Effects of the chemical denervation on the glial cells of the rat pineal gland: an immunocytochemical study during postnatal development.

    abstract::We have studied the postnatal evolution of the glial cells in the rat pineal gland after its chemical pre- and perinatal denervation, by the assessment of the immunocytochemical expression of three antigens characteristic of glial cells i.e., vimentin (VIM), glial fibrillary acidic protein (GFAP), and S-100 protein. T...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: López-Muñoz F,Boya J

    更新日期:1995-05-01 00:00:00

  • Alzheimer beta protein mediated oxidative damage of mitochondrial DNA: prevention by melatonin.

    abstract::Most contemporary progress in Alzheimer's disease (AD) stems from the study of a 42 43 amino acid peptide. called the amyloid beta protein (Abeta), as the main neuropathologic marker of the disorder. It has been demonstrated that Abeta has neurotoxic properties and that such effects are mediated by free-radicals. Expo...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Pappolla MA,Chyan YJ,Poeggeler B,Bozner P,Ghiso J,LeDoux SP,Wilson GL

    更新日期:1999-11-01 00:00:00

  • Effect of melatonin administration on parameters related to oxidative damage in hepatocytes isolated from old Wistar rats.

    abstract::Aging induces changes in several organs and tissues, such as the liver, and this process might be due to oxidative damage caused by free radicals and inflammatory mediators. Melatonin is a secretory product with well-known antioxidant properties. The aim of this study was to investigate the effect of melatonin adminis...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Castillo C,Salazar V,Ariznavarreta C,Vara E,Tresguerres JA

    更新日期:2005-05-01 00:00:00

  • Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea.

    abstract::To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Luboshitzky R,Lavi S,Thuma I,Lavie P

    更新日期:1996-03-01 00:00:00

  • Qualitative and quantitative changes of melatonin levels in physiological and pathological aging and in centenarians.

    abstract::Melatonin secretion is an endogenous synchronizer, and it may possess some anti-aging properties. Thus we examined melatonin levels in physiological aging, in extreme senescence and in senile dementia. In healthy old (age 66-94 yr) and young subjects (age 23-39 yr) and in demented patients (age 68-91 yr) plasma melato...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Magri F,Sarra S,Cinchetti W,Guazzoni V,Fioravanti M,Cravello L,Ferrari E

    更新日期:2004-05-01 00:00:00

  • Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis.

    abstract::Impaired Ca2+ homeostasis and smooth muscle contractility co-exist in acute cholecystitis (AC) leading to gallbladder dysfunction. There is no pharmacological treatment for this pathological condition. Our aim was to evaluate the effects of melatonin treatment on Ca2+ signaling pathways and contractility altered by ch...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Gomez-Pinilla PJ,Camello PJ,Pozo MJ

    更新日期:2008-04-01 00:00:00

  • Melatonin and its synthesizing enzymes (arylalkylamine N-acetyltransferase-like and hydroxyindole-O-methyltransferase) in avian eggs and early embryos.

    abstract::The presence of melatonin and the enzymes (transcripts and activities) involved in its synthesis, i.e. arylalkylamine N-acetyltransferase (AA-NAT) and hydroxyindole-O-methyltransferase (HIOMT), was investigated in the eggs and early embryos of Japanese quail at Hamburger-Hamilton stages 1-10. Melatonin was present in ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Olszańska B,Majewski P,Lewczuk B,Stepińska U

    更新日期:2007-04-01 00:00:00

  • Melatonin is required for H2 O2 - and NO-mediated defense signaling through MAPKKK3 and OXI1 in Arabidopsis thaliana.

    abstract::Melatonin influences plant innate immunity through the mitogen-activated protein kinase (MAPK) pathway. However, the most upstream MAPK component in melatonin signaling and the dependence of generation of a reactive oxygen species (ROS) burst on melatonin synthesis and signaling remain unclear. In this study, treatmen...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Lee HY,Back K

    更新日期:2017-03-01 00:00:00

  • Melatonin prolongs graft survival of pancreas allotransplants in pigs.

    abstract::Oxidative stress is involved in ischemia-reperfusion injury and allograft rejection after transplantation. We studied two well-known antioxidants, melatonin and ascorbic acid (AA), in relation to the survival of a pancreas transplantation model without immunosuppression. Forty-eight Landrace pigs were divided into thr...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: García-Gil FA,Albendea CD,Escartín J,Lampreave F,Fuentes-Broto L,Roselló-Catafau J,López-Pingarrón L,Reiter RJ,Alvarez-Alegret R,García JJ

    更新日期:2011-11-01 00:00:00

  • Melatonin protects oocyte quality from Bisphenol A-induced deterioration in the mouse.

    abstract::Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocy...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Zhang M,Dai X,Lu Y,Miao Y,Zhou C,Cui Z,Liu H,Xiong B

    更新日期:2017-04-01 00:00:00

  • Yeast contribution to melatonin, melatonin isomers and tryptophan ethyl ester during alcoholic fermentation of grape musts.

    abstract::Melatonin (MEL) has been found in some medicinal and food plants, including grapevine, a commodity of particular interest for the production of wine, a beverage of economic relevance. It has also been suggested that MEL in wine may, at least in part, contribute to the health-promoting properties attributed to this bev...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Vigentini I,Gardana C,Fracassetti D,Gabrielli M,Foschino R,Simonetti P,Tirelli A,Iriti M

