Eye Complications During Dupilumab Treatment for Severe Atopic Dermatitis.

Abstract:

:Dupilumab, the first biologic approved for treatment of atopic dermatitis, has demonstrated significant clinical effect and quality of life-enhancing capacity in clinical trials. In these, dupilumab-associated conjunctivitis where reported in a minority of patients. The present case series describe 10 patients treated with dupilumab where eye complications were very common. We have described patient characteristics, including FLG mutations, atopic history and clinical effect of dupilumab. Nine of 10 developed eye-complications, most commonly conjunctivitis (in 7/10). Other adverse events were herpes simplex virus uveitis and varicella-zoster virus meningitis. Although our case series is small, we conclude that dupilumab is an effective treatment option in severe atopic dermatitis, but that the risk of adverse events from the eyes and recurrence of herpes virus infections should be kept in mind. Close collaboration with an ophthalmologist is recommended, especially among patients with severe, long-lasting atopic dermatitis and/or previous eye disease.

journal_name

Acta Derm Venereol

authors

Ivert LU,Wahlgren CF,Ivert L,Lundqvist M,Bradley M

doi

10.2340/00015555-3121

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

375-378

issue

4

eissn

0001-5555

issn

1651-2057

journal_volume

99

pub_type

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