Molecular and cellular pharmacological properties of 5-methoxycarbonylamino-N-acetyltryptamine (MCA-NAT): a nonspecific MT3 ligand.

abstract：:Earlier studies showed that melatonin reduced the growth of 17-beta-estradiol (E(2))-induced rat pituitary prolactin-secreting tumor (prolactinoma) in vivo. The mechanisms of melatonin's inhibitory action on the prolactin-secreting tumor were further explored by investigating the in vitro effects of melatonin on the g...

journal_title：Journal of pineal research

authors： Yang QH,Xu JN,Xu RK,Pang SF

更新日期：2007-03-01 00:00:00

abstract：:Possible role of melatonin in the germination of negatively photoblastic and thermosensitive seeds of Phacelia tanacetifolia Benth was studied. Final germination percentage (FGP) was determined in the presence or absence of light at various temperatures, ranging from 0 to 40°C. The highest FGP was determined as 48.7% ...

journal_title：Journal of pineal research

authors： Tiryaki I,Keles H

更新日期：2012-04-01 00:00:00

abstract：:The association of seasonal changes in health and disease has been known for centuries. The prevalence of psychopathological symptoms with seasonal fluctuations and the use of melatonin as a biological marker of circadian and circannual rhythms is well documented. The aim of this work was to study the variability of m...

journal_title：Journal of pineal research

authors： Morera AL,Abreu P

更新日期：2006-10-01 00:00:00

abstract：:Four weeks of administration of melatonin mixed in the diet (5 mg/kg of food) significantly reduced the incidence of gastric ulcers in young pigs. In control and melatonin supplemented animals, significantly higher levels of melatonin were found in the stomach tissues as compared to jejunum, ileum, or colon. Pigs with...

journal_title：Journal of pineal research

authors： Bubenik GA,Ayles HL,Friendship RM,Brown GM,Ball RO

更新日期：1998-01-01 00:00:00

abstract：:Aging induces changes in several organs and tissues, such as the liver, and this process might be due to oxidative damage caused by free radicals and inflammatory mediators. Melatonin is a secretory product with well-known antioxidant properties. The aim of this study was to investigate the effect of melatonin adminis...

journal_title：Journal of pineal research

authors： Castillo C,Salazar V,Ariznavarreta C,Vara E,Tresguerres JA

更新日期：2005-05-01 00:00:00

abstract：:We tested whether combined melatonin (Mel) and exendin-4 (Ex4) treatment can better preserve glomerular structural integrity after ischemia-reperfusion (IR) injury compared with either alone. Adult male Sprague Dawley rats (n = 50) were equally divided into sham control (SC), IR, IR-Ex4 (10 μg/kg subcutaneously 30 min...

journal_title：Journal of pineal research

authors： Yip HK,Yang CC,Chen KH,Huang TH,Chen YL,Zhen YY,Sung PH,Chiang HJ,Sheu JJ,Chang CL,Chen CH,Chang HW,Chen YT

更新日期：2015-11-01 00:00:00

abstract：:Abnormal proliferation and motility of retinal pigment epithelial cells leads to proliferative vitreoretinopathy (PVR). Melatonin is a known effective antitumour and anti-invasive agent, but whether it affects the formation and underlying mechanisms of PVR remains unclear. In this study, the results of the MTT assay, ...

journal_title：Journal of pineal research

authors： Yang SF,Chen YS,Chien HW,Wang K,Lin CL,Chiou HL,Lee CY,Chen PN,Hsieh YH

更新日期：2020-01-01 00:00:00

abstract：:The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade. Cigarette smoke (CS) is the most important risk factor in the development of COPD. In this study, we investigated the effects of melatonin on the development of COPD using a CS and lipopolysaccharide (LPS)-induc...

journal_title：Journal of pineal research

authors： Shin IS,Shin NR,Park JW,Jeon CM,Hong JM,Kwon OK,Kim JS,Lee IC,Kim JC,Oh SR,Ahn KS

更新日期：2015-01-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC), a disease common in the South-East Asian population, has high lymph node metastatic ability. Melatonin, an endogenously produced substance present in animals, plants, fungi, and bacteria, has oncostatic activity via several mechanisms. The molecular mechanisms involved in melatonin-medi...

journal_title：Journal of pineal research

authors： Ho HY,Lin CW,Chien MH,Reiter RJ,Su SC,Hsieh YH,Yang SF

更新日期：2016-11-01 00:00:00

abstract：:The aim of this study was to investigate the localization in the superior cervical ganglia (SCG) of neuropeptide Y-containing neurons innervating the pineal gland. Following injection of the fluorescent tracer Fluoro-Gold (FG) into the superficial part of the pineal gland and retrograde axonal transport, labeled cells...

