Abstract：
:Testicular germ cell tumors (TGCTs) represent the most common neoplasia among young men. Management of TGCTs is an excellent example of curative outcomes in clinical oncology. The unique sensitivity to cisplatin-based chemotherapy regimens has led to establishing TGCTs as a "model of cancer cure." However, mechanisms and factors underlying pervasive growth of TGCTs are still poorly understood. It is suggested that unique cancer stem cell (CSC) niche exists in the testicular tumor microenvironment. CSC niche potentially contributes to the progression of germ cell tumors. Furthermore, rich infiltration of TGCTs with immune cells indicates involvement of immune system in biology of this cancer type. This review summarizes current knowledge regarding specific cancer microenvironment in TGCTs and discusses the role of cancer stem cells as well as immune mechanisms in these tumors.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Kalavska K,Kucerova L,Schmidtova S,Chovanec M,Mego Mdoi
10.1007/978-3-030-36214-0_9subject
Has Abstractpub_date
2020-01-01 00:00:00pages
111-121eissn
0065-2598issn
2214-8019journal_volume
1226pub_type
杂志文章,评审abstract：:Non-coding RNA (ncRNA) is a class of RNAs that are not act as translational protein templates. They are involved in the regulation of gene transcription, RNA maturation and protein translation, participating in a variety of physiological and physiological processes. NcRNAs have important functions, and are recently on...
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doi：
更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章
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