Structure of the pineal gland in the adult cat.

abstract：:Melatonin, the major secretory product of the pineal gland, is in focus of many research areas because of its ability to scavenge free oxygen radicals and thereby protect cells and tissues from radical damage. Some studies suggest melatonin may be a possible therapeutic agent with potential clinical applications again...

journal_title：Journal of pineal research

authors： Hermann R,Podhajsky S,Jungnickel S,Lerchl A

更新日期：2002-08-01 00:00:00

abstract：:Melatonin regulates mitogen-activated protein kinase (MAPK) and Akt signaling pathways. The MAPK family mainly includes extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK). Our previous study documented that melatonin delays osteoblast proliferation; however, the mechanism of action of ...

journal_title：Journal of pineal research

authors： Liu L,Zhu Y,Xu Y,Reiter RJ

更新日期：2012-08-01 00:00:00

abstract：:The effect of daily injection of the pineal hormone melatonin and naltrexone, an opioid antagonist, on the circadian rhythm and the level of immune parameters (plaque forming cell [PFC] number, serum agglutinin titer, lymphoid gland weight, total white blood cells (WBC) and their fraction number, and serum lysozyme [L...

journal_title：Journal of pineal research

authors： Skwarło-Sońta K,Thaela MJ,Midura M,Lech B,Głuchowska B,Drela N,Kozłowska E,Kowalczyk R

更新日期：1992-01-01 00:00:00

abstract：:Previously it has been found that pinealectomy in rats was associated with increased small bowel crypt cell proliferation. The hypothalamus is thought to play a role in the neural control of crypt cell proliferation and the pineal gland is known to be functionally connected with this component of the autonomic nervous...

journal_title：Journal of pineal research

authors： Callaghan BD

更新日期：1991-01-01 00:00:00

abstract：:The role played by postsynaptic alpha-adrenergic receptors in the stimulation of pineal melatonin production was investigated in the Syrian hamster. The studies were conducted using organ cultured pineal glands collected from both anatomically intact and superior cervical ganglionectomized hamsters. Results obtained i...

journal_title：Journal of pineal research

authors： Santana C,Guerrero JM,Reiter RJ,Menendez-Pelaez A

更新日期：1989-01-01 00:00:00

abstract：:An important role for melatonin in bone formation and restructuring has emerged, and studies demonstrate the multiple mechanisms for these beneficial actions. Statistical analysis shows that even with existing osteoporotic therapies, bone-related disease, and mortality are on the rise, creating a huge financial burden...

journal_title：Journal of pineal research

authors： Maria S,Witt-Enderby PA

更新日期：2014-03-01 00:00:00

abstract：:Melatonin has been shown to have a direct inhibitory action on the proliferation of estrogen-responsive MCF-7 human breast cancer cells in culture. In the present study, we examined by flow cytometry whether this inhibitory effect might be exerted on the G1 phase of the cell cycle, thus causing a transition delay into...

journal_title：Journal of pineal research

authors： Cos S,Blask DE,Lemus-Wilson A,Hill AB

更新日期：1991-01-01 00:00:00

abstract：:Melatonin and somatostatin are known to exert similar effects on locomotor activity. We have previously demonstrated that acute melatonin treatment regulates somatostatin receptor function in the rat frontoparietal cortex. However, the effects of subchronic and chronic melatonin treatment on the somatostatin receptor-...

journal_title：Journal of pineal research

authors： Izquierdo-Claros RM,Boyano-Adánez Mdel C,Arilla-Ferreiro E

更新日期：2002-11-01 00:00:00

abstract：:The present study analyzes the participation of pineal stalk and superior cervical ganglia (SCG) in the conduction of photic evoked potentials (PEP) to the pineal body (PB) in unanesthetized freely moving rats implanted with semimicroelectrodes. The PEPs were recorded in PB, lateral hypothalamus (LH), and habenular co...

journal_title：Journal of pineal research

authors： Barajas-López C,Barrientos-Martinez MA,Reyes-Vázquez C

更新日期：1987-01-01 00:00:00

abstract：:We studied the role of nocturnal illuminance as a possible regulatory factor in the production and secretion of reproductive hormones. Adult male rats were kept under artificial lighting conditions (LD 12/12 hours) where the daily illuminance was 520-550 lx and the nocturnal illuminance 0, less than 0.1, or 1-1.5 lx. ...

journal_title：Journal of pineal research

authors： Laakso ML,Porkka-Heiskanen T,Alila A,Kajander S,Stenberg D,Johansson G

更新日期：1989-01-01 00:00:00

abstract：:Melatonin is a very potent and efficient endogenous radical scavenger. The pineal indolamine reacts with the highly toxic hydroxyl radical and provides on-site protection against oxidative damage to biomolecules within every cellular compartment. Melatonin acts as a primary non-enzymatic antioxidative defense against ...