journal_title：Journal of pineal research

authors： Reuss S,Moore RY

更新日期：1989-01-01 00:00:00

abstract：:Ischemia/reperfusion injury (IRI) is harmful to the cardiovascular system and causes mitochondrial oxidative stress. Numerous data indicate that the JAK2/STAT3 signaling pathway is specifically involved in preventing myocardial IRI. Melatonin has potent activity against IRI and may regulate JAK2/STAT3 signaling. This ...

journal_title：Journal of pineal research

authors： Yang Y,Duan W,Jin Z,Yi W,Yan J,Zhang S,Wang N,Liang Z,Li Y,Chen W,Yi D,Yu S

更新日期：2013-10-01 00:00:00

abstract：:The role played by postsynaptic alpha-adrenergic receptors in the stimulation of pineal melatonin production was investigated in the Syrian hamster. The studies were conducted using organ cultured pineal glands collected from both anatomically intact and superior cervical ganglionectomized hamsters. Results obtained i...

journal_title：Journal of pineal research

authors： Santana C,Guerrero JM,Reiter RJ,Menendez-Pelaez A

更新日期：1989-01-01 00:00:00

abstract：:Excessive activity of NADPH oxidase (Nox) is considered to be of importance for the progress of diabetic nephropathy. The aim of the study was to elucidate the effect of melatonin, known for its nephroprotective properties, on Nox activity under diabetic conditions. The experiments were performed on three groups of an...

journal_title：Journal of pineal research

authors： Winiarska K,Dzik JM,Labudda M,Focht D,Sierakowski B,Owczarek A,Komorowski L,Bielecki W

更新日期：2016-01-01 00:00:00

abstract：:Recently, a species-dependent distribution of melatonin binding sites have been found in lamina I-V and lamina X of the spinal cord. In order to learn more about the function of spinal melatonin receptors, we investigated (i) the gene expression for melatonin receptor subtypes in lumbar and thoracal spinal cord tissue...

journal_title：Journal of pineal research

authors： Zahn PK,Lansmann T,Berger E,Speckmann EJ,Musshoff U

更新日期：2003-08-01 00:00:00

abstract：:Recent investigations have demonstrated that melatonin influences carbohydrate metabolism mediated by insulin-inhibiting effects on pancreatic β-cells. This study evaluated whether melatonin has also an effect on pancreatic α-cells and glucagon expression as well as the glucagon secretion in vitro and in vivo. Glucago...

journal_title：Journal of pineal research

authors： Bähr I,Mühlbauer E,Schucht H,Peschke E

更新日期：2011-04-01 00:00:00

abstract：:Melatonin has been shown to improve in vitro fertilization and offspring survival after bacterial infection, but its role in regulating maternal-fetal communication during early pregnancy has not been investigated. Results of this study demonstrated expression of abundant melatonin receptors in conceptus and endometri...

journal_title：Journal of pineal research

authors： Bae H,Yang C,Lee JY,Park S,Bazer FW,Song G,Lim W

更新日期：2020-09-01 00:00:00

abstract：:Melatonin has shown particular promise as a neuroprotective agent to prevent motoneuron death in animal models of both amyotrophic lateral sclerosis (ALS) and spinal cord injuries (SCI). However, an understanding of the roles of endogenous melatonin receptors including MT1, MT2, and orphan G-protein receptor 50 (GPR50...

journal_title：Journal of pineal research

authors： Das A,Wallace G 4th,Reiter RJ,Varma AK,Ray SK,Banik NL

更新日期：2013-01-01 00:00:00

abstract：:Melatonin is part of the evolutionary conserved highly functional network in vertebrates. It plays a central role in the adaptative behavior of the animal to the environment, including entrainment of daily and annual physiological rhythms, reproductive behavior, food intake, locomotor activity, growth, and breeding pe...

journal_title：Journal of pineal research

authors： Lima-Cabello E,Díaz-Casado ME,Guerrero JA,Otalora BB,Escames G,López LC,Reiter RJ,Acuña-Castroviejo D

更新日期：2014-08-01 00:00:00

abstract：:The age-related changes and the acute effects of intravenous melatonin on the activity of striatal neurons of 1-, 3-, 6-, 12-, and 18-month-old sham-operated and pinealectomized rats were investigated. There was a decline in responsiveness from 3- to 18-months of age, although in sham-pinealectomized rats the response...

journal_title：Journal of pineal research

authors： Castillo-Romero JL,Acuña-Castroviejo D,Escamaes G,Vives F

更新日期：1995-09-01 00:00:00

abstract：:The activity of N-acetyltransferase (NAT) and the content of melatonin (MEL) in the rat pineal have been shown to be sensitive to several types of stressors. This study was designed to assess the role of the adrenals in mediating the effect of one such stressor, insulin-induced hypoglycemia, on pineal synthetic activi...

