Abstract:
:In patients with atopic dermatitis the skin is highly susceptible to infection by bacteria, fungi and viruses. Increasing knowledge about the complex immune network that regulates anti-microbial responses has helped to dissect further the role of infections in atopic dermatitis. Conserved patterns of microbes are recognized by the innate immune system, which mediates microbicidal activity, either directly or through inflammatory responses. New evidence suggests that components of the innate immune system, such as anti-microbial peptides, humoural lectins, nucleotide-binding oligomerization domain-containing (NOD) proteins, and Toll-like receptors not only protect from microbial invasion, but contribute to skin inflammation in atopic dermatitis. In addition, atopic patients tend to develop Th2-dominated immune responses that weaken anti-microbial immunity. This impairment of an appropriate anti-microbial defence compounded by amplified microbe-driven innate and adaptive immune responses leads to the vicious circle of skin inflammation. New microbial management in atopic dermatitis will foster a well-balanced microbial flora, which establishes natural defence mechanisms to maintain immuno-surveillance of the skin. In addition to anti-microbial therapies, other innate immune stimuli may suppress pro-inflammatory signals and help to break the vicious circle of cutaneous inflammation. To elucidate further these different interactions of the skin immune system and microbes in atopic dermatitis, clinical studies and further efforts in basic research are needed.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Biedermann Tdoi
10.2340/00015555-0047subject
Has Abstractpub_date
2006-01-01 00:00:00pages
99-109issue
2eissn
0001-5555issn
1651-2057journal_volume
86pub_type
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Acta dermato-venereologica
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