Serum melatonin circadian profiles in women suffering from cervical cancer.

abstract：:We previously reported that pharmacological melatonin administration to type 2 diabetic rats reduces hyperinsulinemia and improves the altered fatty-acid metabolism. To determine whether melatonin deficiency exacerbates diabetes-associated conditions, we investigated the effect of pinealectomy (i.e. melatonin-deficien...

journal_title：Journal of pineal research

authors： Nishida S,Sato R,Murai I,Nakagawa S

更新日期：2003-11-01 00:00:00

abstract：:Incorporation of new therapeutic agents remains as a major challenge for treatment of patients with malignant haematological disorders. Melatonin is an indolamine without relevant side effects. It has been shown previously to exhibit synergism with several chemotherapeutic drugs in Ewing sarcoma cells by potentiating ...

journal_title：Journal of pineal research

authors： Casado-Zapico S,Martín V,García-Santos G,Rodríguez-Blanco J,Sánchez-Sánchez AM,Luño E,Suárez C,García-Pedrero JM,Menendez ST,Antolín I,Rodriguez C

更新日期：2011-04-01 00:00:00

abstract：:The role played by postsynaptic alpha-adrenergic receptors in the stimulation of pineal melatonin production was investigated in the Syrian hamster. The studies were conducted using organ cultured pineal glands collected from both anatomically intact and superior cervical ganglionectomized hamsters. Results obtained i...

journal_title：Journal of pineal research

authors： Santana C,Guerrero JM,Reiter RJ,Menendez-Pelaez A

更新日期：1989-01-01 00:00:00

abstract：:Melatonin is a powerful antioxidant and free radical scavenger. A large body of in vivo and in vitro evidence shows that melatonin effectively inhibits membrane lipid peroxidation; this damage was based on the measurement of malondialdehyde and/or 4-hydroxynonenal levels. In the current study, for the first time using...

journal_title：Journal of pineal research

authors： Zhang L,Wei W,Xu J,Min F,Wang L,Wang X,Cao S,Tan DX,Qi W,Reiter RJ

更新日期：2006-05-01 00:00:00

abstract：:Djungarian hamsters kept in long photoperiod (16:8 L:D) were injected daily at 0800, 1200, or 1600 with 25 micrograms of melatonin. During 90 days of treatment, body weight and fur coloration were checked at weekly intervals, and at the end of the treatment the reproductive status of the hamsters and their thermoregul...

journal_title：Journal of pineal research

authors： Holtorf AP,Heldmaier G,Thiele G,Steinlechner S

更新日期：1985-01-01 00:00:00

abstract：:Previous studies proved that melatonin protected against secondary brain damage by modulating oxidative stress after experimental subarachnoid hemorrhage (SAH), but it has not been evaluated yet about its effects on inflammatory pathway and secondary cognitive dysfunction in SAH model. This study was undertaken to eva...

journal_title：Journal of pineal research

authors： Wang Z,Wu L,You W,Ji C,Chen G

更新日期：2013-11-01 00:00:00

abstract：:The known neuroprotective actions of melatonin could be due to its antioxidant or radical scavenging activity, or they could be due to specific interactions of the indole with its receptors. A study of structure-activity relationships may provide useful information when a validated macromolecular target has not been (...

journal_title：Journal of pineal research

authors： Mor M,Silva C,Vacondio F,Plazzi PV,Bertoni S,Spadoni G,Diamantini G,Bedini A,Tarzia G,Zusso M,Franceschini D,Giusti P

更新日期：2004-03-01 00:00:00

abstract：:Melatonin, an endogenous neurohormone secreted by the pineal gland, has a variety of physiological functions and neuroprotective effects. However, its protective role on the neural tube defects (NTDs) was not very clear. The aim of this study was to investigate the effects of melatonin on the incidence of NTDs (includ...

journal_title：Journal of pineal research

authors： Liu S,Guo Y,Yuan Q,Pan Y,Wang L,Liu Q,Wang F,Wang J,Hao A

更新日期：2015-11-01 00:00:00

abstract：:Maternal hyperthermia induces early embryonic death via increased oxidative stress to the embryo. In this study, we examined whether melatonin administered to heat-stressed pregnant mice would reduce hyperthermia-induced embryonic death. Mice were heat stressed (12 hr at 35 degrees C, 60% relative humidity) on the day...

journal_title：Journal of pineal research

authors： Matsuzuka T,Sakamoto N,Ozawa M,Ushitani A,Hirabayashi M,Kanai Y

更新日期：2005-10-01 00:00:00

abstract：:Atherosclerosis (AS) is an inflammatory disease linked to endothelial dysfunction. Melatonin is reported to possess substantial anti-inflammatory properties, which has proven to be effective in AS. Emerging literature suggests that pyroptosis plays a critical role during AS progression. However, whether pyroptosis con...

