Structure of the pineal gland in the adult cat.


:The ultrastructure of the pineal gland in the adult cat is described and compared with that of other mammals. Connective tissue spaces showed capillaries with nonfenestrated endothelia and numerous unmyelinated nerve fibers. In the proximal region of the gland, myelinated nerve fibers coming from the anterior commissure were also found. Cat pinealocytes showed a nucleus with prominent nucleoli, a well developed Golgi apparatus, centrioles, granular endoplasmic reticulum, ribosomes, abundant microtubuli and enlarged mitochondria. Pinealocytes showed several long processes with bulbous endings filled with clear vesicles and scarce "synaptic" ribbons. Pineal astrocytes and their processes were characterized by the presence of abundant filaments.


J Pineal Res


Boya J,Calvo JL,Rancaño D




Has Abstract


1995-03-01 00:00:00












  • Serotonin N-acetyltransferase activity in chicken retina: in vivo effects of phosphodiesterase inhibitors, forskolin, and drugs affecting dopamine receptors.

    abstract::A role of D2-dopaminergic neurotransmission in the regulation of melatonin biosynthesis in retina was studied in vivo in chickens. The nighttime rise in serotonin N-acetyltransferase (NAT)--the penultimate and key regulatory melatonin-synthesizing enzyme--was potently inhibited by both acute light exposure and agonist...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Zawilska JB,Kazula A,Zurawska E,Nowak JZ

    更新日期:1991-10-01 00:00:00

  • Melatonin effects on bone: potential use for the prevention and treatment for osteopenia, osteoporosis, and periodontal disease and for use in bone-grafting procedures.

    abstract::An important role for melatonin in bone formation and restructuring has emerged, and studies demonstrate the multiple mechanisms for these beneficial actions. Statistical analysis shows that even with existing osteoporotic therapies, bone-related disease, and mortality are on the rise, creating a huge financial burden...

    journal_title:Journal of pineal research

    pub_type: 杂志文章,评审


    authors: Maria S,Witt-Enderby PA

    更新日期:2014-03-01 00:00:00

  • Effect of melatonin administration on parameters related to oxidative damage in hepatocytes isolated from old Wistar rats.

    abstract::Aging induces changes in several organs and tissues, such as the liver, and this process might be due to oxidative damage caused by free radicals and inflammatory mediators. Melatonin is a secretory product with well-known antioxidant properties. The aim of this study was to investigate the effect of melatonin adminis...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Castillo C,Salazar V,Ariznavarreta C,Vara E,Tresguerres JA

    更新日期:2005-05-01 00:00:00

  • Melatonin prolongs graft survival of pancreas allotransplants in pigs.

    abstract::Oxidative stress is involved in ischemia-reperfusion injury and allograft rejection after transplantation. We studied two well-known antioxidants, melatonin and ascorbic acid (AA), in relation to the survival of a pancreas transplantation model without immunosuppression. Forty-eight Landrace pigs were divided into thr...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: García-Gil FA,Albendea CD,Escartín J,Lampreave F,Fuentes-Broto L,Roselló-Catafau J,López-Pingarrón L,Reiter RJ,Alvarez-Alegret R,García JJ

    更新日期:2011-11-01 00:00:00

  • Seasonality of psychopathology and circannual melatonin rhythm.

    abstract::The association of seasonal changes in health and disease has been known for centuries. The prevalence of psychopathological symptoms with seasonal fluctuations and the use of melatonin as a biological marker of circadian and circannual rhythms is well documented. The aim of this work was to study the variability of m...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Morera AL,Abreu P

    更新日期:2006-10-01 00:00:00

  • Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy.

    abstract::Abnormal proliferation and motility of retinal pigment epithelial cells leads to proliferative vitreoretinopathy (PVR). Melatonin is a known effective antitumour and anti-invasive agent, but whether it affects the formation and underlying mechanisms of PVR remains unclear. In this study, the results of the MTT assay, ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Yang SF,Chen YS,Chien HW,Wang K,Lin CL,Chiou HL,Lee CY,Chen PN,Hsieh YH

    更新日期:2020-01-01 00:00:00

  • A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases.

    abstract::Cardiac tissue loss is one of the most important factors leading to the unsatisfactory recovery even after treatment of ischemic heart disease. Melatonin, a circadian molecule with marked antioxidant properties, protects against ischemia-reperfusion (IR) injury. In particular, the myocardial protection of melatonin is...

