Abstract:
:Sympathetic dysfunction and skin microvascular arteriovenous shunting with insufficient nutritive perfusion and tissue hypoxia have been reported in patients with erythromelalgia. The objective of this study was to determine whether iloprost, a synthetic prostacyclin analogue--primarily a vasodilator and inhibitor of platelet activation--improves symptoms and sympathetic function in patients with erythromelalgia. Erythromelalgia is a rare condition, but we managed to collect 12 primary cases for a double-blind, randomized, parallel-group pilot trial evaluating the effect of iloprost (n = 8) and placebo (n = 4). The treatment effect was determined by the need for cooling of affected skin and by vasoconstrictor tests following Valsalva's manoeuvre and contralateral cooling. The results show a significant reduction in symptoms (p < 0.05) and sympathetic dysfunction (p < 0.05) in the iloprost group. Further studies with oral prostacyclins or analogues are suggested.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Kalgaard OM,Mørk C,Kvernebo Kdoi
10.1080/00015550310015031subject
Has Abstractpub_date
2003-01-01 00:00:00pages
442-4issue
6eissn
0001-5555issn
1651-2057journal_volume
83pub_type
临床试验,杂志文章,随机对照试验abstract::Auto-inoculation from a genital ulcer suspected of being ulcus molle gave redness after 24 hours and after 48 hours vesicles and pustules appeared. Cultivation from the auto-inoculation after the 48 hours was positive for herpes simplex virus type 2. Our observation underlines two points: auto-inoculation for the diag...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::The incidence of malignant melanoma of the skin has increased rapidly among white people during the last decade. Although the pathogenesis of malignant melanoma is not clear, epidemiologic data and experimental work indicates that ultraviolet (UV) radiation plays a critical role in tumorigenesis. Recent data implicate...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Thirty psoriatic out-patients were treated as a right-left comparison with dithranol (0.1, 0.5, 1, 2%) and butantrone (0.66, 1.3, 2.7, 3.9%) short contact therapy, both in white petrolatum. Fifteen of the treated patients cleared well and no obvious differences between the treated sides were clinically observed. Six p...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Sweat from 8 'rusters' and 8 control persons was examined for its sodium concentration. Sweating was induced by iontophoresis of pilocarpine on the distal forearm. In no case did the concentrations exceed the normal upper limit for this procedure, and no difference was found between the two groups. In this way the stu...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Irritant contact dermatitis is a major problem in dermatology. One important group of substances causing irritant dermatitis is detergents. Exposure of the skin to detergents is frequent in both work and domestic environments. In the present paper we have studied how the penetration through the skin, and thus the effe...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555573203207
更新日期:1993-06-01 00:00:00
abstract::An analysis of the month of birth in 210 patients with atopic dermatitis and a positive prick test towards the house dust mite (Dermatophagoides pteronyssinus) showed a significantly higher prevalence of birth in the interval May to November when compared with the expected distribution (p less than 0.01). A subdivisio...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Conflicting results regarding the association of a polymorphism at codon 72 of the p53 tumour suppressor gene and susceptibility to develop human papilloma virus (HPV)-associated cervical cancer have been published over the last year, implicating differences in ethnic background, sample origin, sample size and/or dete...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550152384272
更新日期:2001-05-01 00:00:00
abstract::Glycosaminoglycans are important components of all extracellular matrices. One of the glycosaminoglycans is hyaluronan, which is ubiquitously distributed throughout the connective tissue. Hyaluronan is especially abundant in the skin, in which it is of both structural and functional importance. This study describes th...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155502320624041
更新日期:2002-01-01 00:00:00
abstract::Determinations of the urinary excretion of 5-S-cysteinyldopa were performed in 571 patients previously treated by surgery for melanoma or melanoma metastasis. 90% of the 161 patients with metastases showed values exceeding 0.15 mg/24 h, and 9% of the 410 patients without metastases had such values. The increase in 5-S...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Patients with X-linked recessive ichthyosis (RXLI) were studied as a model of the effect of disturbed epidermal lipid composition on skin barrier function. Thirteen patients with RXLI and 15 age- and sex-matched controls were patch-tested with sodium lauryl sulphate (SLS) 0.5% for 24 h. Basal skin properties and skin ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555575198201
更新日期:1995-05-01 00:00:00
abstract::In this article, the results of 3 studies on 2 hand cleansers (products A and B) are analysed. Three different test models (the patch test, the forearm wash test and the use test) are used to obtain information on the skin irritancy of these 2 products. Test reactivity was assessed by clinical scores and bioengineerin...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155502753600812
更新日期:2002-01-01 00:00:00
abstract::Atopic dermatitis (AD) has a big impact on quality of life. The usefulness of health-related quality of life questionnaires for children with AD in general practice, and the relationship of quality of life to disease severity, as assessed by parents and by investigators, however, is not known. This study used the Infa...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1026
更新日期:2011-03-01 00:00:00
abstract::Dupilumab, the first biologic approved for treatment of atopic dermatitis, has demonstrated significant clinical effect and quality of life-enhancing capacity in clinical trials. In these, dupilumab-associated conjunctivitis where reported in a minority of patients. The present case series describe 10 patients treated...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-3121
更新日期:2019-04-01 00:00:00
abstract::Recent findings indicate that patients with systemic sclerosis have an increased risk of cardiovascular disease. To determine whether patients with systemic sclerosis or localized scleroderma are at increased risk of cardiovascular disease, a cohort study of the entire Danish population aged ≥ 18 and ≤ 100 years was c...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-2842