journal_title：Journal of pineal research

authors： Zhang Y,Liu X,Bai X,Lin Y,Li Z,Fu J,Li M,Zhao T,Yang H,Xu R,Li J,Ju J,Cai B,Xu C,Yang B

更新日期：2018-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers and its incidence is increasing worldwide. Melatonin, an indoleamine hormone, exerts anti-oxidant, immunomodulatory, anti-aging, and antitumor effects. Previous studies have shown that melatonin can act through specific receptors, including MT(1), MT(2),...

journal_title：Journal of pineal research

authors： Carbajo-Pescador S,Martín-Renedo J,García-Palomo A,Tuñón MJ,Mauriz JL,González-Gallego J

更新日期：2009-11-01 00:00:00

abstract：:Melatonin, a potent antioxidant, has shown to be beneficial in murine Venezuelan equine encephalomyelitis (VEE) virus infection. In addition, melatonin can induces the production of interleukin-1 beta (IL-1beta), a cytokine capable of inducing increased expression of inducible nitric oxide synthase; the activity of th...

journal_title：Journal of pineal research

authors： Valero N,MarinaEspina L,Bonilla E,Mosquera J

更新日期：2007-03-01 00:00:00

abstract：:We examined the effects of a single 2.5-mg dose of melatonin on the thermoregulatory and circulatory responses to intermittent exercise at a room temperature of 27.2+/-0.4 degrees C (mean+/-S.D.), a relative humidity of 55+/-3% (mean+/-S.D.), and a light intensity of 200-300 lux. In a double-blind cross-over study, si...

journal_title：Journal of pineal research

authors： Atkinson G,Holder A,Robertson C,Gant N,Drust B,Reilly T,Waterhouse J

更新日期：2005-11-01 00:00:00

abstract：:Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent antioxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA), are one of the hepatokines and are known to be asso...

journal_title：Journal of pineal research

authors： Heo JI,Yoon DW,Yu JH,Kim NH,Yoo HJ,Seo JA,Kim SG,Choi KM,Baik SH,Choi DS,Kim NH

更新日期：2018-09-01 00:00:00

abstract：:Previous research has shown that antioxidant (butylated hydroxyanisole) treatment ameliorates respiratory syncytial virus (RSV)-induced disease and lung inflammation. Melatonin has been reported to exhibit a wide varieties of biological effects, including antioxidant and anti-inflammation, and has no evident toxicity ...

journal_title：Journal of pineal research

authors： Huang SH,Cao XJ,Liu W,Shi XY,Wei W

更新日期：2010-03-01 00:00:00

abstract：:The objective of this study was to apply the radioimmunoassay for 6-sulphatoxymelatonin (aMT6s) to rat urine, and use it to study the source of aMT6s. The radioimmunoassay was found to have acceptable within- and between-assay variation, excellent specificity, and good parallelism between the standard and unknown. Bec...

journal_title：Journal of pineal research

authors： Brown GM,Bar-Or A,Grossi D,Kashur S,Johannson E,Yie SM

更新日期：1991-04-01 00:00:00

abstract：:Excessive production of nitric oxide (NO) may play a detrimental role in the process of hypoxia-related neuropathology. This study explored whether treatment with melatonin would attenuate the neuropathological changes in the vagal ganglia following a severe hypoxic insult. Thirty minutes prior to hypoxia treatment, y...

journal_title：Journal of pineal research

authors： Chang HM,Ling EA,Chen CF,Lue H,Wen CY,Shieh JY

更新日期：2002-03-01 00:00:00

abstract：:In three separate experiments, the effect of acute exposure to either artificial or natural light during darkness of pineal N-acetyltransferase (NAT) activity and melatonin content was studied in the cotton rat (Sigmodon hispidus). The exposure of animals to an artificial-light irradiance of 160,000 microW/cm2 during ...

journal_title：Journal of pineal research

authors： Nürnberger F,Joshi BN,Heinzeller T,Milin J,Reiter RJ

更新日期：1985-01-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC), a disease common in the South-East Asian population, has high lymph node metastatic ability. Melatonin, an endogenously produced substance present in animals, plants, fungi, and bacteria, has oncostatic activity via several mechanisms. The molecular mechanisms involved in melatonin-medi...

journal_title：Journal of pineal research

authors： Ho HY,Lin CW,Chien MH,Reiter RJ,Su SC,Hsieh YH,Yang SF

更新日期：2016-11-01 00:00:00

abstract：:N-[2-(6-methoxyquinazolin-4-yl)-ethyl] acetamide (MQA) is a compound formed from the melatonin metabolite N(1)-acetyl-5-methoxykynuramine (AMK). We followed MQA production in reaction systems containing various putative reaction partners, in the absence and presence of hydrogen peroxide and/or copper(II). Although MQA...

