Age-related changes of neuronal responsiveness to melatonin in the striatum of sham-operated and pinealectomized rats.

abstract：:As for many hormones, melatonin levels in the blood suggest that it is discharged from the pineal gland in a pulsatile manner. Recently, the existence of short-term episodes, superimposed on the circadian pattern of circulating melatonin, has been questioned. Because plasma melatonin levels reflect not only the secret...

journal_title：Journal of pineal research

authors： Follenius M,Weibel L,Brandenberger G

更新日期：1995-04-01 00:00:00

abstract：:We evaluated the antioxidant property of melatonin as it relates to the vasospastic effect of hydrogen peroxide (H2O2) on the human umbilical artery. Helical sections of umbilical arteries were obtained from healthy pregnant women who were delivered between weeks 37 and 39 of gestation. Changes in maximal potassium ch...

journal_title：Journal of pineal research

authors： Okatani Y,Watanabe K,Hayashi K,Wakatsuki A,Sagara Y

更新日期：1997-04-01 00:00:00

abstract：:Irradiation of the melatonin metabolite N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) with UV light of 254 nm causes the release of carbon monoxide (CO) and, thus, deformylation to N(1)-acetyl-5-methoxykynuramine (AMK). Liberation of CO was demonstrated by reduction of PdCl(2) to metallic palladium, under avoidan...

journal_title：Journal of pineal research

authors： Seever K,Hardeland R

更新日期：2008-05-01 00:00:00

abstract：:The serum levels of the pineal hormone melatonin were determined by radioimmunoassay (RIA) in 4-h intervals throughout a 24-h period in elderly men with different types of prostate tumors: benign prostatic hyperplasia (BPH, n = 13), incidental carcinoma (PCi, n = 5), and nonmetastasizing carcinoma (PC, n = 9), as well...

journal_title：Journal of pineal research

authors： Bartsch C,Bartsch H,Flüchter SH,Attanasio A,Gupta D

更新日期：1985-01-01 00:00:00

abstract：:Optic atrophy 1 (OPA1)-related mitochondrial fusion and mitophagy are vital to sustain mitochondrial homeostasis under stress conditions. However, no study has confirmed whether OPA1-related mitochondrial fusion/mitophagy is activated by melatonin and, consequently, attenuates cardiomyocyte death and mitochondrial str...

journal_title：Journal of pineal research

authors： Zhang Y,Wang Y,Xu J,Tian F,Hu S,Chen Y,Fu Z

更新日期：2019-03-01 00:00:00

abstract：:The aim of this study was to determine, in the rat, the interaction between melatonin and cholecystokinin in the regulation of the ileal interdigestive motility. This was analyzed by the chronic electromyography technique. Ileal motility was defined by the presence of intermittent spike bursts corresponding to the con...

journal_title：Journal of pineal research

authors： Bonouali-Pellissier S

更新日期：1994-09-01 00:00:00

abstract：:Epigenetic alterations have emerged as an important mechanism involved in tumorigenesis. The epigenetic impact of DNA methylation in various types of human cancer is not completely understood. Previously, we observed melatonin-induced differential expression of miRNA and miRNA-related genes in human breast cancer cell...

journal_title：Journal of pineal research

authors： Lee SE,Kim SJ,Yoon HJ,Yu SY,Yang H,Jeong SI,Hwang SY,Park CS,Park YS

更新日期：2013-01-01 00:00:00

abstract：:Glioblastoma stem-like cells (GSCs) displaying self-renewing and tumor-propagating capacity play a particularly important role in maintaining tumor growth, therapeutic resistance, and tumor recurrence. Therefore, new therapeutic strategies focusing on impairing GSC maintenance are urgently needed. Here, we used GSCs i...

journal_title：Journal of pineal research

authors： Chen X,Hao A,Li X,Du Z,Li H,Wang H,Yang H,Fang Z

更新日期：2016-09-01 00:00:00

abstract：:A decrease in nocturnal serum melatonin levels was reported in patients with clinically uncharacterized coronary artery disease. To assess whether there was a correlation between melatonin production and disease stage, we measured the nocturnal urinary excretion of 6-sulphatoxymelatonin (an index of blood melatonin co...

journal_title：Journal of pineal research

authors： Girotti L,Lago M,Ianovsky O,Carbajales J,Elizari MV,Brusco LI,Cardinali DP

更新日期：2000-10-01 00:00:00

abstract：:Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent antioxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA), are one of the hepatokines and are known to be asso...

journal_title：Journal of pineal research

authors： Heo JI,Yoon DW,Yu JH,Kim NH,Yoo HJ,Seo JA,Kim SG,Choi KM,Baik SH,Choi DS,Kim NH