journal_title：Journal of pineal research

authors： Poeggeler B,Reiter RJ,Tan DX,Chen LD,Manchester LC

更新日期：1993-05-01 00:00:00

abstract：:Melatonin, the main secretary product of the pineal gland, is potentially effective in the prevention of a number of diseases in which free radical processes are involved. The development of hypercholesterolemia is a multifactorial process in which elevated oxidized low-density lipoprotein (ox-LDL) levels play a centr...

journal_title：Journal of pineal research

authors： Zhu HQ,Cheng XW,Xiao LL,Jiang ZK,Zhou Q,Gui SY,Wei W,Wang Y

更新日期：2008-10-01 00:00:00

abstract：:Malaria, which infects more than 300 million people annually, is a serious disease. Epidemiological surveys indicate that of those who are affected, malaria will claim the lives of more than one million individuals, mostly children. There is evidence that the synchronous maturation of Plasmodium falciparum, the parasi...

journal_title：Journal of pineal research

authors： Srinivasan V,Spence DW,Moscovitch A,Pandi-Perumal SR,Trakht I,Brown GM,Cardinali DP

更新日期：2010-01-01 00:00:00

abstract：:The influence of the pineal gland on the histopathologic changes induced in mammary glands by 7, 12-dimethylbenz(a)-anthracene (DMBA) has been studied. To achieve the maximum expression of pineal action in animals, 28-day-old female Sprague-Dawley rats were subjected to one of the following treatments: blindness + olf...

journal_title：Journal of pineal research

authors： Cos S,Garijo F,Corral J,Mediavilla MD,Sánchez-Barceló EJ

更新日期：1989-01-01 00:00:00

abstract：:Obesity, a major risk factor for ischemic heart disease, is associated with increased oxidative stress and reduced antioxidant status. Melatonin, a potent free radical scavenger and antioxidant, has powerful cardioprotective effects in lean animals but its efficacy in obesity is unknown. We investigated the effects of...

journal_title：Journal of pineal research

authors： Nduhirabandi F,Du Toit EF,Blackhurst D,Marais D,Lochner A

更新日期：2011-03-01 00:00:00

abstract：:In previous studies, we have shown that mitochondrial respiratory chain (MRC) activity is decreased in patients with nonalcoholic steatohepatitis and in ob/ob mice and that peroxynitrite plays a pathogenic role. The present study examined whether melatonin, a peroxynitrite scavenger, prevents: (i) the in vitro effects...

journal_title：Journal of pineal research

authors： Solís-Muñoz P,Solís-Herruzo JA,Fernández-Moreira D,Gómez-Izquierdo E,García-Consuegra I,Muñoz-Yagüe T,García Ruiz I

更新日期：2011-08-01 00:00:00

abstract：:The purpose of this study was to determine whether melatonin treatment would mitigate retinal ganglion cell (RGC) death in the developing retina following a hypoxic insult. Lipid peroxidation (LPO), glutathione (GSH), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) concentrations, expression of vascular end...

journal_title：Journal of pineal research

authors： Kaur C,Sivakumar V,Robinson R,Foulds WS,Luu CD,Ling EA

更新日期：2013-03-01 00:00:00

abstract：:Epigenetic alterations have emerged as an important mechanism involved in tumorigenesis. The epigenetic impact of DNA methylation in various types of human cancer is not completely understood. Previously, we observed melatonin-induced differential expression of miRNA and miRNA-related genes in human breast cancer cell...

journal_title：Journal of pineal research

authors： Lee SE,Kim SJ,Yoon HJ,Yu SY,Yang H,Jeong SI,Hwang SY,Park CS,Park YS

更新日期：2013-01-01 00:00:00

abstract：:Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent antioxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA), are one of the hepatokines and are known to be asso...

journal_title：Journal of pineal research

authors： Heo JI,Yoon DW,Yu JH,Kim NH,Yoo HJ,Seo JA,Kim SG,Choi KM,Baik SH,Choi DS,Kim NH

更新日期：2018-09-01 00:00:00

abstract：:Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality. There have been no material advances in the treatment of preeclampsia for nearly 50 years. Combining in vitro studies and a clinical trial, we aimed to determine whether melatonin could be a useful adjuvant therapy. In a xanthine/x...

journal_title：Journal of pineal research

authors： Hobson SR,Gurusinghe S,Lim R,Alers NO,Miller SL,Kingdom JC,Wallace EM

更新日期：2018-10-01 00:00:00

abstract：:Melatonin, an antioxidant, protects the pancreas against acute inflammation but, although this indole is released mainly at night, no study has been undertaken to determine circadian changes of plasma melatonin levels and the severity of acute pancreatitis. The aims of this study were: (a) to compare the severity of c...

