Light-regulated melatonin biosynthesis in rice during the senescence process in detached leaves.

abstract：:Glioblastoma stem-like cells (GSCs) displaying self-renewing and tumor-propagating capacity play a particularly important role in maintaining tumor growth, therapeutic resistance, and tumor recurrence. Therefore, new therapeutic strategies focusing on impairing GSC maintenance are urgently needed. Here, we used GSCs i...

journal_title：Journal of pineal research

authors： Chen X,Hao A,Li X,Du Z,Li H,Wang H,Yang H,Fang Z

更新日期：2016-09-01 00:00:00

abstract：:The objective of this study was to apply the radioimmunoassay for 6-sulphatoxymelatonin (aMT6s) to rat urine, and use it to study the source of aMT6s. The radioimmunoassay was found to have acceptable within- and between-assay variation, excellent specificity, and good parallelism between the standard and unknown. Bec...

journal_title：Journal of pineal research

authors： Brown GM,Bar-Or A,Grossi D,Kashur S,Johannson E,Yie SM

更新日期：1991-04-01 00:00:00

abstract：:A study was carried out to determine the possible influence of melatonin on the proliferation of Kirkman-Robbins hepatoma cells in Syrian hamsters, both in vivo and in vitro. A highly significant inhibition of the proliferation of transplanted hepatoma cells was observed in vivo following melatonin administration (pro...

journal_title：Journal of pineal research

authors： Karasek M,Liberski P,Kunert-Radek J,Bartkowiak J

更新日期：1992-10-01 00:00:00

abstract：:UV radiation (UVR) induces serious structural and functional alterations in human skin leading to skin aging and carcinogenesis. Reactive oxygen species are key players in UVR-mediated photodamage and induce the DNA-base-oxidized, intermediate 8-hydroxy-2'-deoxyguanosine (8-OHdG). Herein, we report the protective acti...

journal_title：Journal of pineal research

authors： Fischer TW,Kleszczyński K,Hardkop LH,Kruse N,Zillikens D

更新日期：2013-04-01 00:00:00

abstract：:In chronically inflamed animals, adrenal hormones exert a positive control on the secretion of melatonin by the pineal gland. In this paper, the mechanism of corticosterone as a modulator of melatonin and N-acetylserotonin (NAS) was determined. Rat pineal glands in culture, stimulated for 5 hr with noradrenaline (10 n...

journal_title：Journal of pineal research

authors： Ferreira ZS,Fernandes PA,Duma D,Assreuy J,Avellar MC,Markus RP

更新日期：2005-04-01 00:00:00

abstract：:The quantitative autoradiographic 2-[14C]deoxyglucose method was employed to map the metabolic activity of the superior cervical ganglion and the entire brain during unilateral electrical stimulation of the cervical sympathetic trunk in the urethane-anesthetized rat. Stimulation of the cervical sympathetic trunk incre...

journal_title：Journal of pineal research

authors： Ito M,Kadekaro M,Sokoloff L

更新日期：1988-01-01 00:00:00

abstract：:During the past decade, a number of reports indicated that the mammalian pineal gland is magnetosensitive in terms of spatial orientation. This indication is based on observations that artificial alterations of the direction of the earth's magnetic field (MF) markedly decreased the gland's capability to synthesize mel...

journal_title：Journal of pineal research

authors： Lerchl A,Nonaka KO,Reiter RJ

更新日期：1991-04-01 00:00:00

abstract：:The purpose of this study was to evaluate the effect of melatonin on oxidative stress occurring in the brain after routine lobectomy neurosurgery procedures. Different concentrations of melatonin (5, 15 and 150 mg/kg) were administered 1 hr before lobectomy in a rodent surgical brain injury (SBI) model. Neurological o...

journal_title：Journal of pineal research

authors： Lee S,Jadhav V,Ayer RE,Rojas H,Hyong A,Lekic T,Tang J,Zhang JH

更新日期：2009-01-01 00:00:00

abstract：:Melatonin protects cells against various types of oxidative stress-induced apoptosis due primarily to its ability to effectively scavenge pathological and disease condition-augmented generation of mitochondrial reactive oxygen species (mROS). Once produced, mROS indiscriminately damage mitochondrial components and mor...

journal_title：Journal of pineal research

authors： Jou MJ,Peng TI,Hsu LF,Jou SB,Reiter RJ,Yang CM,Chiao CC,Lin YF,Chen CC

更新日期：2010-01-01 00:00:00

abstract：:The effect of melatonin injection on Freund's adjuvant-induced changes in levels and 24-hr rhythms of circulating ACTH, growth hormone (GH), prolactin (PRL), luteinizing hormone (LH), and insulin was assessed in rats. Animals received subcutaneous (s.c.) injections of melatonin (30 microg) or vehicle, 1 hr before ligh...

