Prostacyclin reduces symptoms and sympathetic dysfunction in erythromelalgia in a double-blind randomized pilot study.

Abstract:

:Sympathetic dysfunction and skin microvascular arteriovenous shunting with insufficient nutritive perfusion and tissue hypoxia have been reported in patients with erythromelalgia. The objective of this study was to determine whether iloprost, a synthetic prostacyclin analogue--primarily a vasodilator and inhibitor of platelet activation--improves symptoms and sympathetic function in patients with erythromelalgia. Erythromelalgia is a rare condition, but we managed to collect 12 primary cases for a double-blind, randomized, parallel-group pilot trial evaluating the effect of iloprost (n = 8) and placebo (n = 4). The treatment effect was determined by the need for cooling of affected skin and by vasoconstrictor tests following Valsalva's manoeuvre and contralateral cooling. The results show a significant reduction in symptoms (p < 0.05) and sympathetic dysfunction (p < 0.05) in the iloprost group. Further studies with oral prostacyclins or analogues are suggested.

journal_name

Acta Derm Venereol

authors

Kalgaard OM,Mørk C,Kvernebo K

doi

10.1080/00015550310015031

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

442-4

issue

6

eissn

0001-5555

issn

1651-2057

journal_volume

83

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Jørgensen J,Menné T

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  • 'Rusters'. The corrosive action of palmar sweat: I. Sodium chloride in sweat.

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    authors: Jensen O

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    authors: Beck HI,Hagdrup HK

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  • HPV-related cancer susceptibility and p53 codon 72 polymorphism.

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  • Loss of hyaluronan in the basement membrane zone of the skin correlates to the degree of stiff hands in diabetic patients.

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  • 5 years' experience of 5-S-cysteinyldopa in melanoma diagnosis.

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    pub_type: 杂志文章

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    authors: Agrup G,Agrup P,Andersson T,Hafström L,Hansson C,Jacobsson S,Jönsson PE,Rorsman H,Rosengren AM,Rosengren E

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  • Skin barrier properties in patients with recessive X-linked ichthyosis.

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  • Skin cleansers: three test protocols for the assessment of irritancy ranking.

    abstract::In this article, the results of 3 studies on 2 hand cleansers (products A and B) are analysed. Three different test models (the patch test, the forearm wash test and the use test) are used to obtain information on the skin irritancy of these 2 products. Test reactivity was assessed by clinical scores and bioengineerin...

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  • Quality of life measurement and its relationship to disease severity in children with atopic dermatitis in general practice.

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  • Eye Complications During Dupilumab Treatment for Severe Atopic Dermatitis.

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  • Ultrastructure of murine dermis following topical application of the vitamin D3 analogue KH-1060.

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    更新日期:1997-05-01 00:00:00

  • Candida albicans grown in glucose-free media contains serum-independent chemotactic activity.

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  • Modulation of CD3-dependent lymphocyte proliferation by extracellular matrix proteins in atopic dermatitis.

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    doi:10.2340/0001555575353356

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  • Cutaneous blood flow rates during orthostatic manoeuvres measured by laser Doppler flowmetry.

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  • Acitretin excretion into human breast milk.

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