Abstract：
:The purpose of this investigation was to study the intestinal absorption of L-tryptophan and to assess the absorptive function of the intestine in scleroderma. The oral L-tryptophan loading test was performed in 31 cases of systemic scleroderma (progressive systemic sclerosis, PSS) and 3 cases of localized scleroderma. Serum levels of tryptophan and urinary excretion of indole-acetic acid (IAA) and indican (IS) were determined in order to assess intestinal absorption of tryptophan. In 10 cases the D-xylose test and in 4 cases Schilling's test was also performed. Furthermore, in vitro binding of L-tryptophan by plasma proteins in PSS and in other skin diseases as controls was studied. The normal increase in serum tryptophan after loading was noted in 17 cases (in 14 cases of PSS with a mild, slow progression in 3 cases of PSS with a severe, rapidly progressing course). In 10 of these cases, urinary excretion of IAA was higher than normal and in normal and in 3 cases excretion of urinary IS was also above normal. On the other hand, in 14 cases of severe, rapidly progressing PSS and in 2 of 3 cases of widespread linear scleroderma, serum levels of tryptophan were markedly depressed after loading, while urinary excretion of IAA and IS was normal. In all 4 cases studied, Schilling's test was normal, and only in 2 of 10 cases of PSS was the D-xylose test abnormal. It is concluded that in the majority of cases of PSS, intestinal absorpiton of tryptophan is normal as also is the absorptive function of the intestine. The slight rise in serum tryptophan after loading in some cases of PSS may be a result of increased binding of tryptophan by albumin.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Stachow A,Jablońska S,Skiendzielewska Asubject
Has Abstractpub_date
1976-01-01 00:00:00pages
257-64issue
4eissn
0001-5555issn
1651-2057journal_volume
56pub_type
杂志文章abstract：:Non-melanoma skin cancer (NMSC) is the most frequent malignancy in organ transplant recipients. The aetiology of NMSC after transplant is multifactorial. The aim of this study was to determine the clinical and environmental factors involved in the development of NMSC in a Spanish kidney transplant population from the ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-1525
更新日期：2013-07-06 00:00:00
abstract：:Five patients with a histopathologically confirmed diagnosis of pityriasis lichenoides were treated with PUVA or irradiated with a light source emitting UVB and UVA, without prior intake of psoralens. All patients showed a good response to treatment. Long-term follow up showed that patients remained free of lesions du...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The recovery of skin function and appearance after harvest of split-thickness skin autografts is incompletely described. We followed the kinetics of skin restoration after a partial-thickness skin excision relative to adjacent normal skin over 12 months. Standardized donor site wounds were made on the thigh using a pn...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章
doi：10.2340/00015555-1455
更新日期：2013-05-01 00:00:00
abstract：:Although pemphigus has recently been linked to psoriasis, the risk of emergence of pemphigus during the course of psoriasis is yet to be delineated. The aim of this study was to evaluate the risk of developing pemphigus during the course of psoriasis. A large-scale population-based longitudinal retrospective cohort st...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3607
更新日期：2020-10-20 00:00:00
abstract：:We present a young male patient referred to our hospital with leg ulcers on both legs that were more than 3 years refractory to standard treatment with compression therapy. By thrombophilia screening factor V Leiden mutation, hyperhomocysteinemia and evidence for impaired fibrinolysis were found. Treatment with folic ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155502753600902
更新日期：2002-01-01 00:00:00
abstract：:Necrobiosis lipoidica diabeticorum is a chronic cutaneous complication of diabetes mellitus with microangiopathy as an important pathophysiologic factor. Because of the known success of hyperbaric oxygen in the treatment of chronic non-healing wounds, we used this mode of therapy to treat a diabetic patient with ulcer...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章
doi：10.2340/0001555573447448
更新日期：1993-12-01 00:00:00
