Immunohistochemical studies on the coexistence of catecholamine-synthesizing enzymes and neuropeptide Y in nerve fibers of the porcine pineal gland.

abstract：:We investigated the role of melatonin on water avoidance stress (WAS)-induced degeneration of the gastric, ileal and colonic mucosa. Wistar albino rats were exposed to acute WAS (aWAS group) or chronic WAS (cWAS group). Before exposing animals to acute (aWAS + mel group) or chronic WAS (cWAS + mel group), 10 mg/kg mel...

journal_title：Journal of pineal research

authors： Ercan F,Cetinel S,Contuk G,Cikler E,Sener G

更新日期：2004-09-01 00:00:00

abstract：:Adult female golden hamsters were used to study the effect of short photoperiod on the endogenous opioid system and the effect of pinealectomy on the serum beta-endorphin-like immunoreactivity (beta-end LI) levels. Hamsters were housed under either long photoperiod (14L:10D) or short photoperiod (2L:22D) and the regul...

journal_title：Journal of pineal research

authors： Kumar MS,Besch EL,Millard WJ,Sharp DC,Leadem CA

更新日期：1984-01-01 00:00:00

abstract：:The influence of the pineal gland on the histopathologic changes induced in mammary glands by 7, 12-dimethylbenz(a)-anthracene (DMBA) has been studied. To achieve the maximum expression of pineal action in animals, 28-day-old female Sprague-Dawley rats were subjected to one of the following treatments: blindness + olf...

journal_title：Journal of pineal research

authors： Cos S,Garijo F,Corral J,Mediavilla MD,Sánchez-Barceló EJ

更新日期：1989-01-01 00:00:00

abstract：:Experiments were conducted to determine whether daily melatonin injections could influence reentrainment of circadian locomotor activity rhythms in male Long-Evans rats after phase shifts of the light dark (LD) cycle. When exposed to a 5-h advance of the LD cycle, six out of 15 rats injected daily with melatonin at th...

journal_title：Journal of pineal research

authors： Redman JR,Armstrong SM

更新日期：1988-01-01 00:00:00

abstract：:Melatonin, a major pineal secretory product, exerts a range of physiological and neuroprotective effects. However, the functional significance of melatonin in determining neural identity, and the mechanisms by which this may occur, is unknown. In this study, P19 cells were used as a model system and cell behavior was ...

journal_title：Journal of pineal research

authors： Chen X,Li X,Du Z,Shi W,Yao Y,Wang C,He K,Hao A

更新日期：2014-09-01 00:00:00

abstract：:Grapes are an important economic crop and are widely cultivated around the world. Most grapes are grown in arid or semi-arid regions, and droughts take a heavy toll in grape and wine production areas. Developing effective drought-resistant cultivation measures is a priority for viticulture. Melatonin, an indoleamine, ...

journal_title：Journal of pineal research

authors： Meng JF,Xu TF,Wang ZZ,Fang YL,Xi ZM,Zhang ZW

更新日期：2014-09-01 00:00:00

abstract：:Cardiac tissue loss is one of the most important factors leading to the unsatisfactory recovery even after treatment of ischemic heart disease. Melatonin, a circadian molecule with marked antioxidant properties, protects against ischemia-reperfusion (IR) injury. In particular, the myocardial protection of melatonin is...

journal_title：Journal of pineal research

authors： Yang Y,Sun Y,Yi W,Li Y,Fan C,Xin Z,Jiang S,Di S,Qu Y,Reiter RJ,Yi D

更新日期：2014-11-01 00:00:00

abstract：:We studied the role of nocturnal illuminance as a possible regulatory factor in the production and secretion of reproductive hormones. Adult male rats were kept under artificial lighting conditions (LD 12/12 hours) where the daily illuminance was 520-550 lx and the nocturnal illuminance 0, less than 0.1, or 1-1.5 lx. ...

journal_title：Journal of pineal research

authors： Laakso ML,Porkka-Heiskanen T,Alila A,Kajander S,Stenberg D,Johansson G

更新日期：1989-01-01 00:00:00

abstract：:Melatonin has been identified in primitive photosynthetic bacteria, fungi, plants, and animals including humans. Vegetables, fruits, cereals, wine, and beers all contain melatonin. However, the melatonin content in meats has not been reported previously. Here, for the first time, we report melatonin in meats, eggs, co...

journal_title：Journal of pineal research

authors： Tan DX,Zanghi BM,Manchester LC,Reiter RJ

更新日期：2014-09-01 00:00:00

abstract：:The age-related changes and the acute effects of intravenous melatonin on the activity of striatal neurons of 1-, 3-, 6-, 12-, and 18-month-old sham-operated and pinealectomized rats were investigated. There was a decline in responsiveness from 3- to 18-months of age, although in sham-pinealectomized rats the response...