    journal_title:Journal of pineal research

    pub_type: 杂志文章,评审


    authors: Yang Y,Sun Y,Yi W,Li Y,Fan C,Xin Z,Jiang S,Di S,Qu Y,Reiter RJ,Yi D

    更新日期:2014-11-01 00:00:00

  • 5-MCA-NAT does not act through NQO2 to reduce intraocular pressure in New-Zealand white rabbit.

    abstract::Solid data support the idea that the MT(3) melatonin binding site is an enzyme, quinone reductase 2 (NQO2), rather than a membrane melatonin receptor. However, the melatonin analogue, 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT), reduces intraocular pressure (IOP) via MT(3) melatonin receptors. Therefore, the...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Alarma-Estrany P,Crooke A,Pintor J

    更新日期:2009-09-01 00:00:00

  • Melatonin overcomes gemcitabine resistance in pancreatic ductal adenocarcinoma by abrogating nuclear factor-κB activation.

    abstract::Constitutive activation and gemcitabine induction of nuclear factor-κB (NF-κB) contribute to the aggressive behavior and chemotherapeutic resistance of pancreatic ductal adenocarcinoma (PDAC). Thus, targeting the NF-κB pathway has proven an insurmountable challenge for PDAC therapy. In this study, we investigated whet...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Ju HQ,Li H,Tian T,Lu YX,Bai L,Chen LZ,Sheng H,Mo HY,Zeng JB,Deng W,Chiao PJ,Xu RH

    更新日期:2016-01-01 00:00:00

  • Alzheimer beta protein mediated oxidative damage of mitochondrial DNA: prevention by melatonin.

    abstract::Most contemporary progress in Alzheimer's disease (AD) stems from the study of a 42 43 amino acid peptide. called the amyloid beta protein (Abeta), as the main neuropathologic marker of the disorder. It has been demonstrated that Abeta has neurotoxic properties and that such effects are mediated by free-radicals. Expo...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Pappolla MA,Chyan YJ,Poeggeler B,Bozner P,Ghiso J,LeDoux SP,Wilson GL

    更新日期:1999-11-01 00:00:00

  • Specific binding of 2-[125I]iodomelatonin by rat spleen crude membranes: day-night variations and effect of pinealectomy and continuous light exposure.

    abstract::Melatonin binding sites were characterized in rat spleen crude membranes. The specific binding of 2-[125I]iodomelatonin by spleen crude membranes fulfills all the criteria for binding to a receptor site. Thus, binding was dependent on time and temperature, stable, specific, and increased under constant light exposure ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Rafii-El-Idrissi M,Calvo JR,Giordano M,Guerrero JM

    更新日期:1996-01-01 00:00:00

  • Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells.

    abstract::Melatonin is involved in the control of various physiological functions, such as sleep, cell growth and free radical scavenging. The ability of melatonin to behave as an antioxidant, together with the fact that the Alzheimer-related amyloid β-peptide (Aβ) triggers oxidative stress through hydroxyl radical-induced cell...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Panmanee J,Nopparat C,Chavanich N,Shukla M,Mukda S,Song W,Vincent B,Govitrapong P

    更新日期:2015-10-01 00:00:00

  • Effect of pinealectomy on plasma levels of insulin and leptin and on hepatic lipids in type 2 diabetic rats.

    abstract::We previously reported that pharmacological melatonin administration to type 2 diabetic rats reduces hyperinsulinemia and improves the altered fatty-acid metabolism. To determine whether melatonin deficiency exacerbates diabetes-associated conditions, we investigated the effect of pinealectomy (i.e. melatonin-deficien...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Nishida S,Sato R,Murai I,Nakagawa S

    更新日期:2003-11-01 00:00:00

  • Correlation among cytokines, bronchopulmonary dysplasia and modality of ventilation in preterm newborns: improvement with melatonin treatment.

    abstract::Improved survival because of advances in neonatal care has resulted in an increased number of infants at risk for chronic lung disease. Even though the etiology of lung injury is multifactorial, recent animal and clinical data indicate that pulmonary damage depends in large part on the ventilatory strategies used. Ven...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Gitto E,Reiter RJ,Sabatino G,Buonocore G,Romeo C,Gitto P,Buggé C,Trimarchi G,Barberi I

