Effect of melatonin administration on parameters related to oxidative damage in hepatocytes isolated from old Wistar rats.

abstract：:The circadian system comprises several peripheral oscillators and a central rhythm generator that, in mammals, is located in the suprachiasmatic nucleus of the hypothalamus. Expression of clock genes is a characteristic feature of the central rhythm generator and the peripheral oscillators. With regard to the rhythmic...

journal_title：Journal of pineal research

authors： Torres-Farfan C,Serón-Ferré M,Dinet V,Korf HW

更新日期：2006-01-01 00:00:00

abstract：:The effects of melatonin (3 mg/kg i.p.) and the melatonin receptor agonist S-20098 (3 mg/kg i.p.) on the vigilance states, electroencephalogram power spectra (0.25-25.0 Hz), and cortical temperature were determined in eight rats in the first 6-hr interval of the 12-hr light period. Compared to the vehicle injection bo...

journal_title：Journal of pineal research

authors： Tobler I,Jaggi K,Borbély AA

更新日期：1994-01-01 00:00:00

abstract：:Environmental pollution in the form of particulate matter <2.5 μm (PM2.5 ) is a major risk factor for diseases such as lung cancer, chronic respiratory infections, and major cardiovascular diseases. Our goal was to show that PM2.5 eliciting a proinflammatory response activates the immune-pineal axis, reducing the pine...

journal_title：Journal of pineal research

authors： Carvalho-Sousa CE,Pereira EP,Kinker GS,Veras M,Ferreira ZS,Barbosa-Nunes FP,Martins JO,Saldiva PHN,Reiter RJ,Fernandes PA,da Silveira Cruz-Machado S,Markus RP

更新日期：2020-04-01 00:00:00

abstract：:Recent investigations have demonstrated that melatonin influences carbohydrate metabolism mediated by insulin-inhibiting effects on pancreatic β-cells. This study evaluated whether melatonin has also an effect on pancreatic α-cells and glucagon expression as well as the glucagon secretion in vitro and in vivo. Glucago...

journal_title：Journal of pineal research

authors： Bähr I,Mühlbauer E,Schucht H,Peschke E

更新日期：2011-04-01 00:00:00

abstract：:In mammals, the suprachiasmatic nuclei (SCN) constitute the main circadian clock, receiving input from the retina which allows synchronization of endogenous biological rhythms with the daily light/dark cycle. Over the year, the SCN encodes photoperiodic variations through duration of melatonin secretion, with abundant...

journal_title：Journal of pineal research

authors： Leclercq B,Hicks D,Laurent V

更新日期：2020-12-16 00:00:00

abstract：:Retinopathy of prematurity is a vision-threatening disease associated with retinal hypoxia-ischemia, leading to the death of retinal neurons and chronic neuronal degeneration. During this study, we used the oxygen-induced retinopathy mice model to mimic retinal hypoxia-ischemia phenotypes to investigate further the ne...

journal_title：Journal of pineal research

authors： Huang R,Xu Y,Lu X,Tang X,Lin J,Cui K,Yu S,Shi Y,Ye D,Liu Y,Liang X

更新日期：2021-01-11 00:00:00

abstract：:Melatonin, an antioxidant, protects the pancreas against acute inflammation but, although this indole is released mainly at night, no study has been undertaken to determine circadian changes of plasma melatonin levels and the severity of acute pancreatitis. The aims of this study were: (a) to compare the severity of c...

journal_title：Journal of pineal research

authors： Jaworek J,Konturek SJ,Tomaszewska R,Leja-Szpak A,Bonior J,Nawrot K,Palonek M,Stachura J,Pawlik WW

更新日期：2004-10-01 00:00:00

abstract：:Melatonin, a major pineal secretory product, exerts a range of physiological and neuroprotective effects. However, the functional significance of melatonin in determining neural identity, and the mechanisms by which this may occur, is unknown. In this study, P19 cells were used as a model system and cell behavior was ...

journal_title：Journal of pineal research

authors： Chen X,Li X,Du Z,Shi W,Yao Y,Wang C,He K,Hao A

更新日期：2014-09-01 00:00:00

abstract：:Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent antioxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA), are one of the hepatokines and are known to be asso...

journal_title：Journal of pineal research

authors： Heo JI,Yoon DW,Yu JH,Kim NH,Yoo HJ,Seo JA,Kim SG,Choi KM,Baik SH,Choi DS,Kim NH

更新日期：2018-09-01 00:00:00

abstract：:Seasonal day length has been linked to the prevalence of mood disorders, and however, the mechanisms underlying this relationship remain unknown. Previous work in our laboratory has shown that developmental exposure to seasonal photoperiods has enduring effects on the activity of mouse dorsal raphe serotonergic neuron...