journal_title：Journal of pineal research

authors： Kuesel JT,Hardeland R,Pfoertner H,Aeckerle N

更新日期：2010-01-01 00:00:00

abstract：:GPR50 is an orphan seven transmembrane protein related to the melatonin receptor subfamily comprising MT(1) and MT(2) receptors. In the absence of any known ligand for GPR50, other tools are critical for the characterization of this protein. Here, we describe the generation, purification and characterization of the fi...

journal_title：Journal of pineal research

authors： Hamouda HO,Chen P,Levoye A,Sözer-Topçular N,Daulat AM,Guillaume JL,Ravid R,Savaskan E,Ferry G,Boutin JA,Delagrange P,Jockers R,Maurice P

更新日期：2007-08-01 00:00:00

abstract：:Melatonin, the major secretory product of the pineal gland, is in focus of many research areas because of its ability to scavenge free oxygen radicals and thereby protect cells and tissues from radical damage. Some studies suggest melatonin may be a possible therapeutic agent with potential clinical applications again...

journal_title：Journal of pineal research

authors： Hermann R,Podhajsky S,Jungnickel S,Lerchl A

更新日期：2002-08-01 00:00:00

abstract：:The effects of housing condition and type of stimulation on serum melatonin and N-acetylserotonin (NAS) were investigated. Male rats were housed under a 12/12-hour light-dark cycle, with ad libitum food and water, either individually or in groups of four. At the start of the light phase, separate groups were sacrifice...

journal_title：Journal of pineal research

authors： Seggie J,Campbell L,Brown GM,Grota LJ

更新日期：1985-01-01 00:00:00

abstract：:Melatonin protects cells against various types of oxidative stress-induced apoptosis due primarily to its ability to effectively scavenge pathological and disease condition-augmented generation of mitochondrial reactive oxygen species (mROS). Once produced, mROS indiscriminately damage mitochondrial components and mor...

journal_title：Journal of pineal research

authors： Jou MJ,Peng TI,Hsu LF,Jou SB,Reiter RJ,Yang CM,Chiao CC,Lin YF,Chen CC

更新日期：2010-01-01 00:00:00

abstract：:Day and nighttime melatonin production in the pineal gland was compared in normal and cardiomyopathic (polydystrophic) adult male Syrian hamsters. These strains of hamsters were selected for comparison because the cardiomyopathetic hamster displays a deficient transmembrane Ca(2+)-pump in a number of tissues, and intr...

journal_title：Journal of pineal research

authors： Reiter RJ,White T,Lerchl A,Stokkan KA,Rodriguez C

更新日期：1991-10-01 00:00:00

abstract：:The effect of daily injection of the pineal hormone melatonin and naltrexone, an opioid antagonist, on the circadian rhythm and the level of immune parameters (plaque forming cell [PFC] number, serum agglutinin titer, lymphoid gland weight, total white blood cells (WBC) and their fraction number, and serum lysozyme [L...

journal_title：Journal of pineal research

authors： Skwarło-Sońta K,Thaela MJ,Midura M,Lech B,Głuchowska B,Drela N,Kozłowska E,Kowalczyk R

更新日期：1992-01-01 00:00:00

abstract：:The effects of noradrenergic and cholinergic receptor agonists on intracellular Ca2+ concentration ([Ca2+]i) in single dissociated rat pineal cells were investigated by microfluorimetric measurements in Fura-2 acetoxymethyl ester (Fura-2/AM) loaded cells. Noradrenaline (NA) evoked characteristic biphasic increments of...

journal_title：Journal of pineal research

authors： Marín A,Ureña J,Tabares L

更新日期：1996-08-01 00:00:00

abstract：:Melatonin regulates mitogen-activated protein kinase (MAPK) and Akt signaling pathways. The MAPK family mainly includes extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK). Our previous study documented that melatonin delays osteoblast proliferation; however, the mechanism of action of ...

journal_title：Journal of pineal research

authors： Liu L,Zhu Y,Xu Y,Reiter RJ

更新日期：2012-08-01 00:00:00

abstract：:The circadian system comprises several peripheral oscillators and a central rhythm generator that, in mammals, is located in the suprachiasmatic nucleus of the hypothalamus. Expression of clock genes is a characteristic feature of the central rhythm generator and the peripheral oscillators. With regard to the rhythmic...

journal_title：Journal of pineal research

authors： Torres-Farfan C,Serón-Ferré M,Dinet V,Korf HW

更新日期：2006-01-01 00:00:00

abstract：:Experiments were conducted to determine whether daily melatonin injections could influence reentrainment of circadian locomotor activity rhythms in male Long-Evans rats after phase shifts of the light dark (LD) cycle. When exposed to a 5-h advance of the LD cycle, six out of 15 rats injected daily with melatonin at th...

journal_title：Journal of pineal research

authors： Redman JR,Armstrong SM

更新日期：1988-01-01 00:00:00