Melatonin effect on arachidonic acid metabolism to cyclooxygenase derivatives in human platelets.

abstract：:The binding characteristics of the tritiated pineal hormone, [3H] melatonin, were studied in brain tissues using in vitro binding techniques. In synaptosomal membranes prepared from rat hippocampus and subjected to preincubation at 37 degrees C and multiple washings, high-affinity binding of [3H] melatonin significant...

journal_title：Journal of pineal research

authors： Niles LP

更新日期：1987-01-01 00:00:00

abstract：:We evaluated the antioxidant property of melatonin as it relates to the vasospastic effect of hydrogen peroxide (H2O2) on the human umbilical artery. Helical sections of umbilical arteries were obtained from healthy pregnant women who were delivered between weeks 37 and 39 of gestation. Changes in maximal potassium ch...

journal_title：Journal of pineal research

authors： Okatani Y,Watanabe K,Hayashi K,Wakatsuki A,Sagara Y

更新日期：1997-04-01 00:00:00

abstract：:Cell movement is generated by a driving force provided by dynamic cytoskeletal organization. Two main cytoskeletal-dependent features, essential for migration, are the highly cell polarized structure and focal adhesion complexes. Cell migration and substrate anchorage are finely regulated by external signaling exerted...

journal_title：Journal of pineal research

authors： Ortíz-López L,Morales-Mulia S,Ramírez-Rodríguez G,Benítez-King G

更新日期：2009-01-01 00:00:00

abstract：:Optic atrophy 1 (OPA1)-related mitochondrial fusion and mitophagy are vital to sustain mitochondrial homeostasis under stress conditions. However, no study has confirmed whether OPA1-related mitochondrial fusion/mitophagy is activated by melatonin and, consequently, attenuates cardiomyocyte death and mitochondrial str...

journal_title：Journal of pineal research

authors： Zhang Y,Wang Y,Xu J,Tian F,Hu S,Chen Y,Fu Z

更新日期：2019-03-01 00:00:00

abstract：:There is substantial evidence that magnetic field (MF) exposure influences melatonin secretion in animals. However, data on its influence on human melatonin levels are scarce, and seemingly contradictory. Because of its many beneficial effects, very low-frequency MF exposure is used in physiotherapy of some neurologic...

journal_title：Journal of pineal research

authors： Karasek M,Czernicki J,Woldanska-Okonska M,Zylinska K,Swietoslawski J

更新日期：2000-09-01 00:00:00

abstract：:Djungarian hamsters kept in long photoperiod (16:8 L:D) were injected daily at 0800, 1200, or 1600 with 25 micrograms of melatonin. During 90 days of treatment, body weight and fur coloration were checked at weekly intervals, and at the end of the treatment the reproductive status of the hamsters and their thermoregul...

journal_title：Journal of pineal research

authors： Holtorf AP,Heldmaier G,Thiele G,Steinlechner S

更新日期：1985-01-01 00:00:00

abstract：:Lethal oxidative stress was investigated in the dinoflagellate Gonyaulax polyedra by measuring the dying-peak of bioluminescence during circadian phases of low physiological light emission, low bioluminescence capacity, and low sensitivity to stimulatory agents. Measurements were carried out in constant darkness after...

journal_title：Journal of pineal research

authors： Antolín I,Obst B,Burkhardt S,Hardeland R

更新日期：1997-11-01 00:00:00

abstract：:Melatonin and somatostatin are known to exert similar effects on locomotor activity. We have previously demonstrated that acute melatonin treatment regulates somatostatin receptor function in the rat frontoparietal cortex. However, the effects of subchronic and chronic melatonin treatment on the somatostatin receptor-...

journal_title：Journal of pineal research

authors： Izquierdo-Claros RM,Boyano-Adánez Mdel C,Arilla-Ferreiro E

更新日期：2002-11-01 00:00:00

abstract：:Rabbitfish are a restricted lunar-synchronized spawner that spawns around a species-specific lunar phase. It is not known how the fish perceive changes in cues from the moon. One possible explanation is that rabbitfish utilize changes in moonlight intensity to establish synchrony. The purpose of the present study was ...

journal_title：Journal of pineal research

authors： Takemura A,Ueda S,Hiyakawa N,Nikaido Y

更新日期：2006-04-01 00:00:00

abstract：:In the current study, a fundamental question, that is, the mechanisms related to the beneficial effects of melatonin on mammalian embryonic development, was addressed. To examine the potential beneficial effects of melatonin on bovine embryonic development, different concentrations of melatonin (10(-11), 10(-9), 10(-7...

