Skin cleansers: three test protocols for the assessment of irritancy ranking.

Abstract:

:In this article, the results of 3 studies on 2 hand cleansers (products A and B) are analysed. Three different test models (the patch test, the forearm wash test and the use test) are used to obtain information on the skin irritancy of these 2 products. Test reactivity was assessed by clinical scores and bioengineering methods such as corneometry for skin moisture, transepidermal water loss measurements for barrier function and chromametry for erythema. A correlating trend of product A being more aggressive than product B could be confirmed in all 3 studies and was statistically significant in the patch-testing series. Distinction of the results was dependent on the test protocol employed. Models for testing cleansing preparations should be chosen carefully, depending on the hypothesis to be evaluated.

journal_name

Acta Derm Venereol

authors

Spoo J,Wigger-Alberti W,Berndt U,Fischer T,Elsner P

doi

10.1080/000155502753600812

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

13-7

issue

1

eissn

0001-5555

issn

1651-2057

journal_volume

82

pub_type

杂志文章
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