journal_title：Journal of pineal research

authors： Giannoni-Guzmán MA,Kamitakahara A,Magalong V,Levitt P,McMahon DG

更新日期：2020-11-19 00:00:00

abstract：:There still lacking effective treatment for bladder cancer. This study investigated whether melatonin (Mel) can suppress the growth and invasion of bladder cancer cells. Male C57B/L6 mice were categorized into control group (ie, subcutaneous injection of HT1197 bladder cancer cell line at the back] and treatment group...

journal_title：Journal of pineal research

authors： Chen YT,Yang CC,Shao PL,Huang CR,Yip HK

更新日期：2019-01-01 00:00:00

abstract：:There are functional inter-relationships between the beta cells of the endocrine pancreas and the pineal gland, where the synchronizing circadian molecule melatonin originates. The aim of this study was to elucidate a putative interaction between insulin and melatonin in diabetic patients and a diabetic rat model. We ...

journal_title：Journal of pineal research

authors： Peschke E,Frese T,Chankiewitz E,Peschke D,Preiss U,Schneyer U,Spessert R,Mühlbauer E

更新日期：2006-03-01 00:00:00

abstract：:The objective of this study was to apply the radioimmunoassay for 6-sulphatoxymelatonin (aMT6s) to rat urine, and use it to study the source of aMT6s. The radioimmunoassay was found to have acceptable within- and between-assay variation, excellent specificity, and good parallelism between the standard and unknown. Bec...

journal_title：Journal of pineal research

authors： Brown GM,Bar-Or A,Grossi D,Kashur S,Johannson E,Yie SM

更新日期：1991-04-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC), a disease common in the South-East Asian population, has high lymph node metastatic ability. Melatonin, an endogenously produced substance present in animals, plants, fungi, and bacteria, has oncostatic activity via several mechanisms. The molecular mechanisms involved in melatonin-medi...

journal_title：Journal of pineal research

authors： Ho HY,Lin CW,Chien MH,Reiter RJ,Su SC,Hsieh YH,Yang SF

更新日期：2016-11-01 00:00:00

abstract：:Our objective was to evaluate the maternal-fetal transfer of melatonin in pregnant women. Serum melatonin concentration was measured by high-performance liquid chromatography with electrochemical detection in a maternal vein and in the umbilical artery and umbilical vein at the time of birth. Blood samples were obtain...

journal_title：Journal of pineal research

authors： Okatani Y,Okamoto K,Hayashi K,Wakatsuki A,Tamura S,Sagara Y

更新日期：1998-10-01 00:00:00

abstract：:Incorporation of new therapeutic agents remains as a major challenge for treatment of patients with malignant haematological disorders. Melatonin is an indolamine without relevant side effects. It has been shown previously to exhibit synergism with several chemotherapeutic drugs in Ewing sarcoma cells by potentiating ...

journal_title：Journal of pineal research

authors： Casado-Zapico S,Martín V,García-Santos G,Rodríguez-Blanco J,Sánchez-Sánchez AM,Luño E,Suárez C,García-Pedrero JM,Menendez ST,Antolín I,Rodriguez C

更新日期：2011-04-01 00:00:00

abstract：:Melatonin is a very potent and efficient endogenous radical scavenger. The pineal indolamine reacts with the highly toxic hydroxyl radical and provides on-site protection against oxidative damage to biomolecules within every cellular compartment. Melatonin acts as a primary non-enzymatic antioxidative defense against ...

journal_title：Journal of pineal research

authors： Poeggeler B,Reiter RJ,Tan DX,Chen LD,Manchester LC

更新日期：1993-05-01 00:00:00

abstract：:The purpose of this study was to determine whether melatonin treatment would mitigate retinal ganglion cell (RGC) death in the developing retina following a hypoxic insult. Lipid peroxidation (LPO), glutathione (GSH), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) concentrations, expression of vascular end...

journal_title：Journal of pineal research

authors： Kaur C,Sivakumar V,Robinson R,Foulds WS,Luu CD,Ling EA

更新日期：2013-03-01 00:00:00

abstract：:Female Syrian hamsters were kept in a light (14:10 h light:dark cycle, lights on 0600 h)- and temperature (22 or 30 degrees C)-controlled room; some groups were treated with an afternoon s.c. injection of melatonin (6.25, 12.5, or 25 micrograms/day) for 11 or 14 weeks. The melatonin-induced suppression of the reproduc...

journal_title：Journal of pineal research

authors： Reiter RJ,Li K,Gonzalez-Brito A,Tannenbaum MG,Vaughan MK,Vaughan GM,Villanua MA

更新日期：1988-01-01 00:00:00

abstract：:We examined the association between 6-sulphatoxymelatonin (6-SMT) excretion and sleep in 68 volunteers 60-79 years of age who complained of insomnia or depression. An Actillume wrist monitor was worn for 5-7 consecutive days and nights in home-living conditions. Activity was used to estimate total sleep time (TST) and...