更新日期：2018-09-01 00:00:00

abstract：:Recent studies implicate melatonin in the antinociceptive activity of sensory neurons. However, the underlying mechanisms are still largely unknown. Here, we identify a critical role of melatonin in functionally regulating Cav3.2 T-type Ca2+ channels (T-type channel) in trigeminal ganglion (TG) neurons. Melatonin inhi...

journal_title：Journal of pineal research

authors： Zhang Y,Ji H,Wang J,Sun Y,Qian Z,Jiang X,Snutch TP,Sun Y,Tao J

更新日期：2018-05-01 00:00:00

abstract：:The effect of various cations on activity of hydroxyindole-O-methyltransferase (HIOMT) and N-acetyltransferase (NAT) from pineal gland was studied. Copper inhibited both enzymes while calcium and magnesium inhibited HIOMT; the mechanisms of these inhibitions are unknown at this stage. Calcium, magnesium, potassium, an...

journal_title：Journal of pineal research

authors： Morton DJ

更新日期：1987-01-01 00:00:00

abstract：:Methamphetamine (METH) is a potent psychostimulant drug that may cause neuronal cell degeneration. The underlying mechanisms of METH-induced neuronal toxicity remains poorly understood. In this study, we investigated an important role of calpain-dependent cascades in methamphetamine-induced toxicity in human dopaminer...

journal_title：Journal of pineal research

authors： Suwanjang W,Phansuwan-Pujito P,Govitrapong P,Chetsawang B

更新日期：2010-03-01 00:00:00

abstract：:Dim light exposure of the mother during pregnancy has been proposed as one of the environmental factors that affect the fetal brain development in schizophrenia. Melatonin circulating levels are regulated by the environmental light/dark cycle. This hormone stimulates neuronal differentiation in the adult brain. Howeve...

journal_title：Journal of pineal research

authors： Galván-Arrieta T,Trueta C,Cercós MG,Valdés-Tovar M,Alarcón S,Oikawa J,Zamudio-Meza H,Benítez-King G

更新日期：2017-10-01 00:00:00

abstract：:Respiratory activity is under circadian modulation and the physiological mechanisms may involve the pineal secretory product, melatonin, and the carotid chemoreceptor. We hypothesized that melatonin modulates the carotid chemoreceptor response to hypercapnic acidosis. To determine whether the effect of melatonin on th...

journal_title：Journal of pineal research

authors： Tjong YW,Chen Y,Liong EC,Ip SF,Tipoe GL,Fung ML

更新日期：2004-01-01 00:00:00

abstract：:The circadian clock plays a vital role in physiology and behavior such as the sleep-wake cycle and blood pressure and hormone levels. Immune responses also display circadian rhythmicity and particularly pineal melatonin contributes to immunological processes. Little attention, however, is given to mechanisms underlyin...

journal_title：Journal of pineal research

authors： Ren DL,Li YJ,Hu BB,Wang H,Hu B

更新日期：2015-05-01 00:00:00

abstract：:Five adult pasture-bred Prim Holstein cows were used to document the time invariance of melatonin disposition in the cow. Melatonin was administered by an intravenous route as a bolus (5 micrograms/kg of body weight) at either 1430 or 2230. Data were analysed according to a three-compartment open model with melatonin ...

journal_title：Journal of pineal research

authors： Berthelot X,Ravault JP,Concordet D,Ferney J,Toutain PL

更新日期：1993-10-01 00:00:00

abstract：:Autophagy is an important survival pathway and participates in the host response to infection. Beneficial effects of melatonin have been previously reported in an animal model of acute liver failure (ALF) induced by the rabbit hemorrhagic disease virus (RHDV). This study was aimed to investigate whether melatonin prot...

journal_title：Journal of pineal research

authors： San-Miguel B,Crespo I,Vallejo D,Álvarez M,Prieto J,González-Gallego J,Tuñón MJ

更新日期：2014-04-01 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter/neuromodulator involved in cell-to-cell communication within the central nervous system, is now believed to play a role in neuroendocrine function. In this study we describe a single, saturable, stereospecific, and temperature-, time-, and pH-dependent binding site for glutama...

journal_title：Journal of pineal research

authors： Kus L,Handa RJ,McNulty JA

更新日期：1993-01-01 00:00:00

abstract：:Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression, and type 2 diabetes development. Melatonin receptors are approved drug targets for insomnia, non-24-hour sleep-wake disorders, and major depressive disorders. In mammal...

journal_title：Journal of pineal research

authors： Cecon E,Ivanova A,Luka M,Gbahou F,Friederich A,Guillaume JL,Keller P,Knoch K,Ahmad R,Delagrange P,Solimena M,Jockers R

更新日期：2019-03-01 00:00:00

abstract：:Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant. Among a great number of metabolites that have been tried before, only a few were found (cerulein and quinaldic acid in mice and kynurenic acid in rats). In SHR (bred from Swiss) male mice, intrac...