journal_title：Journal of pineal research

authors： Tannenbaum MG,Reiter RJ,Vaughan MK,Troiani ME,Gonzalez-Brito A

更新日期：1987-01-01 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter/neuromodulator involved in cell-to-cell communication within the central nervous system, is now believed to play a role in neuroendocrine function. In this study we describe a single, saturable, stereospecific, and temperature-, time-, and pH-dependent binding site for glutama...

journal_title：Journal of pineal research

authors： Kus L,Handa RJ,McNulty JA

更新日期：1993-01-01 00:00:00

abstract：:Epigenetic alterations have emerged as an important mechanism involved in tumorigenesis. The epigenetic impact of DNA methylation in various types of human cancer is not completely understood. Previously, we observed melatonin-induced differential expression of miRNA and miRNA-related genes in human breast cancer cell...

journal_title：Journal of pineal research

authors： Lee SE,Kim SJ,Yoon HJ,Yu SY,Yang H,Jeong SI,Hwang SY,Park CS,Park YS

更新日期：2013-01-01 00:00:00

abstract：:Melatonin has been identified in primitive photosynthetic bacteria, fungi, plants, and animals including humans. Vegetables, fruits, cereals, wine, and beers all contain melatonin. However, the melatonin content in meats has not been reported previously. Here, for the first time, we report melatonin in meats, eggs, co...

journal_title：Journal of pineal research

authors： Tan DX,Zanghi BM,Manchester LC,Reiter RJ

更新日期：2014-09-01 00:00:00

abstract：:Melatonin, the main secretary product of the pineal gland, is potentially effective in the prevention of a number of diseases in which free radical processes are involved. The development of hypercholesterolemia is a multifactorial process in which elevated oxidized low-density lipoprotein (ox-LDL) levels play a centr...

journal_title：Journal of pineal research

authors： Zhu HQ,Cheng XW,Xiao LL,Jiang ZK,Zhou Q,Gui SY,Wei W,Wang Y

更新日期：2008-10-01 00:00:00

abstract：:The effect of melatonin (0.1 microM) on freshly isolated islets from adult rats was investigated. Melatonin caused a marked decrease of insulin secretion by islets in response to glucose. The mechanism involved was then examined. Melatonin did not interfere with glucose metabolism as indicated by the measurement of gl...

journal_title：Journal of pineal research

authors： Picinato MC,Haber EP,Cipolla-Neto J,Curi R,de Oliveira Carvalho CR,Carpinelli AR

更新日期：2002-10-01 00:00:00

abstract：:The objective of this study was to determine the role of alpha-adrenoceptors in melatonin production by rat pineal gland. Pineal glands were isolated from adult male rats and maintained in organ baths. The perfusate was sampled every 5 min, stored, and later assayed for melatonin. Exposure to norepinephrine (10 microM...

journal_title：Journal of pineal research

authors： Tobin VA,McCance I,Coleman HA,Parkington HC

更新日期：2002-05-01 00:00:00

abstract：:Constitutive activation and gemcitabine induction of nuclear factor-κB (NF-κB) contribute to the aggressive behavior and chemotherapeutic resistance of pancreatic ductal adenocarcinoma (PDAC). Thus, targeting the NF-κB pathway has proven an insurmountable challenge for PDAC therapy. In this study, we investigated whet...

journal_title：Journal of pineal research

authors： Ju HQ,Li H,Tian T,Lu YX,Bai L,Chen LZ,Sheng H,Mo HY,Zeng JB,Deng W,Chiao PJ,Xu RH

更新日期：2016-01-01 00:00:00

abstract：:Glioblastoma stem-like cells (GSCs) displaying self-renewing and tumor-propagating capacity play a particularly important role in maintaining tumor growth, therapeutic resistance, and tumor recurrence. Therefore, new therapeutic strategies focusing on impairing GSC maintenance are urgently needed. Here, we used GSCs i...

journal_title：Journal of pineal research

authors： Chen X,Hao A,Li X,Du Z,Li H,Wang H,Yang H,Fang Z

更新日期：2016-09-01 00:00:00

abstract：:Rabbitfish are a restricted lunar-synchronized spawner that spawns around a species-specific lunar phase. It is not known how the fish perceive changes in cues from the moon. One possible explanation is that rabbitfish utilize changes in moonlight intensity to establish synchrony. The purpose of the present study was ...

journal_title：Journal of pineal research

authors： Takemura A,Ueda S,Hiyakawa N,Nikaido Y

更新日期：2006-04-01 00:00:00

abstract：:An interaction between melatonin and adrenocorticotropin (ACTH) seems to occur in humans and both hormones respond to beta-adrenergic stimulation. As in lower animal species, human pineal gland also contains alpha2-adrenergic receptors as does the hypothalamus-pituitary axis. In this study the response of the pineal g...

journal_title：Journal of pineal research

authors： Muñóz-Hoyos A,Fernández-García JM,Molina-Carballo A,Macías M,Escames G,Ruiz-Cosano C,Acuña-Castroviejo D

更新日期：2000-08-01 00:00:00