abstract：:Lymphocytes in chronic lymphocytic leukaemia and in other malignant lymphomas exhibit an extreme sensitivity to colchicine and are cytolysed in vitro by 10(-6) M colchicine. This characteristic can be quantified with the colchicine sensitivity index which is used for diagnostic purposes. We have demonstrated that lymp...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:We report the clinical variations and the duration of prodromal symptoms in 20 patients with bullous pemphigoid. Nearly two-thirds of the patients had prodromal symptoms. THe duration of the prodromal eruptions was up to 6 weeks if papular and/or urticarial and up to 2 years if eczematous, before the blisters appeared...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:The antibody activities and complement fixing ability of the IgG subclass antibodies of herpes gestationis (HG) and bullous pemphigoid (BP) antibodies were investigated. IgG was prepared by DEAE Affi-Gel Blue column. IgG3 and IgG 1.2.4 fractions were isolated through Protein-A Sepharose CL-4B column. In HG, neither Ig...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:In a randomized, controlled parallel group study we have shown that cyclosporine at 3 mg/kg/day is as effective as topical betamethasone-17,21-dipropionate in the treatment of chronic hand eczema. In this study we compared the influence of these therapies on the quality of life. Forty-one patients were treated with ei...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.2340/00015555775458
更新日期：1997-01-01 00:00:00
abstract：:Altogether 525 PUVA-treated psoriatics were re-examined. The mean follow-up period since the beginning of PUVA therapy was 2.1 years (range 1-3.6 years). In 107 cases (20%) the total UVA dose was below 100 J/cm2 and in 20 (4%) over 1000 J/cm2. During PUVA treatment or at re-examination of 14 of the 525 patients (3%) w...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Formation of neutrophil extracellular traps has been implicated in autoimmunity. However, the presence and clinical relevance of neutrophil extracellular traps in immune-complex-mediated cutaneous small and medium vessel vasculitides has not been investigated. This study retrospectively analysed 72 patients with histo...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3363
更新日期：2020-10-06 00:00:00
abstract：:Peripheral blood lymphocytes from 45 patients with a positive patch test to cobalt chloride (CoCl2) and 37 controls were stimulated with various concentrations of CoCl2 and/or cobalt sulphate (CoSO4) or cobalt nitrate (Co(NO3)2) or cobalt acetate [CH3COO)2Co) for various days in culture. Lymphocytes from 35 of these p...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Considerable interest has been recently generated concerning the use of natural compounds, anti-oxidants in particular, in photoprotection. Two of the best known anti-oxidants are vitamins C and E, both of which have been shown to be somewhat effective in different models of photodamage. Very little has been reported,...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555576264268
更新日期：1996-07-01 00:00:00
abstract：:Dupilumab, the first biologic approved for treatment of atopic dermatitis, has demonstrated significant clinical effect and quality of life-enhancing capacity in clinical trials. In these, dupilumab-associated conjunctivitis where reported in a minority of patients. The present case series describe 10 patients treated...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3121
更新日期：2019-04-01 00:00:00
abstract：:The incidence of refractory atopic dermatitis has increased in teenagers and young adults. The purpose of this study was to control the skin symptoms of such patients in daily life. Seventy patients repeatedly took a 10-min 42 degrees C acidic hot-spring bath twice daily. The skin symptoms were improved in 76% of case...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章
doi：10.2340/0001555577452454
更新日期：1997-11-01 00:00:00
abstract：:Homogenates of irradiated and non-irradiated skin from 16 patients with chronic polymorphous light eruptions (CPLE) were examined to detect possible light-induced antigen to cell-mediated immunity. The leukocyte migration agarose tests which were performed disclosed no evidence of migration inhibition in either type o...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Nineteen immunocompromised patients with extensive skin lesions caused by Pseudomonas aeruginosa with or without P. aeruginosa bacteremia were analysed. Patients whose lesions originated in the skin were in the majority (14 patients). Skin lesions were located at the site of entry of bacteria (apocrine areas in 12 pat...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The pathogenesis of seborrhoeic dermatitis is controversial and remains unclear. Malassezia is considered to be a commensal fungi and is found not only in the stratum corneum but also in hair follicles. It is an important pathogenic factor in seborrhoeic dermatitis. The aim of this study was to clarify the pathogenesi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3519
