Abstract:
:Post-exposure prophylaxis (PEP) is a promising but under-utilized strategy for HIV prevention in high-risk populations. Between March 2010 and June 2011, two community-based clinics in Los Angeles County provided PEP in a pilot program to 267 unique individuals. Courses were primarily dispensed to men who have sex with men (84%) and consisted overwhelmingly of a three-drug antiretroviral therapy regimen containing two nucleoside reverse transcriptase inhibitors and either an integrase inhibitor (raltegravir) or a boosted protease inhibitor (lopinavir/ritonavir). Approximately 64% of all PEP courses were followed for at least 12 weeks, and seven individuals seroconverted. Of the seven seroconversions, six had subsequent re-exposure. The low rate of PEP failure calls for expanded funding for PEP in other jurisdictions.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Beymer MR,Kofron RM,Tseng CH,Bolan RK,Flynn RP,Sayles JM,Perez MJ,Jordan WC,Landovitz RJdoi
10.1177/0956462417743158subject
Has Abstractpub_date
2018-05-01 00:00:00pages
557-562issue
6eissn
0956-4624issn
1758-1052journal_volume
29pub_type
杂志文章abstract::A pre-treatment and a 3-week post-treatment isolate of Neisseria gonorrhoeae from a 13-year-old boy treated with azithromycin in a single 1 g oral dose were characterized microbiologically. Both isolates were of the same serovar/auxotype (1B6/non-requiring) and had similar antibiograms apart from erythromycin and azit...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462971920127
更新日期:1997-05-01 00:00:00
abstract::A 48-year-old woman with HIV infection developed Cushingoid features while she was taking ritonavir-boosted darunavir. Cushing's syndrome was confirmed due to the drug interaction between ritonavir and budesonide. Diagnosis of iatrogenic Cushing's syndrome in HIV-positive patients who are on ritonavir-boosted protease...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.011408
更新日期:2012-07-01 00:00:00
abstract::In the genitourinary medicine clinic setting, the most practical and widely used method of diagnosing Trichomonas vaginalis (TV) is direct microscopy of a wet mount preparation (WMP) of a sample taken from the posterior vaginal fornix. We retrospectively reviewed the potential impact of further limiting WMP to women w...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207781024892
更新日期:2007-06-01 00:00:00
abstract::AIDS-associated Kaposi's sarcoma (KS) is much more frequent in patients acquiring HIV infection via the sexual route. Epidemiological studies have confirmed the likely involvement of a sexually acquired cofactor in the pathogenesis of this form of KS. We have formulated a set of postulates, epidemiological and experim...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249500600609
更新日期:1995-11-01 00:00:00
abstract::Background In Kenya, HIV incidence and prevalence have declined. HIV rates are lower in rural areas than in urban areas. However, HIV infection is reported higher in men in rural areas (4.5%) compared to those in urban areas (3.7%). Objectives This study examined HIV knowledge, feelings, and interactions towards HIV-i...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462416680764
更新日期:2017-08-01 00:00:00
abstract::Novel HIV testing strategies may improve the uptake of the test. The aim of the present study was to investigate the uptake of HIV testing during Birmingham Pride events in 2009 and 2010. The project was a collaboration between Whittall Street Clinic and Healthy Gay Life. This was a nurse-delivered service that was of...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2012.012023
更新日期:2012-12-01 00:00:00
abstract::We aim to monitor the trends of antimicrobial resistance in Neisseria gonorrhoeae and to compare the results of antimicrobial sensitivity by disc diffusion and minimum inhibitory concentration (MIC). Two hundred and eleven confirmed strains of N. gonorrhoeae were subjected to antimicrobial sensitivity testing by disc ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646240001100209
更新日期:2000-02-01 00:00:00
abstract::Women attending a dedicated medical gynaecology and family planning referral clinic for women with HIV were surveyed using a standard questionnaire about their knowledge and attitudes to post-exposure prophylaxis after sexual exposure (PEPSE) and emergency hormonal contraception (EHC). Eighty percent of them had not h...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2007.007159
更新日期:2008-01-01 00:00:00
abstract::Errors and problems associated with male condom use are very prevalent and increase the likelihood of inconsistent and incomplete use, thereby compromising condom effectiveness. The aim of this study was to assess the perceived benefits of a new condom wrapper/integrated applicator designed to reduce barriers to condo...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418803491
更新日期:2019-03-01 00:00:00
abstract::Safer conception strategies to reduce the HIV transmission risk include antiretroviral therapy for HIV-positive partners, pre-exposure prophylaxis for HIV-negative partners, condomless sex limited to fertile periods, and home-based self-insemination. Resistance to taking treatment or cultural concerns may limit uptake...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462415604091
更新日期:2016-10-01 00:00:00
abstract::Sexually transmitted diseases (STDs) continue to be the most common notifiable infectious conditions worldwide. Their unacceptably high incidence is underlined by the recent emergence of a (presently) incurable and lethal STD--human immunodeficiency virus (HIV) infection--which merits its description as a pandemic, an...
