Abstract：
:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions characterized by different extents of epidermal necrosis and mucosal breakdown. A limited number of studies have reported the long-term patterns of SJS and TEN complications in patient populations over long follow-up periods. The aim of this retrospective study was to collect data on long-term sequelae in patients admitted for SJS, SJS/TEN overlap, or TEN between 1998 and 2012. Among all 102 patients eligible for analysis, the 2 most common sequelae were cutaneous and ocular problems, both with incidences of 44.1%. Visceral organ involvement was observed in 2 patients with irreversible deterioration of chronic kidney disease and in one patient with interstitial lung disease. Autoimmune disease was present in 6 patients: Sjögren's syndrome or Sjögren-like syndrome in 5 patients and concomitant systemic lupus erythematosus and Hashimoto thyroiditis in one patient.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Yang CW,Cho YT,Chen KL,Chen YC,Song HL,Chu CYdoi
10.2340/00015555-2295subject
Has Abstractpub_date
2016-05-01 00:00:00pages
525-9issue
4eissn
0001-5555issn
1651-2057journal_volume
96pub_type
杂志文章abstract：:The aim of this study was to determine the prevalence and type of cutaneous manifestations which occur in patients with granulomatosis with polyangiitis and to explore the potential association between cutaneous and systemic involvement in these patients. A retrospective case series study was designed, including all g...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3506
更新日期：2020-05-28 00:00:00
abstract：:Although pemphigus has recently been linked to psoriasis, the risk of emergence of pemphigus during the course of psoriasis is yet to be delineated. The aim of this study was to evaluate the risk of developing pemphigus during the course of psoriasis. A large-scale population-based longitudinal retrospective cohort st...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3607
更新日期：2020-10-20 00:00:00
abstract：:The delayed-type immune reactivities of 39 patients suffering from moderate to severe papulopustular or nodulo-cystic forms of Acne vulgaris were compared with healthy acne-free controls. In vivo reactivity was assessed by skin testing with four common recall antigens. In vitro the afferent arm of the immune system wa...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:We set out to show that the assumption is incorrect that continuous treatment with cyclosporin is necessary in psoriasis, as this tenet forms a basis for current recommended treatment regimens. Sixty patients with mild to moderate plaque psoriasis were allocated at random to treatment with oral cyclosporin 5 mg/kg/day...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.2340/00015555756569
更新日期：1995-01-01 00:00:00
abstract：:The close chromosomal proximity of major histocompatibility complex and tumour necrosis factor genes may suggest the involvement of the latter in the pathogenesis of immunological diseases associated with HLA antigenes. The major histocompatibility complex antigens may play a certain role in the pathogenesis of lichen...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550510037053
更新日期：2005-01-01 00:00:00
abstract：:Previous studies on skin topically photosensitized with trimethylpsoralen and subsequently irradiated with long-wave UV light have demonstrated an increase in melanosome size and changes in the distribution patterns of melanosomes, suggesting the possibility of gene derepression or the induction of a somatic mutation ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Recessive dystrophic epidermolysis bullosa (RDEB) is an inherited skin disorder caused by mutations in the COL7A1 gene, which encodes collagen VII (COL7). Skin ulcers in RDEB patients are sometimes slow to heal. We describe here the therapeutic response of intractable skin ulcers in two patients with generalized RDEB ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0776
更新日期：2010-03-01 00:00:00
abstract：:A case of simultaneous occurrence of lichen planus (LP) and hepatitis C in the same patient is presented. The patient had received treatment with interferon alpha for her chronic liver disease, and the association between LP, hepatitis C and interferon alpha treatment is discussed. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：101080/000155572380
更新日期：1992-09-01 00:00:00
abstract：:Sensitive skin is a clinical syndrome characterized by the occurrence of unpleasant sensations, such as pruritus, burning or pain, in response to various factors, including skincare products, water, cold, heat, or other physical and/or chemical factors. Although these symptoms suggest inflammation and the activation o...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2235
更新日期：2016-03-01 00:00:00
abstract：:The functions of polymorphonuclear leukocytes (PMNs) emigrating into the skin and of others separated simultaneously from the circulation were determined and compared in healthy individuals. The PMNs emigrating into the skin were separated with a skin chamber technique. The C3 rosette forming capacities of the skin mi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Thirteen patients with port wine stains (PWS) were treated with argon laser therapy. Before and at different points in time following treatment, skin blood perfusion and temperature were mapped with laser Doppler imaging and thermography. In nine patients no elevation in blood perfusion was observed in the PWS in comp...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/0001555572610
更新日期：1992-01-01 00:00:00
abstract：:The aim of the study was to investigate the effect of non-allergenic structural analogues on the sensitizing potential of carvone, a fragrance allergen. The possibility that one molecule might inhibit the allergenic activity of another molecule has been debated for 25 years. The Research Institute for Fragrance Materi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155501317208318
更新日期：2001-11-01 00:00:00
abstract：:Age and sex have been identified as predictors of outcome in malignant melanoma (MM). This aim of this multicentre, cross-sectional study was to analyse the role of age and sex as explanatory variables for the diagnosis of thin MM. A total of 2430 patients with MM were recruited. Cases of in situ-T1 MM were more frequ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,多中心研究
doi：10.2340/00015555-2115
更新日期：2015-11-01 00:00:00