journal_title：Journal of pineal research

authors： Esquifino AI,Castrillón P,García-Bonacho M,Vara E,Cardinali DP

更新日期：1999-08-01 00:00:00

abstract：:In this study, the effect of melatonin on sodium arsenite (arsenite)-induced peripheral neurotoxicity was investigated using dorsal root ganglion (DRG) explants. After 24-hr incubation, arsenite (30 microm) consistently elevated the expression of heat shock protein 70 and haeme oxygenase-1, two well-known stress prote...

journal_title：Journal of pineal research

authors： Lin AM,Feng SF,Chao PL,Yang CH

更新日期：2009-01-01 00:00:00

abstract：:Cardiac tissue loss is one of the most important factors leading to the unsatisfactory recovery even after treatment of ischemic heart disease. Melatonin, a circadian molecule with marked antioxidant properties, protects against ischemia-reperfusion (IR) injury. In particular, the myocardial protection of melatonin is...

journal_title：Journal of pineal research

authors： Yang Y,Sun Y,Yi W,Li Y,Fan C,Xin Z,Jiang S,Di S,Qu Y,Reiter RJ,Yi D

更新日期：2014-11-01 00:00:00

abstract：:Lower global cognitive function scores are a common symptom of autism spectrum disorders (ASDs). This study investigates the effects of melatonin on hippocampal serine/threonine kinase signaling in an experimental ASD model. We found that chronic melatonin (1.0 or 5.0 mg/kg/day, 28 days) treatment significantly rescue...

journal_title：Journal of pineal research

authors： Tian Y,Yabuki Y,Moriguchi S,Fukunaga K,Mao PJ,Hong LJ,Lu YM,Wang R,Ahmed MM,Liao MH,Huang JY,Zhang RT,Zhou TY,Long S,Han F

更新日期：2014-01-01 00:00:00

abstract：:We have studied the effect of the administration of two doses of melatonin (melatonin 100 and melatonin 200 microg/kg bw) on diabetes and oxidative stress experimentally induced by the injection of streptozotocin (STZ) in female Wistar rats. STZ was injected as a single dose (60 mg/kg i.p. in buffered citrate solution...

journal_title：Journal of pineal research

authors： Montilla PL,Vargas JF,Túnez IF,Muñoz de Agueda MC,Valdelvira ME,Cabrera ES

更新日期：1998-09-01 00:00:00

abstract：:Despite state-of-the-art pharmaceutical regimens, continuous improvements in diagnostic techniques as well as refinements in equipment and interventional procedures, many diseases remain refractory to conventional therapies. Recent advances in stem cell (SC) biology have opened an avenue to exploring its therapeutic p...

journal_title：Journal of pineal research

authors： Lee MS,Yin TC,Sung PH,Chiang JY,Sun CK,Yip HK

更新日期：2017-03-01 00:00:00

abstract：:Experiments were conducted to determine whether daily melatonin injections could influence reentrainment of circadian locomotor activity rhythms in male Long-Evans rats after phase shifts of the light dark (LD) cycle. When exposed to a 5-h advance of the LD cycle, six out of 15 rats injected daily with melatonin at th...

journal_title：Journal of pineal research

authors： Redman JR,Armstrong SM

更新日期：1988-01-01 00:00:00

abstract：:Lethal oxidative stress was investigated in the dinoflagellate Gonyaulax polyedra by measuring the dying-peak of bioluminescence during circadian phases of low physiological light emission, low bioluminescence capacity, and low sensitivity to stimulatory agents. Measurements were carried out in constant darkness after...

journal_title：Journal of pineal research

authors： Antolín I,Obst B,Burkhardt S,Hardeland R

更新日期：1997-11-01 00:00:00

abstract：:Melatonin has been identified in primitive photosynthetic bacteria, fungi, plants, and animals including humans. Vegetables, fruits, cereals, wine, and beers all contain melatonin. However, the melatonin content in meats has not been reported previously. Here, for the first time, we report melatonin in meats, eggs, co...

journal_title：Journal of pineal research

authors： Tan DX,Zanghi BM,Manchester LC,Reiter RJ

更新日期：2014-09-01 00:00:00

abstract：:Glaucoma may be associated with circadian disruption due to its association with a loss of intrinsically photosensitive retinal ganglion cells. Clinical evidence demonstrating an association between glaucoma and circadian disruption is limited, and no large-scale studies have been performed. The purpose of this cross-...

journal_title：Journal of pineal research

authors： Yoshikawa T,Obayashi K,Miyata K,Saeki K,Ogata N

更新日期：2020-09-01 00:00:00

abstract：:Chronic hyperhomocysteinemia is a risk factor in cardiovascular diseases and neurodegeneration. Among the putative mechanisms of homocysteine-induced neurotoxicity, an increased production of reactive oxygen species has been suggested. However, elevated homocysteine levels might disturb neurogenesis during brain devel...