journal_title:International journal of STD & AIDS
pub_type: 社论,评审
doi:10.1258/0956462961918419
更新日期:1996-11-01 00:00:00
abstract::This study looks at the sensitivity of microscopy in the diagnosis of Neisseria gonorrhoeae (NG), the effect of microscopy on time to treatment of NG and the added value of microscopy in the management of gonorrhoea. Women diagnosed with NG at an inner city genitourinary (GU) medicine clinic between August 2005 and Ju...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207782193876
更新日期:2007-10-01 00:00:00
abstract::Verbal information-giving is good, but only half of cases were reportedly given written information on chlamydia. Follow-up by 'phoning or texting (43%) was as common as follow-up in clinics (39%). About one-fourth of cases did not have follow up, with no recall for around 60% of these cases. Advice about partner noti...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008138
更新日期:2008-07-01 00:00:00
abstract::Home treatment with podophyllotoxin or imiquimod are commonly prescribed therapies for anogenital warts. It is important to ascertain if patients are locating all lesions for treatment and if they know when they are clear of them. We set out to assess patients' ability to determine the number and location of their gen...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646240401500508
更新日期:2004-05-01 00:00:00
abstract::OptionE incorporates nurse-led HIV clinics, review of blood results by doctors, patient contact by email and the option of home delivery of medication. Patient questionnaires showed increased satisfaction associated with fewer, shorter clinic visits. A retrospective case note review suggested clinical outcomes are as ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2007.007263
更新日期:2008-05-01 00:00:00
abstract::The aims of this study were to understand the prevalence and correlates of syphilis infection among HIV-positive men who have sex with men (MSM) in Shanghai, China. A total of 200 HIV-positive MSM participants were recruited using "snowball" sampling. Participants were tested for syphilis and completed a one-time ques...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462413512804
更新日期:2014-05-01 00:00:00
abstract::The 'dynias' are a group of chronic focal pain syndromes with a predilection for orocervical or urogenital regions. Only exceptionally do they involve both sites in the same patient. Here, we report a case of simultaneous occurrence of dysaesthetic peno/scroto dynia and stomatodynia. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646205774988154
更新日期:2005-12-01 00:00:00
abstract::We present a case of acute limbic encephalitis secondary to HIV seroconversion. The patient made a gradual neurological recovery following treatment with antiretroviral therapy, steroids and intravenous immunoglobulin. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.010331
更新日期:2011-04-01 00:00:00
abstract::The primary aim of the current study was to test the effect of the presentation design of a test alert system on healthcare workers' (HCWs') decision-making regarding blood-borne virus (BBV) testing. The secondary aim was to determine HCWs' acceptance of the system. An online survey used a within-subjects research des...
journal_title:International journal of STD & AIDS
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abstract::Studies in various regions of the world have shown that women infected with HIV-1 are at increased risk for cervical human papillomavirus (HPV) infection as well as for cervical cancer precursor lesions. HIV infection and cervical cancer are both widespread in West Africa, but little is known about the relationship be...
journal_title:International journal of STD & AIDS
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doi:10.1177/095646249400500307
更新日期:1994-05-01 00:00:00
abstract::Fusarium infections are very rare in HIV-infected patients, even in patients in advanced stages of immunosuppression. All the reported cases in the literature are of disseminated infection, and with poor outcomes despite prompt and appropriate treatment. To the best of our knowledge, this is the first report of a loca...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418761259
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abstract::To elicit the needs of asylum seekers attending the Royal Hallamshire genitourinary medicine clinic for the first time in 2002 and whether these differed from British patients, a search of patient records for 2002 identified 43 asylum seekers (21 female, 22 male) who were paired with 43 British patients matched by age...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
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更新日期:2004-08-01 00:00:00
abstract::The expense in time and money limit the use of randomized clinical trials (RCT) and cohort studies for evaluating long-term AIDS treatment outcomes. We conducted a case-control study to characterize predictors of AIDS mortality after the availability of highly active antiretroviral therapy (HAART) in San Francisco, in...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008381
更新日期:2009-05-01 00:00:00
abstract::Antioxidants significantly inhibit oxidative processes. The study seeks to determine the activity of endogenous antioxidants and CD4+ T-cell expression in HIV-serodiscordant-heterosexual partners. The case-control study had the following groups; A- (13 serodiscordant-seronegative subjects), B- (13 serodiscordant-serop...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008031
更新日期:2008-08-01 00:00:00
abstract::We evaluated Cobas Amplicor, a highly automated polymerase chain reaction (PCR) system, to test first-void urine (FVU) and urethral swab specimens for Chlamydia trachomatis and Neisseria gonorrhoeae in men attending a sexually transmitted infection (STI) clinic. Results were compared against an in-house radioimmune do...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462981921594
更新日期:1998-01-01 00:00:00
abstract::This study investigated the epidemiological and clinical characteristics of hepatitis B virus (HBV) in HIV-infected adults at the time of antiretroviral therapy (ART) initiation in Guangdong province, China. A total of 2793 HIV-infected adults were enrolled between January 2004 and September 2011. Demographic data and...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462415600570
更新日期:2016-09-01 00:00:00
abstract::Psoriasis is a prevalent systemic immune-mediated disease with cutaneous manifestations. In HIV-infected patients, psoriasis may have a higher incidence, present atypical and more exuberant clinical features, and is frequently recalcitrant to treatment. Despite this aggravated severity, treatment options for psoriasis...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
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更新日期:2019-05-01 00:00:00
abstract::We assessed if gender and ethnicity were associated with differences in the number of patients satisfactorily treated and number of partners successfully treated for genital gonococcal infection by reviewing 400 cases. There were no differences in the rates of satisfactory treatment of gonorrhoea between men and women...
journal_title:International journal of STD & AIDS
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更新日期:2005-04-01 00:00:00
abstract::Cervical cancer is the leading incident cancer and the main cause of cancer-related mortality among women in sub-Saharan Africa. Furthermore, HIV-infected women are at a higher risk of developing cervical cancer than HIV-negative women. The purpose of this study was to distinguish differences in characteristics of HIV...
journal_title:International journal of STD & AIDS
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abstract::Given the disproportionate HIV burden faced by female sex workers FSWs and limited data regarding their engagement in the HIV cascade of care in conflict-affected settings, we characterized the cascade of care and examined associations with new HIV diagnoses and antiretroviral therapy (ART) use in a community-based co...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00