    更新日期:2005-10-01 00:00:00

  • Characterization of a [3H]glutamate binding site in rat pineal gland: enhanced affinity following superior cervical ganglionectomy.

    abstract::Glutamate, an excitatory neurotransmitter/neuromodulator involved in cell-to-cell communication within the central nervous system, is now believed to play a role in neuroendocrine function. In this study we describe a single, saturable, stereospecific, and temperature-, time-, and pH-dependent binding site for glutama...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Kus L,Handa RJ,McNulty JA

    更新日期:1993-01-01 00:00:00

  • Melatonin enhances thrombopoiesis through ERK1/2 and Akt activation orchestrated by dual adaptor for phosphotyrosine and 3-phosphoinositides.

    abstract::Melatonin (MT), endogenously secreted by the pineal gland, is closely related to multiple biological processes; however, its effect on thrombopoiesis is still not well illustrated. Here, we demonstrate that MT administration can elevate peripheral platelet levels. Analysis of different stages in thrombopoiesis reveals...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Chen S,Qi Y,Wang S,Xu Y,Shen M,Hu M,Du C,Chen F,Chen M,Lu Y,Zhang Z,Quan Y,Wang C,Wang F,Wang J

    更新日期:2020-04-01 00:00:00

  • Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease.

    abstract::A decrease in nocturnal serum melatonin levels was reported in patients with clinically uncharacterized coronary artery disease. To assess whether there was a correlation between melatonin production and disease stage, we measured the nocturnal urinary excretion of 6-sulphatoxymelatonin (an index of blood melatonin co...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Girotti L,Lago M,Ianovsky O,Carbajales J,Elizari MV,Brusco LI,Cardinali DP

    更新日期:2000-10-01 00:00:00

  • HPLC validation of a circadian melatonin rhythm in the pineal gland of inbred mice.

    abstract::Production of melatonin in the pineal gland of inbred mice such as C57B1/6J, BALB/c and AKR strains is still a matter of debate. In previous studies, we and other authors showed that these strains of inbred mice have a clear-cut circadian rhythm of serum melatonin and urinary 6-hydroxy-melatonin-sulphate. In contrast,...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Conti A,Maestroni GJ

    更新日期:1996-04-01 00:00:00

  • Yeast contribution to melatonin, melatonin isomers and tryptophan ethyl ester during alcoholic fermentation of grape musts.

    abstract::Melatonin (MEL) has been found in some medicinal and food plants, including grapevine, a commodity of particular interest for the production of wine, a beverage of economic relevance. It has also been suggested that MEL in wine may, at least in part, contribute to the health-promoting properties attributed to this bev...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Vigentini I,Gardana C,Fracassetti D,Gabrielli M,Foschino R,Simonetti P,Tirelli A,Iriti M

    更新日期:2015-05-01 00:00:00

  • Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo.

    abstract::Melatonin is known to regulate a variety of physiological processes including control of circadian rhythms, regulation of seasonal reproductive function, regulation of body temperature, and so forth. Accumulating evidence from in vitro and in vivo experiments using rodent and chicken has also suggested that melatonin ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Satomura K,Tobiume S,Tokuyama R,Yamasaki Y,Kudoh K,Maeda E,Nagayama M

    更新日期:2007-04-01 00:00:00

  • Molecular cloning of a plant N-acetylserotonin methyltransferase and its expression characteristics in rice.

    abstract::N-acetylserotonin methyltransferase (ASMT), the last enzyme in the synthesis of melatonin, catalyzes N-acetylserotonin into melatonin. For the first time, we cloned ASMT from rice through the analysis of recombinant Escherichia coli harboring putative rice O-methyltransferase (OMT) cDNAs. In total, 18 full-length cDNA...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Kang K,Kong K,Park S,Natsagdorj U,Kim YS,Back K

    更新日期:2011-04-01 00:00:00

  • Elevated environmental temperature alters the responses of the reproductive and thyroid axes of female Syrian hamsters to afternoon melatonin injections.

    abstract::Female Syrian hamsters were kept in a light (14:10 h light:dark cycle, lights on 0600 h)- and temperature (22 or 30 degrees C)-controlled room; some groups were treated with an afternoon s.c. injection of melatonin (6.25, 12.5, or 25 micrograms/day) for 11 or 14 weeks. The melatonin-induced suppression of the reproduc...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Reiter RJ,Li K,Gonzalez-Brito A,Tannenbaum MG,Vaughan MK,Vaughan GM,Villanua MA