abstract：:The effects of topical calcipotriol/betamethasone combination therapy and betamethasone monotherapy on inflammatory T-cell numbers and molecular markers were compared in patients with psoriasis. Combination therapy down-regulated the expression of tumour necrosis factor (TNF)-α, interleukin (IL)-23A, IL-17A, S100A7, C...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,随机对照试验
doi：10.2340/00015555-2579
更新日期：2017-04-06 00:00:00
abstract：:We evaluated the effect of acupuncture on histamine-induced itch and flare in healthy volunteers (n = 25) and compared it with the effect of a pseudo-acupuncture procedure and of no-intervention in a single-blind randomized cross-over study. A cumulative itch index is defined and was found to be smaller with acupunctu...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1984-01-01 00:00:00
abstract：:Extracts of psoriatic scales from patients with chronic plaque psoriasis and of normal human post-mortem skin were tested for their effects on the migration of healthy human mononuclear cells in a modified Boyden chamber. A preparation of cells containing 12-32% monocytes was obtained from whole blood by a density gra...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Although pruritus is an essential symptom of atopic dermatitis, its complex pathomechanism is not fully understood. The aim of this study was to characterize the clinical pattern of itch in adult subjects with atopic dermatitis. A total of 89 patients (59 females, 30 males) with atopic dermatitis, age range 18-60 year...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0676
更新日期：2009-01-01 00:00:00
abstract：:Epidemiological studies on cutaneous melanoma in Mediterranean countries are scarce. Our aim was to perform a descriptive analysis of melanoma cases diagnosed in Valencia, Spain, and to evaluate the relationship between Breslow thickness and some clinical features. A total of 1571 patients with histologically confirme...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0004
更新日期：2006-01-01 00:00:00
abstract：:Blister fluid from tense bullae of 10 patients with bullous pemphigoid was investigated using a radial caseinolysis assay and zymography. Proteolytic activity, varying from 4.7 to 10 micrograms/ml, was found in 3 out of 10 patients, by using the caseinolysis assay. Zymography revealed that a major part of this caseino...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Pigmented basal cell carcinomas can be difficult to distinguish clinically from melanoma. Dermoscopy has proven to be useful in the differential diagnosis of the two tumour types. SIAscopy (Spectrophotometric intracutaneous analysis) is a fairly new technique of imaging pigmented skin lesions that has been presented p...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0234
更新日期：2007-01-01 00:00:00
abstract：:In patients with atopic dermatitis the skin is highly susceptible to infection by bacteria, fungi and viruses. Increasing knowledge about the complex immune network that regulates anti-microbial responses has helped to dissect further the role of infections in atopic dermatitis. Conserved patterns of microbes are reco...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,评审
doi：10.2340/00015555-0047
更新日期：2006-01-01 00:00:00
abstract：UNLABELLED:Disperse dyes, which are used for colouring synthetic textile fibres, are well-known contact sensitisers. To investigate the outcome of patch-testing with a textile dye mix (TDM) at 7 dermatology clinics in Sweden, a TDM tested at 2 concentrations was included into the baseline series during one year. The mi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,多中心研究
doi：10.2340/00015555-1956
更新日期：2015-04-01 00:00:00
abstract：:Papillon-Lefèvre syndrome is an autosomal recessive disorder characterized by palmoplantar hyperkeratosis and aggressive periodontitis. The aim of the study was to identify underlying cathepsin C mutations in 39 subjects with Papillon-Lefèvre syndrome and to explore any phenotypic associations. Genotyping and mutation...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550510011619
更新日期：2006-01-01 00:00:00
abstract：:Loricrin, the major component of the cornified envelope, is normally expressed in the granular layer of epidermis during the last steps of keratinocyte differentiation. Using an antiloricrin antiserum (A8-73), an increased expression of this envelope precursor was found in some disorders of hyperorthokeratosis (ichthy...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/0001555572407409
更新日期：1992-11-01 00:00:00
abstract：:Low molecular weight oligomers of an epoxy resin of bisphenol A diglycidyl ether type were isolated by gel permeation chromatography. The sensitizing capacity of these oligomers was assessed with the "guinea pig maximization test". The oligomer with the molecular weight of 340 sensitized 80% to 100% of the animals, bu...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:The authors describe a 74-year-old man who presented with a 2-cm nodule on the ventral face of the penis, showing histologically a cyst lined by both epidermal and urethroid epithelium. The authors discuss the various histological forms of raphe median cysts of the penis. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Urinary excretion of proline and hydroxyproline was studied in five groups of subjects, viz. controls, pituitary dwarfs, familial dwarfs, patients with fibrodysplasia ossificans progressive and patients with generalized scleroderma. The ratio Pro/Hyp in the urinary fraction precipitated with 5 parts of acetone (1 + 5 ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:The Thomsen-Friedenreich (T) antigen is the core disaccharide of cancer-associated carbohydrates, whose expression allegedly correlates with the prognosis of some carcinomas. We studied the expression of the T antigen and its precursor (Tn) with monoclonal antibodies in formalin-fixed specimens of normal skin and vari...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155598441468
更新日期：1998-05-01 00:00:00
abstract：:The issue as to whether oral lichen planus is a premalignant disorder is still controversial. This study aimed to examine oral malignancies associated with oral lichen planus and to investigate whether oral lichen planus has an intrinsic malignant potential or whether there are also contributing external risk factors....
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550510036676
更新日期：2005-01-01 00:00:00
abstract：:The hairless mouse has been used as a model to distinguish between local and systemic atrophogenic effects of topical steroids. Hydrocortisone-17-butyrate, betamethasone-17-valerate, budesonide and clobetasol-17-propionate were applied topically daily for 21 days. Skinfold thickness and dermal DNA synthesis of treated...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