journal_title：Journal of pineal research

authors： Youngstedt SD,Kripke DF,Elliott JA

更新日期：1998-04-01 00:00:00

abstract：:Although there is an increasing evidence that the pineal gland may play a role in human malignancy, the studies on melatonin concentrations in different types of malignant tumors brought about controversial results. However, changes in melatonin concentrations have been observed in some types of human malignant tumors...

journal_title：Journal of pineal research

authors： Karasek M,Kowalski AJ,Suzin J,Zylinska K,Swietoslawski J

更新日期：2005-08-01 00:00:00

abstract：:Carbon tetrachloride (CCl4) exerts its toxic effects by the generation of free radicals. In this study we investigated whether melatonin, a potent free radical scavenger, could prevent the deleterious effects of CCl4. Liver homogenates and liver microsomes were incubated with CCl4 in the presence of melatonin and lipi...

journal_title：Journal of pineal research

authors： Daniels WM,Reiter RJ,Melchiorri D,Sewerynek E,Pablos MI,Ortiz GG

更新日期：1995-08-01 00:00:00

abstract：:Lethal oxidative stress was investigated in the dinoflagellate Gonyaulax polyedra by measuring the dying-peak of bioluminescence during circadian phases of low physiological light emission, low bioluminescence capacity, and low sensitivity to stimulatory agents. Measurements were carried out in constant darkness after...

journal_title：Journal of pineal research

authors： Antolín I,Obst B,Burkhardt S,Hardeland R

更新日期：1997-11-01 00:00:00

abstract：:The rod outer segment (ROSg) membranes are essentially lipoprotein complexes. Rhodopsin, the major integral protein of ROSg, is surrounded by phospholipids highly enriched in docosahexaenoic acid (22:6 n3). This fluid environment plays an important role for conformational changes after photo-activation. Thus, ROSg mem...

journal_title：Journal of pineal research

authors： Guajardo MH,Terrasa AM,Catalá A

更新日期：2006-10-01 00:00:00

abstract：:Four-week-old male hamsters, born and raised in total darkness or in LD 14:10 (hr) were exposed to several low levels of illumination for 14 weeks. Analyses showed that testicular weights were significantly affected by both photic history and illuminance levels. Animals born in the dark possessed larger testes than th...

journal_title：Journal of pineal research

authors： Hoffman RA,Johnson LB

更新日期：1985-01-01 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter/neuromodulator involved in cell-to-cell communication within the central nervous system, is now believed to play a role in neuroendocrine function. In this study we describe a single, saturable, stereospecific, and temperature-, time-, and pH-dependent binding site for glutama...

journal_title：Journal of pineal research

authors： Kus L,Handa RJ,McNulty JA

更新日期：1993-01-01 00:00:00

abstract：:The activity of N-acetyltransferase (NAT) and the content of melatonin (MEL) in the rat pineal have been shown to be sensitive to several types of stressors. This study was designed to assess the role of the adrenals in mediating the effect of one such stressor, insulin-induced hypoglycemia, on pineal synthetic activi...

journal_title：Journal of pineal research

authors： Tannenbaum MG,Reiter RJ,Vaughan MK,Troiani ME,Gonzalez-Brito A

更新日期：1987-01-01 00:00:00

abstract：:The presence of melatonin and the enzymes (transcripts and activities) involved in its synthesis, i.e. arylalkylamine N-acetyltransferase (AA-NAT) and hydroxyindole-O-methyltransferase (HIOMT), was investigated in the eggs and early embryos of Japanese quail at Hamburger-Hamilton stages 1-10. Melatonin was present in ...

journal_title：Journal of pineal research

authors： Olszańska B,Majewski P,Lewczuk B,Stepińska U

更新日期：2007-04-01 00:00:00

abstract：:We tested whether combined melatonin (Mel) and exendin-4 (Ex4) treatment can better preserve glomerular structural integrity after ischemia-reperfusion (IR) injury compared with either alone. Adult male Sprague Dawley rats (n = 50) were equally divided into sham control (SC), IR, IR-Ex4 (10 μg/kg subcutaneously 30 min...

journal_title：Journal of pineal research

authors： Yip HK,Yang CC,Chen KH,Huang TH,Chen YL,Zhen YY,Sung PH,Chiang HJ,Sheu JJ,Chang CL,Chen CH,Chang HW,Chen YT

更新日期：2015-11-01 00:00:00

abstract：:The effect of melatonin injection on Freund's adjuvant-induced changes in levels and 24-hr rhythms of circulating ACTH, growth hormone (GH), prolactin (PRL), luteinizing hormone (LH), and insulin was assessed in rats. Animals received subcutaneous (s.c.) injections of melatonin (30 microg) or vehicle, 1 hr before ligh...

journal_title：Journal of pineal research

authors： Esquifino AI,Castrillón P,García-Bonacho M,Vara E,Cardinali DP

更新日期：1999-08-01 00:00:00