    更新日期:1988-01-01 00:00:00

  • Distribution and density of melatonin receptors in human main pancreatic islet cell types.

    abstract::Recent investigations of our group established that melatonin modulates hormone secretion of pancreatic islets via melatonin receptor types MT1 and MT2. Expression of MT1 and MT2 has been shown in mouse, rat, and human pancreatic islets as well as in the β-, α-, and δ-cell lines INS-1, αTC1.9, and QGP-1. In view of th...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Zibolka J,Bazwinsky-Wutschke I,Mühlbauer E,Peschke E

    更新日期:2018-08-01 00:00:00

  • Melatonin and farm animals: endogenous rhythms and exogenous applications.

    abstract::Studies on farm animals have contributed significantly to our increased understanding of basic melatonin-related physiological mechanisms, as well as to the regulation of reproduction and pelage in individual domestic species. This review concentrates on recent work on the role of melatonin in the regulation of porcin...

    journal_title:Journal of pineal research

    pub_type: 杂志文章,评审


    authors: Paterson AM,Foldes A

    更新日期:1994-05-01 00:00:00

  • Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo.

    abstract::Melatonin displays antioxidant and free radical scavenger properties. Due to its ability with which it enters cells, these protective effects are manifested in all subcellular compartments. Recent studies suggest a role for melatonin in mitochondrial metabolism. To study the effects of melatonin on this organelle we u...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Martín M,Macías M,Escames G,Reiter RJ,Agapito MT,Ortiz GG,Acuña-Castroviejo D

    更新日期:2000-05-01 00:00:00

  • Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications.

    abstract::A review of the literature indicates that the absolute oral bioavailability of exogenous melatonin in humans or in preclinical animal models has not been adequately characterized; hence, this study was undertaken. Pharmacokinetics of melatonin was studied in rats, dogs, and monkeys following intravenous and oral admin...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Yeleswaram K,McLaughlin LG,Knipe JO,Schabdach D

    更新日期:1997-01-01 00:00:00

  • Melatonin excretion is not related to sleep in the elderly.

    abstract::We examined the association between 6-sulphatoxymelatonin (6-SMT) excretion and sleep in 68 volunteers 60-79 years of age who complained of insomnia or depression. An Actillume wrist monitor was worn for 5-7 consecutive days and nights in home-living conditions. Activity was used to estimate total sleep time (TST) and...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Youngstedt SD,Kripke DF,Elliott JA

    更新日期:1998-04-01 00:00:00

  • Efficacy of melatonin, mercaptoethylguanidine and 1400W in doxorubicin- and trastuzumab-induced cardiotoxicity.

    abstract::Doxorubicin (DOX) and Trastuzumab (TRAST) are effective agents for the treatment of many neoplastic diseases. Cardiotoxicity is a major side effect of these drugs and limit their use. In this study, the possible protective effects of melatonin (MEL), mercaptoethylguanidine (MEG), or N-(3-(aminomethyl) benzyl) acetamid...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Ozturk M,Ozler M,Kurt YG,Ozturk B,Uysal B,Ersoz N,Yasar M,Demirbas S,Kurt B,Acikel C,Oztas Y,Arpaci F,Topal T,Ozet A,Ataergin S,Kuzhan O,Oter S,Korkmaz A

    更新日期:2011-01-01 00:00:00

  • Androgenic function in adult rats: influence of the pineal gland of the mother and of the offspring.

    abstract::Female rats exposed to long (LD 18:6) or short (LD 6:18) photoperiods from 21 days of age were mated when they reached 55 days of age. On day 2 of gestation animals of each group were either pinealectomized or sham-operated. Lighting regimens were not changed during the course of the study. Male offspring of the four ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Jarrige JF,Boucher D

    更新日期:1992-09-01 00:00:00

  • Overexpression of rice serotonin N-acetyltransferase 1 in transgenic rice plants confers resistance to cadmium and senescence and increases grain yield.

    abstract::While ectopic overexpression of serotonin N-acetyltransferase (SNAT) in plants has been accomplished using animal SNAT genes, ectopic overexpression of plant SNAT genes in plants has not been investigated. Because the plant SNAT protein differs from that of animals in its subcellular localization and enzyme kinetics, ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章


    authors: Lee K,Back K

    更新日期:2017-04-01 00:00:00