journal_title：Journal of pineal research

authors： Castillo-Romero JL,Acuña-Castroviejo D,Escamaes G,Vives F

更新日期：1995-09-01 00:00:00

abstract：:Melatonin and its precursor, l-tryptophan, have been shown to exert gastroprotective effects in animals, but their influence on the gastric damage by aspirin (ASA) in humans has been sparingly investigated. In this study, we designed to determine the effects of melatonin and l-tryptophan on ASA-induced gastric mucosal...

journal_title：Journal of pineal research

authors： Konturek PC,Konturek SJ,Celinski K,Slomka M,Cichoz-Lach H,Bielanski W,Reiter RJ

更新日期：2010-05-01 00:00:00

abstract：:Our objective was to evaluate the maternal-fetal transfer of melatonin in pregnant women. Serum melatonin concentration was measured by high-performance liquid chromatography with electrochemical detection in a maternal vein and in the umbilical artery and umbilical vein at the time of birth. Blood samples were obtain...

journal_title：Journal of pineal research

authors： Okatani Y,Okamoto K,Hayashi K,Wakatsuki A,Tamura S,Sagara Y

更新日期：1998-10-01 00:00:00

abstract：:We examined the association between 6-sulphatoxymelatonin (6-SMT) excretion and sleep in 68 volunteers 60-79 years of age who complained of insomnia or depression. An Actillume wrist monitor was worn for 5-7 consecutive days and nights in home-living conditions. Activity was used to estimate total sleep time (TST) and...

journal_title：Journal of pineal research

authors： Youngstedt SD,Kripke DF,Elliott JA

更新日期：1998-04-01 00:00:00

abstract：:Melatonin is known to regulate a variety of physiological processes including control of circadian rhythms, regulation of seasonal reproductive function, regulation of body temperature, and so forth. Accumulating evidence from in vitro and in vivo experiments using rodent and chicken has also suggested that melatonin ...

journal_title：Journal of pineal research

authors： Satomura K,Tobiume S,Tokuyama R,Yamasaki Y,Kudoh K,Maeda E,Nagayama M

更新日期：2007-04-01 00:00:00

abstract：:The effect on nocturnal melatonin secretion of acute administration of the indirectly acting serotonin (5-HT) receptor agonists d-fenfluramine (30 mg) and paroxetine (20 mg) and a partial 5-HT1A receptor agonist ipsapirone (20 mg) was investigated in healthy male volunteers and compared to a placebo condition. Each su...

journal_title：Journal of pineal research

authors： Nathan PJ,Norman TR,Burrows GD

更新日期：1996-09-01 00:00:00

abstract：:The milk-ejecting response of lactating mouse mammary gland tissue to ovine pineal extracts indicated the presence of a neurohormone-like bioactivity in this tissue. After successive fractionation on gel permeation chromatography and reversed-phase liquid chromatography (HPLC) in conjunction with radioimmunoassays (RI...

journal_title：Journal of pineal research

authors： Noteborn HP,Ebels I,Reinharz AC,Pévet P,Benson B,Salemink CA

更新日期：1988-01-01 00:00:00

abstract：:We tested the hypothesis that melatonin (Mel) enhances exogenous mitochondria (Mito) treatment against rodent hepatic ischemia-reperfusion (IR) injury. In vitro study utilized three groups of hepatocytes (i.e. nontreatment, menadione, and menadione-melatonin treatment, 4.0 × 10(5) each), while in vivo study used adult...

journal_title：Journal of pineal research

authors： Chen HH,Chen YT,Yang CC,Chen KH,Sung PH,Chiang HJ,Chen CH,Chua S,Chung SY,Chen YL,Huang TH,Kao GS,Chen SY,Lee MS,Yip HK

更新日期：2016-08-01 00:00:00

abstract：:The role of antioxidants in reducing cancer initiation and progression has been highlighted in recent years. Not only antioxidants limit cancer cell growth but also, in some situations, they promote the effectiveness of conventional treatments. Melatonin, an endogenously synthesized antioxidant, reduces cell growth of...

journal_title：Journal of pineal research

authors： Sainz RM,Reiter RJ,Tan DX,Roldan F,Natarajan M,Quiros I,Hevia D,Rodriguez C,Mayo JC

更新日期：2008-10-01 00:00:00

abstract：:When organic compounds are irradiated with UV light at 254 nm, part of their covalent bonds can dissociate if the compound absorbs light at that wavelength. Therefore, photo-degradation depends strongly on the wavelength used. The energy of a light quanta at 254 nm amounts to approximately 110 kcal/mol quanta, which i...

journal_title：Journal of pineal research

authors： Brömme HJ,Peschke E,Israel G

更新日期：2008-05-01 00:00:00

abstract：:Environmental pollution in the form of particulate matter <2.5 μm (PM2.5 ) is a major risk factor for diseases such as lung cancer, chronic respiratory infections, and major cardiovascular diseases. Our goal was to show that PM2.5 eliciting a proinflammatory response activates the immune-pineal axis, reducing the pine...

journal_title：Journal of pineal research

authors： Carvalho-Sousa CE,Pereira EP,Kinker GS,Veras M,Ferreira ZS,Barbosa-Nunes FP,Martins JO,Saldiva PHN,Reiter RJ,Fernandes PA,da Silveira Cruz-Machado S,Markus RP