更新日期：2020-06-15 00:00:00
abstract：:Despite advances in atopic dermatitis (AD) treatments, research into AD prevention has been slow. Systematic reviews of prevention strategies promoting exclusive and prolonged breastfeeding, or interventions that reduce ingested or airborne allergens during pregnancy and after birth have generally not shown convincing...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3516
更新日期：2020-06-09 00:00:00
abstract：:Preservative Kathon CG (K-CG) is a commercial preparation, consisting of the two active ingredients (a.i.), 2-methyl-4-isothiazolin-3-one (243-K-CG) and 5-chloro-2-methyl-4-isothiazolin-3-one (5243-K-CG) and also of other components. Both a.i. are known contact sensitizers in humans. In this study guinea pig maximizat...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The Thomsen-Friedenreich (T) antigen is the core disaccharide of cancer-associated carbohydrates, whose expression allegedly correlates with the prognosis of some carcinomas. We studied the expression of the T antigen and its precursor (Tn) with monoclonal antibodies in formalin-fixed specimens of normal skin and vari...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155598441468
更新日期：1998-05-01 00:00:00
abstract：:Two female patients suffering from progressive systemic sclerosis (PSS) of generalized type were treated with estriol for 10 months. Although complete cure was not achieved, considerable beneficial effects were observed in these patients, but no serious side effects. Thus, skin softening was observed on all involved p...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Patients with the autosomal-dominant form of multiple familial trichoepithelioma develop numerous tumours on the face, neck and upper trunk, beginning in childhood. Malignant transformation of such lesions is quite rare; only one case of "malignant trichoepithelioma" has been reported previously, inferring pilomatrix ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,评审
doi：10.2340/00015555-0322
更新日期：2008-01-01 00:00:00
abstract：:To characterize the exposome of the Spanish population and its association with skin ageing a cross-sectional epidemiological study was conducted in men and women (18-60 years old). A total of 1,474 participants were included. Mean age (± standard deviation) was 40.84 ± 10.26 years. Most participants had Fitzpatrick s...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3500
更新日期：2020-05-28 00:00:00
abstract：:Three women with hyperkeratosis lenticularis perstans (HLP) are described. The lesions developed after the age of 45 and there was no family history of this disease. The possible role of UV-light in the pathogenesis of this disease is discussed. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:We took biopsies from similar sites on the scalps of normal controls, normal looking and hair loss areas of patients with alopecia areata. The specimens were sectioned serially and horizontally. We measured morphological parameters, such as the diameter of the hair shaft, the thickness of the inner root sheath, the di...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155599750011002
更新日期：1999-05-01 00:00:00
abstract：:Balanoposthitis is an inflammatory disorder of the prepuce and glans penis. Microbes involved in balanoposthitis have been investigated, but no single study has covered the growth of both bacteria, Candida and Malassezia. We report here the prevalence of these microbes in 100 patients with balanoposthitis and in 26 co...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0478
更新日期：2008-01-01 00:00:00
abstract：:Determinations of the urinary excretion of 5-S-cysteinyldopa were performed in 571 patients previously treated by surgery for melanoma or melanoma metastasis. 90% of the 161 patients with metastases showed values exceeding 0.15 mg/24 h, and 9% of the 410 patients without metastases had such values. The increase in 5-S...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:We investigated the usefulness of the restriction enzyme (RE) fingerprinting for epidemiological tracing in gonococcal disease. The RE patterns of three paired gonococcal isolates showed corresponding identical fingerprints. Within each of the three pairs of epidemiologically linked isolates the respective restriction...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