更新日期:2018-03-13 00:00:00
abstract::The aim of this study, was to observe the effects of KH-1060, a new vitamin D3 analogue, on the dermis of hairless mice by electron microscopy. KH-1060 (0.2 micrograms/ml in isopropanol) or KH-1060 following betamethasone 17-valerate (2 mg/ml in isopropanol) was applied topically to the backs of hairless mice for 4 we...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555577198202
更新日期:1997-05-01 00:00:00
abstract::Infection of skin with Candida albicans is usually followed by infiltration of neutrophil granulocytes (PMN). So far, chemotaxins for PMN have been isolated from C. albicans cultures grown in the presence of glucose. However, since glucose is not present in skin in vivo, a contribution of such factors to Candida-trigg...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/000155557213
更新日期:1992-01-01 00:00:00
abstract::Patients with atopic dermatitis were found to have an about 7-fold increased spontaneous proliferative response of peripheral blood lymphocytes and an about 4-fold elevation of CD3-dependent lymphocyte transformation as compared to normal controls. The CD3-dependent lymphocyte response in patients with severe atopic d...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555575353356
更新日期:1995-09-01 00:00:00
abstract::The validity of Laser Doppler Flowmetry for measurements of changes in skin blood flow rates during orthostatic manoeuvres was evaluated. Fifteen healthy subjects were investigated. Relative skin blood flow rates on the dorsum of the hand were measured during stepwise raising and lowering of the arm in 10 cm increment...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555570144147
更新日期:1990-01-01 00:00:00
abstract::Two cases of subacute cutaneous lupus erythematosus are described. Features which delayed diagnosis are discussed. The potential clinical and histopathological overlap between this condition and erythema multiforme is emphasized, drawing attention to the histological features which allow distinction. The possibility t...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015559850135869
更新日期:1998-01-01 00:00:00
abstract::To evaluate plasma lipid peroxidation and enzymatic and non-enzymatic antioxidant systems in patients with Behçet's disease, plasma malondialdehyde levels and total antioxidant status, erythrocyte superoxide dismutase and whole blood glutathione peroxidase activities were studied in 15 patients with active disease and...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550310003782
更新日期:2003-01-01 00:00:00
abstract::The increasing incidence of melanoma prompts a need for efficient management of this patient group. In this study, we use the number needed to excise (NNE), as a measurement of the efficiency of diagnosing melanoma. From January 2009 to December 2012, postoperative records from all patients were prospectively register...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1831
更新日期:2014-11-01 00:00:00
abstract::Two female patients suffering from progressive systemic sclerosis (PSS) of generalized type were treated with estriol for 10 months. Although complete cure was not achieved, considerable beneficial effects were observed in these patients, but no serious side effects. Thus, skin softening was observed on all involved p...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Cinnamic alcohol and cinnamic aldehyde are a cause of allergic contact dermatitis in man and give rise to similar rates of positive reactions in routine patch testing. However, data from animal models indicates that the aldehyde is the stronger sensitizer of the two. Circumstantial evidence has pointed to the conversi...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555572264265
更新日期:1992-08-01 00:00:00
abstract::Retinoid transfer into breast milk was studied in a psoriatric woman receiving oral acitretin at a dosage of 40 mg once daily. Concentrations of the parent compound and its main metabolite, 13-cis acitretin, were measured in serum and mature milk during the initial nine days of therapy, using reverse-phase high perfor...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555570487490
更新日期:1990-01-01 00:00:00
abstract::Vulvar vestibulitis is a major cause of entry dyspareunia in young women. The aim of this study was to evaluate a self-reported history of bacterial vaginosis, candidiasis, use of oral contraception and nulli-pregnancy as risk factors for vestibulitis. A retrospective examination of medical records was performed for 4...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0250
更新日期:2007-01-01 00:00:00
abstract::In Behçet's disease, severe pathological changes are observed in the post-capillary venules, indicating that the venous side of the circulation is generally involved. It is proposed that one of the initial pathological changes is multiplication of the basal lamina surrounding the post-capillary venule. ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::The principles behind the primary localization of lesions in fixed drug eruption are still unknown. Studies investigating the predilection areas indicated drug-related, trauma-related or inflammation-related specific site involvement in fixed drug eruption. This study presents new findings of primary site involvement ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0307
更新日期:2007-01-01 00:00:00
abstract::Eight out of 30 consecutive patients with AIDS and cryptococcal meningoencephalitis (26,7%) presented cutaneous involvement, in the form of papulo-nodular lesions in 3 patients, molluscum contagiosum-like lesions in 3 patients, and pustular-ulcerative lesions in 2 patients. Skin localization represented an untoward pr...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555767274
更新日期:1996-01-01 00:00:00
abstract::Anisakis simplex is a seafish nematode, which is responsible for the well-known human infection (anisakiasis) and can induce IgE-mediated reactions. IgE sensitization to Anisakis simplex can be frequent in particular countries and should be suspected in patients with acute allergic symptoms after ingestion of fish. Th...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550252948167
更新日期:2002-01-01 00:00:00
abstract::The purpose of this investigation was to study the intestinal absorption of L-tryptophan and to assess the absorptive function of the intestine in scleroderma. The oral L-tryptophan loading test was performed in 31 cases of systemic scleroderma (progressive systemic sclerosis, PSS) and 3 cases of localized scleroderma...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00