journal_title：Journal of pineal research

authors： Wang F,Tian X,Zhang L,Gao C,He C,Fu Y,Ji P,Li Y,Li N,Liu G

更新日期：2014-04-01 00:00:00

abstract：:Impaired Ca2+ homeostasis and smooth muscle contractility co-exist in acute cholecystitis (AC) leading to gallbladder dysfunction. There is no pharmacological treatment for this pathological condition. Our aim was to evaluate the effects of melatonin treatment on Ca2+ signaling pathways and contractility altered by ch...

journal_title：Journal of pineal research

authors： Gomez-Pinilla PJ,Camello PJ,Pozo MJ

更新日期：2008-04-01 00:00:00

abstract：:While ectopic overexpression of serotonin N-acetyltransferase (SNAT) in plants has been accomplished using animal SNAT genes, ectopic overexpression of plant SNAT genes in plants has not been investigated. Because the plant SNAT protein differs from that of animals in its subcellular localization and enzyme kinetics, ...

journal_title：Journal of pineal research

authors： Lee K,Back K

更新日期：2017-04-01 00:00:00

abstract：:The presence of melatonin and the enzymes (transcripts and activities) involved in its synthesis, i.e. arylalkylamine N-acetyltransferase (AA-NAT) and hydroxyindole-O-methyltransferase (HIOMT), was investigated in the eggs and early embryos of Japanese quail at Hamburger-Hamilton stages 1-10. Melatonin was present in ...

journal_title：Journal of pineal research

authors： Olszańska B,Majewski P,Lewczuk B,Stepińska U

更新日期：2007-04-01 00:00:00

abstract：:Although there is an increasing evidence that the pineal gland may play a role in human malignancy, the studies on melatonin concentrations in different types of malignant tumors brought about controversial results. However, changes in melatonin concentrations have been observed in some types of human malignant tumors...

journal_title：Journal of pineal research

authors： Karasek M,Kowalski AJ,Suzin J,Zylinska K,Swietoslawski J

更新日期：2005-08-01 00:00:00

abstract：:Melatonin possesses a number of important biologic activities including oncostatic, anti-oxidant, and immunostimulatory actions. This study was designed to assess the effects of melatonin on inflammation-related gene expression in lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs), us...

journal_title：Journal of pineal research

authors： Park HJ,Kim HJ,Ra J,Hong SJ,Baik HH,Park HK,Yim SV,Nah SS,Cho JJ,Chung JH

更新日期：2007-09-01 00:00:00

abstract：:Irradiation of the melatonin metabolite N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) with UV light of 254 nm causes the release of carbon monoxide (CO) and, thus, deformylation to N(1)-acetyl-5-methoxykynuramine (AMK). Liberation of CO was demonstrated by reduction of PdCl(2) to metallic palladium, under avoidan...

journal_title：Journal of pineal research

authors： Seever K,Hardeland R

更新日期：2008-05-01 00:00:00

abstract：:N-acetylserotonin methyltransferase (ASMT), the last enzyme in the synthesis of melatonin, catalyzes N-acetylserotonin into melatonin. For the first time, we cloned ASMT from rice through the analysis of recombinant Escherichia coli harboring putative rice O-methyltransferase (OMT) cDNAs. In total, 18 full-length cDNA...

journal_title：Journal of pineal research

authors： Kang K,Kong K,Park S,Natsagdorj U,Kim YS,Back K

更新日期：2011-04-01 00:00:00

abstract：:Experiments were designed to test the hypothesis that the pineal gland mediates the effects of changing day length and thereby synchronizes implantation within the population of spotted skunks. Intact, sham-superior cervical ganglionectomized (SCGx), SCGx, and SCGx/bilateral orbitally enucleated (B1) pregnant skunks w...

journal_title：Journal of pineal research

authors： May R,Mead RA

更新日期：1986-01-01 00:00:00

abstract：:Carbon tetrachloride (CCl4) exerts its toxic effects by the generation of free radicals. In this study we investigated whether melatonin, a potent free radical scavenger, could prevent the deleterious effects of CCl4. Liver homogenates and liver microsomes were incubated with CCl4 in the presence of melatonin and lipi...

journal_title：Journal of pineal research

authors： Daniels WM,Reiter RJ,Melchiorri D,Sewerynek E,Pablos MI,Ortiz GG

更新日期：1995-08-01 00:00:00

abstract：:Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality. There have been no material advances in the treatment of preeclampsia for nearly 50 years. Combining in vitro studies and a clinical trial, we aimed to determine whether melatonin could be a useful adjuvant therapy. In a xanthine/x...

journal_title：Journal of pineal research

authors： Hobson SR,Gurusinghe S,Lim R,Alers NO,Miller SL,Kingdom JC,Wallace EM

更新日期：2018-10-01 00:00:00

abstract：:Melatonin is found in a wide variety of plant species. Several investigators have studied the physiological roles of melatonin in plants. However, its role is not well understood because of the limited information on its biosynthetic pathway. To clarify melatonin biosynthesis in plants, we isolated a cDNA-coded arylal...