更新日期：2020-04-01 00:00:00

abstract：:The binding characteristics of the tritiated pineal hormone, [3H] melatonin, were studied in brain tissues using in vitro binding techniques. In synaptosomal membranes prepared from rat hippocampus and subjected to preincubation at 37 degrees C and multiple washings, high-affinity binding of [3H] melatonin significant...

journal_title：Journal of pineal research

authors： Niles LP

更新日期：1987-01-01 00:00:00

abstract：:N-nitrosomelatonin (NOMela) is well-known for its capabilities of transnitrosating nucleophiles such as thiols and ascorbate, thereby generating nitric oxide (NO)-releasing compounds. It is unknown, however, whether NOMela can be successfully applied as a precursor of NO in a complex biological environment like a cell...

journal_title：Journal of pineal research

authors： Berchner-Pfannschmidt U,Tug S,Trinidad B,Becker M,Oehme F,Flamme I,Fandrey J,Kirsch M

更新日期：2008-11-01 00:00:00

abstract：:The quantitative autoradiographic 2-[14C]deoxyglucose method was employed to map the metabolic activity of the superior cervical ganglion and the entire brain during unilateral electrical stimulation of the cervical sympathetic trunk in the urethane-anesthetized rat. Stimulation of the cervical sympathetic trunk incre...

journal_title：Journal of pineal research

authors： Ito M,Kadekaro M,Sokoloff L

更新日期：1988-01-01 00:00:00

abstract：:Melatonin has been proposed as a possible treatment for the deleterious effects of hypoxia/reoxygenation (H/R), such as autophagy, inflammation, and apoptosis. Pathological pregnancies, such as preeclampsia, are associated with placental H/R, and decreased placental melatonin synthesis as well as lower melatonin level...

journal_title：Journal of pineal research

authors： Sagrillo-Fagundes L,Assunção Salustiano EM,Ruano R,Markus RP,Vaillancourt C

更新日期：2018-11-01 00:00:00

abstract：:Rat pineal hydroxyindole-O-methyltransferase (HIOMT; EC 2.1.1.4) was purified by affinity chromatography using an S-adenosyl-L-homocysteine agarose column. This single-step procedure, which is rapid, simple, and applicable to small quantities of tissue, gave a large enrichment of a protein (Mr approximately 38,000) id...

journal_title：Journal of pineal research

authors： Sugden D,Voisin P,Klein DC

更新日期：1986-01-01 00:00:00

abstract：:The known neuroprotective actions of melatonin could be due to its antioxidant or radical scavenging activity, or they could be due to specific interactions of the indole with its receptors. A study of structure-activity relationships may provide useful information when a validated macromolecular target has not been (...

journal_title：Journal of pineal research

authors： Mor M,Silva C,Vacondio F,Plazzi PV,Bertoni S,Spadoni G,Diamantini G,Bedini A,Tarzia G,Zusso M,Franceschini D,Giusti P

更新日期：2004-03-01 00:00:00

abstract：:Four weeks of administration of melatonin mixed in the diet (5 mg/kg of food) significantly reduced the incidence of gastric ulcers in young pigs. In control and melatonin supplemented animals, significantly higher levels of melatonin were found in the stomach tissues as compared to jejunum, ileum, or colon. Pigs with...

journal_title：Journal of pineal research

authors： Bubenik GA,Ayles HL,Friendship RM,Brown GM,Ball RO

更新日期：1998-01-01 00:00:00

abstract：:Melatonin is part of the evolutionary conserved highly functional network in vertebrates. It plays a central role in the adaptative behavior of the animal to the environment, including entrainment of daily and annual physiological rhythms, reproductive behavior, food intake, locomotor activity, growth, and breeding pe...

journal_title：Journal of pineal research

authors： Lima-Cabello E,Díaz-Casado ME,Guerrero JA,Otalora BB,Escames G,López LC,Reiter RJ,Acuña-Castroviejo D

更新日期：2014-08-01 00:00:00

abstract：:Melatonin, a molecule produced in the pineal gland and retina of vertebrates, plays a major role in day-night circadian rhythms and other physiological processes, including the immune responses. Because little is known in this respect in fish, we have evaluated the in vivo role of melatonin in the main innate immune a...

journal_title：Journal of pineal research

authors： Cuesta A,Cerezuela R,Esteban MA,Meseguer J

更新日期：2008-08-01 00:00:00

abstract：:Glioblastoma stem-like cells (GSCs) displaying self-renewing and tumor-propagating capacity play a particularly important role in maintaining tumor growth, therapeutic resistance, and tumor recurrence. Therefore, new therapeutic strategies focusing on impairing GSC maintenance are urgently needed. Here, we used GSCs i...

journal_title：Journal of pineal research

authors： Chen X,Hao A,Li X,Du Z,Li H,Wang H,Yang H,Fang Z

更新日期：2016-09-01 00:00:00