Results from the post-exposure prophylaxis pilot program (P-QUAD) demonstration project in Los Angeles County.

Abstract:

:Post-exposure prophylaxis (PEP) is a promising but under-utilized strategy for HIV prevention in high-risk populations. Between March 2010 and June 2011, two community-based clinics in Los Angeles County provided PEP in a pilot program to 267 unique individuals. Courses were primarily dispensed to men who have sex with men (84%) and consisted overwhelmingly of a three-drug antiretroviral therapy regimen containing two nucleoside reverse transcriptase inhibitors and either an integrase inhibitor (raltegravir) or a boosted protease inhibitor (lopinavir/ritonavir). Approximately 64% of all PEP courses were followed for at least 12 weeks, and seven individuals seroconverted. Of the seven seroconversions, six had subsequent re-exposure. The low rate of PEP failure calls for expanded funding for PEP in other jurisdictions.

journal_name

Int J STD AIDS

authors

Beymer MR,Kofron RM,Tseng CH,Bolan RK,Flynn RP,Sayles JM,Perez MJ,Jordan WC,Landovitz RJ

doi

10.1177/0956462417743158

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

557-562

issue

6

eissn

0956-4624

issn

1758-1052

journal_volume

29

pub_type

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