journal_title：Journal of pineal research

authors： Okazaki M,Higuchi K,Hanawa Y,Shiraiwa Y,Ezura H

更新日期：2009-05-01 00:00:00

abstract：:The known neuroprotective actions of melatonin could be due to its antioxidant or radical scavenging activity, or they could be due to specific interactions of the indole with its receptors. A study of structure-activity relationships may provide useful information when a validated macromolecular target has not been (...

journal_title：Journal of pineal research

authors： Mor M,Silva C,Vacondio F,Plazzi PV,Bertoni S,Spadoni G,Diamantini G,Bedini A,Tarzia G,Zusso M,Franceschini D,Giusti P

更新日期：2004-03-01 00:00:00

abstract：:Malaria, which infects more than 300 million people annually, is a serious disease. Epidemiological surveys indicate that of those who are affected, malaria will claim the lives of more than one million individuals, mostly children. There is evidence that the synchronous maturation of Plasmodium falciparum, the parasi...

journal_title：Journal of pineal research

authors： Srinivasan V,Spence DW,Moscovitch A,Pandi-Perumal SR,Trakht I,Brown GM,Cardinali DP

更新日期：2010-01-01 00:00:00

abstract：:Early studies on the physiological effects of melatonin typically reported hypnotic 'side-effects'. Later studies, specifically addressing this action, failed to reliably replicate hypnotic effects using standard polysomnography. This difference may be related to differences in the basic physiological action of melato...

journal_title：Journal of pineal research

authors： Dawson D,Encel N

更新日期：1993-08-01 00:00:00

abstract：:A review of the literature indicates that the absolute oral bioavailability of exogenous melatonin in humans or in preclinical animal models has not been adequately characterized; hence, this study was undertaken. Pharmacokinetics of melatonin was studied in rats, dogs, and monkeys following intravenous and oral admin...

journal_title：Journal of pineal research

authors： Yeleswaram K,McLaughlin LG,Knipe JO,Schabdach D

更新日期：1997-01-01 00:00:00

abstract：:Senescence-accelerated mice (SAMP8) and senescence-accelerated resistant mice (SAMR1) were studied at 5 and 10 months of age, respectively. In the animals, neurodegenerative processes and how they were influenced by melatonin were examined. Melatonin (10 mg/kg) or vehicle (ethanol at 0.066%) treatments were administra...

journal_title：Journal of pineal research

authors： Caballero B,Vega-Naredo I,Sierra V,Huidobro-Fernández C,Soria-Valles C,De Gonzalo-Calvo D,Tolivia D,Gutierrez-Cuesta J,Pallas M,Camins A,Rodríguez-Colunga MJ,Coto-Montes A

更新日期：2008-10-01 00:00:00

abstract：:The effect of melatonin was evaluated on three phosphatidylcholine-based membrane models. Changes in liposome dynamics were monitored by fluorescence, following the response of the probe merocyanine-540, as well as by differential scanning calorimetry (DSC). Langmuir monolayers were investigated using molecular area m...

journal_title：Journal of pineal research

authors： de Lima VR,Caro MS,Munford ML,Desbat B,Dufourc E,Pasa AA,Creczynski-Pasa TB

更新日期：2010-09-01 00:00:00

abstract：:This study examined the factors that may be involved in altering the function of pineal gland in hypoxic conditions. Adult Wistar rats were subjected to hypoxia and the pineal gland was examined for the mRNA and protein expression of hypoxia-inducible factor-1alpha (HIF-1alpha), vascular endothelial growth factor (VEG...

journal_title：Journal of pineal research

authors： Kaur C,Sivakumar V,Lu J,Ling EA

更新日期：2007-04-01 00:00:00

abstract：:Melatonin secretion is an endogenous synchronizer, and it may possess some anti-aging properties. Thus we examined melatonin levels in physiological aging, in extreme senescence and in senile dementia. In healthy old (age 66-94 yr) and young subjects (age 23-39 yr) and in demented patients (age 68-91 yr) plasma melato...

journal_title：Journal of pineal research

authors： Magri F,Sarra S,Cinchetti W,Guazzoni V,Fioravanti M,Cravello L,Ferrari E

更新日期：2004-05-01 00:00:00

abstract：:Previously it has been found that pinealectomy in rats was associated with increased small bowel crypt cell proliferation. The hypothalamus is thought to play a role in the neural control of crypt cell proliferation and the pineal gland is known to be functionally connected with this component of the autonomic nervous...

journal_title：Journal of pineal research

authors： Callaghan BD

更新日期：1991-01-01 00:00:00