journal_title：Journal of pineal research

authors： Lapin IP,Mirzaev SM,Ryzov IV,Oxenkrug GF

更新日期：1998-05-01 00:00:00

abstract：:Melatonin has previously been shown to be neuroprotective in rodent models of ischemic stroke. Herein, we tested whether this antioxidant may also be suitable for prophylactic use against stroke. To clarify this issue, melatonin was administrated orally for 9 wk (4 mg/kg/day) in mice and its effects on subsequent inju...

journal_title：Journal of pineal research

authors： Kilic E,Kilic U,Reiter RJ,Bassetti CL,Hermann DM

更新日期：2004-11-01 00:00:00

abstract：:We tested the hypothesis that melatonin (Mel) enhances exogenous mitochondria (Mito) treatment against rodent hepatic ischemia-reperfusion (IR) injury. In vitro study utilized three groups of hepatocytes (i.e. nontreatment, menadione, and menadione-melatonin treatment, 4.0 × 10(5) each), while in vivo study used adult...

journal_title：Journal of pineal research

authors： Chen HH,Chen YT,Yang CC,Chen KH,Sung PH,Chiang HJ,Chen CH,Chua S,Chung SY,Chen YL,Huang TH,Kao GS,Chen SY,Lee MS,Yip HK

更新日期：2016-08-01 00:00:00

abstract：:In the current study, a fundamental question, that is, the mechanisms related to the beneficial effects of melatonin on mammalian embryonic development, was addressed. To examine the potential beneficial effects of melatonin on bovine embryonic development, different concentrations of melatonin (10(-11), 10(-9), 10(-7...

journal_title：Journal of pineal research

authors： Wang F,Tian X,Zhang L,Gao C,He C,Fu Y,Ji P,Li Y,Li N,Liu G

更新日期：2014-04-01 00:00:00

abstract：:The Syrian hamster pineal displays age-dependent changes in melatonin output measured in vitro. Between the ages of 4 and 19 days, pineal melatonin generation in response to 10 microM norepinephrine (NE) increased 34-fold. Production of melatonin by cultured pineals from 1-week-old hamsters showed a clear dose respons...

journal_title：Journal of pineal research

authors： Kaufman CM,Menaker M

更新日期：1991-10-01 00:00:00

abstract：:Lower global cognitive function scores are a common symptom of autism spectrum disorders (ASDs). This study investigates the effects of melatonin on hippocampal serine/threonine kinase signaling in an experimental ASD model. We found that chronic melatonin (1.0 or 5.0 mg/kg/day, 28 days) treatment significantly rescue...

journal_title：Journal of pineal research

authors： Tian Y,Yabuki Y,Moriguchi S,Fukunaga K,Mao PJ,Hong LJ,Lu YM,Wang R,Ahmed MM,Liao MH,Huang JY,Zhang RT,Zhou TY,Long S,Han F

更新日期：2014-01-01 00:00:00

abstract：:The purpose of the present studies using artificial light was to determine how the timing and duration of exposure influence the light-induced suppression of pineal melatonin levels in hamsters. An 8-min exposure to 0.186 microW/cm2 of cool white fluorescent light caused a continued depression of pineal melatonin even...

journal_title：Journal of pineal research

authors： Brainard GC,Richardson BA,Hurlbut EC,Steinlechner S,Matthews SA,Reiter RJ

更新日期：1984-01-01 00:00:00

abstract：:In desert areas, mammals such as camel and goat are exposed to harsh environmental conditions. The ambient temperature (Ta) cycles have been shown to entrain the circadian clock in the camel. In the present work, we assumed that, in the goat living in a desert biotope, Ta cycles would have the same synchronizing effec...

journal_title：Journal of pineal research

authors： Farsi H,Harti D,Achaâban MR,Piro M,Raverot V,Bothorel B,Ouassat M,Challet E,Pévet P,El Allali K

更新日期：2020-04-01 00:00:00

abstract：:The aim of this study was to evaluate the effect of the topical application of melatonin on osteointegration of dental implants in Beagle dogs 14 days after their insertion. In preparation for subsequent insertion of dental implants, upper and lower premolars and molars were extracted from 12 Beagle dogs. Each mandibl...

journal_title：Journal of pineal research

authors： Cutando A,Gómez-Moreno G,Arana C,Muñoz F,Lopez-Peña M,Stephenson J,Reiter RJ

更新日期：2008-09-01 00:00:00

abstract：:Previous studies have identified and characterized D1- and D2-dopamine receptors in bovine pineal glands. The data indicate that the density of D1-dopamine receptors (974 fmol/mg protein) far exceed that of D2-dopamine receptors (37 fmol/mg protein). The objective of this study was to identify the mRNAs for both D1- a...

journal_title：Journal of pineal research

authors： Santanavanich C,Chetsawang B,Ebadi M,Govitrapong P

更新日期：2003-10-01 00:00:00