Pathophysiological Study of Sensitive Skin.

Abstract:

:Sensitive skin is a clinical syndrome characterized by the occurrence of unpleasant sensations, such as pruritus, burning or pain, in response to various factors, including skincare products, water, cold, heat, or other physical and/or chemical factors. Although these symptoms suggest inflammation and the activation of peripheral innervation, the pathophysiogeny of sensitive skin remains unknown. We systematically analysed cutaneous biopsies from 50 healthy women with non-sensitive or sensitive skin and demonstrated that the intraepidermal nerve fibre density, especially that of peptidergic C-fibres, was lower in the sensitive skin group. These fibres are involved in pain, itching and temperature perception, and their degeneration may promote allodynia and similar symptoms. These results suggest that the pathophysiology of skin sensitivity resembles that of neuropathic pruritus within the context of small fibre neuropathy, and that environmental factors may alter skin innervation.

journal_name

Acta Derm Venereol

authors

Buhé V,Vié K,Guéré C,Natalizio A,Lhéritier C,Le Gall-Ianotto C,Huet F,Talagas M,Lebonvallet N,Marcorelles P,Carré JL,Misery L

doi

10.2340/00015555-2235

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

314-8

issue

3

eissn

0001-5555

issn

1651-2057

journal_volume

96

pub_type

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