Absorption of 8-hydroxyquinolines through the human skin.

Abstract:

:The skin absorption of clioquinol and chloroquinaldol in ointment or cream base was studied in fourteen patients with widespread dermatoses. A serum concentration in the range of 0.3--1.3 microgram/ml using clioquinol and 0.05--0.1 microgram/ml with chloroquinaldol was reached by the second day and persisted throughout the topical treatment. The mean serum half-life of clioquinol and of chloroquinaldol was estimated to 25 and 6 hours, respectively. Local application of zinc oxide ointment after the end of the treatment chelate-bound the skin deposits of clioquinol and lowered the serum half-life to 11 hours. The mean daily urinary excretion of the applied amount of clioquinol and chloroquinaldol was 4.5 and 6%, respectively.

journal_name

Acta Derm Venereol

authors

Fischer T,Fagerlund C,Hartvig P

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

407-11

issue

5

eissn

0001-5555

issn

1651-2057

journal_volume

58

pub_type

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