Abstract:
:External genital warts, caused by human papillomavirus, have a significant clinical, epidemiological, and financial impact, including the risk for malignant transformation. Treatment modalities include: (a) destructive (ablative); (b) cytotoxic (proapoptotic) and (c) immunomodulatory, with success and recurrence rates varying from 23% to 94% and from 4.1% to 77%, respectively. Most studies evaluated only single modality therapy, with few reports examining a combined approach for external genital warts management. The introduction of sinecatechins ointment in recent years has resulted in very low recurrence rates of 4.1-10.6%, despite lower initial clearance rates than ablative methods. We present a retrospective review of 27 patients who underwent combined therapy for external genital warts by using one or two sessions of cryodestruction combined with 25% podophyllin as the cytotoxic agent, and post-ablation immunomodulation with topical sinecatechins 15% ointment. This approach resulted in an excellent initial clearance rate of 96.3% with a recurrence rate of 7.4% after a total period of six months of follow-up. We suggest the importance of the combined approach in external genital warts management including post-ablative immunomodulation to augment the immune response and combat the residual latent infection. We hope to encourage trials examining the combined approach to the treatment of external genital warts.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Juhl ME,Seferovic V,Antonijevic S,Krunic Adoi
10.1177/0956462415607375subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1071-1078issue
12eissn
0956-4624issn
1758-1052pii
0956462415607375journal_volume
27pub_type
杂志文章abstract::The limited published data support the assumption that lesbians are a low risk group for sexually transmitted diseases (STDs). However, there are virtually no contemporary data and the older papers do not take into account genital wart virus infection, now the third most prevalent STD in Britain. One of the dangers in...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249000100304
更新日期:1990-05-01 00:00:00
abstract::We evaluated associations between history of syphilis infection and both cognitive function and depressive symptoms in people living with HIV (PLHIV) and comparable HIV-negative controls. Syphilis serological tests, cognitive function and depression were assessed in PLHIV and controls participating in the Pharmacokine...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418817612
更新日期:2019-04-01 00:00:00
abstract::Individuals diagnosed with HIV before 1996 had poor prognoses. Few HIV care centers can track patients continuously from the 1980s to present. We determined the sociodemographic, clinical, and health care utilization characteristics of patients diagnosed and followed for >20 years (i.e. long-term HIV/AIDS survivors) t...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418778705
更新日期:2018-11-01 00:00:00
abstract::Two hundred consecutive patients with herpes zoster attending the skin clinic at the Kilimanjaro Christian Medical Centre (KCMC) were examined and checked for HIV infection. They ranged in age from 10 months to 86 years with the majority in their 20s and 30s. The dermatomes involved were thoracic (97), trigeminal (50)...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462001915804
更新日期:2000-04-01 00:00:00
abstract::Post-exposure prophylaxis (PEP) is a promising but under-utilized strategy for HIV prevention in high-risk populations. Between March 2010 and June 2011, two community-based clinics in Los Angeles County provided PEP in a pilot program to 267 unique individuals. Courses were primarily dispensed to men who have sex wit...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462417743158
更新日期:2018-05-01 00:00:00
abstract::Little is known about the prevalence of rectal chlamydial infection amongst men who have sex with men (MSM). Previous studies using culture methods reported this to be between 4-6%. The emergence of nucleic acid amplification tests has significantly increased the sensitivity and specificity for chlamydial detection, m...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646204322916588
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abstract::A 48-year-old woman with HIV infection developed Cushingoid features while she was taking ritonavir-boosted darunavir. Cushing's syndrome was confirmed due to the drug interaction between ritonavir and budesonide. Diagnosis of iatrogenic Cushing's syndrome in HIV-positive patients who are on ritonavir-boosted protease...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
abstract::The sexual health services in the Birmingham and Solihull area of the United Kingdom, called Umbrella, has been offering home-based testing for sexually transmitted infections to patients since August 2015. The aim of this service evaluation was to evaluate the uptake, return rate and new diagnosis rates of home-based...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462419900461
更新日期:2020-06-01 00:00:00
abstract::Racial/ethnic minorities in the Southeastern USA are disproportionately affected by HIV, and would benefit from a preventive vaccine. We conducted a cross-sectional survey of 220 community college students in Atlanta to evaluate racial/ethnic differences in knowledge and willingness to participate in HIV vaccine trial...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646206775455667
更新日期:2006-02-01 00:00:00
abstract::Previous research conducted to examine the implications of using audio-computerized (A-CASI) procedures to gather sensitive sexual behaviour data has provided mixed results. The purpose of this study was to assess differences in the disclosure of HIV risk behaviours between subjects interviewed face to face and subjec...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646202320753754
更新日期:2002-11-01 00:00:00
abstract::The aim of this study was to assess the HIV/AIDS-related knowledge among junior high-school students in Shanghai, China, and the factors influencing this knowledge. A cross-sectional study was conducted in 20 middle schools of two districts by a cluster-stratified selection procedure in Shanghai, China. The 2432 sampl...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009065
更新日期:2012-03-01 00:00:00
abstract::The frequency of spontaneous genital arousal (GA) and persistent genital arousal disorder (PGAD) in women is unknown. The aim of this study was to conduct an anonymous survey to assess the frequency and nature of spontaneous GA and PGAD in women attending a walk-in sexual health clinic in London. Female patients compl...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008492
更新日期:2009-08-01 00:00:00
abstract::Using data from eligible participants, we evaluated procedures of a multi-step enrollment process for an mHealth, pilot randomized controlled trial aimed to promote regular HIV testing among at-risk, diverse sexual minority men. Completion rates of eligible participants were calculated and characterized for these enro...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462419831854