journal_title：Journal of pineal research

authors： Jaworek J,Konturek SJ,Tomaszewska R,Leja-Szpak A,Bonior J,Nawrot K,Palonek M,Stachura J,Pawlik WW

更新日期：2004-10-01 00:00:00

abstract：:Melatonin influences plant innate immunity through the mitogen-activated protein kinase (MAPK) pathway. However, the most upstream MAPK component in melatonin signaling and the dependence of generation of a reactive oxygen species (ROS) burst on melatonin synthesis and signaling remain unclear. In this study, treatmen...

journal_title：Journal of pineal research

authors： Lee HY,Back K

更新日期：2017-03-01 00:00:00

abstract：:Previous studies showed that melatonin or dehydroepiandrosterone (DHEA) enhances the immune response against parasitic pathogens. The present study investigated the in vitro activity of melatonin combined with DHEA in a period of 24 hr during the course of in vivo T. cruzi infection. The in vitro activity of melatonin...

journal_title：Journal of pineal research

authors： Kuehn CC,Rodrigues Oliveira LG,Santos CD,Ferreira DS,Alonso Toldo MP,de Albuquerque S,do Prado JC Jr

更新日期：2009-10-01 00:00:00

abstract：:A physiologically based model of arousal dynamics is improved to incorporate the effects of the light spectrum on circadian phase resetting, melatonin suppression, and subjective sleepiness. To account for these nonvisual effects of light, melanopic irradiance replaces photopic illuminance that was used previously in ...

journal_title：Journal of pineal research

authors： Tekieh T,Lockley SW,Robinson PA,McCloskey S,Zobaer MS,Postnova S

更新日期：2020-10-01 00:00:00

abstract：:In three separate experiments, the effect of acute exposure to either artificial or natural light during darkness of pineal N-acetyltransferase (NAT) activity and melatonin content was studied in the cotton rat (Sigmodon hispidus). The exposure of animals to an artificial-light irradiance of 160,000 microW/cm2 during ...

journal_title：Journal of pineal research

authors： Nürnberger F,Joshi BN,Heinzeller T,Milin J,Reiter RJ

更新日期：1985-01-01 00:00:00

abstract：:The distribution of 14C-Melatonin (14C-MT) after systemic injection was studied in the plasma, cerebrospinal fluid (CSF), and brain of rats. Chromatographic analysis (thin-layer chromatography and high-performance liquid chromatography) indicated that the radioactivity from biological samples taken at various times fo...

journal_title：Journal of pineal research

authors： Vitte PA,Harthe C,Lestage P,Claustrat B,Bobillier P

更新日期：1988-01-01 00:00:00

abstract：:The age-related changes and the acute effects of intravenous melatonin on the activity of striatal neurons of 1-, 3-, 6-, 12-, and 18-month-old sham-operated and pinealectomized rats were investigated. There was a decline in responsiveness from 3- to 18-months of age, although in sham-pinealectomized rats the response...

journal_title：Journal of pineal research

authors： Castillo-Romero JL,Acuña-Castroviejo D,Escamaes G,Vives F

更新日期：1995-09-01 00:00:00

abstract：:Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression, and type 2 diabetes development. Melatonin receptors are approved drug targets for insomnia, non-24-hour sleep-wake disorders, and major depressive disorders. In mammal...

journal_title：Journal of pineal research

authors： Cecon E,Ivanova A,Luka M,Gbahou F,Friederich A,Guillaume JL,Keller P,Knoch K,Ahmad R,Delagrange P,Solimena M,Jockers R

更新日期：2019-03-01 00:00:00

abstract：:A major goal of plant biotechnology is to improve the nutritional qualities of crop plants through metabolic engineering. Melatonin is a well-known bioactive molecule with an array of health-promoting properties, including potent antioxidant capability. To generate melatonin-rich rice plants, we first independently ov...

journal_title：Journal of pineal research

authors： Byeon Y,Park S,Lee HY,Kim YS,Back K

更新日期：2014-04-01 00:00:00

abstract：:We evaluated the feasibility of using morning urine samples in epidemiological studies aimed at clarifying the relationship between nocturnal melatonin levels and breast cancer risk. Initially, a laboratory-based study of 29 women (40- 70 yr old) was performed to examine the correlation between plasma melatonin levels...

journal_title：Journal of pineal research

authors： Cook MR,Graham C,Kavet R,Stevens RG,Davis S,Kheifets L

更新日期：2000-01-01 00:00:00