    更新日期:2015-05-01 00:00:00

  • Melatonin promotes the acquisition of neural identity through extracellular-signal-regulated kinases 1/2 activation.

    abstract::Melatonin, a major pineal secretory product, exerts a range of physiological and neuroprotective effects. However, the functional significance of melatonin in determining neural identity, and the mechanisms by which this may occur, is unknown. In this study, P19 cells were used as a model system and cell behavior was ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Chen X,Li X,Du Z,Shi W,Yao Y,Wang C,He K,Hao A

    更新日期:2014-09-01 00:00:00

  • Effect of various cations on the activity of pineal gland N-acetyltransferase (EC and hydroxyindole-O-methyl transferase (EC in vitro.

    abstract::The effect of various cations on activity of hydroxyindole-O-methyltransferase (HIOMT) and N-acetyltransferase (NAT) from pineal gland was studied. Copper inhibited both enzymes while calcium and magnesium inhibited HIOMT; the mechanisms of these inhibitions are unknown at this stage. Calcium, magnesium, potassium, an...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Morton DJ

    更新日期:1987-01-01 00:00:00

  • Reentrainment of rat circadian activity rhythms: effects of melatonin.

    abstract::Experiments were conducted to determine whether daily melatonin injections could influence reentrainment of circadian locomotor activity rhythms in male Long-Evans rats after phase shifts of the light dark (LD) cycle. When exposed to a 5-h advance of the LD cycle, six out of 15 rats injected daily with melatonin at th...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Redman JR,Armstrong SM

    更新日期:1988-01-01 00:00:00

  • Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo.

    abstract::Melatonin is known to regulate a variety of physiological processes including control of circadian rhythms, regulation of seasonal reproductive function, regulation of body temperature, and so forth. Accumulating evidence from in vitro and in vivo experiments using rodent and chicken has also suggested that melatonin ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Satomura K,Tobiume S,Tokuyama R,Yamasaki Y,Kudoh K,Maeda E,Nagayama M

    更新日期:2007-04-01 00:00:00

  • Consumption of vegetables alters morning urinary 6-sulfatoxymelatonin concentration.

    abstract::Melatonin, which is contained in certain vegetables, may have an influence on circulatory melatonin concentrations. This study examined the effects of the consumption of vegetables on 6-sulfatoxymelatonin concentrations in morning urine. Ninety-four healthy women aged 24-55 were recruited through a city public health ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章,随机对照试验


    authors: Oba S,Nakamura K,Sahashi Y,Hattori A,Nagata C

    更新日期:2008-08-01 00:00:00

  • Elevated environmental temperature alters the responses of the reproductive and thyroid axes of female Syrian hamsters to afternoon melatonin injections.

    abstract::Female Syrian hamsters were kept in a light (14:10 h light:dark cycle, lights on 0600 h)- and temperature (22 or 30 degrees C)-controlled room; some groups were treated with an afternoon s.c. injection of melatonin (6.25, 12.5, or 25 micrograms/day) for 11 or 14 weeks. The melatonin-induced suppression of the reproduc...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Reiter RJ,Li K,Gonzalez-Brito A,Tannenbaum MG,Vaughan MK,Vaughan GM,Villanua MA

    更新日期:1988-01-01 00:00:00

  • The interplay between mast cells, pineal gland, and circadian rhythm: Links between histamine, melatonin, and inflammatory mediators.

    abstract::Our daily rhythmicity is controlled by a circadian clock with a specific set of genes located in the suprachiasmatic nucleus in the hypothalamus. Mast cells (MCs) are major effector cells that play a protective role against pathogens and inflammation. MC distribution and activation are associated with the circadian rh...

    journal_title:Journal of pineal research

    pub_type: 杂志文章,评审


    authors: Pham L,Baiocchi L,Kennedy L,Sato K,Meadows V,Meng F,Huang CK,Kundu D,Zhou T,Chen L,Alpini G,Francis H

    更新日期:2020-10-05 00:00:00

  • Melatonin prevents oxidized low-density lipoprotein-induced increase of myosin light chain kinase activation and expression in HUVEC through ERK/MAPK signal transduction.

    abstract::Melatonin, the main secretary product of the pineal gland, is potentially effective in the prevention of a number of diseases in which free radical processes are involved. The development of hypercholesterolemia is a multifactorial process in which elevated oxidized low-density lipoprotein (ox-LDL) levels play a centr...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Zhu HQ,Cheng XW,Xiao LL,Jiang ZK,Zhou Q,Gui SY,Wei W,Wang Y

    更新日期:2008-10-01 00:00:00

  • Effect of different nocturnal illuminances on melatonin, prolactin, and gonadotropins in male rats.

    abstract::We studied the role of nocturnal illuminance as a possible regulatory factor in the production and secretion of reproductive hormones. Adult male rats were kept under artificial lighting conditions (LD 12/12 hours) where the daily illuminance was 520-550 lx and the nocturnal illuminance 0, less than 0.1, or 1-1.5 lx. ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Laakso ML,Porkka-Heiskanen T,Alila A,Kajander S,Stenberg D,Johansson G

    更新日期:1989-01-01 00:00:00