journal_title：Journal of pineal research

authors： Baydas G,Koz ST,Tuzcu M,Nedzvetsky VS

更新日期：2008-03-01 00:00:00

abstract：:There is substantial evidence that magnetic field (MF) exposure influences melatonin secretion in animals. However, data on its influence on human melatonin levels are scarce, and seemingly contradictory. Because of its many beneficial effects, very low-frequency MF exposure is used in physiotherapy of some neurologic...

journal_title：Journal of pineal research

authors： Karasek M,Czernicki J,Woldanska-Okonska M,Zylinska K,Swietoslawski J

更新日期：2000-09-01 00:00:00

abstract：:The frequency of mitoses of adrenaline (A) cells and noradrenaline (N) cells in the adrenal medulla of nonoperated (NO), sham-operated (SPX), and pinealectomized (PX) male, 53-day-old Holtzman rats (n = 133) was investigated by means of light microscopy. Animals were killed at eight time points during a standardized 2...

journal_title：Journal of pineal research

authors： Kachi T,Quay WB,Banerji TK,Imagawa T

更新日期：1990-01-01 00:00:00

abstract：:As for many hormones, melatonin levels in the blood suggest that it is discharged from the pineal gland in a pulsatile manner. Recently, the existence of short-term episodes, superimposed on the circadian pattern of circulating melatonin, has been questioned. Because plasma melatonin levels reflect not only the secret...

journal_title：Journal of pineal research

authors： Follenius M,Weibel L,Brandenberger G

更新日期：1995-04-01 00:00:00

abstract：:Solid data support the idea that the MT(3) melatonin binding site is an enzyme, quinone reductase 2 (NQO2), rather than a membrane melatonin receptor. However, the melatonin analogue, 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT), reduces intraocular pressure (IOP) via MT(3) melatonin receptors. Therefore, the...

journal_title：Journal of pineal research

authors： Alarma-Estrany P,Crooke A,Pintor J

更新日期：2009-09-01 00:00:00

abstract：:Maternal hyperthermia induces early embryonic death via increased oxidative stress to the embryo. In this study, we examined whether melatonin administered to heat-stressed pregnant mice would reduce hyperthermia-induced embryonic death. Mice were heat stressed (12 hr at 35 degrees C, 60% relative humidity) on the day...

journal_title：Journal of pineal research

authors： Matsuzuka T,Sakamoto N,Ozawa M,Ushitani A,Hirabayashi M,Kanai Y

更新日期：2005-10-01 00:00:00

abstract：:Excessive activity of NADPH oxidase (Nox) is considered to be of importance for the progress of diabetic nephropathy. The aim of the study was to elucidate the effect of melatonin, known for its nephroprotective properties, on Nox activity under diabetic conditions. The experiments were performed on three groups of an...

journal_title：Journal of pineal research

authors： Winiarska K,Dzik JM,Labudda M,Focht D,Sierakowski B,Owczarek A,Komorowski L,Bielecki W

更新日期：2016-01-01 00:00:00

abstract：:The circadian clock plays a vital role in physiology and behavior such as the sleep-wake cycle and blood pressure and hormone levels. Immune responses also display circadian rhythmicity and particularly pineal melatonin contributes to immunological processes. Little attention, however, is given to mechanisms underlyin...

journal_title：Journal of pineal research

authors： Ren DL,Li YJ,Hu BB,Wang H,Hu B

更新日期：2015-05-01 00:00:00

abstract：:Dim light exposure of the mother during pregnancy has been proposed as one of the environmental factors that affect the fetal brain development in schizophrenia. Melatonin circulating levels are regulated by the environmental light/dark cycle. This hormone stimulates neuronal differentiation in the adult brain. Howeve...

journal_title：Journal of pineal research

authors： Galván-Arrieta T,Trueta C,Cercós MG,Valdés-Tovar M,Alarcón S,Oikawa J,Zamudio-Meza H,Benítez-King G

更新日期：2017-10-01 00:00:00

abstract：:Melatonin, the major secretory product of the pineal gland, is in focus of many research areas because of its ability to scavenge free oxygen radicals and thereby protect cells and tissues from radical damage. Some studies suggest melatonin may be a possible therapeutic agent with potential clinical applications again...

journal_title：Journal of pineal research

authors： Hermann R,Podhajsky S,Jungnickel S,Lerchl A

更新日期：2002-08-01 00:00:00

abstract：:To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every ...

journal_title：Journal of pineal research

authors： Luboshitzky R,Lavi S,Thuma I,Lavie P

更新日期：1996-03-01 00:00:00