Abstract:
:Fatty acid oxidation increases in response to exercise, but at high intensities the contribution of fatty acid oxidation to energy production decreases. The carnitine palmitoyl transferase (CPT) complex appears to be a plausible site of regulation of fatty acid oxidation at rest and during exercise. Muscle malonyl-CoA, a potent inhibitor of CPT I, decreases during muscle contraction as a consequence of phosphorylation and inactivation of acetyl-CoA carboxylase (ACC) by AMP-activated protein kinase (AMPK). When AMPK is artificially activated with AICA riboside, ACC is inactivated, malonyl-CoA decreases, and fatty acid oxidation increases. Factors other than the muscle malonyl-CoA concentration are likely responsible for the decline in fatty acid oxidation during exercise at high intensities.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Winder WWdoi
10.1007/978-1-4899-1928-1_22subject
Has Abstractpub_date
1998-01-01 00:00:00pages
239-48eissn
0065-2598issn
2214-8019journal_volume
441pub_type
杂志文章,评审abstract::Cyclopiazonic acid (CPA) is a toxic indole tetramic acid that has been isolated from numerous species of Aspergillus and Penicillium. It has been found as a natural contaminant of cheese, corn, peanuts and various feedstuffs. Historically, thin-layer chromatography has been the most widely used method for quantitative...
journal_title:Advances in experimental medicine and biology
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doi:10.1007/978-1-4615-0629-4_11
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
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更新日期:1980-01-01 00:00:00