更新日期:2019-06-01 00:00:00
abstract::UK post-exposure prophylaxis (PEP) guidelines were updated by the British Association for Sexual Health and HIV (BASHH) in 2011. In 2013, we changed policy to omit day 5 PEP follow-up at 56 Dean Street as it was felt clinically unnecessary. This audit compares our performance against BASHH standards for PEP attenders ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414547090
更新日期:2015-07-01 00:00:00
abstract::Public health authorities have long believed that the preponderance of AIDS cases in Africa are attributable to 'heterosexual transmission'; most people silently assume this rubric to indicate penile-vaginal intercourse only. Recent epidemiologic analyses suggest that the majority of HIV cases in sub-Saharan Africa ma...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/095646203322025704
更新日期:2003-07-01 00:00:00
abstract::A 46-year-old Caucasian heterosexual male was referred to a dedicated AIN clinic from colorectal multidisciplinary meeting (MDM) with AIN 3 following complete resection of anal squamous cell carcinoma (SCC). On further questioning, he revealed that he also had a lesion on his penis. Histology of the penile lesion demo...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011255
更新日期:2012-04-01 00:00:00
abstract::Vertical HIV transmission rates and associated factors among mother-infant pairs cared for at a Brazilian reference centre from 1988 to 1993 (period 1), and from 1996 to 1999 (period 2) were evaluated. A total of 150 and 239 infants born to HIV+ mothers were enrolled at birth during these periods. No zidovudine prophy...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646203322556156
更新日期:2003-12-01 00:00:00
abstract::Bowenoid papulosis is a pre-malignant condition affecting the ano-genital area. Pathogenesis may be associated with high-risk human papillomavirus genotypes, and sexual transmission is the most likely mode of acquisition. Risk of progression to invasive disease is low. Treatment usually involves locally destructive or...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462042563774
更新日期:2004-12-01 00:00:00
abstract::The copper intrauterine contraceptive device (IUCD) is strongly associated with bacterial vaginosis (BV). Hormonal influences may play a role in the control of vaginal flora. It is unclear whether use of the progesterone-incorporated intrauterine system (IUS; Mirena) is associated with abnormal vaginal flora or genita...
journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章
doi:10.1258/ijsa.2008.008391
更新日期:2009-06-01 00:00:00
abstract::We compared HIV-1 RNA levels using the nucleic acid sequenced based amplification (NASBA) test kit in 2 samples taken one year apart from participants infected with env subtype A or D in a population-based cohort in Uganda. Fifty participants were infected with subtype A and 70 with subtype D. HIV-1 RNA levels were si...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462011916758
更新日期:2001-02-01 00:00:00
abstract::Late HIV diagnosis in the UK remains a major cause of morbidity and mortality. In line with British HIV Association recommendations, we implemented routine HIV Screening in Croydon University Hospital Acute Medical Unit in London after an audit in 2011 revealed very high levels of late diagnosis. Our re-audit assessed...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462415597346
更新日期:2016-06-01 00:00:00
abstract::Self sampling of the secretions of the female genital tract for microbiological investigations for Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis was assessed in female attenders of the genitourinary medicine clinic in Coventry and Warwickshire Hospital. The purpose of the study was to evaluate...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249400500411
更新日期:1994-07-01 00:00:00
abstract::Chlamydia trachomatis and Neisseria gonorrhoeae testing guidance recommends extragenital screening with locally validated nucleic acid amplification tests, with anatomical sites tested separately. Evidence supports multi-patient combined aliquot pooled sampling (PS) for population screening; evidence for within-patien...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462417742318
更新日期:2018-05-01 00:00:00
abstract::We sought to analyse reasons for attendance of older women (defined as aged 46 years and over) to genitourinary (GU) medicine services at two UK clinics. We used KC60 coding data to count new episode attendances by year from 1998 to 2008 and to further dissect reason for attendance in 2827 new episodes during 2003-200...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2012.011426
更新日期:2012-08-01 00:00:00
abstract::South Africa has a massive burden of HIV and alcohol disease, and these pandemics are inextricably linked. Much evidence indicates that alcohol independently influences decisions around sex, and undermines skills for condom negotiation and correct use. Thus, not surprisingly, people with problem drinking in Africa hav...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/ijsa.2000.009432
更新日期:2010-01-01 00:00:00
abstract::This paper describes the effect of HIV prevention intervention among female sex workers in Delhi. Over a 2-year period we found a marked increase in condom use with little increase in HIV seroprevalence. The prevalence of HIV infection did not increase during the study period (1 positive among 701 in 1988 vs 1 positiv...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249400500113
更新日期:1994-01-01 00:00:00
abstract::A national Scottish audit of 282 patients with HIV infection attending 11 clinics showed the following levels of performance against quality improvement Scotland Sexual Health Services Standards: syphilis serology was offered in the previous six months to 55% of patients (range: 12-97% of patients in individual clinic...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011379
更新日期:2012-06-01 00:00:00
abstract::People tend to believe that their chance of experiencing undesirable events is lower and their chance of experiencing desirable events is higher than that of the average person like them. Two explanatory models of such 'unrealistic optimism' (UO) have been proposed: While the motivational account holds that UO serves ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646206775809169
更新日期:2006-03-01 00:00:00
abstract::We present a case of acute limbic encephalitis secondary to HIV seroconversion. The patient made a gradual neurological recovery following treatment with antiretroviral therapy, steroids and intravenous immunoglobulin. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.010331
更新日期:2011-04-01 00:00:00
abstract::Our objectives were to determine the prevalence of Neisseria gonorrhoeae and its association with other STD causing organisms. Three hundred and thirty-six consecutive women (female sex workers (FSWs) and married contacts), attending a sexually transmitted disease (STD) clinic in Mumbai, were screened for N. gonorrhoe...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462001914896
更新日期:2000-01-01 00:00:00